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  1. There is growing evidence to suggest that transthoracic echocardiography (TTE) should be used to identify the cardiac origin of respiratory weaning failure. The aims of our study were: first, to evaluate the a...

    Authors: Sébastien Moschietto, Denis Doyen, Ludovic Grech, Jean Dellamonica, Hervé Hyvernat and Gilles Bernardin
    Citation: Critical Care 2012 16:R81
    Content type: Research Published on:

  2. Optic nerve sheath diameter (ONSD) measurement with bedside ultrasound has been shown in many studies to accurately detect high intracranial pressure (ICP). The accuracy of point-in-time ONSD measurement in th...

    Authors: Venkatakrishna Rajajee, Jeffrey James Fletcher, Lauryn Renee Rochlen and Teresa Lee Jacobs
    Citation: Critical Care 2012 16:R79
    Content type: Research Published on:

  8. In the past two decades, healthcare adopted industrial strategies for process measurement and control. In the industry model, care is taken to avoid minimal deviations from a standard. In healthcare there is s...

    Authors: Andre CKB Amaral, Lars Kure and Angie Jeffs
    Citation: Critical Care 2012 16:R78
    Content type: Research Published on:

  9. Morbid obesity and its consequences are considered risk factors for adverse outcome in trauma, although the pathophysiologic mechanisms are incompletely understood. The aim of this study was to compare initial...

    Authors: Jana Nelson, Adrian T Billeter, Burkhardt Seifert, Valentin Neuhaus, Otmar Trentz, Christoph K Hofer and Matthias Turina
    Citation: Critical Care 2012 16:R77
    Content type: Research Published on:

  10. Patients with septic shock require fluid, but the optimum amount is unknown. Therefore we assessed patient characteristics and outcome associated with fluid volume in unselected patients with septic shock incl...

    Authors: Søren H Smith and Anders Perner
    Citation: Critical Care 2012 16:R76
    Content type: Research Published on:

  11. Hepatic mitochondrial dysfunction may play a critical role in the pathogenesis of metformin-induced lactic acidosis. However, patients with severe metformin intoxication may have a 30 to 60% decrease in their ...

    Authors: Alessandro Protti, Francesco Fortunato, Massimo Monti, Sarah Vecchio, Stefano Gatti, Giacomo P Comi, Rachele De Giuseppe and Luciano Gattinoni
    Citation: Critical Care 2012 16:R75
    Content type: Research Published on:

  12. Early identification of septic patients at high risk of dying remains a challenge. The prognostic role of brain natriuretic peptide (BNP) or N-terminal pro-B-type natriuretic peptide (NT-proBNP) in septic pati...

    Authors: Fei Wang, Youping Wu, Lu Tang, Weimin Zhu, Feng Chen, Tao Xu, Lulong Bo, Jinbao Li and Xiaoming Deng
    Citation: Critical Care 2012 16:R74
    Content type: Research Published on:

  13. This study hypothesised that a reduction of sound during the night using earplugs could be beneficial in the prevention of intensive care delirium. Two research questions were formulated. First, does the use o...

    Authors: Bart Van Rompaey, Monique M Elseviers, Wim Van Drom, Veronique Fromont and Philippe G Jorens
    Citation: Critical Care 2012 16:R73
    Content type: Research Published on:

  14. Recent data have suggested that patient admission during intensive care unit (ICU) morning bedside rounds is associated with less favorable outcome. We undertook the present study to explore the association be...

    Authors: IvensAugusto O de Souza, Constantine J Karvellas, RT Noel Gibney and Sean M Bagshaw
    Citation: Critical Care 2012 16:R72
    Content type: Research Published on:

  15. Left ventricular (LV) dysfunction is common in septic shock. Its association with the clinical outcome is still controversial. Tissue Doppler imaging (TDI) is a useful tool to quantify LV function; however, li...

    Authors: Li Weng, Yong-tai Liu, Bin Du, Jian-fang Zhou, Xiao-xiao Guo, Jin-min Peng, Xiao-yun Hu, Shu-yang Zhang, Quan Fang and Wen-ling Zhu
    Citation: Critical Care 2012 16:R71
    Content type: Research Published on:

  16. Mortality is the most widely measured outcome parameter. Improvement of this outcome parameter in critical care is nowadays expected not to come from new technologies or treatment, but from delivering the righ...

    Authors: L Marjon Dijkema, Willem Dieperink, Matijs van Meurs and Jan G Zijlstra
    Citation: Critical Care 2012 16:309
    Content type: Viewpoint Published on:

  18. Data from interventional trials of systemic anticoagulation for sepsis inconsistently suggest beneficial effects in case of acute lung injury (ALI). Severe systemic bleeding due to anticoagulation may have off...

    Authors: Pieter R Tuinman, Barry Dixon, Marcel Levi, Nicole P Juffermans and Marcus J Schultz
    Citation: Critical Care 2012 16:R70
    Content type: Research Published on:

  19. The correction of hypovolemia with acellular fluids results in acute normovolemic anemia. Whether the choice of the infusion fluid has an impact on the maintenance of oxygen (O2) supply during acute normovolemic ...

    Authors: Andreas Pape, Saskia Kutschker, Harry Kertscho, Peter Stein, Oliver Horn, Mischa Lossen, Bernhard Zwissler and Oliver Habler
    Citation: Critical Care 2012 16:R69
    Content type: Research Published on:

  22. The translation of knowledge into rational care is as essential and pressing a task as the development of new diagnostic or therapeutic devices, and is arguably more important. The emerging science of health c...

    Authors: Brian W Pickering, John M Litell, Vitaly Herasevich and Ognjen Gajic
    Citation: Critical Care 2012 16:220
    Content type: Review Published on:

  23. Monitoring plays an important role in the current management of patients with acute respiratory failure but sometimes lacks definition regarding which 'signals' and 'derived variables' should be prioritized as...

    Authors: Laurent Brochard, Greg S Martin, Lluis Blanch, Paolo Pelosi, F Javier Belda, Amal Jubran, Luciano Gattinoni, Jordi Mancebo, V Marco Ranieri, Jean-Christophe M Richard, Diederik Gommers, Antoine Vieillard-Baron, Antonio Pesenti, Samir Jaber, Ola Stenqvist and Jean-Louis Vincent
    Citation: Critical Care 2012 16:219
    Content type: Review Published on:

  25. Critical illness is characterized by oxidative stress, which is a major promoter of systemic inflammation and organ failure due to excessive free radical production, depletion of antioxidant defenses, or both....

    Authors: William Manzanares, Rupinder Dhaliwal, Xuran Jiang, Lauren Murch and Daren K Heyland
    Citation: Critical Care 2012 16:R66
    Content type: Research Published on:

  30. Disseminated intravascular coagulation (DIC) is characterized by the concomitant activation of coagulofibrinolytic disorders and systemic inflammation associated with endothelial dysfunction-induced microvascu...

    Authors: Takeshi Wada, Subrina Jesmin, Satoshi Gando, Sayeeda N Sultana, Sohel Zaedi and Hiroyuki Yokota
    Citation: Critical Care 2012 16:R63
    Content type: Research Published on:

  31. Ventilator-associated pneumonia (VAP) may contribute to the mortality associated with acute respiratory distress syndrome (ARDS). We aimed to determine the incidence, outcome, and risk factors of bacterial VAP...

    Authors: Jean-Marie Forel, François Voillet, Daniel Pulina, Arnaud Gacouin, Gilles Perrin, Karine Barrau, Samir Jaber, Jean-Michel Arnal, Mohamed Fathallah, Pascal Auquier, Antoine Roch, Elie Azoulay and Laurent Papazian
    Citation: Critical Care 2012 16:R65
    Content type: Research Published on:

  33. Many supposed low-risk intensive care unit (ICU) admissions develop acute organ failure (AOF). Identifying patients at high risk of developing AOF and targeting them with preventative strategies may be effecti...

    Authors: Marius Terblanche, Peter Kruger, Stefania di Gangi, Sadiq Gearay, Lynn Gilfeather, Niall D Ferguson, Rupert Pearse, Richard Beale, Andrew Rhodes, Stephen J Brett and Daniel F McAuley
    Citation: Critical Care 2012 16:R61
    Content type: Research Published on:

  34. Apolipoprotein M (apoM) is present in 5% of high-density lipoprotein (HDL) particles in plasma. It is a carrier of sphingosine-1-phosphate (S1P), which is important for vascular barrier protection. The aim was...

    Authors: Sunil B Kumaraswamy, Adam Linder, Per Åkesson and Björn Dahlbäck
    Citation: Critical Care 2012 16:R60
    Content type: Research Published on:

  35. During severe sepsis or septic shock, activation of the inflammatory and coagulatory systems can result in microcirculatory dysfunction as well as microvascular thrombosis, culminating in multiple organ dysfun...

    Authors: Yu-Chang Yeh, Ming-Jiuh Wang, Chih-Peng Lin, Shou-Zen Fan, Jui-Chang Tsai, Wei-Zen Sun and Wen-Je Ko
    Citation: Critical Care 2012 16:R59
    Content type: Research Published on:

  36. The aim of the present study was to investigate the relationship between the blood IL-6 level, the blood glucose level, and glucose control in septic patients.

    Authors: Masataka Nakamura, Shigeto Oda, Tomohito Sadahiro, Eizo Watanabe, Ryuzo Abe, Taka-aki Nakada, Yasumasa Morita and Hiroyuki Hirasawa
    Citation: Critical Care 2012 16:R58
    Content type: Research Published on:

  38. Candida prophylaxis in ICU is still a matter of debate. Oral chemoprophylaxis has been advocated to reduce the incidence of Candida colonisation and infection.

    Authors: Mariateresa Giglio, Giuseppina Caggiano, Lidia Dalfino, Nicola Brienza, Ilaria Alicino, Aurelia Sgobio, Antonella Favale, Caterina Coretti, Maria Teresa Montagna, Francesco Bruno and Filomena Puntillo
    Citation: Critical Care 2012 16:R57
    Content type: Research Published on:

  40. Hyperglycemia and protein loss are common in critically ill patients. Insulin can be used to lower blood glucose and inhibit proteolysis. The impact of moderate insulin therapy on protein metabolism in critica...

    Authors: Chien-Wei Hsu, Shu-Fen Sun, Shoa-Lin Lin, Hsiu-Hua Huang and Kam-Fai Wong
    Citation: Critical Care 2012 16:R56
    Content type: Research Published on:

  43. Accumulating evidence suggests that, in critically ill patients, a lower hemoglobin transfusion threshold is safe. However, the optimal hemoglobin level and associated transfusion threshold remain unknown in n...

    Authors: Philippe Desjardins, Alexis F Turgeon, Marie-Hélène Tremblay, François Lauzier, Ryan Zarychanski, Amélie Boutin, Lynne Moore, Lauralyn A McIntyre, Shane W English, Andrea Rigamonti, Jacques Lacroix and Dean A Fergusson
    Citation: Critical Care 2012 16:R54
    Content type: Research Published on:

  46. Sepsis is the third largest cause of death in industrialised countries, but treatment remains largely supportive and effective therapeutic interventions are urgently needed. Disruption and dysfunction of the m...

    Authors: Anne Burke-Gaffney and Timothy W Evans
    Citation: Critical Care 2012 16:121
    Content type: Commentary Published on:

  47. Community-acquired pneumonia (CAP) requiring intensive care unit (ICU) admission remains a severe medical condition, presenting ICU mortality rates reaching 30%. The aim of this study was to assess the value o...

    Authors: Luís M Coelho, Jorge IF Salluh, Márcio Soares, Fernando A Bozza, JuanCarlos R Verdeal, Hugo C Castro-Faria-Neto, José Roberto Lapa e Silva, Patrícia T Bozza and Pedro Póvoa
    Citation: Critical Care 2012 16:R53
    Content type: Research Published on:
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  • ISSN: 1364-8535 (electronic)

Critical Care

ISSN: 1364-8535