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Citation: Critical Care 2020 24:9
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Vitamin C: a misunderstood ally?
Citation: Critical Care 2020 24:8 -
ECPR for out-of-hospital cardiac arrest: more evidence is needed
Citation: Critical Care 2020 24:7 -
High Quality Targeted Temperature Management (TTM) After Cardiac Arrest
Targeted temperature management (TTM) is a complex intervention used with the aim of minimizing post-anoxic injury and improving neurological outcome after cardiac arrest. There is large variability in the dev...
Citation: Critical Care 2020 24:6 -
Brainstem dysfunction in critically ill patients
The brainstem conveys sensory and motor inputs between the spinal cord and the brain, and contains nuclei of the cranial nerves. It controls the sleep-wake cycle and vital functions via the ascending reticular...
Citation: Critical Care 2020 24:5 -
Correction to: The association between premorbid beta blocker exposure and mortality in sepsis—a systematic review
In the publication of this article [1], there was an error in the cited reference 23 [2] within the Family Name. This has now been updated in the original article.
Citation: Critical Care 2020 24:3 -
Acute kidney injury in burn patients admitted to the intensive care unit: a systematic review and meta-analysis
Acute kidney injury (AKI) is a common complication in burn patients admitted to the intensive care unit (ICU) associated with increased morbidity and mortality. Our primary aim was to review incidence, risk fa...
Citation: Critical Care 2020 24:2 -
0.9% saline versus Plasma-Lyte as initial fluid in children with diabetic ketoacidosis (SPinK trial): a double-blind randomized controlled trial
Acute kidney injury (AKI) is an important complication encountered during the course of diabetic ketoacidosis (DKA). Plasma-Lyte with lower chloride concentration than saline has been shown to be associated wi...
Citation: Critical Care 2020 24:1 -
Enhancer polymorphism rs10865710 associated with traumatic sepsis is a regulator of PPARG gene expression
Peroxisome proliferator-activated receptor gamma (PPARγ) is a major regulator in sepsis. Our previous study identified the enhancer polymorphism rs10865710C/G to be associated with susceptibility to sepsis in ...
Citation: Critical Care 2019 23:430 -
Defining benefit threshold for extracorporeal membrane oxygenation in children with sepsis—a binational multicenter cohort study
The surviving sepsis campaign recommends consideration for extracorporeal membrane oxygenation (ECMO) in refractory septic shock. We aimed to define the benefit threshold of ECMO in pediatric septic shock.
Citation: Critical Care 2019 23:429 -
Prophylactic use of levosimendan in pediatric patients undergoing cardiac surgery: a prospective randomized controlled trial
The administration of levosimendan prophylactically to patients undergoing cardiac surgery remains a controversial practice, and few studies have specifically assessed the value of this approach in pediatric p...
Citation: Critical Care 2019 23:428 -
Lasting s-ketamine block of spreading depolarizations in subarachnoid hemorrhage: a retrospective cohort study
Spreading depolarizations (SD) are characterized by breakdown of transmembrane ion gradients and excitotoxicity. Experimentally, N-methyl-d-aspartate receptor (NMDAR) antagonists block a majority of SDs. In many ...
Citation: Critical Care 2019 23:427 -
Non-pulsatile blood flow is associated with enhanced cerebrovascular carbon dioxide reactivity and an attenuated relationship between cerebral blood flow and regional brain oxygenation
Systemic blood flow in patients on extracorporeal assist devices is frequently not or only minimally pulsatile. Loss of pulsatile brain perfusion, however, has been implicated in neurological complications. Fu...
Citation: Critical Care 2019 23:426 -
Adjuvant vitamin C for sepsis: mono or triple?
Citation: Critical Care 2019 23:425 -
Driving pressure is not associated with mortality in mechanically ventilated patients without ARDS
In patients with acute respiratory distress syndrome (ARDS), low tidal volume ventilation has been associated with reduced mortality. Driving pressure (tidal volume normalized to respiratory system compliance)...
Citation: Critical Care 2019 23:424 -
How much centralization of critical care services in the era of telemedicine?
Citation: Critical Care 2019 23:423 -
Dynamic hyperinflation and intrinsic PEEP in ARDS patients: who, when, and how needs more focus?
Citation: Critical Care 2019 23:422 -
Association between hydroxocobalamin administration and acute kidney injury after smoke inhalation: a multicenter retrospective study
The use of hydroxocobalamin has long been advocated for treating suspected cyanide poisoning after smoke inhalation. Intravenous hydroxocobalamin has however been shown to cause oxalate nephropathy in a single...
Citation: Critical Care 2019 23:421 -
How I use Transcranial Doppler
Citation: Critical Care 2019 23:420 -
Outcomes of hospitalized hematologic oncology patients receiving rapid response system activation for acute deterioration: another time, another way
Citation: Critical Care 2019 23:419 -
“Better be awake”—a role for awake extracorporeal membrane oxygenation in acute respiratory distress syndrome due to Pneumocystis pneumonia
Citation: Critical Care 2019 23:418 -
Early identification of patients at high risk of group A streptococcus-associated necrotizing skin and soft tissue infections: a retrospective cohort study
Citation: Critical Care 2019 23:417 -
Global warming “heating up” the ICU through Candida auris infections: the climate changes theory
Citation: Critical Care 2019 23:416 -
Influence of dyskalemia at admission and early dyskalemia correction on survival and cardiac events of critically ill patients
Our objectives were (1) to characterize the distribution of serum potassium levels at ICU admission, (2) to examine the relationship between dyskalemia at ICU admission and occurrence of cardiac events, and (3...
Citation: Critical Care 2019 23:415 -
A longitudinal study highlights shared aspects of the transcriptomic response to cardiogenic and septic shock
Septic shock (SS) and cardiogenic shock (CS) are two types of circulatory shock with a different etiology. Several studies have described the molecular alterations in SS patients, whereas the molecular factors...
Citation: Critical Care 2019 23:414 -
Mechanism of arrhythmias during the infusion of Ringer’s acetate and Ringer’s lactate solutions during cardiac surgery: new insights
Citation: Critical Care 2019 23:413 -
How I set up positive end-expiratory pressure: evidence- and physiology-based!
Citation: Critical Care 2019 23:412 -
The impact of intensive care unit diaries on patients’ and relatives’ outcomes: a systematic review and meta-analysis
Memory gaps in intensive care unit (ICU) survivors are associated with psychiatric disorders. The ICU diaries improve the patient’s factual memory of the ICU, but it is not clear if they reduce the incidence o...
Citation: Critical Care 2019 23:411 -
Development of a biomarker mortality risk model in acute respiratory distress syndrome
There is a compelling unmet medical need for biomarker-based models to risk-stratify patients with acute respiratory distress syndrome. Effective stratification would optimize participant selection for clinica...
Citation: Critical Care 2019 23:410 -
Improving identification of pulmonary embolism-related out-of-hospital cardiac arrest to optimize thrombolytic therapy during resuscitation
Citation: Critical Care 2019 23:409 -
Predicting the clinical trajectory in critically ill patients with sepsis: a cohort study
To develop a mathematical model to estimate daily evolution of disease severity using routinely available parameters in patients admitted to the intensive care unit (ICU).
Citation: Critical Care 2019 23:408 -
Effect of high-dose vitamin C therapy on severe burn patients: a nationwide cohort study
Vitamin C is a well-documented antioxidant that reduces oxidative stress and fluid infusion in high doses; however, the association between high-dose vitamin C and reduced mortality remains unclear. This study...
Citation: Critical Care 2019 23:407 -
Optimizing ceftolozane-tazobactam dosage during continuous renal replacement therapy: additional insights
Citation: Critical Care 2019 23:406 -
Biomarker suPAR seems a good prognostic factor for community-acquired pneumonia but less prominent for septic shock
Citation: Critical Care 2019 23:405 -
High PEEP may have reduced injurious transpulmonary pressure swings in the ROSE trial
Citation: Critical Care 2019 23:404 -
Dysbiosis of the microbiota in neurocritically ill patients associated with coma and death: ammonia as a potential missing link
Citation: Critical Care 2019 23:403 -
The effect of dexmedetomidine and clonidine on the inflammatory response in critical illness: a systematic review of animal and human studies
The α2 agonists, dexmedetomidine and clonidine, are used as sedative drugs during critical illness. These drugs may have anti-inflammatory effects, which might be relevant to critical illness, but a systematic...
Citation: Critical Care 2019 23:402 -
Predicting outcome in patients with moderate to severe traumatic brain injury using electroencephalography
Better outcome prediction could assist in reliable quantification and classification of traumatic brain injury (TBI) severity to support clinical decision-making. We developed a multifactorial model combining ...
Citation: Critical Care 2019 23:401 -
Plasma sTNFR1 and IL8 for prognostic enrichment in sepsis trials: a prospective cohort study
Enrichment strategies improve therapeutic targeting and trial efficiency, but enrichment factors for sepsis trials are lacking. We determined whether concentrations of soluble tumor necrosis factor receptor-1 ...
Citation: Critical Care 2019 23:400 -
Initial therapy affects duration of diarrhoea in critically ill patients with Clostridioides difficile infection (CDI)
Critically ill patients in the intensive care unit (ICU) are at high risk for developing Clostridioides difficile infections (CDI). Risk factors predicting their mortality or standardized treatment recommendation...
Citation: Critical Care 2019 23:399 -
Risk factors for the development of acute respiratory distress syndrome in mechanically ventilated adults in Peru: a multicenter observational study
Clinical and epidemiological differences between acute respiratory distress syndrome (ARDS) that presents at the initiation of mechanical ventilation [MV] (ARDS at MV onset) and that which develops during the ...
Citation: Critical Care 2019 23:398 -
Interleukin-26 is a promising biomarker of sepsis but is it always reliable?
Citation: Critical Care 2019 23:397 -
A meta-analysis of the effects of therapeutic hypothermia in adult patients with traumatic brain injury
Therapeutic hypothermia management remains controversial in patients with traumatic brain injury. We conducted a meta-analysis to evaluate the risks and benefits of therapeutic hypothermia management in patien...
Citation: Critical Care 2019 23:396 -
Expiratory flow limitation in intensive care: prevalence and risk factors
Expiratory flow limitation (EFL) is characterised by a markedly reduced expiratory flow insensitive to the expiratory driving pressure. The presence of EFL can influence the respiratory and cardiovascular func...
Citation: Critical Care 2019 23:395 -
Cortisol total/CRP ratio for the prediction of hospital-acquired pneumonia and initiation of corticosteroid therapy in traumatic brain-injured patients
To propose a combination of blood biomarkers for the prediction of hospital-acquired pneumonia (HAP) and for the selection of traumatic brain-injured (TBI) patients eligible for corticosteroid therapy for the ...
Citation: Critical Care 2019 23:394 -
Epidemiology and prognosis of anti-infective therapy in the ICU setting during acute pancreatitis: a cohort study
Recent international guidelines for acute pancreatitis (AP) recommend limiting anti-infective therapy (AIT) to cases of suspected necrotizing AP or nosocomial extrapancreatic infection. Limited data are availa...
Citation: Critical Care 2019 23:393 -
Cumulative fluid accumulation is associated with the development of acute kidney injury and non-recovery of renal function: a retrospective analysis
Acute kidney injury (AKI) is common in patients in the intensive care unit (ICU) and may be present on admission or develop during ICU stay. Our objectives were (a) to identify factors independently associated...
Citation: Critical Care 2019 23:392 -
Temporal trends in the use of targeted temperature management after cardiac arrest and association with outcome: insights from the Paris Sudden Death Expertise Centre
Recent doubts regarding the efficacy may have resulted in a loss of interest for targeted temperature management (TTM) in comatose cardiac arrest (CA) patients, with uncertain consequences on outcome. We aimed...
Citation: Critical Care 2019 23:391 -
The prognostic value of serum procalcitonin measurements in critically injured patients: a systematic review
Major trauma is associated with high incidence of septic complications and multiple organ dysfunction (MOD), which markedly influence the outcome of injured patients. Early identification of patients at risk o...
Citation: Critical Care 2019 23:390 -
Ultrasound-based clinical profiles for predicting the risk of intradialytic hypotension in critically ill patients on intermittent dialysis: a prospective observational study
Intradialytic hypotension, a complication of intermittent hemodialysis, decreases the efficacy of dialysis and increases long-term mortality. This study was aimed to determine whether different predialysis ult...
Citation: Critical Care 2019 23:389
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- ISSN: 1364-8535 (electronic)