Page 23 of 139
This article is part of a Supplement: Volume 16 Supplement 3
In this issue of Critical Care..., the study from Laterre and colleagues offers suggestions for the role of clinical evaluation committees (CECs) in future sepsis trials. Despite encouraging preliminary results, ...
This article is part of a Supplement: Volume 17 Supplement 4
Sepsis-associated encephalopathy (SAE) resembles metabolic encephalopathies...
In the previous issue of Critical Care..., Maslove and colleagues studied circulating neutrophil transcriptional expression to discover and validate a molecular subclassification of adult patients with sepsis. Th...
This article is part of a Supplement: Volume 13 Supplement 4
This article is part of a Supplement: Volume 14 Supplement 2
Rusavy and colleagues recently endeavoured to dissect out the metabolic effects of insulin in patients with severe sepsis, in the setting of normoglycaemia. Twenty ... demand and catabolism of protein in patients...
Sepsis is the third largest cause of death ... are now recognised to underpin the pathophysiology of sepsis. Biomarkers of endothelial activation may therefore assume...
The inflammatory response of sepsis results in organ dysfunction, including myocardial dysfunction...
A recent report from the PROGRESS registry highlighted that low dose corticosteroids are widely used in patients with sepsis around the world. In this report,...
Neutrophils are circulating leukocytes with great cytotoxic potential, responsible for the first combat against invading pathogens. Their accumulation in tissues must be highly controlled so that the number of ne...
Adrenomedullin is a vasodilatory polypeptide with pleiotropic effects secreted by various organs. Adrenomedullin is produced first as a prepropeptide, and then cleaved into mature adrenomedullin and mid-regional ...
This article is part of a Supplement: Volume 15 Supplement 3
This article is part of a Supplement: Volume 15 Supplement 3
The original article was published in Critical Care 2022 26:67
The original article was published in Critical Care 2022 26:4
This article is part of a Supplement: Volume 16 Supplement 3
This article is part of a Supplement: Volume 16 Supplement 3
Many prior studies have shown that, in critically ill patients, acute kidney injury (AKI) commonly occurs in association with sepsis and its presence portends an increased likelihood ... AKI on the long-term risk...
This article is part of a Supplement: Volume 16 Supplement 3
The original article was published in Critical Care 2023 27:275
Prior analyses suggest that empiric fluconazole for ICU patients with sepsis is cost-effective. Using updated estimates of...Candida species. Their results are limited by inflated estimates of efficacy, life expe...
Severe sepsis and septic shock cause considerable morbidity and...
This article is part of a Supplement: Volume 15 Supplement 3
This article is part of a Supplement: Volume 18 Supplement 2
Sepsis is one of the leading causes of ... and severity are high. Also, treatment of sepsis is highly debated and potential new targets...Critical Care...Kumaraswamy and colleagues have investigated whether plasm...
This article is part of a Supplement: Volume 18 Supplement 2
No abstract.
Etomidate is an intravenous induction agent that is associated with hemodynamic stability during intubation. The agent is therefore attractive for use in critically ill patients who have a high risk of hemodynami...
Endothelial injury has emerged as a crucial early event in the pathogenesis of microcirculatory dysfunction, capillary leakage and multiorgan dysfunction syndrome. The endothelial-specific angiopoietin (Ang)/T...
Although many pharmaceutical and technological advances are heavily touted, they have had relatively little impact on overall outcome improvements in the critically ill. Acting on the increasing recognition th...
Sepsis is a complex clinical condition that is ... ill patients with sterile inflammation from those with sepsis. Such biomarkers may aid the clinician in...Critical Care by a study of critically ill children.
The choice of induction agent for endotracheal intubation can have significant downstream effects, especially in critically ill patients. In a retrospective study, Ray and McKeown found that the choice of indu...
Severe sepsis, defined as sepsis associated with acute organ dysfunction, results from ... host response to infection. Coagulopathy in severe sepsis is commonly associated with multiple organ dysfunction, ... pla...
This article is part of a Supplement: Volume 5 Supplement 2
In daily clinical practice the diagnosis of sepsis is imprecise and often delayed. In part ... as there is evidence that early events in sepsis may determine outcome. A more objective set of measurements for conf...
Severe sepsis is a major challenge for clinicians caring ... of plasma CRP concentrations in patients with severe sepsis and the interpretation of its patterns may...
Oxidative stress has been postulated as a mechanism of organ dysfunction - and thus a potential therapeutic target - in sepsis. Lorente and colleagues report increased serum levels ... -induced lipid peroxidation...
Hypocholesterolemia is an important observation following trauma. In a study of critically ill trauma patients, mean cholesterol levels were significantly lower (119 ± 44 mg/dl) than expected values (201 ± 17 mg/...
This article is part of a Supplement: Volume 18 Supplement 2
The high morbidity and mortality of severe sepsis and septic shock fosters a continuous search...N-acetylcysteine shows great promise. Beside proven anti-oxidant, anti-inflammatory and cytoprotective effects, N-a...
Critical Care