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In a centrally catheterized, fluid-resuscitated, antibiotic-treated mouse model of prolonged sepsis, we compared markers of lipolysis and fatty...n = 117). Next, we compared markers of muscle wasting and weakness...
This article is part of a Supplement: Volume 20 Supplement 3
Sepsis-associated encephalopathy (SAE) is a state ... infection. We propose that systemic inflammation during sepsis causes increased adhesion of leukocytes to the ... to measure inflammatory analytes in plasma o...
This article is part of a Supplement: Volume 15 Supplement 3
This article is part of a Supplement: Volume 13 Supplement 4
This article is part of a Supplement: Volume 27 Supplement 1
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This article is part of a Supplement: Volume 8 Supplement 1
This article is part of a Supplement: Volume 15 Supplement 3
This article is part of a Supplement: Volume 15 Supplement 3
This article is part of a Supplement: Volume 14 Supplement 2
This article is part of a Supplement: Volume 13 Supplement 4
This article is part of a Supplement: Volume 8 Supplement 1
This article is part of a Supplement: Volume 15 Supplement 3
This article is part of a Supplement: Volume 14 Supplement 2
This article is part of a Supplement: Volume 14 Supplement 2
We hypothesized that the cardiovascular responses to Surviving Sepsis Guidelines (SSG)-defined resuscitation are predictable...
Sepsis refers to severe systemic inflammation leading to ... However, its role in ALI caused by sepsis remains unexplored. We hypothesize that treatment with ... -OPN Ab) protects mice against ALI during sepsis.
Kallistatin levels in the circulation are reduced in patients with sepsis and liver disease. Transgenic mice expressing kallistatin ... and organ damage in mouse models of established sepsis.
Sepsis is one of the main reasons for ... . We characterized children admitted with community-acquired sepsis to European PICUs and studied risk factors...
The Editorial to this article has been published in Critical Care 2018 22:224
Obesity is associated with the development of acute respiratory distress syndrome (ARDS) in at-risk patients. Low plasma levels of adiponectin, a circulating hormone-like molecule, have been implicated as a possi...
Diabetes is associated with chronic inflammation and activation of the vascular endothelium and the coagulation system, which in a more acute manner are also observed in sepsis. Insulin and metformin exert immune...
The Editorial to this article has been published in Critical Care 2016 20:321
Hypothermia is associated with adverse outcome in patients with sepsis. The objective of this study was to ... the host immune response in patients with hypothermic sepsis in order to determine if an excessive .....
The Letter to this article has been published in Critical Care 2017 21:8
Neutrophil gelatinase-associated lipocalin (NGAL) has been identified as an early biomarker for prediction of acute kidney injury (AKI). However, the utility of NGAL to predict the occurrence of AKI in septic pat...
The Commentary to this article has been published in Critical Care 2016 20:201
Claims-based analyses report that the incidence of sepsis-associated organ dysfunction is increasing. We examined ... whether this is biasing estimates of rising severe sepsis incidence and severity.
The Letter to this article has been published in Critical Care 2016 20:9
Early administration of antibiotics for sepsis, and of fluid boluses and vasoactive agents...
The Commentary to this article has been published in Critical Care 2015 19:447
Prior to 2001 there was no standard for early management of severe sepsis and septic shock in the emergency department. ... largely incorporated into the first 6 hours of sepsis management (resuscitation bundle) ...
Over a 3-year period, we prospectively enrolled consecutive adults with sepsis and categorized patients as (1) being...
The Correction to this article has been published in Critical Care 2020 24:41
We performed a randomized, double-blind, pilot trial at a single, tertiary care hospital. Adults (age ≥18 years) with severe sepsis or septic shock between November 2012 and...c levels, and 4) clinical outcomes. ...
The interaction between hyperaldosteronism and immune dysfunction has been reported and glucocorticoid co-secretion is frequently found in primary aldosteronism (PA). The aforementioned conditions raise the possi...
The endothelial glycocalyx (eGC) covers the luminal surface of the vascular endothelium and plays an important protective role in systemic inflammatory states and particularly in sepsis. Its breakdown leads to ca...
Acute respiratory distress syndrome (ARDS) and hospital-acquired pneumonia (HAP) are major problems of public health in intensive care units (ICUs), occurring in 15% of critically ill patients. Among the factors ...
The Letter to this article has been published in Critical Care 2019 23:184
Peroxisome proliferator-activated receptor gamma (PPARγ) is a major regulator in sepsis. Our previous study identified the enhancer polymorphism ... rs10865710C/G to be associated with susceptibility to sepsis in...
Fractalkine is a chemokine implicated as a mediator in a variety of inflammatory conditions. Knowledge of fractalkine release in patients presenting with infection to the Intensive Care Unit (ICU) is highly limit...
Most patients with sepsis and acute lung injury require mechanical ventilation ... pulmonary fibrosis in a clinically relevant model of sepsis-induced lung injury.
Fluid challenge (FC) is one of the most common practices in Intensive Care Unit (ICU). The present study aimed to evaluate whether echocardiographic assessment of the response to FC at the end of the infusion ...
Inflammatory and protein mediators (cytokine, chemokine, acute phase proteins) play an important, but still not completely understood, role in the morbidity and mortality of intra-abdominal sepsis/injury. We ther...
The surviving sepsis campaign recommends consideration for extracorporeal membrane oxygenation...
The Letter to this article has been published in Critical Care 2020 24:88
High tidal volume ventilation of healthy lungs or exacerbation of existing acute lung injury (ALI) by more moderate mechanical ventilation (MTV) produces ventilator-induced lung injury. It is less clear whether e...
We prospectively performed transthoracic echocardiography in patients with severe sepsis or septic shock and measured (1)...2. We excluded patients for whom image quality was inadequate or for whom ScvO2 values w...
Secondary analysis of the prospectively collected patient-level dataset from a cluster randomized quality improvement trial was performed. The trial included sepsis patients with organ dysfunction treated in the....
In early sepsis stages, optimal treatment could contribute to prevention of progression to severe sepsis. Therefore, we investigated if there was ... department (ED) patients with mild to severe sepsis stages.
The usefulness of the quick Sequential (Sepsis-related) Organ Failure Assessment (qSOFA) score...
Dysbiosis of intestinal microbiota likely plays an important role in the development of gut-derived infections, making it a potential therapeutic target against sepsis. However, experience with fecal microbiota t...
Sphingosine-1-phosphate (S1P) is a signaling lipid that regulates pathophysiological processes involved in sepsis progression, including endothelial permeability, cytokine release, ... are associated with disease...
Randomised controlled trials (RCTs) enrolling patients with sepsis or acute respiratory distress syndrome (ARDS) ... HTE). We assessed whether HTE in two sepsis and one ARDS RCTs could explain indeterminate...
Left ventricular diastolic dysfunction is common in patients with severe sepsis or septic shock, but the best approach...
Sepsis-induced myocardial dysfunction is associated with poor ... the prognostic value of GLS in patients with sepsis and/or septic shock.
The Letter to this article has been published in Critical Care 2019 23:38
Managing blood pressure in patients with acute kidney injury (AKI) could effectively prevent severe-stage progression. However, the effect of hypotension duration in the early phase of AKI remains poorly understo...
Early appropriate antibiotic treatment is essential in sepsis. We aimed to evaluate the impact of...
Critical Care