Skip to main content

Costs of relaparotomy on-demand versus planned relaparotomy in patients with severe peritonitis: an economic evaluation within a randomized controlled trial



Results of the first randomized trial comparing on-demand versus planned-relaparotomy strategy in patients with severe peritonitis (RELAP trial) indicated no clear differences in primary outcomes. We now report the full economic evaluation for this trial, including detailed methods, nonmedical costs, further differentiated cost calculations, and robustness of different assumptions in sensitivity analyses.


An economic evaluation was conducted from a societal perspective alongside a randomized controlled trial in 229 patients with severe secondary peritonitis and an acute physiology and chronic health evaluation (APACHE)-II score ≥11 from two academic and five regional teaching hospitals in the Netherlands. After the index laparotomy, patients were randomly allocated to an on-demand or a planned-relaparotomy strategy. Primary resource-utilization data were used to estimate mean total costs per patient during the index admission and after discharge until 1 year after the index operation. Overall differences in costs between the on-demand relaparotomy strategy and the planned strategy, as well as relative differences across several clinical subgroups, were evaluated.


Costs were substantially lower in the on-demand group (mean, €65,768 versus €83,450 per patient in the planned group; mean absolute difference, €17,682; 95% CI, €5,062 to €29,004). Relative differences in mean total costs per patient (approximately 21%) were robust to various alternative assumptions. Planned relaparotomy consistently generated more costs across the whole range of different courses of disease (quick recovery and few resources used on one end of the spectrum; slow recovery and many resources used on the other end). This difference in costs between the two surgical strategies also did not vary significantly across several clinical subgroups.


The reduction in societal costs renders the on-demand strategy a more-efficient relaparotomy strategy in patients with severe peritonitis. These differences were found across the full range of healthcare resources as well as across patients with different courses of disease.

Trial Registration



Secondary peritonitis or abdominal sepsis is a serious condition with high in-hospital mortality (estimates vary between 20% and 60%) and considerable major disease-related morbidity [14]. Patients with severe peritonitis require intensive monitoring and medical treatment, often including lengthy ICU stays. With an estimated incidence for the United States of 9.3 cases of patients with secondary peritonitis per 1,000 emergency hospital admissions [5], these patients incur substantial costs to the healthcare system.

The initial treatment of abdominal sepsis consists of an emergency laparotomy aimed at eliminating the source of the infection. Thereafter, two surgical strategies are used world-wide: planned relaparotomy or relaparotomy on demand. In the planned strategy, a relaparotomy is performed every other day (24 to 36 h) until findings are negative for (ongoing) peritonitis. This strategy may incur the risk of potential surgery-related complications. The on-demand strategy uses 'watchful waiting,' in which a relaparotomy is performed only in those patients showing clinical deterioration or lack of improvement. Fewer relaparotomies are likely to be performed with this strategy [3], which may benefit the already critically ill patients, but may lead to a potentially harmful delay.

The debate about the preferred relaparotomy strategy (on-demand versus planned) in these patients is longstanding, with both strategies having their proponents. We recently published the results of the first randomized trial comparing these two surgical strategies and demonstrated that patients in the on-demand group did not have a significantly lower rate of adverse clinical outcomes compared with the planned group [6]. However, the economic evaluation from a healthcare perspective showed that total costs after 12 months of follow-up were estimated at 23% lower per patient in the on-demand group (€62,741 (US, $86,077)) as compared with a planned-relaparotomy strategy (€81,532 (US, $111,858)).

Here we present the economic evaluation comparing costs generated by an on-demand and a planned-relaparotomy strategy from a societal perspective. More details are reported, regarding both methods and the clinical process driving these costs. Sensitivity analyses were performed to evaluate the robustness of the findings for several assumptions and methodologic choices. Furthermore, differences in costs are assessed across patients with different clinical characteristics and courses of disease.

Materials and methods

Design and eligibility

This economic evaluation was part of the RELAP trial, a randomized controlled multicenter trial comparing an on-demand relaparotomy strategy with a planned-relaparotomy strategy in patients with severe peritonitis. Details about the design, conduct, and major clinical findings of this trial were reported elsewhere [6]. In brief, we included patients diagnosed with secondary peritonitis and requiring an emergency laparotomy, an Acute Physiologic and Chronic Health Evaluation (APACHE) II score greater than 10 in the initial 24-h period [7], and aged between 18 and 80 years [6]. The clinical diagnosis of peritonitis was confirmed during the index laparotomy. Excluded were patients with continuous ambulatory peritoneal dialysis (CAPD)-related peritonitis and pancreatitis. Specialized randomization software was used to allocate patients centrally, with stratification by study site and APACHE-II classification as a minimization factor [8]. The operating surgeon was unaware of the allocated treatment strategy while performing the initial emergency laparotomy. The study was approved by the medical ethics committees of all participating centers.

The appropriate type of economic evaluation is conditional on the results of the primary end points (mortality, major disease-related morbidity) and health-related quality-of-life (HR-QoL). In case of one clearly superior strategy, a cost-effectiveness analysis (CEA) would be required to combine clinical and economic outcomes. In case of comparable outcomes in clinical effectiveness, a cost-minimization analysis (CMA) would suffice [9]. As clinical end points in this study were comparable or even in favor of the on-demand strategy, this economic evaluation was set up as a cost-minimization analysis.

Economic evaluation

Healthcare utilization and other resources were prospectively documented for individual patients [10], by using registration forms of the clinical study, and by acquiring data from additional sources where needed. The horizon for the economic evaluation was 12 months after the initial emergency laparotomy.

The cost analysis was set up from a societal perspective, which consists of three cost categories [11]. These include direct medical costs, direct nonmedical costs, and indirect costs [9, 12]. Direct medical costs are generated by healthcare utilization and include hospital and ICU admission periods, therapeutic and diagnostic procedures, medication, and visits to primary and paramedical healthcare providers after discharge. Direct nonmedical costs are generated by expenses for travel to and from healthcare providers. Indirect costs are associated with loss of productivity due to impaired ability to work [12]. This societal perspective allows a more complete economic evaluation as compared with a healthcare perspective, used for earlier cost estimates [6].

To exclude potential protocol-driven costs, we assessed the extent to which procedures and follow-up visits are part of the usual care for these patients or are relevant only for the conduct of the trial. Basically, some surgical and diagnostic interventions formed protocols for the study, but this was because they are inherent to the surgical strategy; other procedures and interventions were at the discretion of the surgeon, reflecting usual care.

Resource utilization

Data on resource utilization during the index hospital admission included the number of surgical interventions (including relaparotomies), percutaneous drainage procedures, diagnostic procedures (abdominal computer tomography (CT), ultrasound (US), plain radiograph of the abdomen), postoperative hospital stay from index laparotomy onward, and ICU stay. The initial summary cost analyses reported with the main clinical findings [6] were further refined by differentiating between relaparotomies (performing further abdominal repair) and second-look relaparotomies; the latter were assumed to generate fewer costs.

All data were registered alongside the clinical study. Resource utilization after discharge was documented in specifically developed, self-administered questionnaires that were sent to surviving discharged patients at 3, 6, 9, and 12 months of follow-up. Patients reported use of primary, secondary, and paramedic healthcare services. Employment status and absence from paid work was also documented by using the Health and Labour Questionnaire [13]. Nonresponse to the mailed questionnaires was followed by a reminder by phone, and a new questionnaire after 1 month.

Unit costs

Estimates of unit costs were derived from different sources [see Additional File 1]: Dutch reference data from the handbook of the Dutch Health Council [12, 14]; Dutch pharmaceutical unit cost listings [15]; insurance reimbursement fees [16]; top-down cost calculations; and bottom-up cost calculations performed by the authors. All costs were set at the year 2004 price level by using the price index rate for the Dutch healthcare sector.

Costs: calculations

Costs were calculated for individual patients by multiplying actually used healthcare resources and unit costs. Data concerning postdischarge healthcare utilization were not always complete because of partial or nonresponse to the self-administered questionnaires. In these cases, the average resource utilization for an out-of-hospital day was estimated within each study/treatment group, and extrapolated over the total out-of-hospital period. Productivity costs due to illness or recovery in patients younger than 65 years were estimated based on patient-reported absences from paid work. Productivity costs were calculated by using a friction cost approach, which assumes that after a friction period (154 days), each employee is replaced in the workforce [12].

Statistical analyses

All analyses were performed according to the intention-to-treat principle [17]. Data management and analyses were performed with SPSS 12 (SPSS Inc., Chicago, IL), MS Excel 2003, and SAS 9.1 (SAS Institute, Cary, NC).

Mean volumes of resource utilization and associated costs during the index admission and 1-year follow-up were estimated for the two surgical strategies. Differences in volumes were tested for significance by using a nonparametric Wilcoxon Mann-Whitney test.

Total costs per patient were estimated as the sum of direct medical costs, direct nonmedical costs, and indirect costs. Differences in total costs between the two surgical strategies were tested based on their geometric means [18].

Robustness of our results were evaluated in sensitivity analyses regarding the extent to which cost differences can be attributed to costs of relaparotomies alone, as well as for unit costs for a range of cost drivers [5, 6]. We evaluated whether differences in costs were consistent across patients with varying clinical conditions, or whether these differences were more pronounced in more severely ill patients. We hypothesized that the total costs are a proxy for severity of the clinical condition, as more severely ill patients would require more-complicated care and more-intensive treatment, thereby generating more resource utilization and costs. Based on this assumption, we compared the distribution of costs across patients with different clinical conditions (from those patients with a relatively quick recovery and less resource utilization to patients with a more-severe course of disease with slower recovery and extensive use of healthcare resources) between the two strategies. The comparison was graphically presented by ranking patients within each study group by their total costs, and comparing total costs of patients with similar ranks.

Finally, we hypothesized that the relative difference between the on-demand relaparotomy strategy and the planned strategy could be different across clinical subgroups: between patients with and without any major comorbidity (defined as malignancy, cardiovascular disease, respiratory disease, renal disease, or diabetes), patients with high (>20) versus patients with lower (11-20) APACHE-II scores, and between patients surviving and those who died before 12 months of follow-up. A linear regression model was used, with the log-transformed costs as the outcome measure to improve the normality of the residuals required in such models. Differences between clinical subgroups were estimated and statistically tested by adding this as an interaction effect with the type of surgical strategy to the model.


Main clinical findings

In total, 229 patients were correctly randomized and included in this study. In both surgical strategies, one patient withdrew informed consent, and one patient was lost to follow-up, meaning that data on the initial admission were available for 229 patients (114 on-demand and 115 planned strategy), and data on the 1-year follow-up, for 225 patients (112 on-demand and 113 planned strategy).

Demographic and clinical baseline characteristics of these randomized patients are presented in Table 1, together with a summary of the main clinical outcomes. The results show that morbidity and mortality were comparable. More details on the clinical outcomes can be found in the trial publication of clinical outcomes [6].

Table 1 Patient characteristics and summary of main clinical outcomes in the on-demand and planned-relaparotomy groups [6]

Resource utilization and costs

Data available for analysis from the index admission and follow-up admissions were available for all patients. Additional data on use of healthcare resources outside the hospital (outpatient care and other healthcare providers), travel, and absence from work were reported for at least one follow-up period by 76 patients in the on-demand group and 74 patients in the planned group. For both strategies, mean costs per out-of-hospital day were estimated and extrapolated to patients who did not report this part of the follow-up.

Results of the cost analyses are presented by reporting mean volumes, total costs, mean costs per patient per strategy for the on-demand group and the planned group for resource utilization during the index admission, and follow-up (Table 2). Mean costs per patient associated with relaparotomy procedures during the index admission were estimated as €4,617 (index laparotomy plus 113 relaparotomies in 114 patients) for the on-demand group and €6,641 (index laparotomy plus 233 relaparotomies in 115 patients) for the planned group (P < 0.001). Although in the on-demand group, significantly fewer relaparotomies comprised additional surgical procedures (42 in the on-demand and 54 in the planned-relaparotomy group; P = 0.022), the associated mean costs per patient (€1,211 for the on-demand group and €1,543 for the planned group) of these additional procedure differed only marginally (€332).

Table 2 Mean use of resources and costs in the on-demand and planned-relaparotomy groups during index admission and follow-up until 1 year after randomization

Higher costs generated by additional US- or CT-guided percutaneous drainages (€147 (27% received PCD) for the on-demand group and €233 (39% received PCD; P = 0.038)) for the planned group) did not compensate for the lower numbers of relaparotomies in the on-demand group.

As a large majority of patients were admitted to the ICU, substantial costs were generated by the ICU stay. Mean estimated costs per patient generated by the ICU stay were €21,040 (90% of the patients; mean stay, 12 days) in the on-demand group and €31,248 (94% of the patients; mean stay, 18 days; P = 0.001) for the planned-relaparotomy group (mean difference, €10,208). Costs associated with mechanical ventilation showed a similar picture, with mean costs estimated as €3,080 (mean, 8.3 days) for the on-demand group and €4,360 (mean, 12 days; P = 0.004) for the planned group (mean cost difference, €1,280). Costs generated by hospital stay on the ward (excluding ICU days) were estimated as €11,609 for the on-demand group and €11,784 for the planned-relaparotomy group. Although the total length of hospital stay for the index admission was substantially shorter for patients in the on-demand group (mean, 38 days, versus mean, 45 days in the planned group), length of stay on the ward was comparable (mean, 26 and 27 days, respectively; P = 0.21).

The on-demand group used substantially less medication and material (for example, days with enterostomy care, blood transfusions). Mean costs per patient for medication were €474 versus €619; for blood products, €89 versus €178; and for enterostomy care, €741 and €917, comparing the on-demand group and the planned-relaparotomy group. Direct medical costs during admission were significantly lower in the on-demand group, with a mean difference of €14,418 (95% CI, €5,274 to €22,983).

Costs associated with readmissions during the 1-year follow-up were comparable (mean number of hospital days, 9.5 versus 11.8 days (P = 0.88), with mean costs €4,280 for the on-demand patients versus €5,083 for the planned patients). On average, enterostomy care and associated costs during follow-up were considerable. Patients had an enterostomy for a mean of 140 days (€4,449) in the on-demand group and 150 days (€4,767) in the planned-relaparotomy group (P = 0.44).

Distinct differences in resource utilization and associated costs of outpatient and secondary healthcare providers were found for home care supplied by district nurses and stay in rehabilitation centers, in which the on-demand group received less home care (45 hours per patient versus 71 hours in the planned-relaparotomy group; P = 0.16) and had shorter stays in rehabilitation centers than did the planned-relaparotomy group (19 versus 23 days; P = 0.90). Differences between the study groups in utilization and associated costs of outpatient care and visits to secondary healthcare providers (general practitioner, company doctor) were marginal. The direct medical costs during follow-up (between discharge and 12 months after the index laparotomy) were lower in the on-demand group, with a mean difference per patient of €4,069 (95% CI, €2,660 to €7,063).

Among patients reporting to have paid work, only the occasional patient reported a return to work within 12 months. For all nonresponding patients younger than 65 years, we therefore assumed that they were at least absent for the full friction period (154 days). The mean number of days absent from paid work was estimated as 70 days in the on-demand group versus 50 days in the planned group (P = 0.038). Costs associated with lost productivity for these days were estimated as €2,854 and €2,048, respectively.

Overall, for the 1-year study period, mean total costs per patient associated with the on-demand strategy were €65,768 versus €83,450 with the planned strategy (absolute difference, €17,682; 95% CI, €5,062 to €29,004; Wilcoxon-Mann-Whitney test, P < 0.005; relative difference, 21%). Of these total costs, 75% were generated during the initial admission, of which 45% to 55% were ICU costs.

Subsequent sensitivity analyses showed that the results of the cost analysis were robust for changes in various assumptions (Table 3). Absolute estimates of total costs were found to change within a limited range for each strategy (<€8,000 for on-demand, and <€10,000 for planned relaparotomy), whereas the relative difference between the two strategies remained stable (21% to 22%).

Table 3 Summary of sensitivity analyses: mean total costs and estimated absolute and relative differences between relaparotomy on demand and planned relaparotomy across alternative assumptions and calculation methods

To answer the question whether this difference is consistent across patients with different clinical course, Figure 1 shows the distribution of total costs per patient in each group after patients are ranked according to their total costs. Costs were found to be consistently lower in the on-demand group compared with the planned-relaparotomy group across the whole range of costs, except for a small number of patients at the very high end of total costs.

Figure 1

Comparing on-demand and planned-relaparotomy strategies for patients ranked according to their total costs. Total costs could be taken as proxy for clinical condition and recovery. The observed difference in total costs per patient was similar for patients with the most favorable conditions and courses of recovery, as compared with patients with more severe conditions or complicated courses of recovery or both. PR, planned relaparotomy; OD, on-demand relaparotomy.

Relative differences in costs between the on-demand relaparotomy strategy and the planned strategy varied substantially across clinical subgroups: in some subgroups, the mean costs in the planned group are almost twice those in the on-demand group (patients surviving for 12 months versus patients dying within 12 months), whereas costs associated with both strategies appear to be rather comparable in others (for example, anastomotic leakage) (Table 4). In patients who did not survive, 12-months costs were lower in the on-demand group. As none of the formal statistical tests for interaction was significant at the 5% level, the assumption that relative difference in costs between the on-demand and the planned strategy are constant across subgroups has not been rejected.

Table 4 Variation in relative differences in total costs between on-demand and planned relaparotomy strategies across various clinical subgroups


We present an economic evaluation within a randomized clinical trial comparing two commonly used surgical strategies for patients with secondary peritonitis after their initial emergency laparotomy, on-demand relaparotomy and planned relaparotomy. In an earlier publication focusing on the clinical outcomes of the RELAP trial, we demonstrated that patients in the on-demand group did not have a significantly lower rate of poor outcomes compared with the planned group [6]. The results of the detailed cost analyses presented here indicate that, across the full range of healthcare resources, as well as across patients with different disease and recovery courses, resource utilization and associated costs generated by treatment and follow-up of severe abdominal sepsis were substantially lower for the on-demand strategy than for the planned strategy. Furthermore, these relative differences in costs between the two strategies appeared to be quite consistent across a range of clinical subgroups, although for some (for example, anastomotic leakage), this study may have had insufficient power to statistically demonstrate such differences.

The observed cost differences were predominantly related to lengthier ICU stays and duration of mechanical ventilation during the index admission period. Costs of rehabilitation centers and home care and of readmissions to a general hospital during follow-up were also substantial contributors to these cost differences. Although the planned strategy per definition involved at least one relaparotomy procedure, costs generated only by this extra procedure were only a mere fraction of the encountered cost differences. When costs associated with relaparotomy procedures were disregarded, major cost differences between the surgical strategies remained present.

An important component of the total direct medical costs was the ICU stay (often involving mechanical ventilation). Consequently, total costs were highly influenced by the unit costs estimate for an ICU day. We used a reference price based on data from a range of general and academic hospitals in the Netherlands [14]. In the literature, considerable variation was encountered in cost estimates for an ICU stay, if reported at all. This variation due to differences in calculation methods, patient groups, but also in local organization and facilities (staff allocation and remuneration, equipment costs, nonclinical support services and premises) [10] and (national) healthcare system. To enhance the generalizing of our findings to other countries, we presented the consequences of using cost estimates found for the United Kingdom [10], Austria [19], France [20], Canada [21], Germany [22], and Norway [23]. Estimates for countries with publicly funded healthcare systems were better reported in the literature than estimates for countries with other types of healthcare systems (for example, the United States). Information pertaining to these costs and studies addressing the real costs of health care resources appeared to be lacking for non-publicly funded healthcare systems.

In general, resource utilization was found to be higher in the planned group than in the on-demand group. Therefore, adjustments in unit costs would result in changing total costs, rather than affecting the difference between on-demand and planned relaparotomy. Total costs varied to some degree with the different assumptions regarding unit-cost prices, but the relative difference between the strategies remained consistent across these analyses. On average, the on-demand strategy generated approximately 21% less costs than planned relaparotomy. Per 1,000 patients admitted to an emergency room with severe peritonitis, half of whom are currently operated on according to the planned strategy, some €10 million could be saved.

No other studies have reported a detailed description of costs associated with resource utilization generated by abdominal sepsis patients treated by either strategy, and we can compare volumes only; our findings were comparable to those of a retrospective study comparing on-demand and planned relaparotomy, reporting similar figures for average length of hospital stay (49.5 vs. 52.0 (including ICU) and average length of ICU stay (12.6 versus 17.8 days). Duration of mechanical ventilation was a few days longer (10.3 versus 13.9) as compared with our results (8.5 versus 12 days), but the difference (on-demand, 2.5 days shorter ventilation period) was consistent with our findings [3, 6].

This study has some strengths and limitations. First, the economic evaluation was performed as part of a randomized, controlled trial that stratified for severity of disease, ensuring that the patients in both strategies were comparable with respect to clinical and prognostic factors. Differences in resource utilization and related costs can therefore confidently be attributed to the surgical strategy. Furthermore, the economic evaluation was based on data on resource utilization required for the clinical trial and extended with additional relevant information acquired with self-administered questionnaires. This bottom-up strategy provided insight into the healthcare process and main cost-driving factors. Although the majority of costs were generated during index admission, systematic documentation during follow-up demonstrated that these differences remain unchanged from a societal perspective.

Currently, support of the on-demand strategy is growing [2427], and sound empiric evidence regarding the optimal approach is now available from a prospective randomized comparison. The clinical results of the RELAP trial, reported elsewhere [6], and the present economic evaluation support further implementation of an on-demand relaparotomy strategy for treatment of patients with abdominal sepsis.


This economic evaluation prospectively demonstrated that resource utilization and associated costs generated during treatment and follow-up of severe peritonitis were substantially lower for an on-demand strategy compared with a planned strategy. These differences were found across the full range of healthcare resources as well as across patients with different courses of disease. Considering that patients in the on-demand relaparotomy strategy group had a lower (albeit not statistically significant) rate of adverse outcomes compared with the planned-relaparotomy group [6], the reduction in costs (21%) associated with healthcare utilization renders the on-demand relaparotomy a more efficient surgical strategy in patients with severe peritonitis. Implementation of an on-demand relaparotomy strategy could have a positive impact on the healthcare expenses for this severe and costly medical condition.

Key messages

  • Patients with severe peritonitis require intensive monitoring and medical treatment, often including lengthy ICU stays, and therefore incur substantial costs to the healthcare system.

  • The first randomized clinical trial comparing on-demand versus a planned-relaparotomy strategy in patients with severe peritonitis (RELAP trial) indicated no clear differences in primary clinical outcomes.

  • To assess the economic impact of differences in resource use, we performed a full economic evaluation from a societal perspective alongside this trial.

  • Mean total costs per patient were 20% lower in the on-demand group as compared with the planned group.

  • The substantial difference in costs renders the on-demand strategy a far more efficient relaparotomy strategy in patients with severe peritonitis.



Acute Physiology and Chronic Health Evaluation


clinical report form


cost-effectiveness analysis


cost-minimization analysis


computed tomography


fresh frozen plasma


health-related quality of life


intensive care unit


on demand relaparotomy


percutaneous drainage


planned relaparotomy

RELAP trial:

randomized controlled trial comparing relaparotomy on demand with planned relaparotomy




United States dollar

95% CI:

95% confidence interval.


  1. 1.

    Christou NV, Barie PS, Dellinger EP, Waymack JP, Stone HH: Surgical Infection Society intra-abdominal infection study: prospective evaluation of management techniques and outcome. Arch Surg 1993, 128: 193-198.

    CAS  Article  PubMed  Google Scholar 

  2. 2.

    Koperna T, Schulz F: Prognosis and treatment of peritonitis: do we need new scoring systems? Arch Surg 1996, 131: 180-186.

    CAS  Article  PubMed  Google Scholar 

  3. 3.

    Lamme B, Boermeester MA, Belt EJ, van Till JW, Gouma DJ, Obertop H: Mortality and morbidity of planned relaparotomy versus relaparotomy on demand for secondary peritonitis. Br J Surg 2004, 91: 1046-1054. 10.1002/bjs.4517

    CAS  Article  PubMed  Google Scholar 

  4. 4.

    Wittmann DH, Schein M, Condon RE: Management of secondary peritonitis. Ann Surg 1996, 224: 10-18. 10.1097/00000658-199607000-00003

    PubMed Central  CAS  Article  PubMed  Google Scholar 

  5. 5.

    Anaya DA, Nathens AB: Risk factors for severe sepsis in secondary peritonitis. Surg Infect (Larchmt ) 2003, 4: 355-362. 10.1089/109629603322761418

    Article  Google Scholar 

  6. 6.

    van Ruler O, Mahler CW, Boer KR, Reuland EA, Gooszen HG, Opmeer BC, de Graaf PW, Lamme B, Gerhards MF, Steller EP, van Till JW, de Borgie CJ, Gouma DJ, Reitsma JB, Boermeester MA, Dutch Peritonitis Study Group: Comparison of on-demand vs planned relaparotomy strategy in patients with severe peritonitis: a randomized trial. JAMA 2007, 298: 865-872. 10.1001/jama.298.8.865

    CAS  Article  PubMed  Google Scholar 

  7. 7.

    Knaus WA, Harrell FE Jr, Lynn J, Goldman L, Phillips RS, Connors AF Jr, Dawson NV, Fulkerson WJ Jr, Califf RM, Desbiens N, Layde P, Oye RK, Bellamy PE, Hakim RB, Wagner DP: The SUPPORT prognostic model: objective estimates of survival for seriously ill hospitalized adults: study to understand prognoses and preferences for outcomes and risks of treatments. Ann Intern Med 1995, 122: 191-203.

    CAS  Article  PubMed  Google Scholar 

  8. 8.

    Bohnen JM, Mustard RA, Oxholm SE, Schouten BD: APACHE II score and abdominal sepsis: a prospective study. Arch Surg 1988, 123: 225-229.

    CAS  Article  PubMed  Google Scholar 

  9. 9.

    Gold MR, Siegel JE, Russel LB: Cost-effectiveness in Health and Medicine. New York: Oxford University Press; 1996.

    Google Scholar 

  10. 10.

    Edbrooke D, Hibbert C, Ridley S, Long T, Dickie H: The development of a method for comparative costing of individual intensive care units: The Intensive Care Working Group on Costing. Anaesthesia 1999, 54: 110-120. 10.1046/j.1365-2044.1999.00650.x

    CAS  Article  PubMed  Google Scholar 

  11. 11.

    Riteco JA, Heij LJ, Luijn JC, Wolff I: Richtlijnen voor farmaco-economisch onderzoek [Guidelines for pharmaco-economic research]. Amstelveen: College voor Zorgverzekeringen (CvZ) [Health Insurance Board]; 1999.

    Google Scholar 

  12. 12.

    Oostenbrink JB, Koopmanschap MA, Rutten FF: Standardisation of costs: the Dutch Manual for Costing in economic evaluations. Pharmacoeconomics 2002, 20: 443-454. 10.2165/00019053-200220070-00002

    Article  PubMed  Google Scholar 

  13. 13.

    van Roijen L, Essink-Bot ML, Koopmanschap MA, Bonsel G, Rutten FF: Labor and health status in economic evaluation of health care: The Health and Labor Questionnaire. Int J Technol Assess Health Care 1996, 12: 405-415.

    CAS  Article  PubMed  Google Scholar 

  14. 14.

    Oostenbrink JB, Buijs-Van der WT, van AM, Koopmanschap MA, Rutten FF: Unit costs of inpatient hospital days. Pharmacoeconomics 2003, 21: 263-271. 10.2165/00019053-200321040-00004

    Article  PubMed  Google Scholar 

  15. 15.

    Van der Kuy A: Farmacotherapeutisch Kompas 2000/2001 [Pharmacotherapeutic Compass 2000/2001]. Amstelveen: College voor zorgverzekeringen (CvZ) [Health Insurance Board]; 2000.

    Google Scholar 

  16. 16.

    Huiskes LG: Tarieflijst instellingen 2001 [Tariff list institutions 2001]. College Tarieven Gezondheidszorg (CTG) [National Health Tariffs Authority]; 2000.

    Google Scholar 

  17. 17.

    Roland M, Torgerson DJ: What are pragmatic trials? BMJ 1998, 316: 285.

    PubMed Central  CAS  Article  PubMed  Google Scholar 

  18. 18.

    Ramsey S, Willke R, Briggs A, Brown R, Buxton M, Chawla A, Cook J, Glick H, Liljas B, Petitti D, Reed S: Good research practices for cost-effectiveness analysis alongside clinical trials: The ISPOR RCT-CEA task force report. Value Health 2005, 8: 521-533. 10.1111/j.1524-4733.2005.00045.x

    Article  PubMed  Google Scholar 

  19. 19.

    Koperna T: Cost-effectiveness of defunctioning stomas in low anterior resections for rectal cancer: a call for benchmarking. Arch Surg 2003, 138: 1334-1338. 10.1001/archsurg.138.12.1334

    Article  PubMed  Google Scholar 

  20. 20.

    Sznajder M, Aegerter P, Launois R, Merliere Y, Guidet B, CubRea : A cost-effectiveness analysis of stays in intensive care units. Intensive Care Med 2001, 27: 146-153. 10.1007/s001340000760

    CAS  Article  PubMed  Google Scholar 

  21. 21.

    Heyland DK, Konopad E, Noseworthy TW, Johnston R, Gafni A: Is it 'worthwhile' to continue treating patients with a prolonged stay (>14 days) in the ICU? An economic evaluation. Chest 1998, 114: 192-198. 10.1378/chest.114.1.192

    CAS  Article  PubMed  Google Scholar 

  22. 22.

    Moerer O, Schmid A, Hofmann M, Herklotz A, Reinhart K, Werdan K, Schneider H, Burchardi H: Direct costs of severe sepsis in three German intensive care units based on retrospective electronic patient record analysis of resource use. Intensive Care Med 2002, 28: 1440-1446. 10.1007/s00134-002-1429-9

    Article  PubMed  Google Scholar 

  23. 23.

    Flaatten H, Kvale R: Cost of intensive care in a Norwegian University hospital 1997-1999. Crit Care 2003, 7: 72-78. 10.1186/cc2331

    PubMed Central  Article  PubMed  Google Scholar 

  24. 24.

    Hau T, Ohmann C, Wolmershauser A, Wacha H, Yang Q: Planned relaparotomy vs relaparotomy on demand in the treatment of intra-abdominal infections: The Peritonitis Study Group of the Surgical Infection Society-Europe. Arch Surg 1995, 130: 1193-1196.

    CAS  Article  PubMed  Google Scholar 

  25. 25.

    Lamme B, Boermeester MA, Reitsma JB, Mahler CW, Obertop H, Gouma DJ: Meta-analysis of relaparotomy for secondary peritonitis. Br J Surg 2002, 89: 1516-1524. 10.1046/j.1365-2168.2002.02293.x

    CAS  Article  PubMed  Google Scholar 

  26. 26.

    Lamme B, Boermeester MA, de VR, van RO, van Till JW, Obertop H: Survey among surgeons on surgical treatment strategies for secondary peritonitis. Dig Surg 2003, 21: 387-395. 10.1159/000081883

    Article  PubMed  Google Scholar 

  27. 27.

    van Goor H, Hulsebos RG, Bleichrodt RP: Complications of planned relaparotomy in patients with severe general peritonitis. Eur J Surg 1997, 163: 61-66.

    CAS  PubMed  Google Scholar 

  28. 28.

    Wacha H, Linder MM, Feldmann U, Wesch G, Gundlach E, Steifensand RA: Mannheim Peritonitis Index: prediction of risk of death from peritonitis: construction of a statistical and validation of an emperically based index. Theor Surg 1987, 2: 169-177.

    Google Scholar 

  29. 29.

    Giesbers H: Beddencapaciteit ziekenhuizen. In Volksgezondheid Toekomst Verkenning, Nationale Atlas Volksgezondheid. Bilthoven: RIVM; 2003.

    Google Scholar 

Download references


Dutch Peritonitis Study Group

RELAP trial clinical centers and investigators of the Dutch Peritonitis Study Group All investigators are from Departments of Surgery unless specified: (E) Clinical Epidemiology and Biostatistics, (I) Intensive Care, or (MP) Medical Psychology.

O van Ruler MD; KR Boer MSc (E); JB Reitsma MD, PhD (E); CW Mahler MD; EA Reuland MSc; JWO van Till MD; BC Opmeer PhD (E); PMM Bossuyt PhD (E); MJ Schultz MD, PhD (I); MA Sprangers MD, PhD (MP); DJ Gouma MD, PhD; H Obertop MD, PhD; CAJM de Borgie MD, PhD (E); MA Boermeester MD, PhD, Academic Medical Center, Amsterdam; EPh Steller MD, PhD; P. Tanis MD, PhD; H Hart MD (I), St Lucas Andreas Hospital, Amsterdam; MF Gerhards MD, PhD; M Guijt MD; HM Oudemans MD, PhD (I), Onze Lieve Vrouwe Gasthuis, Amsterdam; K. Bosscha MD, PhD; E Ritchie MD; M Vermeer, Bosch Medical Centre, Den Bosch; PW de Graaf MD, PhD; B van Etten MD, PhD; C Haazer (I); E Salm MD, PhD (I); Reinier de Graaf Hospital, Delft; B Lamme MD, PhD; EJ Hesselink MD, PhD; H Rommes MD, PhD (I), Gelre Hospitals, Lucas Hospital Apeldoorn; RJ Oostenbroek MD, PhD; L te Velde MD; G Govaert MD; HH Ponssen MD (I), Albert Schweitzer Hospital, Dordrecht; HG Gooszen MD, PhD; MK Dinkelman MD; LPH Leenen MD, PhD (I), University Medical Centre Utrecht; EGJM Pierik MD, PhD; KWW Lansink MD; J Bakker MD, PhD (I), Isala Clinics, Zwolle.

Key staff and steering committee at coordinating center RELAP trial:

O van Ruler (investigator), EA Reuland (data management), CW Mahler (investigator), JB Reitsma (epidemiologist), CAJM de Borgie (epidemiologist), KR Boer (quality of life investigator), BC Opmeer (health economist), MA Boermeester (principle investigator, project supervisor, gastrointestinal surgeon) from the Department of Surgery, Academic Medical Center Amsterdam, The Netherlands.

The key staff and steering committee received compensation from the grant provided by ZonMw, The Hague, The Netherlands.

Financial support:

Dutch Organization for Health Research and Development (ZonMw), The Hague, The Netherlands. Health Care Efficiency Program. Grant number: 945-02-028

ZonMw approved the study protocol (including design and conduct of the study, data collection and management) after consulting national and international independent reviewers. Final analyses, interpretation of data, manuscript preparation, review and approval of the manuscript were left to the authors' discretion and were not influenced in any way by ZonMw.

Supported by the Netherlands Organization for Health Research and Development (ZonMW), The Hague, The Netherlands. Grant no. 945-02-028.

Author information



Corresponding author

Correspondence to Brent C Opmeer.

Additional information

Competing interests

The authors declare that they have no competing interests.

Authors' contributions

MAB, DJG, HO, JBR, and CAJMB designed the clinical study. BCO, CAJMB, and MAB designed the economic evaluation alongside the clinical trial. OR and CWM were responsible for the coordination of the study, including contacting patients and collecting and entering data. KRB and OR were responsible for assessment and processing of follow-up data. BCO, KRB, OR, JBR, and MAB were responsible for the cost analyses. HGG, PWG, BL, MFG, and EPS were responsible for including more than 10% of the randomized patients in their participating hospital. BCO analyzed data and prepared initial versions of the manuscript. BCO, KRB, OR, JBR, and MAB were responsible for the final manuscript. BCO, KRB, OR, JBR, and MAB interpreted and discussed all data. All authors read, reviewed, and approved the final manuscript.

Electronic supplementary material

Authors’ original submitted files for images

Below are the links to the authors’ original submitted files for images.

Authors’ original file for figure 1

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Opmeer, B.C., Boer, K.R., van Ruler, O. et al. Costs of relaparotomy on-demand versus planned relaparotomy in patients with severe peritonitis: an economic evaluation within a randomized controlled trial. Crit Care 14, R97 (2010).

Download citation


  • Economic Evaluation
  • Direct Medical Cost
  • Index Admission
  • Abdominal Sepsis
  • Secondary Peritonitis