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6939 result(s) for 'sepsis' within Critical Care

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  8. Nitric oxide (NO) regulates processes involved in sepsis progression, including vascular and immune function. ... concentrations of SDMA and ADMA are markers for sepsis survival.

    Authors: Martin Sebastian Winkler, Axel Nierhaus, Gilbert Rösler, Susanne Lezius, Olaf Harlandt, Edzard Schwedhelm, Rainer H. Böger and Stefan Kluge
    Citation: Critical Care 2018 22:216
    Content type: Research Published on:

  9. It remains unclear whether sepsis-related cardiovascular complications have an adverse impact ... . To investigate the survival impact of post-sepsis cardiovascular complications among sepsis survivors, we conduc...

    Authors: Meng-Huan Wu, Po-Yang Tsou, Yu-Hsun Wang, Meng-tse Gabriel Lee, Christin Chih Ting Chao, Wan-Chien Lee, Si-Huei Lee, Jiun-Ruey Hu, Jiunn-Yih Wu, Shy-Shin Chang and Chien-Chang Lee
    Citation: Critical Care 2019 23:293
    Content type: Research Published on:

  10. Previous studies have identified critical roles of IL-27 in the pathological mechanisms of sepsis, and blockade of IL-27 may be a promising alternative therapy for sepsis. The purpose of this study was to...IL-27

    Authors: Junbing He, Quanfu Zhang, Wenying Zhang, Feng Chen, Tian Zhao, Yao Lin, Jia Li, Yansong Liu, Yuchun Liu and Yiming Shao
    Citation: Critical Care 2018 22:248
    Content type: Research Published on:

  12. Sepsis is a serious syndrome that is caused ... role in the orchestration of inflammatory response during sepsis. IL-26 is an emerging proinflammatory member ... However, its role in the pathogenesis of sepsis re...

    Authors: Hongmei Tu, Xiaofei Lai, Jiaxi Li, Lili Huang, Yi Liu and Ju Cao
    Citation: Critical Care 2019 23:290
    Content type: Research Published on:

    The Letter to this article has been published in Critical Care 2019 23:397

  14. Sepsis survivors often develop chronic critical illness (CCI ... proBNP blood levels in the acute phase of sepsis are associated with physical function and muscle ... strength impairment at 6 and 12 months after

    Authors: Carlo Custodero, Quran Wu, Gabriela L. Ghita, Stephen D. Anton, Scott C. Brakenridge, Babette A. Brumback, Philip A. Efron, Anna K. Gardner, Christiaan Leeuwenburgh, Lyle L. Moldawer, John W. Petersen, Frederick A. Moore and Robert T. Mankowski
    Citation: Critical Care 2019 23:230
    Content type: Research Published on:

    The Letter to this article has been published in Critical Care 2020 24:93

    The Letter to this article has been published in Critical Care 2019 23:341

  15. Although genetic variants of the A disintegrin and metalloproteinase 10 (ADAM10) gene have been shown to be associated with susceptibility to several inflammatory-related diseases, to date little is known about t...

    Authors: Lili Cui, Yan Gao, Yuliu Xie, Yan Wang, Yujie Cai, Xin Shao, Xiaotang Ma, You LI, Guoda Ma, Gen Liu, Wanwen Cheng, Yu Liu, Tingting Liu, Qunwen Pan, Hua Tao, Zhou Liu…
    Citation: Critical Care 2015 19:73
    Content type: Research Published on:

  16. Immunocompromised patients who develop sepsis while neutropenic are at high risk for ... mortality; however, it is unknown if neutropenic sepsis is associated with distinct clinical and biological...

    Authors: John P. Reilly, Brian J. Anderson, Kristin M. Hudock, Thomas G. Dunn, Altaf Kazi, Anna Tommasini, Dudley Charles, Michael G. S. Shashaty, Mark E. Mikkelsen, Jason D. Christie and Nuala J. Meyer
    Citation: Critical Care 2016 20:222
    Content type: Research Published on:

  17. Adrenomedullin (ADM) regulates vascular tone and endothelial permeability during sepsis. Levels of circulating biologically active ADM ( ... present prospective observational multinational Adrenomedullin and Outc...

    Authors: Alexandre Mebazaa, Christopher Geven, Alexa Hollinger, Xavier Wittebole, Benjamin Glen Chousterman, Alice Blet, Etienne Gayat, Oliver Hartmann, Paul Scigalla, Joachim Struck, Andreas Bergmann, Massimo Antonelli, Albertus Beishuizen, Jean-Michel Constantin, Charles Damoisel, Nicolas Deye…
    Citation: Critical Care 2018 22:354
    Content type: Research Published on:

  18. Reduced microvascular perfusion has been implicated in organ dysfunction and multiple organ failure associated with severe sepsis. The precise mechanisms underlying microvascular dysfunction remain...

    Authors: Jean-Louis Vincent and Daniel De Backer
    Citation: Critical Care 2005 9(Suppl 4):S9
    Content type: Review Published on:

    This article is part of a Supplement: Volume 9 Supplement 4

  19. Derangement of nitric oxide (NO) metabolism represents one of the key mechanisms contributing to macro- and microcirculatory failure in sepsis. Sepsis-related therapy combining fluid resuscitation with administra...

    Authors: Corinna Lupp, Silke Baasner, Can Ince, Frank Nocken, John F Stover and Martin Westphal
    Citation: Critical Care 2013 17:311
    Content type: Review Published on:

  20. Our aim was to define early changes of lymphocytes and of NK cells in severe sepsis and to correlate them with serum levels...

    Authors: Evangelos J Giamarellos-Bourboulis, Thomas Tsaganos, Ekaterini Spyridaki, Maria Mouktaroudi, Diamantis Plachouras, Ilia Vaki, Vassiliki Karagianni, Anastasia Antonopoulou, Vassiliki Veloni and Helen Giamarellou
    Citation: Critical Care 2006 10:R166
    Content type: Research Published on:

  22. In Europe, vitamin D deficiency is highly prevalent varying between 40% and 60% in the healthy general adult population. The consequences of vitamin D deficiency for sepsis and outcome in critically ill patients ...

    Authors: Kim de Haan, AB Johan Groeneveld, Hilde RH de Geus, Mohamud Egal and Ard Struijs
    Citation: Critical Care 2014 18:660
    Content type: Research Published on:

  23. A recent randomised controlled trial failed to demonstrate a beneficial effect of recombinant human thrombomodulin (rhTM) on sepsis. However, there is still controversy in the effects of rhTM for sepsis due to th...

    Authors: Tadahiro Goto, Daisuke Kudo, Ryo Uchimido, Mineji Hayakawa, Kazuma Yamakawa, Toshikazu Abe, Atsushi Shiraishi and Shigeki Kushimoto
    Citation: Critical Care 2022 26:145
    Content type: Brief Report Published on:

  24. The Endotoxin Activity Assay (EAA) is a useful test to risk stratify patients with severe sepsis and assess for Gram negative infection. However...

    Authors: Arino Yaguchi, Junji Yuzawa, David J Klein, Munekasu Takeda and Tomoyuki Harada
    Citation: Critical Care 2012 16:R88
    Content type: Research Published on:

  25. The present review discusses the hemodynamic effects of hypertonic saline in experimental shock and in patients with sepsis. We comment on the mechanisms of action ... . Specific actions of hypertonic saline in s...

    Authors: Roselaine P Oliveira, Irineu Velasco, Francisco Garcia Soriano and Gilberto Friedman
    Citation: Critical Care 2002 6:418
    Content type: Review Published on:

  26. Sepsis causes microvascular dysfunction. Increased heterogeneity of capillary ... mortality: it improves rapidly in survivors of sepsis but fails to improve in nonsurvivors. This ... a therapeutic goal. In animal...

    Authors: Ryon M Bateman and Keith R Walley
    Citation: Critical Care 2005 9(Suppl 4):S27
    Content type: Review Published on:

    This article is part of a Supplement: Volume 9 Supplement 4

  27. It is now possible to partition the base deficit at the bedside with enough accuracy to permit clinical use. This provides valuable information on the aetiology of acid–base disturbance when applied to a cohort o...

    Authors: Ellen O'Dell, Shane M Tibby, Andrew Durward, Jo Aspell and Ian A Murdoch
    Citation: Critical Care 2005 9:R464
    Content type: Research Published on:

  30. Dopexamine may be a therapeutic option to improve hepatosplanchnic perfusion in sepsis. To investigate this possibility, we administered dopexamine in an experimental sepsis model in rats.

    Authors: Jürgen Birnbaum, Edda Klotz, Claudia D Spies, Björn Lorenz, Patrick Stuebs, Ortrud Vargas Hein, Matthias Gründling, Dragan Pavlovic, Taras Usichenko, Michael Wendt, Wolfgang J Kox and Christian Lehmann
    Citation: Critical Care 2006 10:R117
    Content type: Research Published on:

  31. Experimental studies in ischemia–reperfusion and sepsis indicate that activated protein C (APC)...In vivo..., however, the mechanisms of action have not been characterized thus far. Intravital multifluorescence m...

    Authors: Johannes N Hoffmann, Brigitte Vollmar, Matthias W Laschke, Jan M Fertmann, Karl-Walter Jauch and Michael D Menger
    Citation: Critical Care 2005 9(Suppl 4):S33
    Content type: Review Published on:

    This article is part of a Supplement: Volume 9 Supplement 4

  32. We aimed to establish whether the use of nonsteroidal anti-inflammatory drugs (NSAIDs) during evolving bacterial community-acquired infection in adults is associated with severe sepsis or septic shock.

    Authors: Annick Legras, Bruno Giraudeau, Annie-Pierre Jonville-Bera, Christophe Camus, Bruno François, Isabelle Runge, Achille Kouatchet, Anne Veinstein, Jérome Tayoro, Daniel Villers and Elisabeth Autret-Leca
    Citation: Critical Care 2009 13:R43
    Content type: Research Published on:

  33. The present report highlights the most important papers appearing in Critical Care and other major journals about severe sepsis, the systemic inflammatory response and multiorgan dysfunction ... studies will have...

    Authors: Steven M Opal and Steven P LaRosa
    Citation: Critical Care 2009 13:224
    Content type: Review Published on:

  36. Drotrecogin alfa (activated) (DrotAA) is licensed in the United States and the European Union for the treatment of severe sepsis with multiple organ failure. Patients with severe sepsis on renal replacement thera...

    Authors: Luigi Camporota, Eleonora Corno, Eleonora Menaldo, John Smith, Katie Lei, Richard Beale and Duncan Wyncoll
    Citation: Critical Care 2008 12:R163
    Content type: Research Published on:

  37. Discrepancies of 5-24% between superior vena cava oxygen saturation (ScvO2) and mixed venous oxygen saturation (SvO2) have been reported in patients with severe heart failure. Thenar muscle tissue oxygenation (St...

    Authors: Hugo Možina and Matej Podbregar
    Citation: Critical Care 2010 14:R42
    Content type: Research Published on:

  39. The role of nitric oxide synthase (NOS) in the pathophysiology of acute respiratory distress syndrome (ARDS) is not well understood. Inducible NOS is upregulated during physiologic stress; however, if NOS substra...

    Authors: Lorraine B Ware, Jordan A Magarik, Nancy Wickersham, Gary Cunningham, Todd W Rice, Brian W Christman, Arthur P Wheeler, Gordon R Bernard and Marshall L Summar
    Citation: Critical Care 2013 17:R10
    Content type: Research Published on:

  42. Sepsis is characterized by a dysregulated immune response ... and inflammation in relationship with adverse outcomes in sepsis patients is unclear.

    Authors: Aline H. de Nooijer, Antigone Kotsaki, Eleftheria Kranidioti, Matthijs Kox, Peter Pickkers, Erik J. M. Toonen, Evangelos J. Giamarellos-Bourboulis and Mihai G. Netea
    Citation: Critical Care 2023 27:63
    Content type: Brief Report Published on:

  43. All patients admitted to the multidisciplinary neonatal and paediatric intensive care unit of a university children's hospital will be included. Patients will be allocated either to routine sepsis work up or to t...

    Authors: Thomas Horisberger, Stephan Harbarth, David Nadal, Oskar Baenziger and Joachim E Fischer
    Citation: Critical Care 2004 8:R443
    Content type: Research Published on:

  44. The increasing prevalence of multiresistant Gram-negative strains in intensive care units (ICUs) has recently rekindled interest in colistin, a bactericidal antibiotic that was used in the 1960s for treatment of ...

    Authors: Nikolaos Markou, Haralampos Apostolakos, Christiana Koumoudiou, Maria Athanasiou, Alexandra Koutsoukou, Ioannis Alamanos and Leonidas Gregorakos
    Citation: Critical Care 2003 7:R78
    Content type: Research Published on:

  45. Recombinant human activated protein C (rhAPC) is the first drug for which a reduction of mortality in severe sepsis has been demonstrated. However, the mechanism ... fibrinolytic action of rhAPC in patients with ...

    Authors: Anne-Cornélie JM de Pont, Kamran Bakhtiari, Barbara A Hutten, Evert de Jonge, Margreeth B Vroom, Joost CM Meijers, Harry R Büller and Marcel Levi
    Citation: Critical Care 2005 9:R490
    Content type: Research Published on:

  46. Previous studies have found higher circulating levels of tissue inhibitor of matrix metalloproteinase (TIMP)-1 in nonsurviving septic patients than in surviving septic patients, and an association between the 372...

    Authors: Leonardo Lorente, Mar Martín, Fátima Plasencia, Jordi Solé-Violán, José Blanquer, Lorenzo Labarta, César Díaz, Juan María Borreguero-León, Alejandro Jiménez, José Antonio Páramo, Josune Orbe, José A Rodríguez and Eduardo Salido
    Citation: Critical Care 2013 17:R94
    Content type: Research Published on:

  47. In acute disseminated intravascular coagulation, the effect of antithrombin (AT) administration on elevated levels of D-dimer is not well established. In the present study, we report on changes in circulating lev...

    Authors: Jordan Kountchev, Klaudija Bijuklic, Romuald Bellmann, Christian J Wiedermann and Michael Joannidis
    Citation: Critical Care 2005 9:R596
    Content type: Research Published on:

  48. Early infection diagnosis as the cause of a patient's systemic inflammatory syndrome is an important facet of sepsis care bundles aimed at saving lives. Microbiological ... are essential during the immediate mana...

    Authors: Paul M Dark, Paul Dean and Geoffrey Warhurst
    Citation: Critical Care 2009 13:217
    Content type: Review Published on:

  49. The incidence of death among patients admitted for severe sepsis or septic shock is high. Adrenomedullin ( ... the hyperdynamic response during the early stages of sepsis. Pilot studies indicate an association of...

    Authors: Rossella Marino, Joachim Struck, Alan S Maisel, Laura Magrini, Andreas Bergmann and Salvatore Di Somma
    Citation: Critical Care 2014 18:R34
    Content type: Research Published on:

  50. Protein disulfide isomerase (PDI) is an important factor for the protein modification step in the post-translational event. PDI plays an essential role in cell survival under various stress conditions. It has bee...

    Authors: Mian Zhou, Asha Jacob, Natalie Ho, Michael Miksa, Rongqian Wu, Subir R Maitra and Ping Wang
    Citation: Critical Care 2008 12:R100
    Content type: Research Published on:
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Critical Care

ISSN: 1364-8535