Articles
Page 122 of 376
-
Citation: Critical Care 2013 17:472
-
Inhibition of the inflammatory cytokine tumor necrosis factor-alpha with etanercept provides protection against lethal H1N1 influenza infection in mice
Factors implicated in influenza-mediated morbidity and mortality include robust cytokine production (cytokine storm), excessive inflammatory infiltrates, and virus-induced tissue destruction. Tumor necrosis fa...
Citation: Critical Care 2013 17:R301 -
Continuous positive airway pressure and ventilation are more effective with a nasal mask than a full face mask in unconscious subjects: a randomized controlled trial
Upper airway obstruction (UAO) is a major problem in unconscious subjects, making full face mask ventilation difficult. The mechanism of UAO in unconscious subjects shares many similarities with that of obstru...
Citation: Critical Care 2013 17:R300 -
Early fluid resuscitation with hydroxyethyl starch 130/0.4 (6%) in severe burn injury: a randomized, controlled, double-blind clinical trial
There are limited data on the efficacy of early fluid resuscitation with third-generation hydroxyethyl starch (HES 130) in burn injury. Adverse effects of HES on survival and organ function have been reported.
Citation: Critical Care 2013 17:R299 -
End-stage renal disease and outcome in a surgical intensive care unit
End-stage renal disease (ESRD) is associated with an increased propensity for critical illness, but whether ESRD is independently associated with a greater risk of death after major surgical procedures is uncl...
Citation: Critical Care 2013 17:R298 -
Rigorous scoping review of randomized trials in pediatric critical care highlights need for a rigorous rethink
The randomized controlled trial (RCT) remains the highest-ranked study design when grading recommendations for clinical practice. In the previous issue of Critical Care, Duffett and colleagues published a scoping...
Citation: Critical Care 2013 17:1024 -
Gut instinct
Barriers to the use of selective digestive decontamination include concerns about emergence of resistant organisms, over-estimation of current performance in preventing ventilator-associated pneumonia (VAP), a...
Citation: Critical Care 2013 17:1025 -
The use of diaries in psychological recovery from intensive care
Intensive care patients frequently experience memory loss, nightmares, and delusional memories and some may develop symptoms of anxiety, depression, and post-traumatic stress. The use of diaries is emerging as...
Citation: Critical Care 2013 17:253 -
A randomized, controlled, multicenter trial of the effects of antithrombin on disseminated intravascular coagulation in patients with sepsis
To test the hypothesis that the administration of antithrombin concentrate improves disseminated intravascular coagulation (DIC), resulting in recovery from DIC and better outcomes in patients with sepsis, we ...
Citation: Critical Care 2013 17:R297 -
High-mobility group box 1 and the receptor for advanced glycation end products contribute to lung injury during Staphylococcus aureus pneumonia
Staphylococcus (S.) aureus has emerged as an important cause of necrotizing pneumonia. Lung injury during S. aureus pneumonia may be enhanced by local release of damage associated molecular patterns such as high-...
Citation: Critical Care 2013 17:R296 -
Hemodynamic variables and progression of acute kidney injury in critically ill patients with severe sepsis: data from the prospective observational FINNAKI study
Knowledge of the association of hemodynamics with progression of septic acute kidney injury (AKI) is limited. However, some recent data suggest that mean arterial pressure (MAP) exceeding current guidelines (6...
Citation: Critical Care 2013 17:R295 -
Persistently high venous-to-arterial carbon dioxide differences during early resuscitation are associated with poor outcomes in septic shock
Venous-to-arterial carbon dioxide difference (Pv-aCO2) may reflect the adequacy of blood flow during shock states. We sought to test whether the development of Pv-aCO2 during the very early phases of resuscitatio...
Citation: Critical Care 2013 17:R294 -
Influence of acute kidney injury on short- and long-term outcomes in patients undergoing cardiac surgery: risk factors and prognostic value of a modified RIFLE classification
The development of acute kidney injury (AKI) is associated with poor outcome. The modified RIFLE (risk, injury, failure, loss of kidney function, and end-stage renal failure) classification for AKI, which clas...
Citation: Critical Care 2013 17:R293 -
Post-operative acute kidney injury and five-year risk of death, myocardial infarction, and stroke among elective cardiac surgical patients: a cohort study
The prognostic impact of acute kidney injury (AKI) on long-term clinical outcomes remains controversial. We examined the five-year risk of death, myocardial infarction, and stroke after elective cardiac surger...
Citation: Critical Care 2013 17:R292 -
Metformin improves survival in intensive care unit patients, but why?
Citation: Critical Care 2013 17:471 -
Procalcitonin-guided therapy in intensive care unit patients with severe sepsis and septic shock – a systematic review and meta-analysis
Procalcitonin (PCT) algorithms for antibiotic treatment decisions have been studied in adult patients from primary care, emergency department, and intensive care unit (ICU) settings, suggesting that procalcito...
Citation: Critical Care 2013 17:R291 -
Sustained high serum malondialdehyde levels are associated with severity and mortality in septic patients
There is a hyperoxidative state in sepsis. The objective of this study was to determine serum malondialdehyde (MDA) levels during the first week of follow up, whether such levels are associated with severity d...
Citation: Critical Care 2013 17:R290 -
The obesity paradox and acute kidney injury: beneficial effects of hyper-inflammation?
In the general population, obesity is associated with an increased mortality risk, whereas several epidemiological studies demonstrated a protective effect of obesity in critically ill patients. In this contex...
Citation: Critical Care 2013 17:1023 -
Monitoring treatment response in abdominal sepsis with procalcitonin - if only!
The ideal management of infection includes not only the early identification and start of effective therapy but also the correct categorization of non-infected patients in order to avoid unnecessary use of ant...
Citation: Critical Care 2013 17:1017 -
Diagnosis and management of temperature abnormality in ICUs: a EUROBACT investigators' survey
Although fever and hypothermia are common abnormal physical signs observed in patients admitted to intensive care units (ICU), little data exist on their optimal management. The objective of this study was to ...
Citation: Critical Care 2013 17:R289 -
The effect of excess fluid balance on the mortality rate of surgical patients: a multicenter prospective study
In some studies including small populations of patients undergoing specific surgery, an intraoperative liberal infusion of fluids was associated with increasing morbidity when compared to restrictive strategie...
Citation: Critical Care 2013 17:R288 -
Decreased HLA-DR antigen-associated invariant chain (CD74) mRNA expression predicts mortality after septic shock
Septic syndromes remain the leading cause of mortality in intensive care units (ICU). Septic patients rapidly develop immune dysfunctions, the intensity and duration of which have been linked with deleterious ...
Citation: Critical Care 2013 17:R287 -
BTLA as a biomarker and mediator of sepsis-induced immunosuppression
Recent research indicates that T-lymphocyte dysfunction may contribute to sepsis-associated morbidity and mortality. B and T lymphocyte attenuator (BTLA) is a co-inhibitory receptor expressed by T lymphocytes ...
Citation: Critical Care 2013 17:1022 -
Improving ascertainment and communication of prognosis in intracerebral hemorrhage
Prognostication after intracerebral hemorrhage remains a significant challenge for the field of neurocritical care. Despite several available tools that can predict mortality and, to some degree, functional ou...
Citation: Critical Care 2013 17:1021 -
Subglottic secretion drainage in prevention of ventilator-associated pneumonia: mind the gap between studies and reality
Citation: Critical Care 2013 17:R286 -
Dysfunction of alveolar macrophages after cardiac surgery and postoperative pneumonia? - an observational study
Patients undergoing cardiac surgery have an increased risk of postoperative pneumonia. Pulmonary immune dysfunction might be a contributing factor. We therefore determined changes of the surface molecules on a...
Citation: Critical Care 2013 17:R285 -
Galectin-9 prolongs the survival of septic mice by expanding tim-3-expressing natural killer T cells and PDCA-1+ CD11c+macrophages
Galectin-9 ameliorates various inflammatory conditions including autoimmune diseases by regulating T cell and macrophage/dendritic cell (DC) functions. However, the effect of galectin-9 on polymicrobial sepsis...
Citation: Critical Care 2013 17:R284 -
The role of intestinal mucosa injury induced by intra-abdominal hypertension in the development of abdominal compartment syndrome and multiple organ dysfunction syndrome
Abdominal distension is common in critical illness. There is a growing recognition that intra-abdominal hypertension (IAH) may complicate nonsurgical critical illness as well as after abdominal surgery. Howeve...
Citation: Critical Care 2013 17:R283 -
An increase in red blood cell distribution width from baseline predicts mortality in patients with severe sepsis or septic shock
A potential independent association was recently demonstrated between high red blood cell distribution width (RDW) and the risk of all-cause mortality in critically ill patients, although the mechanism underly...
Citation: Critical Care 2013 17:R282 -
Effects of thoracic epidural anesthesia on survival and microcirculation in severe acute pancreatitis: a randomized experimental trial
Severe acute pancreatitis is still a potentially life threatening disease with high mortality. The aim of this study was to evaluate the therapeutic effect of thoracic epidural anaesthesia (TEA) on survival, m...
Citation: Critical Care 2013 17:R281 -
Noninvasive ventilation and the upper airway: should we pay more attention?
In an effort to reduce the complications related to invasive ventilation, the use of noninvasive ventilation (NIV) has increased over the last years in patients with acute respiratory failure. However, failure...
Citation: Critical Care 2013 17:245 -
Rapid diagnosis of sepsis using biomarker signatures
Diagnosis of sepsis is complicated by non-specific clinical definitions and delays in laboratory analysis using tests which may have very poor predictive values. The use of host biomarker signature sets, which...
Citation: Critical Care 2013 17:1020 -
Of ions and temperature: the complicated interplay of temperature, fluids, and electrolytes on myocardial function
This article discusses the potential of levosimendan to treat calcium-induced myocardial dysfunction associated with deep hypothermia. Moderate hypothermia (30 to 34°C) usually improves myocardial contractilit...
Citation: Critical Care 2013 17:1018 -
A new way of thinking: hydrocortisone in traumatic brain-injured patients
Data suggest that treatment of critical illness-related corticosteroid insufficiency after traumatic brain injury (TBI) with a stress dose of hydrocortisone may improve the neurological outcome and the mortali...
Citation: Critical Care 2013 17:1016 -
Clinical review: Ethics and end-of-life care for critically ill patients in China
Critical care medicine in China has made great advances in recent decades. This has led to an unavoidable issue: end-of-life ethics. With advances in medical technology and therapeutics allowing the seemingly ...
Citation: Critical Care 2013 17:244 -
Video laryngoscopy improves intubation success and reduces esophageal intubations compared with direct laryngoscopy in the medical intensive care unit
Urgent and emergent airway management outside the operating room is fraught with complications due to the nature of its acuity, single or multiple system dysfunction or failure, and physiological disturbances....
Citation: Critical Care 2013 17:1019 -
Development of clinical decision rules to predict recurrent shock in dengue
Mortality from dengue infection is mostly due to shock. Among dengue patients with shock, approximately 30% have recurrent shock that requires a treatment change. Here, we report development of a clinical rule...
Citation: Critical Care 2013 17:R280 -
Optimal dosing of antibiotics in critically ill patients by using continuous/extended infusions: a systematic review and meta-analysis
The aim of this study was to determine whether using pharmacodynamic-based dosing of antimicrobials, such as extended/continuous infusions, in critically ill patients is associated with improved outcomes as co...
Citation: Critical Care 2013 17:R279 -
Association between systemic hemodynamics and septic acute kidney injury in critically ill patients: a retrospective observational study
The role of systemic hemodynamics in the pathogenesis of septic acute kidney injury (AKI) has received little attention. The purpose of this study was to investigate the association between systemic hemodynami...
Citation: Critical Care 2013 17:R278 -
Gender-specific differences in severely injured patients between 2002 and 2011: data analysis with matched-pair analysis
Previous studies reported divergent results concerning the effect of gender on patient outcome after severe injury. Results suggest that women have better outcomes because they have lower rates of sepsis and m...
Citation: Critical Care 2013 17:R277 -
B and T lymphocyte attenuator expression on CD4+ T-cells associates with sepsis and subsequent infections in ICU patients
Sepsis is a deadly inflammatory condition that often leads to an immune suppressed state; however, the events leading to this state remain poorly understood. B and T lymphocyte attenuator (BTLA) is an immune-r...
Citation: Critical Care 2013 17:R276 -
A novel risk score to predict 1-year functional outcome after intracerebral hemorrhage and comparison with existing scores
Spontaneous intracerebral hemorrhage (ICH) is one of leading causes of mortality and morbidity worldwide. Several predictive models have been developed for ICH; however, none of them have been consistently use...
Citation: Critical Care 2013 17:R275 -
Year in review 2012: Critical Care - respiratory infections
Over the last two decades, considerable progress has been made in the understanding of disease mechanisms and infection control strategies related to infections, particularly pneumonia, in critically ill patie...
Citation: Critical Care 2013 17:251 -
Year in review 2012: Critical Care -management
Outcomes research plays a key role in defining the effects of medical care in critical care. Last year Critical Care published a number of papers that evaluated patient-centered and policy-relevant outcomes. We p...
Citation: Critical Care 2013 17:250 -
Year in review 2012: Critical Care - respirology
Acute respiratory failure is a dominant feature of critical illness. In this review, we discuss 17 studies published last year in Critical Care. The discussion focuses on articles on several topics: respiratory m...
Citation: Critical Care 2013 17:249 -
Year in review 2012: Critical Care - out-of-hospital cardiac arrest and trauma
In 2012 Critical Care published many articles pertaining to the resuscitation of out-of-hospital cardiac arrest and trauma. In this review, we summarize several of these articles, including those regarding advanc...
Citation: Critical Care 2013 17:248 -
Year in review 2012: Critical Care - cardiology
In this review I discuss key research papers in cardiology and intensive care published in Critical Care during 2012 with related studies published in other journals quoted whenever appropriate. These studies are...
Citation: Critical Care 2013 17:247 -
Year in review 2012: Critical Care - nephrology
We summarize original research in the field of critical care nephrology accepted or published in 2012 in Critical Care and, when considered relevant or directly linked to this research, in other journals. Three m...
Citation: Critical Care 2013 17:246 -
Shock index: blunt clinical predictions
Citation: Critical Care 2013 17:468 -
Automated detection of patient-ventilator asynchrony: new tool or new toy?
Although severe patient-ventilator asynchrony is frequent during invasive and non-invasive mechanical ventilation, diagnosing such asynchronies usually requires the presence at the bedside of an experienced cl...
Citation: Critical Care 2013 17:1015
Follow
- ISSN: 1364-8535 (electronic)