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Since the Sepsis-3 criteria, change in Sequential Organ Failure ... ) score has become a key component of sepsis identification. Thus, it could be argued...SOFA) may reflect sepsis response and could be used as m...
Severe systemic inflammatory response to infection results in severe sepsis and septic shock, which are the leading ... cofactor for optimal activity. Patients with severe sepsis present with hypovitaminosis C, a...
Septic shock is a major healthcare problem with a high mortality rate that might be caused by immunosuppression. Programmed cell death receptor-1 (PD-1) and programmed cell death receptor ligand-1 (PD-L1), which ...
The Commentary to this article has been published in Critical Care 2016 20:186
Recent studies have reported that preadmission metformin users had lower mortality than non-metformin users in patients with sepsis and diabetes mellitus; however, these results...
From the 10,069 adult intensive care unit (ICU) patients in the Intensive Care Over Nations database, all those with creatinine and urine output data were included in this substudy. Patients who developed sepsis ...
The histopathology of sepsis-associated acute kidney injury (AKI) in ... (ATN) is not the only driver of sepsis-AKI. The focus of this study was ... to identify additional candidate processes that may drive sepsis
A clinical suspicion of infection is mandatory for diagnosing sepsis in patients with a systemic inflammatory response ... of infection in patients who were treated for sepsis upon admission to the ICU, and quant...
Systemic inflammatory response syndrome (SIRS) and sepsis are now frequently identified by observations of...
The Editorial to this article has been published in Critical Care 2017 21:10
Stress hyperglycaemia (SHG) is a common complication in sepsis associated with poor outcome. Chemerin is an ... are linked to glucose metabolism and prognosis in sepsis.
The first steps in goal-directed therapy for sepsis are early diagnosis followed by appropriate triage. ... to determine biomarker phenotypes that differentiate children with sepsis who require intensive care fro...
In addition to acute hospital mortality, sepsis is associated with higher risk of death ... of epidemiological evidence supporting a causal link between sepsis and mortality after hospital discharge by systematic...
Data that indicate vitamin A status in critically ill children with sepsis are sparse. The association between serum vitamin A levels and the clinical outcomes of sepsis has not been well assessed. The aim ... vi...
Dyslipidemia is a risk factor for cardiovascular disease, with elevated low-density lipoprotein cholesterol (LDL-C) and decreased high-density lipoprotein cholesterol (HDL-C) recognized as risk factors for acute ...
Sepsis remains one of the most important causes ... approximately 30–50% of cases of suspected sepsis, no pathogen is isolated, disabling the ... patient outcomes between culture-positive and culture-negative sepsis
The Letter to this article has been published in Critical Care 2019 23:332
Nitric oxide (NO) regulates processes involved in sepsis progression, including vascular function and pathogen defense ... surrogate markers for NO bioavailability are associated with sepsis severity.
Sepsis is a leading cause of death and ... incidence, clinical characteristics, and evolving management of sepsis is important. Thus, this study aimed ... management, and outcomes of patients with severe sepsis i...
Sepsis is the leading cause of death among ... agent is currently approved for the treatment of sepsis.
Brain homeostasis deteriorates in sepsis, giving rise to a mostly reversible sepsis-associated encephalopathy (SAE). Some survivors experience ... this study, we investigated neuroaxonal pathology in sepsis.
During sepsis, the glycocalyx is degraded via inflammatory mechanisms ... with organ dysfunction, severity, and mortality in sepsis.
The Tie2/angiopoietin (Tie2/Ang) and vascular endothelial growth factor receptor-ligand systems (VEGFR/VEGF) are recognized to play important roles in the regulation of microvascular endothelial function. Downreg...
Vascular endothelial cadherin (VE-cadherin) is a membrane protein that is the major component of adherens junctions between endothelial cells. It is crucial for regulating vascular integrity, endothelial permeabi...
The Letter to this article has been published in Critical Care 2019 23:167
The Letter to this article has been published in Critical Care 2019 23:57
This article is one of ten reviews selected from the Annual Update in Intensive Care and Emergency medicine 2016. Other selected articles can be found online at
Sepsis is an established global health priority with ... sought to characterize trends in the awareness of sepsis by examining temporal, geographic, and other changes in search engine utilization for sepsis infor...
Two recent, independent, studies conducted novel metabolomics analyses relevant to human sepsis progression; one was a human model of ... and the other was community acquired pneumonia and sepsis outcome diagnost...
Aetiology and outcomes of sepsis in sub-Saharan Africa (sSA) are...
Published data revealed that host genetic variants have a substantial influence on sepsis susceptibility. However, the results have been ... effects of these variants on the risk of sepsis.
Sepsis is a major contributor to the global burden of disease. The majority of sepsis cases and deaths are estimated to occur ... . Barriers to reducing the global burden of sepsis include difficulty quantifying ...
Public hospitals in emerging countries pose a challenge to quality improvement initiatives in sepsis. Our objective was to evaluate the results of a quality improvement initiative in sepsis in a network of public...
Time to antibiotic administration is a key element in sepsis care; however, it is difficult to implement sepsis care bundles. Additionally, sepsis is different from other emergent conditions including ... antibio...
The Letter to this article has been published in Critical Care 2020 24:17
Administrative health data have been used to study sepsis in large population-based studies. The validity ... to assess the validity of case definitions of sepsis used with administrative data.
New-onset atrial fibrillation (NeOAF) is a common type of tachyarrhythmia in critically ill patients and is associated with increased mortality in patients with sepsis. However, the prognostic impact of restored....
Our aim in the present study was to assess the mortality impact of hospital-acquired post-operative sepsis up to 1 year after hospital discharge...
Severe sepsis is a challenge for healthcare systems, and ... strategy should be used to reliably identify severe sepsis. This study assesses the use of explicit codes to define severe sepsis and the impacts of th...
The Editorial to this article has been published in Critical Care 2016 20:396
Sepsis results from a dysregulated host response to ... expression of cytokines involved in the pathophysiology of sepsis. However, the outcomes of patients with autoimmune disease who develop sepsis have not bee...
Long-lasting impairment of the immune system is believed to be the underlying reason for delayed deaths after surviving sepsis. We tested the hypothesis of persisting changes to the immune system in survivors of
At least 25 % of adults admitted to intensive care units (ICU) in the United States have an overweight, obese or morbidly obese body mass index (BMI). The effect of BMI on adjusted mortality in adults requiring I...
Sepsis coincides with altered gene expression in different...
Sepsis is an increasingly significant challenge throughout the ... . Central to the host immunologic response to sepsis is the increase in circulating myeloid-derived ... how the suppressive phenotype of MDSCs ev...
Consensus criteria for pediatric severe sepsis have standardized enrollment for research studies. However ... by consensus criteria reflect physician diagnosis of severe sepsis, which underlies external validity ...
This study was performed to assess the early diagnostic, risk stratification, and prognostic value of the angiopoietin-2/angiopoietin-1 ratio (Ang-2/Ang-1) and angiopoietin-1/tyrosine kinase with immunoglobulin-l...
The intestinal epithelium compartmentalizes the sterile bloodstream and the commensal bacteria in the gut. Accumulating evidence suggests that this barrier is impaired in sepsis, aggravating systemic inflammation...
Neutrophil gelatinase-associated lipocalin (NGAL), cystatin C (Cys-C), and soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) are novel diagnostic biomarkers of acute kidney injury (AKI). We aimed...
Despite many animal studies and clinical trials, mortality in sepsis remains high. This may be due to the fact that most experimental studies of sepsis employ young animals, whereas the majority of ... of the pre...
The Editorial to this article has been published in Critical Care 2017 21:286
Exosomes isolated from plasma of patients with sepsis may induce vascular apoptosis and myocardial dysfunction ... to cellular communication, their molecular cargo during sepsis is relatively unknown. In this stu...
This article is part of a Supplement: Volume 22 Supplement 1
This article is part of a Supplement: Volume 21 Supplement 1
Sepsis is a major public health problem. Prior ... using hospital-based data describe higher rates of sepsis among black than whites participants. We sought to characterize racial differences in incident sepsis i...
The effect of premorbid β-blocker exposure on clinical outcomes in patients with sepsis is not well characterized. We aimed to ... between premorbid β-blocker exposure and mortality in sepsis.
The Correction to this article has been published in Critical Care 2020 24:3
P001 - Sepsis impairs the capillary response within hypoxic capillaries...
This article is part of a Supplement: Volume 20 Supplement 2
The prevalence and mortality of sepsis are largely unknown in Turkey, a country ... the prevalence, causative microorganisms, and outcome of sepsis in intensive care units (ICUs) in...
Critical Care