Articles
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Citation: Critical Care 2011 15:448
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Dynamic lactate indices as predictors of outcome in critically ill patients
Dynamic changes in lactate concentrations in the critically ill may predict patient outcome more accurately than static indices. We aimed to compare the predictive value of dynamic indices of lactatemia in the...
Citation: Critical Care 2011 15:R242 -
Pharmacological postconditioning with sevoflurane after cardiopulmonary resuscitation reduces myocardial dysfunction
In this study, we sought to examine whether pharmacological postconditioning with sevoflurane (SEVO) is neuro- and cardioprotective in a pig model of cardiopulmonary resuscitation.
Citation: Critical Care 2011 15:R241 -
Presence of tobramycin in blood and urine during selective decontamination of the digestive tract in critically ill patients, a prospective cohort study
Tobramycin is one of the components used for selective decontamination of the digestive tract (SDD), applied to prevent colonization and subsequent infections in critically ill patients. Tobramycin is administ...
Citation: Critical Care 2011 15:R240 -
A dynamic view of mHLA-DR expression in management of severe septic patients
Increasing evidence suggests that the secondary phase of sepsis (that is, after the first proinflammatory hours) is characterized by the occurrence of a systemic failure of the immune system. In the most immun...
Citation: Critical Care 2011 15:198 -
Clinical effectiveness of fresh frozen plasma compared with fibrinogen concentrate: a systematic review
Haemostatic therapy in surgical and/or massive trauma patients typically involves transfusion of fresh frozen plasma (FFP). Purified human fibrinogen concentrate may offer an alternative to FFP in some instanc...
Citation: Critical Care 2011 15:R239 -
Glucocorticoids in sepsis: dissecting facts from fiction
Citation: Critical Care 2011 15:446 -
Severe metabolic or mixed acidemia on intensive care unit admission: incidence, prognosis and administration of buffer therapy. a prospective, multiple-center study
In this study, we sought describe the incidence and outcomes of severe metabolic or mixed acidemia in critically ill patients as well as the use of sodium bicarbonate therapy to treat these illnesses.
Citation: Critical Care 2011 15:R238 -
Collecting core data in severely injured patients using a consensus trauma template: an international multicentre study
No worldwide, standardised definitions exist for documenting, reporting and comparing data from severely injured trauma patients. This study evaluated the feasibility of collecting the data variables of the in...
Citation: Critical Care 2011 15:R237 -
Transpulmonary thermodilution assessments: precise measurements require a precise procedure
When incorporating the values of a hemodynamic parameter into the care of patients, the precision of the measurement method should always be considered. A prospective analysis in the previous issue of Critical Ca...
Citation: Critical Care 2011 15:195 -
Microparticles as biological vectors of activated protein C treatment in sepsis
Activated protein C (APC), a physiological coagulation inhibitor, has been shown to reduce mortality in patients with severe sepsis. APC exerts pleiotropic cytoprotection by a mechanism that requires its inter...
Citation: Critical Care 2011 15:197 -
Massive bleeding in polytrauma: how can we make progress?
Trauma is a major cause of death worldwide, with some 30% of deaths associated with hemorrhage. Rapid control of bleeding in such patients is thus an essential aspect of trauma care. Recombinant human factor V...
Citation: Critical Care 2011 15:196 -
Perioperative hemodynamic therapy: quality improvement programs should help to resolve our uncertainty
Citation: Critical Care 2011 15:445 -
Comparison of supraglottic airway versus endotracheal intubation for the pre-hospital treatment of out-of-hospital cardiac arrest
Both supraglottic airway devices (SGA) and endotracheal intubation (ETI) have been used by emergency life-saving technicians (ELST) in Japan to treat out-of-hospital cardiac arrests (OHCAs). Despite traditiona...
Citation: Critical Care 2011 15:R236 -
Remarkable changes in the choice of timing to discuss organ donation with the relatives of a patient: a study in 228 organ donations in 20 years
We studied whether the choice of timing of discussing organ donation for the first time with the relatives of a patient with catastrophic brain injury in The Netherlands has changed over time and explored its ...
Citation: Critical Care 2011 15:R235 -
Clinical review: flow cytometry perspectives in the ICU - from diagnosis of infection to monitoring of injury-induced immune dysfunctions
Septic syndromes represent a major healthcare problem worldwide. Clinical and experimental evidence indicates that septic patients rapidly present with numerous compromised immune functions. Although flow cyto...
Citation: Critical Care 2011 15:231 -
Coenzyme Q10 deficiency in septic shock patients
Donnino and colleagues provide new insights into the field of oxidative stress and mitochondrial dysfunction during septic shock. These authors suggest a coenzyme Q10 (CoQ10) deficiency in patients with septic sh...
Citation: Critical Care 2011 15:194 -
Is decompressive craniectomy useless in severe traumatic brain injury?
Recently, a multicenter randomized controlled trial (RCT) by Cooper and colleagues indicated that decompressive craniectomy (DC) may be associated with a worse functional outcome in patients with diffuse traum...
Citation: Critical Care 2011 15:193 -
Neuromuscular blockers and ARDS: Thou shalt not breathe, move, or die!
Citation: Critical Care 2011 15:311 -
The feasibility and safety of fiberoptic bronchoscopy during noninvasive ventilation in patients with established acute lung injury: another small brick in the wall
In hypoxemic patients needing fiberoptic bronchoscopy (FOB), noninvasive ventilation (NIV) has been used to prevent gas-exchange deterioration associated with FOB and to compensate for the increase in work of ...
Citation: Critical Care 2011 15:191 -
The tracheal tube: gateway to ventilator-associated pneumonia
Ventilator-associated pneumonia (VAP) is a major healthcare-associated complication with considerable attributable morbidity, mortality and cost. Inherent design flaws in the standard high-volume low-pressure ...
Citation: Critical Care 2011 15:310 -
Extracorporeal membrane oxygenation as a bridge to liver transplantation for acute respiratory distress syndrome-induced life-threatening hypoxaemia aggravated by hepatopulmonary syndrome
Combined with massive lung aeration loss resulting from acute respiratory distress syndrome, hepatopulmonary syndrome, a liver-induced vascular lung disorder characterized by diffuse or localized dilated pulmo...
Citation: Critical Care 2011 15:R234 -
Plasma from septic shock patients induces loss of muscle protein
ICU-acquired muscle weakness commonly occurs in patients with septic shock and is associated with poor outcome. Although atrophy is known to be involved, it is unclear whether ligands in plasma from these pati...
Citation: Critical Care 2011 15:R233 -
Major sources of critical incidents in intensive care
In recent years, critical incident (CI) reporting has increasingly been regarded as part of ongoing quality management. CI databanks also aim to improve health and safety issues for patients as well as staff. ...
Citation: Critical Care 2011 15:R232 -
Postextubation dysphagia is persistent and associated with poor outcomes in survivors of critical illness
Dysphagia is common among survivors of critical illness who required mechanical ventilation during treatment. The risk factors associated with the development of postextubation dysphagia, and the effects of dy...
Citation: Critical Care 2011 15:R231 -
Short-term effects of combining upright and prone positions in patients with ARDS: a prospective randomized study
Prone position is known to improve oxygenation in patients with acute lung injury (ALI) and the acute respiratory distress syndrome (ARDS). Supine upright (semirecumbent) position also exerts beneficial effect...
Citation: Critical Care 2011 15:R230 -
Obituary: Dr Max Harry Weil
Citation: Critical Care 2011 15:192 -
Dobutamine administration in patients after cardiac surgery: beneficial or harmful?
Citation: Critical Care 2011 15:444 -
Outcome effectiveness of the severe sepsis resuscitation bundle with addition of lactate clearance as a bundle item: a multi-national evaluation
Implementation of the Surviving Sepsis Campaign (SSC) guidelines has been associated with improved outcome in patients with severe sepsis. Resolution of lactate elevations or lactate clearance has also been sh...
Citation: Critical Care 2011 15:R229 -
Is Drotrecogin alfa (activated) for adults with severe sepsis, cost-effective in routine clinical practice?
Previous cost-effectiveness analyses (CEA) reported that Drotrecogin alfa (DrotAA) is cost-effective based on a Phase III clinical trial (PROWESS). There is little evidence on whether DrotAA is cost-effective ...
Citation: Critical Care 2011 15:R228 -
Leptin and leptin receptor polymorphisms are associated with poor outcome (death) in patients with non-appendicular secondary peritonitis
Leptin (LEP) and its receptor (LEPR) participate in the immunological response during infection. LEP serum levels rise during sepsis. In patients with peritonitis, an insufficient elevation in serum LEP is ass...
Citation: Critical Care 2011 15:R227 -
Restrictive strategy of intraoperative fluid maintenance during optimization of oxygen delivery decreases major complications after high-risk surgery
Optimal fluid management is crucial for patients who undergo major and prolonged surgery. Persistent hypovolemia is associated with complications, but fluid overload is also harmful. We evaluated the effects o...
Citation: Critical Care 2011 15:R226 -
The physiologic responses to epinephrine during cooling and after rewarming in vivo
The purpose of our study was to determine whether hypothermia has any effects on physiological hemodynamic responses to epinephrine (Epi), and whether rewarming reverses these effects.
Citation: Critical Care 2011 15:R225 -
Rapid sequence induction with rocuronium - a challenge to the gold standard
Succinylcholine has been indicted on account of the diverse risks associated with its administration, which include hyperkalemia, vagal arrest, and malignant hyperthermia. However, it provides excellent intuba...
Citation: Critical Care 2011 15:190 -
Serial increase of IL-12 response and human leukocyte antigen-DR expression in severe sepsis survivors
Sepsis-induced immunosuppression may result in death. The mechanisms of immune suppression include loss of macrophage and monocyte expression of the major histocompatibility complex, increased anti-inflammator...
Citation: Critical Care 2011 15:R224 -
The association of near-infrared spectroscopy-derived tissue oxygenation measurements with sepsis syndromes, organ dysfunction and mortality in emergency department patients with sepsis
Near-infrared spectroscopy (NIRS) noninvasively measures peripheral tissue oxygen saturation (StO2). NIRS may be utilized along with a vascular occlusion test, in which limb blood flow is temporarily occluded and...
Citation: Critical Care 2011 15:R223 -
Clinical prediction rules for invasive candidiasis in the ICU: ready for prime time?
Invasive candidiasis is a major source of morbidity and mortality in critically ill patients. The creation and validation of clinical prediction rules to identify patients at high risk has given clinicians acc...
Citation: Critical Care 2011 15:189 -
Effects of changes in arterial pressure on organ perfusion during septic shock
Septic shock is characterized by altered tissue perfusion associated with persistent arterial hypotension. Vasopressor therapy is generally required to restore organ perfusion but the optimal mean arterial pre...
Citation: Critical Care 2011 15:R222 -
Red blood cell transfusion and outcomes in patients with acute lung injury, sepsis and shock
In this study, we sought to determine the association between red blood cell (RBC) transfusion and outcomes in patients with acute lung injury (ALI), sepsis and shock.
Citation: Critical Care 2011 15:R221 -
Changes of monocyte human leukocyte antigen-DR expression as a reliable predictor of mortality in severe sepsis
Many studies have shown that monocyte human leukocyte antigen-DR (mHLA-DR) expression may be a good predictor for mortality in severe septic patients. On the contrary, other studies found mHLA-DR was not a use...
Citation: Critical Care 2011 15:R220 -
Effect of fluid loading during hypovolaemic shock on caspofungin pharmacokinetic parameters in pig
Caspofungin treatment is frequently initiated in shock patients. In the present study, we investigated the influence of hypovolaemic shock requiring fluid loading on the plasma and pulmonary pharmacokinetic pa...
Citation: Critical Care 2011 15:R219 -
Preoperative regional cerebral oxygen saturation is a predictor of postoperative delirium in on-pump cardiac surgery patients: a prospective observational trial
Postoperative delirium is an important problem in patients undergoing major surgery. Cerebral oximetry is a non-invasive method to detect imbalances in the cerebral oxygen supply/demand-ratio. Low preoperative...
Citation: Critical Care 2011 15:R218 -
Effects of vasopressinergic receptor agonists on sublingual microcirculation in norepinephrine-dependent septic shock
The present study was designed to determine the effects of continuously infused norepinephrine (NE) plus (1) terlipressin (TP) or (2) arginine vasopressin (AVP) or (3) placebo on sublingual microcirculation in...
Citation: Critical Care 2011 15:R217 -
Brain injury clinical trials: new agents or new statistics?
Failure of the vast majority of clinical trials evaluating recovery after severe brain injury from stroke or trauma has triggered interest in novel statistical techniques that are more powerful than convention...
Citation: Critical Care 2011 15:188 -
Passive leg raising can predict fluid responsiveness in patients placed on venovenous extracorporeal membrane oxygenation
In ICUs, fluid administration is frequently used to treat hypovolaemia. Because volume expansion (VE) can worsen acute respiratory distress syndrome (ARDS) and volume overload must be avoided, predictive indic...
Citation: Critical Care 2011 15:R216 -
Impact of quetiapine on resolution of individual delirium symptoms in critically ill patients with delirium: a post-hoc analysis of a double-blind, randomized, placebo-controlled study
We hypothesized that delirium symptoms may respond differently to antipsychotic therapy. The purpose of this paper was to retrospectively compare duration and time to first resolution of individual delirium sy...
Citation: Critical Care 2011 15:R215 -
Real-time ultrasound-guided percutaneous dilatational tracheostomy
Citation: Critical Care 2011 15:443 -
Use of near-infrared spectroscopy during a vascular occlusion test to assess the microcirculatory response during fluid challenge
Adequate volume expansion (VE) in patients with evidence of hypoperfusion should be aimed not only at achieving an increase in stroke volume (SV) and cardiac index (CI) but also at improved tissue perfusion an...
Citation: Critical Care 2011 15:R214 -
Improved ICU design reduces acquisition of antibiotic-resistant bacteria: a quasi-experimental observational study
The role of ICU design and particularly single-patient rooms in decreasing bacterial transmission between ICU patients has been debated. A recent change in our ICU allowed further investigation.
Citation: Critical Care 2011 15:R211 -
Erratum to: C-reactive protein/albumin ratio at ICU discharge as a predictor of post-ICU death: a new useful tool
Citation: Critical Care 2011 15(Suppl 2):P67
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- ISSN: 1364-8535 (electronic)