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  1. The effect of hyperglycaemia on the brain cells of septic shock patients is unknown. The objective of this study was to evaluate the relationship between hyperglycaemia and apoptosis in the brains of septic sh...

    Authors: Andrea Polito, Jean-Philippe Brouland, Raphael Porcher, Romain Sonneville, Shidasp Siami, Robert D Stevens, Céline Guidoux, Virginie Maxime, Geoffroy Lorin de la Grandmaison, Fabrice C Chrétien, Françoise Gray, Djillali Annane and Tarek Sharshar
    Citation: Critical Care 2011 15:R131
  2. Care bundles aim to improve standard of care and patient outcome by promoting the consistent implementation of a group of effective interventions. However, a variety of barriers prevent their full application ...

    Authors: Luigi Camporota and Stephen Brett
    Citation: Critical Care 2011 15:159
  3. Socio-demographic and clinical factors associated with increased sepsis risk, including older age, non-white race and specific co-morbidities, are more common among patients with Medicare or Medicaid or no hea...

    Authors: James M O'Brien Jr, Bo Lu, Naeem A Ali, Deborah A Levine, Scott K Aberegg and Stanley Lemeshow
    Citation: Critical Care 2011 15:R130
  4. Several biomarkers have been studied in febrile neutropenia. Our aim was to assess C-reactive protein (CRP) concentration in septic critically ill cancer patients and to compare those with and without neutrope...

    Authors: Pedro Póvoa, Vicente Ces Souza-Dantas, Márcio Soares and Jorge IF Salluh
    Citation: Critical Care 2011 15:R129
  5. In this study, we aimed to assess the association between acute kidney injury (AKI) and mortality in critically ill patients using an original competing risks approach.

    Authors: Christophe Clec'h, Frédéric Gonzalez, Alexandre Lautrette, Molière Nguile-Makao, Maïté Garrouste-Orgeas, Samir Jamali, Dany Golgran-Toledano, Adrien Descorps-Declere, Frank Chemouni, Rebecca Hamidfar-Roy, Elie Azoulay and Jean-François Timsit
    Citation: Critical Care 2011 15:R128
  6. In clinical trials, ordinal outcome measures are often dichotomized into two categories. In traumatic brain injury (TBI) the 5-point Glasgow outcome scale (GOS) is collapsed into unfavourable versus favourable...

    Authors: Bob Roozenbeek, Hester F Lingsma, Pablo Perel, Phil Edwards, Ian Roberts, Gordon D Murray, Andrew IR Maas and Ewout W Steyerberg
    Citation: Critical Care 2011 15:R127
  7. Among the various methods for improving oxygenation while decreasing the risk of ventilation-induced lung injury in patients with acute respiratory distress syndrome (ARDS), a ventilation strategy combining pr...

    Authors: Gilles Rival, Cyrille Patry, Nathalie Floret, Jean Christophe Navellou, Evelyne Belle and Gilles Capellier
    Citation: Critical Care 2011 15:R125
  8. Survivors of critical illness often have significant long-term brain dysfunction, and routine clinical procedures like mechanical ventilation (MV) may affect long-term brain outcome. We aimed to investigate th...

    Authors: María Elisa Quilez, Gemma Fuster, Jesús Villar, Carlos Flores, Octavi Martí-Sistac, Lluís Blanch and Josefina López-Aguilar
    Citation: Critical Care 2011 15:R124

    The Erratum to this article has been published in Critical Care 2015 19:379

  9. Cross-talk between the coagulation system and inflammatory reactions during sepsis causes organ damage followed by multiple organ dysfunction syndrome or even death. Therefore, anticoagulant therapies have bee...

    Authors: Kazuma Yamakawa, Satoshi Fujimi, Tomoyoshi Mohri, Hiroki Matsuda, Yasushi Nakamori, Tomoya Hirose, Osamu Tasaki, Hiroshi Ogura, Yasuyuki Kuwagata, Toshimitsu Hamasaki and Takeshi Shimazu
    Citation: Critical Care 2011 15:R123
  10. Since 2003, we have routinely used percutaneous coronary intervention (PCI) and mild therapeutic hypothermia (MTH) to treat patients < 80 years of age after out-of-hospital cardiac arrest (OHCA) related to ven...

    Authors: Pierrick Cronier, Philippe Vignon, Koceila Bouferrache, Philippe Aegerter, Cyril Charron, François Templier, Samuel Castro, Rami El Mahmoud, Cécile Lory, Nicolas Pichon, Olivier Dubourg and Antoine Vieillard-Baron
    Citation: Critical Care 2011 15:R122
  11. Acute kidney injury (AKI) is common in critically ill patients and associated with important morbidity and mortality. Although alterations in renal perfusion are thought to play a causative role in the pathoge...

    Authors: Antoine Schneider, Lynne Johnson, Mark Goodwin, Anthony Schelleman and Rinaldo Bellomo
    Citation: Critical Care 2011 15:157
  12. Expanding the criteria for deceased organ donors increases the risk of delayed graft function (DGF) and complicates kidney transplant outcome. We studied whether donor neutrophil gelatinase-associated lipocali...

    Authors: Maria E Hollmen, Lauri E Kyllönen, Kaija A Inkinen, Martti LT Lalla, Jussi Merenmies and Kaija T Salmela
    Citation: Critical Care 2011 15:R121
  13. The relationship between collapse to emergency medical service (EMS) cardiopulmonary resuscitation (CPR) interval and outcome has been well documented. However, most studies have only analyzed cases of cardiac...

    Authors: Soichi Koike, Toshio Ogawa, Senzan Tanabe, Shinya Matsumoto, Manabu Akahane, Hideo Yasunaga, Hiromasa Horiguchi and Tomoaki Imamura
    Citation: Critical Care 2011 15:R120
  14. Protocols using high levels of positive end-expiratory pressure (PEEP) in combination with low tidal volumes have been shown to reduce mortality in patients with severe acute respiratory distress syndrome (ARD...

    Authors: Peter Kostic, Emanuela Zannin, Marie Andersson Olerud, Pasquale P Pompilio, Göran Hedenstierna, Antonio Pedotti, Anders Larsson, Peter Frykholm and Raffaele L Dellaca
    Citation: Critical Care 2011 15:R126
  15. Monitoring of hemodynamic and volumetric parameters after severe burns is of critical importance. Pulmonary artery catheters, however, have been associated with many risks. Our aim was to show the feasibility ...

    Authors: Ludwik K Branski, David N Herndon, Jaron F Byrd, Michael P Kinsky, Jong O Lee, Shawn P Fagan and Marc G Jeschke
    Citation: Critical Care 2011 15:R118
  16. Purulent pericarditis (PP) is a potentially life-threatening disease. Reported mortality rates are between 20 and 30%. Constrictive pericarditis occurs over the course of PP in at least 3.5% of cases. The freq...

    Authors: Pascal Augustin, Mathieu Desmard, Pierre Mordant, Sigismond Lasocki, Jean-Michel Maury, Nicholas Heming and Philippe Montravers
    Citation: Critical Care 2011 15:220
  17. Authors: Adriano Peris, Manuela Bonizzoli, Dario Iozzelli, Maria Luisa Migliaccio, Giovanni Zagli, Alberto Bacchereti, Marta Debolini, Elisetta Vannini, Massimo Solaro, Ilaria Balzi, Elisa Bendoni, Ilaria Bacchi, Monica Trevisan, Valtere Giovannini and Laura Belloni
    Citation: Critical Care 2011 15:418

    The original article was published in Critical Care 2011 15:R41

  18. Marked variability in transfusion practice exists in cardiac surgical patients, with consumption of approximately 20% of the worldwide allogeneic blood supply. Observational studies have reported an associatio...

    Authors: Lena M Napolitano
    Citation: Critical Care 2011 15:152
  19. Our purpose in conducting this study was to determine whether administration of high-dose tranexamic acid (TA) at the time of diagnosis of postpartum haemorrhage (PPH) could reduce blood loss.

    Authors: Anne-Sophie Ducloy-Bouthors, Brigitte Jude, Alain Duhamel, Françoise Broisin, Cyril Huissoud, Hawa Keita-Meyer, Laurent Mandelbrot, Nadia Tillouche, Sylvie Fontaine, Françoise Le Goueff, Sandrine Depret-Mosser, Benoit Vallet and Sophie Susen
    Citation: Critical Care 2011 15:R117
  20. In critically ill patients, it is uncertain whether exposure to older red blood cells (RBCs) may contribute to mortality. We therefore aimed to evaluate the association between the age of RBCs and outcome in a...

    Authors: Ville Pettilä, Andrew J Westbrook, Alistair D Nichol, Michael J Bailey, Erica M Wood, Gillian Syres, Louise E Phillips, Alison Street, Craig French, Lynnette Murray, Neil Orford, John D Santamaria, Rinaldo Bellomo and David J Cooper
    Citation: Critical Care 2011 15:R116
  21. The triggering receptor expressed on myeloid cells-1 (TREM-1) is known to be expressed during bacterial infections. We investigated whether TREM-1 is also expressed in non-infectious inflammation following tra...

    Authors: Tobias M Bingold, Barbara Pullmann, Sven Sartorius, Emanuel V Geiger, Ingo Marzi, Kai Zacharowski, Heimo Wissing and Bertram Scheller
    Citation: Critical Care 2011 15:R115
  22. We studied the diagnostic accuracy of bedside lung ultrasound (the presence of a comet-tail sign), N-terminal pro-brain natriuretic peptide (NT-proBNP) and clinical assessment (according to the modified Boston...

    Authors: Gregor Prosen, Petra Klemen, Matej Strnad and Å tefek Grmec
    Citation: Critical Care 2011 15:R114

    The Erratum to this article has been published in Critical Care 2011 15:450

  23. Thrombomodulin, which is expressed solely on monocytes, along with tissue factor (TF), takes part in coagulation and inflammation. Circulating blood monocytes can be divided into 3 major subtypes on the basis ...

    Authors: Sang Mee Hwang, Ji-Eun Kim, Kyou-Sup Han and Hyun Kyung Kim
    Citation: Critical Care 2011 15:R113
  24. Respiratory-associated variations in stroke volume and pulse pressure are frequently used to predict the response to fluid administration. However, it has been demonstrated that low tidal volume ventilation ma...

    Authors: Daniel De Backer and Sabino Scolletta
    Citation: Critical Care 2011 15:150
  25. Although Pseudomonas aeruginosa is a leading pathogen responsible for ventilator-associated pneumonia (VAP), the excess in mortality associated with multi-resistance in patients with P. aeruginosa VAP (PA-VAP), t...

    Authors: Catherine Kaminski, Jean-François Timsit, Yohann Dubois, Jean-Ralph Zahar, Maïté Garrouste-Orgeas, Aurélien Vesin, Elie Azoulay, Céline Feger, Anne-Sylvie Dumenil, Christophe Adrie, Yves Cohen and Bernard Allaouchiche
    Citation: Critical Care 2011 15:R112
  26. A semi-upright position in ventilated patients is recommended to prevent ventilator-associated pneumonia (VAP) and is one of the components in the Ventilator Bundle of the Institute for Health Care Improvement...

    Authors: Barbara S Niël-Weise, Petra Gastmeier, Axel Kola, Ralf P Vonberg, Jan C Wille and Peterhans J van den Broek
    Citation: Critical Care 2011 15:R111
  27. Out-of-hospital cardiac arrest is a leading cause of death in developed countries and early resuscitation attempts are crucial to improve survival rates and neurological outcome. Gräsner and colleagues perform...

    Authors: Enrica Golia, Maddalena Piro and Marco Tubaro
    Citation: Critical Care 2011 15:149