Articles
Page 202 of 376
-
Citation: Critical Care 2010 14:416
-
Beneficial effects of loxapine on agitation and breathing patterns during weaning from mechanical ventilation
Interruption of sedation during weaning from mechanical ventilation often leads to patient agitation because of withdrawal syndrome. We tested the short-term efficacy and tolerance of loxapine in this situation.
Citation: Critical Care 2010 14:R86 -
Urinary cystatin C is diagnostic of acute kidney injury and sepsis, and predicts mortality in the intensive care unit
To evaluate the utility of urinary cystatin C (uCysC) as a diagnostic marker of acute kidney injury (AKI) and sepsis, and predictor of mortality in critically ill patients.
Citation: Critical Care 2010 14:R85 -
Medical resource utilization among patients with ventilator-associated pneumonia: pooled analysis of randomized studies of doripenem versus comparators
Ventilator-associated pneumonia (VAP) is associated with increased medical resource utilization, but few randomized studies have been conducted to evaluate the effect of initial antibiotic therapy. To assess m...
Citation: Critical Care 2010 14:R84 -
Reducing mortality in severe sepsis with the implementation of a core 6-hour bundle: results from the Portuguese community-acquired sepsis study (SACiUCI study)
To evaluate the impact of compliance with a core version of the Surviving Sepsis Campaign 6-hour bundle on 28 days mortality.
Citation: Critical Care 2010 14:R83 -
To dose or not to dose: that is the (starch) question ...
The present study describes the impact on renal function of a modern starch used for resuscitation in the intensive care unit. The role of starch in renal dysfunction, the importance of the definition of acute...
Citation: Critical Care 2010 14:148 -
Pulmonary and renal protection: targeting PARP to ventilator-induced lung and kidney injury?
Both acute lung injury and acute kidney injury (AKI) are frequent and serious problems in intensive care medicine. Therefore, the avoiding of any iatrogenic insult to these organs is of great importance. While...
Citation: Critical Care 2010 14:147 -
All bleeding stops: how we can help...
Rossaint and colleagues provide the critical care community with a comprehensive review of evidence-based data in an updated European guideline on management of bleeding following major trauma. In addition to ...
Citation: Critical Care 2010 14:146 -
Fluid accumulation, recognition and staging of acute kidney injury in critically-ill patients
Serum creatinine concentration (sCr) is the marker used for diagnosing and staging acute kidney injury (AKI) in the RIFLE and AKIN classification systems, but is influenced by several factors including its vol...
Citation: Critical Care 2010 14:R82 -
Blood glucose control in the intensive care unit: discrepancy between belief and practice
A survey among pediatric intensive care physicians showed that a great disparity exists between physicians' beliefs regarding hyperglycemia in critically ill patients and their daily practices to screen and tr...
Citation: Critical Care 2010 14:145 -
Endotoxemia-induced inflammation and the effect on the human brain
Effects of systemic inflammation on cerebral function are not clear, as both inflammation-induced encephalopathy as well as stress-hormone mediated alertness have been described.
Citation: Critical Care 2010 14:R81 -
Bench-to-bedside review: Carbon dioxide
Carbon dioxide is a waste product of aerobic cellular respiration in all aerobic life forms. PaCO2 represents the balance between the carbon dioxide produced and that eliminated. Hypocapnia remains a common - and...
Citation: Critical Care 2010 14:220 -
Inhaled activated protein C: a new therapy for the prevention of ventilator-induced lung injury?
Systemic administration of activated protein C (APC) has been shown to reduce pulmonary inflammation in preclinical models of acute lung injury. However, there is only limited information concerning the effect...
Citation: Critical Care 2010 14:144 -
Early fiberoptic bronchoscopy during non-invasive ventilation in patients with decompensated chronic obstructive pulmonary disease due to community-acquired-pneumonia
Inefficient clearance of copious respiratory secretion is a cause of non-invasive positive pressure ventilation (NPPV) failure, especially in chronic respiratory patients with community-acquired-pneumonia (CAP...
Citation: Critical Care 2010 14:R80 -
4G/5G polymorphism of PAI-1 gene is associated with multiple organ dysfunction and septic shock in pneumonia induced severe sepsis: prospective, observational, genetic study
Activation of inflammation and coagulation are closely related and mutually interdependent in sepsis. The acute-phase protein, plasminogen activator inhibitor-1 (PAI-1) is a key element in the inhibition of fi...
Citation: Critical Care 2010 14:R79 -
Enhanced protein-energy provision via the enteral route in critically ill patients: a single center feasibility trial of the PEP uP protocol
The purpose of this pilot study is to assess the feasibility, acceptability, and safety of a new feeding protocol designed to enhance the delivery of enteral nutrition (EN).
Citation: Critical Care 2010 14:R78 -
Delta inflation: a bias in the design of randomized controlled trials in critical care medicine
Mortality is the most widely accepted outcome measure in randomized controlled trials of therapies for critically ill adults, but most of these trials fail to show a statistically significant mortality benefit...
Citation: Critical Care 2010 14:R77 -
Noise levels produced by high-frequency oscillation
Citation: Critical Care 2010 14:415 -
Clinical review: Practical recommendations on the management of perioperative heart failure in cardiac surgery
Acute cardiovascular dysfunction occurs perioperatively in more than 20% of cardiosurgical patients, yet current acute heart failure (HF) classification is not applicable to this period. Indicators of major pe...
Citation: Critical Care 2010 14:201 -
A recruitment maneuver increases oxygenation after intubation of hypoxemic intensive care unit patients: a randomized controlled study
Tracheal intubation and anaesthesia promotes lung collapse and hypoxemia. In acute lung injury patients, recruitment maneuvers (RMs) increase lung volume and oxygenation, and decrease atelectasis. The aim of t...
Citation: Critical Care 2010 14:R76 -
Insulin like growth factor-I in acute subarachnoid hemorrhage: a prospective cohort study
Neuroendocrine deficiencies may affect recovery after aneurysmal subarachnoid hemorrhage (aSAH). Insulin like growth factor-I (IGF-I) regulates neuronal growth and apoptosis in ischemic stroke. Our study was d...
Citation: Critical Care 2010 14:R75 -
Electrical muscle stimulation prevents critical illness polyneuromyopathy: a randomized parallel intervention trial
Critical illness polyneuromyopathy (CIPNM) is a common complication of critical illness presenting with muscle weakness and is associated with increased duration of mechanical ventilation and weaning period. N...
Citation: Critical Care 2010 14:R74 -
Ave, CESAR, morituri te salutant! (Hail, CESAR, those who are about to die salute you!)
Citation: Critical Care 2010 14:308 -
Re-inspiration of CO2 from ventilator circuit: effects of circuit flushing and aspiration of dead space up to high respiratory rate
Dead space negatively influences carbon dioxide (CO2) elimination, particularly at high respiratory rates (RR) used at low tidal volume ventilation in acute respiratory distress syndrome (ARDS). Aspiration of dea...
Citation: Critical Care 2010 14:R73 -
A novel effect of eicosapentaenoic acid: improved diaphragm strength in endotoxemia
Respiratory muscle weakness is commonplace in critically ill patients, impairing the ability of those patients to breath, prolonging the need for ventilatory support, and increasing the likelihood of respirato...
Citation: Critical Care 2010 14:143 -
Adequate thromboprophylaxis in critically ill patients
Venous thromboembolism is a relatively frequently occurring complication in critically ill patients admitted to the ICU despite prophylactic treatment with subcutaneous low molecular weight heparin. Several st...
Citation: Critical Care 2010 14:142 -
A plea for balanced reporting
Citation: Critical Care 2010 14:414 -
Prophylactic anticoagulation to prevent venous thromboembolism in traumatic intracranial hemorrhage: a decision analysis
Patients with intracranial hemorrhage due to traumatic brain injury are at high risk of developing venous thromboembolism including deep vein thrombosis (DVT) and pulmonary embolism (PE). Thus, there is a trad...
Citation: Critical Care 2010 14:R72 -
Vacuum-assisted closure device in intensive care unit patients and dissemination of Gram-negative bacteria
Citation: Critical Care 2010 14:413 -
Bench-to-bedside review: Bacterial pneumonia with influenza - pathogenesis and clinical implications
Seasonal and pandemic influenza are frequently complicated by bacterial infections, causing additional hospitalization and mortality. Secondary bacterial respiratory infection can be subdivided into combined v...
Citation: Critical Care 2010 14:219 -
Statins for acutely hospitalized patients: randomized controlled trials are long overdue
From the earliest studies of statins for control of plasma cholesterol, observations have been made that the reductions in mortality observed occurred in a manner seemingly independent from what could be antic...
Citation: Critical Care 2010 14:141 -
Effect of an analgo-sedation protocol for neurointensive patients: a two-phase interventional non-randomized pilot study
Sedation protocols are needed for neurointensive patients. The aim of this pilot study was to describe sedation practice at a neurointensive care unit and to assess the feasibility and efficacy of a new sedati...
Citation: Critical Care 2010 14:R71 -
Inhaled activated protein C protects mice from ventilator-induced lung injury
Activated Protein C (APC), an endogenous anticoagulant, improves tissue microperfusion and endothelial cell survival in systemic inflammatory states such as sepsis, but intravenous administration may cause sev...
Citation: Critical Care 2010 14:R70 -
Mild therapeutic hypothermia alters neuron specific enolase as an outcome predictor after resuscitation: 97 prospective hypothermia patients compared to 133 historical non-hypothermia patients
Neuron specific enolase (NSE) has been proven effective in predicting neurological outcome after cardiac arrest with a current cut off recommendation of 33 μg/l. However, most of the corresponding studies were...
Citation: Critical Care 2010 14:R69 -
Febrile neutropenia in French emergency departments: results of a prospective multicentre survey
Febrile neutropenia (FN) is common in cancer patients receiving myelotoxic therapy. The procedures to treat FN are well established in oncology, but it is unclear whether management is adequate in the emergenc...
Citation: Critical Care 2010 14:R68 -
Effects of earplugs and eye masks on nocturnal sleep, melatonin and cortisol in a simulated intensive care unit environment
Environmental stimulus, especially noise and light, is thought to disrupt sleep in patients in the intensive care unit (ICU). This study aimed to determine the physiological and psychological effects of ICU no...
Citation: Critical Care 2010 14:R66 -
Bench-to-bedside review: Vaccine protection strategies during pandemic flu outbreaks
Vaccination is the most effective means for the prevention of influenza, including pandemic strains. An ideal pandemic influenza vaccine should provide effective protection with the fewest number of doses in t...
Citation: Critical Care 2010 14:218 -
Wet lungs, broken hearts and difficult therapies after subarachnoid hemorrhage
Pulmonary edema (PE) can occur after subarachnoid hemorrhage and can jeopardize arterial oxygenation, which is essential for a suffering brain. In some cases PE is evident in the emergency room, being the dire...
Citation: Critical Care 2010 14:140 -
Pre-existing disease: the most important factor for health related quality of life long-term after critical illness: a prospective, longitudinal, multicentre trial
The aim of the present multicenter study was to assess long term (36 months) health related quality of life in patients after critical illness, compare ICU survivors health related quality of life to that of t...
Citation: Critical Care 2010 14:R67 -
Freeze dried plasma: a French army specialty
Citation: Critical Care 2010 14:412 -
Clinical features of H1N1 2009 infection in critically ill immunocompromised patients
Seasonal influenza virus has been described as an emerging and severe pathogen in immunocompromised hosts. Since the beginning of the 2009 influenza A novel H1N1 pandemic, several series have described the cli...
Citation: Critical Care 2010 14:139 -
Activated protein C ameliorates coagulopathy but does not influence outcome in lethal H1N1 influenza: a controlled laboratory study
Influenza accounts for 5 to 10% of community-acquired pneumonias and is a major cause of mortality. Sterile and bacterial lung injuries are associated with procoagulant and inflammatory derangements in the lun...
Citation: Critical Care 2010 14:R65 -
Inter-rater reliability of the Full Outline of UnResponsiveness score and the Glasgow Coma Scale in critically ill patients: a prospective observational study
The Glasgow Coma Scale (GCS) is the most widely used scoring system for comatose patients in intensive care. Limitations of the GCS include the impossibility to assess the verbal score in intubated or aphasic ...
Citation: Critical Care 2010 14:R64 -
Low hemoglobin is associated with poor functional outcome after non-traumatic, supratentorial intracerebral hemorrhage
The impact of anemia on functional outcome and mortality in patients suffering from non-traumatic intracerebral hemorrhage (ICH) has not been investigated. Here, we assessed the relationship between hemoglobin...
Citation: Critical Care 2010 14:R63 -
Effects of different fibrinogen concentrations on blood loss and coagulation parameters in a pig model of coagulopathy with blunt liver injury
The early application of fibrinogen could potentially reverse haemodilution-induced coagulopathy, although the impact of varying concentrations of fibrinogen to reverse dilutional coagulopathy has not been stu...
Citation: Critical Care 2010 14:R62 -
Cytokine profiles of suction pulmonary secretions from children infected with pandemic influenza A(H1N1) 2009
Citation: Critical Care 2010 14:411 -
Differential down-regulation of HLA-DR on monocyte subpopulations during systemic inflammation
Decreased expression of human leukocyte antigen class II (HLA-DR) on monocytes is a hallmark of altered immune status in patients with a systemic inflammatory response syndrome (SIRS). So far, the analyses wer...
Citation: Critical Care 2010 14:R61 -
One-year mortality, quality of life and predicted life-time cost-utility in critically ill patients with acute respiratory failure
High daily intensive care unit (ICU) costs are associated with the use of mechanical ventilation (MV) to treat acute respiratory failure (ARF), and assessment of quality of life (QOL) after critical illness an...
Citation: Critical Care 2010 14:R60 -
Is albumin use SAFE in patients with traumatic brain injury?
Citation: Critical Care 2010 14:307 -
Leptin in sepsis: a well-suited biomarker in critically ill patients?
The value of monitoring serum leptin in critically ill patients is important for early diagnosis and differentiation between sepsis and non-infectious systemic inflammatory response syndrome (SIRS). The early ...
Citation: Critical Care 2010 14:138
Follow
- ISSN: 1364-8535 (electronic)