Articles
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Citation: Critical Care 2002 6:468
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Influence of flow on mucosal-to-arterial carbon dioxide difference
Intramucosal-to-arterial carbon dioxide difference (the so-called PCO2 [partial carbon dioxide tension] gap) remains largely unaltered during decreased oxygen delivery, if the latter is reduced as flow is maintai...
Citation: Critical Care 2002 6:463 -
The International Sepsis Forum's controversies in sepsis: my initial vasopressor agent in septic shock is norepinephrine rather than dopamine
Vasopressor agents are often used in patients with septic shock when aggressive fluid resuscitation fails to correct hypotension. Dopamine and norepinephrine are two such vasopressor agents. In the past, fear ...
Citation: Critical Care 2002 7:3 -
The limitations of observational studies on the treatment of severe sepsis – authors' response
Citation: Critical Care 2002 6:548 -
The effects of IgM-enriched immunoglobulin preparations in patients with severe sepsis: another point of view – authors' response
Citation: Critical Care 2002 6:545 -
Lung recruitment manoeuvres are effective in regaining lung volume and oxygenation after open endotracheal suctioning in acute respiratory distress syndrome
Lung collapse is a contributory factor in the hypoxaemia that is observed after open endotracheal suctioning (ETS) in patients with acute lung injury and acute respiratory distress syndrome. Lung recruitment (...
Citation: Critical Care 2002 7:55 -
Usefulness of procalcitonin for diagnosis of sepsis in the intensive care unit
The diagnosis of sepsis in critically ill patients is challenging because traditional markers of infection are often misleading. The present study was conducted to determine the procalcitonin level at early di...
Citation: Critical Care 2002 7:85 -
The limitations of observational studies on the treatment of severe sepsis
Observational studies usually agree with randomised, controlled trials. It is a logical fallacy, however, to suggest that agreement in one direction implies prediction in the other direction. Observational stu...
Citation: Critical Care 2002 6:546 -
The effects of IgM-enriched immunoglobulin preparations in patients with severe sepsis: another point of view
Citation: Critical Care 2002 6:543 -
Isabel
Citation: Critical Care 2002 7:99 -
Science review: Mechanisms of ventilator-induced injury
Acute respiratory distress syndrome (ARDS) and acute lung injury are among the most frequent reasons for intensive care unit admission, accounting for approximately one-third of admissions. Mortality from ARDS...
Citation: Critical Care 2002 7:233 -
Science review: Redox and oxygen-sensitive transcription factors in the regulation of oxidant-mediated lung injury: role for nuclear factor-κB
The primary role of pulmonary airways is to conduct air to the alveolar epithelium, where gas exchange can efficiently occur. Injuries to airways resulting from inhalation of airborne pollutants and parenteral...
Citation: Critical Care 2002 6:481 -
Science review: Redox and oxygen-sensitive transcription factors in the regulation of oxidant-mediated lung injury: role for hypoxia-inducible factor-1α
A progressive rise of oxidative stress due to altered reduction–oxidation (redox) homeostasis appears to be one of the hallmarks of the processes that regulate gene transcription in physiology and pathophysiol...
Citation: Critical Care 2002 7:47 -
Web reports: critically appraising online resources
The Internet is an invaluable resource for critical care clinicians. However, the search for useful Internet resources can be frustrating and time-consuming. In this issue, Critical Care launches a new section en...
Citation: Critical Care 2002 6:462 -
Introducing Critical Care's ongoing reviews of science
The explosion in biomedical research and the use of computers to access and disseminate ideas has increased our knowledge but has also strikingly shortened the time for new concepts to move from initial basic ...
Citation: Critical Care 2002 6:461 -
Glucose–insulin–potassium infusion in sepsis and septic shock: no hard evidence yet
There is no hard evidence yet for a positive effect of glucose–insulin–potassium infusion in sepsis, septic shock or burn patients. Each individual element of the glucose–insulin–potassium regimen, and eventua...
Citation: Critical Care 2002 7:13 -
Understanding the roles of the transcription factors nuclear factor-κB and hypoxia-inducible factor-1α in lung injury
The role of oxidative stress in regulating transcription factors and specific gene responses in critical illness is a new and emerging area. A better understanding of the proinflammatory oxidant stimuli of rea...
Citation: Critical Care 2002 6:471 -
Science review: Role of coagulation protease cascades in sepsis
Cellular signaling by proteases of the blood coagulation cascade through members of the protease-activated receptor (PAR) family can profoundly impact on the inflammatory balance in sepsis. The coagulation ini...
Citation: Critical Care 2002 7:123 -
Bovine colostrum in oral treatment of enterogenic endotoxaemia in rats
Under conditions of shock, bacteria and endotoxins in the intestines can traverse the mucosal barrier by translocation and enter the blood and lymphatic system. Immunoglobulins and lactoferrin have been report...
Citation: Critical Care 2002 6:536 -
Stress ulcer prophylaxis in trauma patients
A number of issues concerning stress ulcer prophylaxis remain unresolved despite numerous randomized, controlled trials and several meta-analyses. The role of stress ulcer prophylaxis, particularly in trauma p...
Citation: Critical Care 2002 6:526 -
Science review: Key inflammatory and stress pathways in critical illness – the central role of the Toll-like receptors
A pure reductionist approach can sometimes be used to solve an exceptionally complicated biologic problem, and sepsis is nothing if not complicated. A serious infection promptly leads to changes in many aspect...
Citation: Critical Care 2002 7:39 -
Brachial plexopathy after prone positioning
Two cases of brachial plexus injury after prone position in the intensive care unit are described. Mechanisms of brachial plexus injury are described, as are methods for prevention of this unusual complication.
Citation: Critical Care 2002 6:540 -
Cricothyroidotomy for elective airway management in critically ill trauma patients with technically challenging neck anatomy
To assess the value of elective cricothyroidotomy for airway management in critically ill trauma patients with technically challenging neck anatomy.
Citation: Critical Care 2002 6:531 -
ICUs worldwide: A brief description of intensive care development in Argentina
The present commentary reviews the development and present situation of critical care medicine in Argentina. Critical care has a long history in our country that began in 1958. Its development has not been uni...
Citation: Critical Care 2002 7:21 -
Statistics review 6: Nonparametric methods
The present review introduces nonparametric methods. Three of the more common nonparametric methods are described in detail, and the advantages and disadvantages of nonparametric versus parametric methods in g...
Citation: Critical Care 2002 6:509 -
Clinical review: Myocardial depression in sepsis and septic shock
Myocardial dysfunction frequently accompanies severe sepsis and septic shock. Whereas myocardial depression was previously considered a preterminal event, it is now clear that cardiac dysfunction as evidenced ...
Citation: Critical Care 2002 6:500 -
Bench-to-bedside review: Cytopathic hypoxia
The rate of oxygen consumption by certain tissues is impaired when mice or rats are injected with lipopolysaccharide. A similar change in the rate of oxygen consumption is observed when Caco-2 human enterocyte...
Citation: Critical Care 2002 6:491 -
Medicine and the Internet: untangling the web
Citation: Critical Care 2002 6:460 -
Recently published papers: New evidence for old debates, new drugs and some timely reminders
Citation: Critical Care 2002 6:407 -
Hemofiltration, adsorption, sieving and the challenge of sepsis therapy design
Circulating inflammatory mediators spilling into the circulation from sites of active inflammation are considered the source of remote tissue injury and associated organ dysfunction in sepsis. Hemofiltration h...
Citation: Critical Care 2002 6:394 -
Prone positioning does not affect cannula function during extracorporeal membrane oxygenation or continuous renal replacement therapy
Prone positioning in respiratory failure has been shown to be a useful adjunct in the treatment of severe hypoxia. However, the prone position can result in dislodgment or malfunction of tubes and cannulae. Ce...
Citation: Critical Care 2002 6:452 -
Intramucosal–arterial PCO2 gap fails to reflect intestinal dysoxia in hypoxic hypoxia
An elevation in intramucosal–arterial PCO2 gradient (ΔPCO2) could be determined either by tissue hypoxia or by reduced blood flow. Our hypothesis was that in hypoxic hypoxia with preserved blood flow, ΔPCO2 shoul...
Citation: Critical Care 2002 6:514 -
Is UpToDate ready for the ICU?
Citation: Critical Care 2002 6:550 -
Association of lipid peroxidation with hepatocellular injury in preterm infants
We wished to determine whether cholestasis induced by total parenteral nutrition (TPN) in preterm newborn infants is associated with increased oxidative stress secondary to increased reactive oxygen intermedia...
Citation: Critical Care 2002 6:521 -
Hypertonic saline resuscitation in sepsis
The review by Oliveira and colleagues on the subject of hypertonic saline resuscitation in sepsis (included in the present issue) suggests possible benefits for hypertonic saline. There is a firm experimental ...
Citation: Critical Care 2002 6:397 -
Ethics roundtable: Using new, expensive drugs
Costly genetically engineered therapies, which threaten to cripple the health care industry economy and undermine the common good if applied indiscriminately, loom on the horizon. The spectrum of applicable ca...
Citation: Critical Care 2002 6:473 -
Antibiotic guide
Citation: Critical Care 2002 6:549 -
Hypothermia and neurologic outcome in patients following cardiac arrest: should we be hot to cool off our patients?
Hypothermia as a protectant of neurologic function in the treatment of cardiac arrest patients, although not a new concept, is now supported by two recent randomized, prospective clinical trials. The basic sci...
Citation: Critical Care 2002 6:377 -
Clinical review: Intensive care follow-up – what has it told us?
The majority of intensive care practitioners, until comparatively recently, was content to discharge surviving patients to the care of referring primary specialty colleagues who would undertake subsequent inpa...
Citation: Critical Care 2002 6:411 -
Pro/con ethics debate: Should mechanical ventilation be continued to allow for progression to brain death so that organs can be donated?
Organ transplants continue to redefine medical frontiers. Unfortunately, current demand for organs far surpasses availability, waiting lists are long and many people die before the organ they desperately need ...
Citation: Critical Care 2002 6:399 -
ICUs worldwide: Critical care in India
Critical care practices in India have evolved significantly over the past decade. Critical care initially began as a service in major hospitals, but with the formation of the Indian Society of Critical Care Me...
Citation: Critical Care 2002 6:479 -
Clinical review: Hypertonic saline resuscitation in sepsis
The present review discusses the hemodynamic effects of hypertonic saline in experimental shock and in patients with sepsis. We comment on the mechanisms of action of hypertonic saline, calling upon data in he...
Citation: Critical Care 2002 6:418 -
ICUs worldwide: Results of a nationwide survey of Colombian intensive care units
Sixty-three of 89 identified intensive care units in Colombia (Evaluation of Intensive Care in Colombia) participated in this voluntary study. A convenience sample of 20 intensive care units, each submitting 2...
Citation: Critical Care 2002 6:405 -
Is insulin an endogenous cardioprotector?
Stress hyperglycemia and diabetes mellitus with myocardial infarction are associated with increased risk for in-hospital mortality, congestive heart failure, or cardiogenic shock. Hyperglycemia triggers free r...
Citation: Critical Care 2002 6:389 -
Antithrombin III in patients admitted to intensive care units: a multicenter observational study
The administration of antithrombin III (ATIII) is useful in patients with congenital deficiency, but evidence for the other therapeutic indications of this drug is still uncertain. In Italy, the use of ATIII i...
Citation: Critical Care 2002 6:447 -
The International Sepsis Forum's controversies in sepsis: how will sepsis be treated in 2051?
Sepsis, the life-threatening illness that arises from innate immunity to overwhelming infection, is treated symptomatically at the start of the 21st century. Looking ahead 50 years, one can perhaps foresee pro...
Citation: Critical Care 2002 6:465 -
The International Sepsis Forum's controversies in sepsis: corticosteroids should not be routinely used to treat septic shock
Corticosteroid treatment of severe sepsis has been one of the most controversial clinical issues in critical care. In fact, few agents can claim to have been evaluated in scores of studies spanning 3–4 decades...
Citation: Critical Care 2002 6:384 -
The International Sepsis Forum's controversies in sepsis: corticosteroids should be used to treat septic shock
The use of corticosteroids in septic shock remains controversial. It has been demonstrated that high doses of steroids (30 mg/kg methylprednisolone) for short periods of time are not beneficial. More recent st...
Citation: Critical Care 2002 6:381 -
Statistics review 5: Comparison of means
The present review introduces the commonly used t-test, used to compare a single mean with a hypothesized value, two means arising from paired data, or two means arising from unpaired data. The assumptions und...
Citation: Critical Care 2002 6:424 -
Case report: Survival after deliberate strychnine self-poisoning, with toxicokinetic data
Strychnine poisoning is uncommon, and in most severe cases, the patient dies before reaching hospital. The management of strychnine poisoning is well documented, although there are few data on the kinetics of ...
Citation: Critical Care 2002 6:456
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- ISSN: 1364-8535 (electronic)