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  3. Measurement of prohormones representing different pathophysiological pathways could enhance risk stratification in patients with community-acquired pneumonia (CAP) and other lower respiratory tract infections ...

    Authors: Philipp Schuetz, Marcel Wolbers, Mirjam Christ-Crain, Robert Thomann, Claudine Falconnier, Isabelle Widmer, Stefanie Neidert, Thomas Fricker, Claudine Blum, Ursula Schild, Nils G Morgenthaler, Ronald Schoenenberger, Christoph Henzen, Thomas Bregenzer, Claus Hoess, Martin Krause…
    Citation: Critical Care 2010 14:R106
    Content type: Research Published on:

  4. Extravascular lung water index (EVLWI) can be measured at the bedside using the transpulmonary thermodilution technique (TPTD). The goal of this study was to compare EVLWI values with a chest x-ray score of pu...

    Authors: Joris Lemson, Lya E van Die, Anique EA Hemelaar and Johannes G van der Hoeven
    Citation: Critical Care 2010 14:R105
    Content type: Research Published on:

  5. Glycemic control aiming at normoglycemia, frequently referred to as 'strict glycemic control' (SGC), decreased mortality and morbidity of adult critically ill patients in two randomized controlled trials (RCTs...

    Authors: Marcus J Schultz, Robin E Harmsen and Peter E Spronk
    Citation: Critical Care 2010 14:223
    Content type: Review Published on:

  7. Ischemia and reperfusion after cardiopulmonary resuscitation (CPR) induce endothelial activation and systemic inflammatory response, resulting in post-resuscitation disease. In this study we analyzed direct ma...

    Authors: Katrin Fink, Meike Schwarz, Linda Feldbrügge, Julia N Sunkomat, Tilmann Schwab, Natascha Bourgeois, Manfred Olschewski, Constantin von zur Mühlen, Christoph Bode and Hans-Jörg Busch
    Citation: Critical Care 2010 14:R104
    Content type: Research Published on:

  9. It has been proposed that individual genetic variation contributes to the course of severe infections and sepsis. Recent studies of single nucleotide polymorphisms (SNPs) within the endotoxin receptor and its ...

    Authors: Oliver Kumpf, Evangelos J Giamarellos-Bourboulis, Alexander Koch, Lutz Hamann, Maria Mouktaroudi, Djin-Ye Oh, Eicke Latz, Eva Lorenz, David A Schwartz, Bart Ferwerda, Christina Routsi, Chryssanthi Skalioti, Bart-Jan Kullberg, Jos WM van der Meer, Peter M Schlag, Mihai G Netea…
    Citation: Critical Care 2010 14:R103
    Content type: Research Published on:

  10. The benefits and use of low-dose corticosteroids (LDCs) in severe sepsis and septic shock remain controversial. Surviving sepsis campaign guidelines suggest LDC use for septic shock patients poorly responsive ...

    Authors: Richard Beale, Jonathan M Janes, Frank M Brunkhorst, Geoffrey Dobb, Mitchell M Levy, Greg S Martin, Graham Ramsay, Eliezer Silva, Charles L Sprung, Benoit Vallet, Jean-Louis Vincent, Timothy M Costigan, Amy G Leishman, Mark D Williams and Konrad Reinhart
    Citation: Critical Care 2010 14:R102
    Content type: Research Published on:

  11. Left ventricular (LV) dysfunction frequently occurs after cardiac surgery, requiring inotropic treatment and/or mechanical circulatory support. In this study, we aimed to identify clinical, surgical and echoca...

    Authors: Marc Licker, Mustafa Cikirikcioglu, Cidgem Inan, Vanessa Cartier, Afksendyios Kalangos, Thomas Theologou, Tiziano Cassina and John Diaper
    Citation: Critical Care 2010 14:R101
    Content type: Research Published on:

  12. Schochl and co-authors have described a 5-year retrospective study that outlines a novel, important and controversial transfusion concept in seriously injured trauma patients. Traditionally, clinicians have be...

    Authors: John B Holcomb
    Citation: Critical Care 2010 14:162
    Content type: Commentary Published on:

  13. As it becomes clear that mechanical ventilation can exaggerate lung injury, individual titration of ventilator settings is of special interest. Electrical impedance tomography (EIT) has been proposed as a beds...

    Authors: Ido G Bikker, Steffen Leonhardt, Dinis Reis Miranda, Jan Bakker and Diederik Gommers
    Citation: Critical Care 2010 14:R100
    Content type: Research Published on:

  14. The availability of advanced diagnostic tools has grown in the past decades. Hence, a growing false belief exists that everything is known about the patient before death. Moreover, intensivists may wrongly bel...

    Authors: Greet Yvonne Agnes De Vlieger, Elien Marie Jeanne Lia Mahieu and Wouter Meersseman
    Citation: Critical Care 2010 14:221
    Content type: Review Published on:

  17. In patients with acute kidney injury and concomitant severe hyponatraemia or hypernatraemia, rapid correction of the serum Na+ concentration needs to be avoided. The present paper outlines the principles of how t...

    Authors: Marlies Ostermann, Helen Dickie, Linda Tovey and David Treacher
    Citation: Critical Care 2010 14:418
    Content type: Letter Published on:

  19. Critical care medicine is a relatively young but rapidly evolving specialty. On the occasion of the 30th International Symposium on Intensive Care and Emergency Medicine, we put together some thoughts from a f...

    Authors: Jean-Louis Vincent, Mervyn Singer, John J Marini, Rui Moreno, Mitchell Levy, Michael A Matthay, Michael Pinsky, Andrew Rhodes, Niall D Ferguson, Timothy Evans, Djillali Annane and Jesse B Hall
    Citation: Critical Care 2010 14:311
    Content type: Viewpoint Published on:

  21. The prognostic value of cardiac troponin I (cTnI) in patients having a heat-related illness during a heat wave has been poorly documented.

    Authors: Pierre Hausfater, Benoît Doumenc, Sébastien Chopin, Yannick Le Manach, Aline Santin, Sandrine Dautheville, Anabela Patzak, Philippe Hericord, Bruno Mégarbane, Marc Andronikof, Nabila Terbaoui and Bruno Riou
    Citation: Critical Care 2010 14:R99
    Content type: Research Published on:

  22. Candidemia raises numerous therapeutic issues for intensive care physicians. Epidemiological data that could guide the choice of initial therapy are still required. This analysis sought to compare the characte...

    Authors: Olivier Leroy, Jean-Paul Mira, Philippe Montravers, Jean-Pierre Gangneux and Olivier Lortholary
    Citation: Critical Care 2010 14:R98
    Content type: Research Published on:

  23. Results of the first randomized trial comparing on-demand versus planned-relaparotomy strategy in patients with severe peritonitis (RELAP trial) indicated no clear differences in primary outcomes. We now repor...

    Authors: Brent C Opmeer, Kimberly R Boer, Oddeke van Ruler, Johannes B Reitsma, Hein G Gooszen, Peter W de Graaf, Bas Lamme, Michael F Gerhards, E Philip Steller, Cecilia M Mahler, Huug Obertop, Dirk J Gouma, Patrick MM Bossuyt, Corianne AJM de Borgie and Marja A Boermeester
    Citation: Critical Care 2010 14:R97
    Content type: Research Published on:

  24. Although major changes of the immune system have been described in sepsis, it has never been studied whether these may differ in relation to the type of underlying infection or not. This was studied for the fi...

    Authors: Charalambos Gogos, Antigone Kotsaki, Aimilia Pelekanou, George Giannikopoulos, Ilia Vaki, Panagiota Maravitsa, Stephanos Adamis, Zoi Alexiou, George Andrianopoulos, Anastasia Antonopoulou, Sofia Athanassia, Fotini Baziaka, Aikaterini Charalambous, Sofia Christodoulou, Ioanna Dimopoulou, Ioannis Floros…
    Citation: Critical Care 2010 14:R96
    Content type: Research Published on:

  26. Advanced hemodynamic monitoring using transpulmonary thermodilution (TPTD) is established for measurement of cardiac index (CI), global end-diastolic volume index (GEDVI) and extra-vascular lung water index (E...

    Authors: Bernd Saugel, Andreas Umgelter, Tibor Schuster, Veit Phillip, Roland M Schmid and Wolfgang Huber
    Citation: Critical Care 2010 14:R95
    Content type: Research Published on:

  27. Ghrelin has been recently identified as a mediator of various beneficial effects in animal models of sepsis. At present, no data are available concerning specific properties of ghrelin in critically ill patien...

    Authors: Alexander Koch, Edouard Sanson, Anita Helm, Sebastian Voigt, Christian Trautwein and Frank Tacke
    Citation: Critical Care 2010 14:R94
    Content type: Research Published on:

  29. Endotracheal intubation in critically ill patients is associated with severe life-threatening complications in about 20%, mainly due to hypoxemia. We hypothesized that apneic oxygenation via a pharyngeal cathe...

    Authors: Joakim Engström, Göran Hedenstierna and Anders Larsson
    Citation: Critical Care 2010 14:R93
    Content type: Research Published on:

  30. Studies in intensive care unit (ICU) patients have suggested that anemia and blood transfusions can influence outcomes, but these effects have not been widely investigated specifically in surgical ICU patients.

    Authors: Yasser Sakr, Suzana Lobo, Stefanie Knuepfer, Elizabeth Esser, Michael Bauer, Utz Settmacher, Dagmar Barz and Konrad Reinhart
    Citation: Critical Care 2010 14:R92
    Content type: Research Published on:

  31. Sepsis-associated encephalopathy (SAE) resembles metabolic encephalopathies but with a difference: there is the potential for enduring brain damage/dysfunction. The pathogenesis of SAE is likely multifactorial...

    Authors: G Bryan Young
    Citation: Critical Care 2010 14:159
    Content type: Commentary Published on:

  32. Severe sepsis is a disease of the microcirculation, with endothelial dysfunction playing a key role in its pathogenesis and subsequent associated mortality. Angiogenesis in damaged small vessels may ameliorate...

    Authors: Limangeni A Mankhambo, Daniel L Banda, Graham Jeffers, Sarah A White, Paul Balmer, Standwell Nkhoma, Happy Phiri, Elizabeth M Molyneux, C Anthony Hart, Malcolm E Molyneux, Robert S Heyderman and Enitan D Carrol
    Citation: Critical Care 2010 14:R91
    Content type: Research Published on:

  34. Critically ill patients are frequently prescribed sedatives and analgesics to ensure patient safety, to relieve pain and anxiety, to reduce stress and oxygen consumption, and to prevent patient ventilator dysy...

    Authors: Pratik Pandharipande, Arna Banerjee, Stuart McGrane and E Wesley Ely
    Citation: Critical Care 2010 14:157
    Content type: Commentary Published on:

  35. Heparin-induced thrombocytopenia (HIT) is a serious, prothrombotic, immune-mediated adverse reaction triggered by heparin therapy. When HIT is diagnosed or suspected, heparins should be discontinued, and an al...

    Authors: Bernd Saugel, Veit Phillip, Georg Moessmer, Roland M Schmid and Wolfgang Huber
    Citation: Critical Care 2010 14:R90
    Content type: Research Published on:

    The Erratum to this article has been published in Critical Care 2012 16:415

  37. Angiopoietin-2 (ang-2), an angiogenic peptide released by endothelial cell Weibel-Palade bodies (WPBs), increases endothelial activation and vascular permeability. Ang-2 is raised in severe sepsis but the mech...

    Authors: Joshua S Davis, Tsin W Yeo, Kim A Piera, Tonia Woodberry, David S Celermajer, Dianne P Stephens and Nicholas M Anstey
    Citation: Critical Care 2010 14:R89
    Content type: Research Published on:

  39. Over 500 million of the current world population will die from diseases caused by smoking cigarettes. The symptoms and signs of nicotine withdrawal are not well described in the critically ill. Since the vario...

    Authors: Bekele Afessa and Mark T Keegan
    Citation: Critical Care 2010 14:155
    Content type: Commentary Published on:

  44. The impact of pro-inflammatory cytokines on neuroinflammation and cognitive function after lipopolysaccharide (LPS) challenge remains elusive. Herein we provide evidence that there is a temporal correlation be...

    Authors: Niccolò Terrando, António Rei Fidalgo, Marcela Vizcaychipi, Mario Cibelli, Daqing Ma, Claudia Monaco, Marc Feldmann and Mervyn Maze
    Citation: Critical Care 2010 14:R88
    Content type: Research Published on:

  48. Sequential or concomitant influenza and bacterial pneumonia are two common syndromes seen in community-acquired pneumonia. Inadequacies of diagnostic testing make separating simple pneumonia with either bacter...

    Authors: Richard G Wunderink
    Citation: Critical Care 2010 14:150
    Content type: Commentary Published on:
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  • ISSN: 1364-8535 (electronic)

Critical Care

ISSN: 1364-8535