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The high prevalence and pervasive impact of delirium in critically ill patients has been demonstrated in multiple studies. Subsequently there has grown a body of literature regarding delirium assessment in cri...
In this issue of Critical Care, Dutch investigators report that, in a cohort of patients with sepsis/septic shock admitted to three different intensive care units (ICUs), low central venous oxygen saturation (Scv...
Information about Medical Emergency Teams (METs) in Australia and New Zealand (ANZ) is limited to local studies and a cluster randomised controlled trial (the Medical Emergency Response and Intervention Trial ...
Drotrecogin alfa (activated; DrotAA) treatment, a 96-hour infusion, reduces 28-day mortality in severe sepsis to approximately 25%. The question remains whether a longer infusion or higher dose could increase ...
Myocardial infarction remains a major cause of death despite contemporary therapeutic strategies. Diagnosis in the intensive care unit is challenging, but is essential to target therapy accurately. In this iss...
Pneumonia is a very common nosocomial infection in intensive care units (ICUs). Many studies have investigated risk factors for the development of infection and its consequences. However, the evaluation in mos...
Systemic inflammatory mediators, including high mobility group box 1 (HMGB1), play an important role in the development of sepsis. Anticoagulants, such as danaparoid sodium (DA), may be able to inhibit sepsis-...
Maintenance of airway secretion clearance, or airway hygiene, is important for the preservation of airway patency and the prevention of respiratory tract infection. Impaired airway clearance often prompts admi...
Critically ill patients with a tracheostomy who are recovering from respiratory failure eventually require evaluation for airway decannulation. Although expert recommendations guide decisions for managing deca...
The measurement of pulmonary artery occlusion pressure (PAOP) is important for estimation of left ventricular filling pressure and for distinction between cardiac and non-cardiac etiology of pulmonary edema. C...
The pathogenesis of septic acute kidney injury (AKI) is not well understood. In the present issue of Critical Care, the combined clinical and experimental study from Mariano's group provides new insight into the ...
Using recruitment manoeuvres in acute lung injury remains a controversial issue because no convincing outcome data support their general use, although many physiological studies have demonstrated beneficial ef...
Following subarachnoid hemorrhage, hyperglycemia is strongly associated with complications and with impaired neurological recovery. Targeted insulin therapy for glycemic control might, on the contrary, have ha...
Optimal vasopressor support during resuscitation should theoretically enhance aortic diastolic and coronary perfusion pressure as well as coronary and cerebral blood flow/oxygen delivery without increasing cel...
Acute lung injury (ALI) and the acute respiratory distress syndrome (ARDS) remain important causes of morbidity and mortality in the critically ill patient, with far-reaching short-term and long-term implicati...
Studies have indicated that measuring biochemical measures of epithelial injury in plasma and alveolar fluid may be useful in predicting outcome in acute lung injury. The present commentary briefly reviews the...
The choice of inotropic agent, particularly in catecholamine-resistant septic shock, remains an area of debate. Here we discuss a recent trial examining the use of vasopressin in a carefully controlled trial s...
Severe burn is a systemic illness often complicated by sepsis. Kidney is one of the organs invariably affected, and proteinuria is a constant clinical finding. We studied the relationships between proteinuria ...
Acute lung injury (ALI) is a major cause of acute respiratory failure with high mortality despite lung-protective ventilation. Prior work has shown disordered inflammation and coagulation in ALI, with strong c...
Patients with cirrhosis who develop tense ascites and hepatorenal syndrome have a very high mortality and present a management challenge. Current debate stems from a lack of studies evaluating changes in effec...
Many parameters have been associated with sepsis prognosis. In the present issue of Critical Care, Kumar and colleagues demonstrate that a preserved cardiac answer to dobutamine evaluated by radionucleotide measu...
Epinephrine remains the drug of choice for cardiopulmonary resuscitation. The aim of the present study is to assess whether the combination of vasopressin and epinephrine, given their different mechanisms of a...
This article is part of a Supplement: Volume 12 Supplement 2
This article is part of a Supplement: Volume 12 Supplement 2
This article is part of a Supplement: Volume 12 Supplement 2
This article is part of a Supplement: Volume 12 Supplement 2
This article is part of a Supplement: Volume 12 Supplement 2
This article is part of a Supplement: Volume 12 Supplement 2
This article is part of a Supplement: Volume 12 Supplement 2
This article is part of a Supplement: Volume 12 Supplement 2
This article is part of a Supplement: Volume 12 Supplement 2
This article is part of a Supplement: Volume 12 Supplement 2
This article is part of a Supplement: Volume 12 Supplement 2
This article is part of a Supplement: Volume 12 Supplement 2
This article is part of a Supplement: Volume 12 Supplement 2
This article is part of a Supplement: Volume 12 Supplement 2
This article is part of a Supplement: Volume 12 Supplement 2
This article is part of a Supplement: Volume 12 Supplement 2
This article is part of a Supplement: Volume 12 Supplement 2
This article is part of a Supplement: Volume 12 Supplement 2
This article is part of a Supplement: Volume 12 Supplement 2
This article is part of a Supplement: Volume 12 Supplement 2
This article is part of a Supplement: Volume 12 Supplement 2
This article is part of a Supplement: Volume 12 Supplement 2
This article is part of a Supplement: Volume 12 Supplement 2
This article is part of a Supplement: Volume 12 Supplement 2
This article is part of a Supplement: Volume 12 Supplement 2
This article is part of a Supplement: Volume 12 Supplement 2
This article is part of a Supplement: Volume 12 Supplement 2
Critical Care