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  2. Factors implicated in influenza-mediated morbidity and mortality include robust cytokine production (cytokine storm), excessive inflammatory infiltrates, and virus-induced tissue destruction. Tumor necrosis fa...

    Authors: Xunlong Shi, Wei Zhou, Hai Huang, Hongguang Zhu, Pei Zhou, Haiyan Zhu and Dianwen Ju
    Citation: Critical Care 2013 17:R301
    Content type: Research Published on:

  3. Upper airway obstruction (UAO) is a major problem in unconscious subjects, making full face mask ventilation difficult. The mechanism of UAO in unconscious subjects shares many similarities with that of obstru...

    Authors: Jun Oto, Qian Li, William R Kimball, Jingping Wang, Abdolnabi S Sabouri, Priscilla G Harrell, Robert M Kacmarek and Yandong Jiang
    Citation: Critical Care 2013 17:R300
    Content type: Research Published on:

  4. There are limited data on the efficacy of early fluid resuscitation with third-generation hydroxyethyl starch (HES 130) in burn injury. Adverse effects of HES on survival and organ function have been reported.

    Authors: Markus Béchir, Milo A Puhan, Mario Fasshauer, Reto A Schuepbach, Reto Stocker and Thomas A Neff
    Citation: Critical Care 2013 17:R299
    Content type: Research Published on:

  5. End-stage renal disease (ESRD) is associated with an increased propensity for critical illness, but whether ESRD is independently associated with a greater risk of death after major surgical procedures is uncl...

    Authors: Mareike Apel, Vivian PL Maia, Mohamed Zeidan, Claudia Schinkoethe, Gunter Wolf, Konrad Reinhart and Yasser Sakr
    Citation: Critical Care 2013 17:R298
    Content type: Research Published on:

  7. Barriers to the use of selective digestive decontamination include concerns about emergence of resistant organisms, over-estimation of current performance in preventing ventilator-associated pneumonia (VAP), a...

    Authors: Julian Bion
    Citation: Critical Care 2013 17:1025
    Content type: Commentary Published on:

  8. Intensive care patients frequently experience memory loss, nightmares, and delusional memories and some may develop symptoms of anxiety, depression, and post-traumatic stress. The use of diaries is emerging as...

    Authors: Leanne M Aitken, Janice Rattray, Alastair Hull, Justin A Kenardy, Robyne Le Brocque and Amanda J Ullman
    Citation: Critical Care 2013 17:253
    Content type: Review Published on:

  9. To test the hypothesis that the administration of antithrombin concentrate improves disseminated intravascular coagulation (DIC), resulting in recovery from DIC and better outcomes in patients with sepsis, we ...

    Authors: Satoshi Gando, Daizoh Saitoh, Hiroyasu Ishikura, Masashi Ueyama, Yasuhiro Otomo, Shigeto Oda, Shigeki Kushimoto, Katsuhisa Tanjoh, Toshihiko Mayumi, Toshiaki Ikeda, Toshiaki Iba, Yutaka Eguchi, Kohji Okamoto, Hiroshi Ogura, Kazuhide Koseki, Yuichiro Sakamoto…
    Citation: Critical Care 2013 17:R297
    Content type: Research Published on:

  10. Staphylococcus (S.) aureus has emerged as an important cause of necrotizing pneumonia. Lung injury during S. aureus pneumonia may be enhanced by local release of damage associated molecular patterns such as high-...

    Authors: Ahmed Achouiti, Anne Jan van der Meer, Sandrine Florquin, Huan Yang, Kevin J Tracey, Cornelis van ’t Veer, Alex F de Vos and Tom van der Poll
    Citation: Critical Care 2013 17:R296
    Content type: Research Published on:

  11. Knowledge of the association of hemodynamics with progression of septic acute kidney injury (AKI) is limited. However, some recent data suggest that mean arterial pressure (MAP) exceeding current guidelines (6...

    Authors: Meri Poukkanen, Erika Wilkman, Suvi T Vaara, Ville Pettilä, Kirsi-Maija Kaukonen, Anna-Maija Korhonen, Ari Uusaro, Seppo Hovilehto, Outi Inkinen, Raili Laru-Sompa, Raku Hautamäki, Anne Kuitunen and Sari Karlsson
    Citation: Critical Care 2013 17:R295
    Content type: Research Published on:

  12. Venous-to-arterial carbon dioxide difference (Pv-aCO2) may reflect the adequacy of blood flow during shock states. We sought to test whether the development of Pv-aCO2 during the very early phases of resuscitatio...

    Authors: Gustavo A Ospina-Tascón, Diego F Bautista-Rincón, Mauricio Umaña, José D Tafur, Alejandro Gutiérrez, Alberto F García, William Bermúdez, Marcela Granados, César Arango-Dávila and Glenn Hernández
    Citation: Critical Care 2013 17:R294
    Content type: Research Published on:

  13. The development of acute kidney injury (AKI) is associated with poor outcome. The modified RIFLE (risk, injury, failure, loss of kidney function, and end-stage renal failure) classification for AKI, which clas...

    Authors: Juan C Lopez-Delgado, Francisco Esteve, Herminia Torrado, David Rodríguez-Castro, Maria L Carrio, Elisabet Farrero, Casimiro Javierre, Josep L Ventura and Rafael Manez
    Citation: Critical Care 2013 17:R293
    Content type: Research Published on:

  14. The prognostic impact of acute kidney injury (AKI) on long-term clinical outcomes remains controversial. We examined the five-year risk of death, myocardial infarction, and stroke after elective cardiac surger...

    Authors: Malene Kærslund Hansen, Henrik Gammelager, Martin Majlund Mikkelsen, Vibeke Elisabeth Hjortdal, J Bradley Layton, Søren Paaske Johnsen and Christian Fynbo Christiansen
    Citation: Critical Care 2013 17:R292
    Content type: Research Published on:

  16. Procalcitonin (PCT) algorithms for antibiotic treatment decisions have been studied in adult patients from primary care, emergency department, and intensive care unit (ICU) settings, suggesting that procalcito...

    Authors: Anna Prkno, Christina Wacker, Frank M Brunkhorst and Peter Schlattmann
    Citation: Critical Care 2013 17:R291
    Content type: Research Published on:

  17. There is a hyperoxidative state in sepsis. The objective of this study was to determine serum malondialdehyde (MDA) levels during the first week of follow up, whether such levels are associated with severity d...

    Authors: Leonardo Lorente, María M Martín, Pedro Abreu-González, Alberto Domínguez-Rodriguez, Lorenzo Labarta, César Díaz, Jordi Solé-Violán, José Ferreres, Judith Cabrera, Jose Carlos Igeño and Alejandro Jiménez
    Citation: Critical Care 2013 17:R290
    Content type: Research Published on:

  18. In the general population, obesity is associated with an increased mortality risk, whereas several epidemiological studies demonstrated a protective effect of obesity in critically ill patients. In this contex...

    Authors: Sebastian Hafner, Andreas Hillenbrand, Uwe Knippschild and Peter Radermacher
    Citation: Critical Care 2013 17:1023
    Content type: Commentary Published on:

  20. Although fever and hypothermia are common abnormal physical signs observed in patients admitted to intensive care units (ICU), little data exist on their optimal management. The objective of this study was to ...

    Authors: Daniel J Niven, Kevin B Laupland, Alexis Tabah, Aurélien Vesin, Jordi Rello, Despoina Koulenti, George Dimopoulos, Jan de Waele and Jean-Francois Timsit
    Citation: Critical Care 2013 17:R289
    Content type: Research Published on:

  21. In some studies including small populations of patients undergoing specific surgery, an intraoperative liberal infusion of fluids was associated with increasing morbidity when compared to restrictive strategie...

    Authors: João M Silva Jr, Amanda Maria RibasRosa de Oliveira, Fernando Augusto Mendes Nogueira, Pedro Monferrari Monteiro Vianna, Marcos Cruz Pereira Filho, Leandro Ferreira Dias, Vivian Paz Leão Maia, Cesar de Souza Neucamp, Cristina Prata Amendola, Maria Jose Carvalho Carmona and Luiz M Sá Malbouisson
    Citation: Critical Care 2013 17:R288
    Content type: Research Published on:

  22. Septic syndromes remain the leading cause of mortality in intensive care units (ICU). Septic patients rapidly develop immune dysfunctions, the intensity and duration of which have been linked with deleterious ...

    Authors: Marie-Angélique Cazalis, Arnaud Friggeri, Laura Cavé, Julie Demaret, Véronique Barbalat, Elisabeth Cerrato, Alain Lepape, Alexandre Pachot, Guillaume Monneret and Fabienne Venet
    Citation: Critical Care 2013 17:R287
    Content type: Research Published on:

  26. Patients undergoing cardiac surgery have an increased risk of postoperative pneumonia. Pulmonary immune dysfunction might be a contributing factor. We therefore determined changes of the surface molecules on a...

    Authors: Katharina Chalk, Christian Meisel, Claudia Spies, Thomas Volk, Karin Thuenemann, Jörg Linneweber, Klaus-Dieter Wernecke and Michael Sander
    Citation: Critical Care 2013 17:R285
    Content type: Research Published on:

  27. Galectin-9 ameliorates various inflammatory conditions including autoimmune diseases by regulating T cell and macrophage/dendritic cell (DC) functions. However, the effect of galectin-9 on polymicrobial sepsis...

    Authors: Takashi Kadowaki, Asahiro Morishita, Toshiro Niki, Junko Hara, Miwa Sato, Joji Tani, Hisaaki Miyoshi, Hirohito Yoneyama, Tsutomu Masaki, Toshio Hattori, Akihiro Matsukawa and Mitsuomi Hirashima
    Citation: Critical Care 2013 17:R284
    Content type: Research Published on:

  28. Abdominal distension is common in critical illness. There is a growing recognition that intra-abdominal hypertension (IAH) may complicate nonsurgical critical illness as well as after abdominal surgery. Howeve...

    Authors: Juntao Cheng, Zhiyi Wei, Xia Liu, Ximei Li, Zhiqiang Yuan, Jiang Zheng, Xiaodong Chen, Guangxia Xiao and Xiaoyi Li
    Citation: Critical Care 2013 17:R283
    Content type: Research Published on:

  29. A potential independent association was recently demonstrated between high red blood cell distribution width (RDW) and the risk of all-cause mortality in critically ill patients, although the mechanism underly...

    Authors: Chan Ho Kim, Jung Tak Park, Eun Jin Kim, Jae Hyun Han, Ji Suk Han, Jun Yong Choi, Seung Hyeok Han, Tae-Hyun Yoo, Young Sam Kim, Shin Wook Kang and Hyung Jung Oh
    Citation: Critical Care 2013 17:R282
    Content type: Research Published on:

  30. Severe acute pancreatitis is still a potentially life threatening disease with high mortality. The aim of this study was to evaluate the therapeutic effect of thoracic epidural anaesthesia (TEA) on survival, m...

    Authors: Kai A Bachmann, Constantin JC Trepte, Lena Tomkötter, Andrea Hinsch, Jan Stork, Wilken Bergmann, Lena Heidelmann, Tim Strate, Alwin E Goetz, Daniel A Reuter, Jakob R Izbicki and Oliver Mann
    Citation: Critical Care 2013 17:R281
    Content type: Research Published on:

  31. In an effort to reduce the complications related to invasive ventilation, the use of noninvasive ventilation (NIV) has increased over the last years in patients with acute respiratory failure. However, failure...

    Authors: Eline Oppersma, Jonne Doorduin, Erik HFM van der Heijden, Johannes G van der Hoeven and Leo MA Heunks
    Citation: Critical Care 2013 17:245
    Content type: Review Published on:

  32. Diagnosis of sepsis is complicated by non-specific clinical definitions and delays in laboratory analysis using tests which may have very poor predictive values. The use of host biomarker signature sets, which...

    Authors: Nigel James Silman
    Citation: Critical Care 2013 17:1020
    Content type: Commentary Published on:

  36. Urgent and emergent airway management outside the operating room is fraught with complications due to the nature of its acuity, single or multiple system dysfunction or failure, and physiological disturbances....

    Authors: Thomas C Mort
    Citation: Critical Care 2013 17:1019
    Content type: Commentary Published on:

  37. Mortality from dengue infection is mostly due to shock. Among dengue patients with shock, approximately 30% have recurrent shock that requires a treatment change. Here, we report development of a clinical rule...

    Authors: Nguyen Tien Huy, Nguyen Thanh Hong Thao, Tran Thi Ngoc Ha, Nguyen Thi Phuong Lan, Phan Thi Thanh Nga, Tran Thi Thuy, Ha Manh Tuan, Cao Thi Phi Nga, Vo Van Tuong, Tran Van Dat, Vu Thi Que Huong, Juntra Karbwang and Kenji Hirayama
    Citation: Critical Care 2013 17:R280
    Content type: Research Published on:

  38. The aim of this study was to determine whether using pharmacodynamic-based dosing of antimicrobials, such as extended/continuous infusions, in critically ill patients is associated with improved outcomes as co...

    Authors: Clarence Chant, Ann Leung and Jan O Friedrich
    Citation: Critical Care 2013 17:R279
    Content type: Research Published on:

  39. The role of systemic hemodynamics in the pathogenesis of septic acute kidney injury (AKI) has received little attention. The purpose of this study was to investigate the association between systemic hemodynami...

    Authors: Matthieu Legrand, Claire Dupuis, Christelle Simon, Etienne Gayat, Joaquim Mateo, Anne-Claire Lukaszewicz and Didier Payen
    Citation: Critical Care 2013 17:R278
    Content type: Research Published on:

  40. Previous studies reported divergent results concerning the effect of gender on patient outcome after severe injury. Results suggest that women have better outcomes because they have lower rates of sepsis and m...

    Authors: Carsten Schoeneberg, Max Daniel Kauther, Bjoern Hussmann, Judith Keitel, Daniel Schmitz and Sven Lendemans
    Citation: Critical Care 2013 17:R277
    Content type: Research Published on:

  41. Sepsis is a deadly inflammatory condition that often leads to an immune suppressed state; however, the events leading to this state remain poorly understood. B and T lymphocyte attenuator (BTLA) is an immune-r...

    Authors: Nicholas J Shubin, Sean F Monaghan, Daithi S Heffernan, Chun-Shiang Chung and Alfred Ayala
    Citation: Critical Care 2013 17:R276
    Content type: Research Published on:

  42. Spontaneous intracerebral hemorrhage (ICH) is one of leading causes of mortality and morbidity worldwide. Several predictive models have been developed for ICH; however, none of them have been consistently use...

    Authors: Ruijun Ji, Haipeng Shen, Yuesong Pan, Penglian Wang, Gaifen Liu, Yilong Wang, Hao Li, Xingquan Zhao and Yongjun Wang
    Citation: Critical Care 2013 17:R275
    Content type: Research Published on:

  43. Over the last two decades, considerable progress has been made in the understanding of disease mechanisms and infection control strategies related to infections, particularly pneumonia, in critically ill patie...

    Authors: Girish B Nair and Michael S Niederman
    Citation: Critical Care 2013 17:251
    Content type: Review Published on:

  44. Outcomes research plays a key role in defining the effects of medical care in critical care. Last year Critical Care published a number of papers that evaluated patient-centered and policy-relevant outcomes. We p...

    Authors: Abhijit Duggal and Gordon Rubenfeld
    Citation: Critical Care 2013 17:250
    Content type: Review Published on:

  45. Acute respiratory failure is a dominant feature of critical illness. In this review, we discuss 17 studies published last year in Critical Care. The discussion focuses on articles on several topics: respiratory m...

    Authors: Ewan C Goligher, Eddy Fan and Arthur S Slutsky
    Citation: Critical Care 2013 17:249
    Content type: Review Published on:

  47. In this review I discuss key research papers in cardiology and intensive care published in Critical Care during 2012 with related studies published in other journals quoted whenever appropriate. These studies are...

    Authors: Daniel De Backer
    Citation: Critical Care 2013 17:247
    Content type: Review Published on:

  48. We summarize original research in the field of critical care nephrology accepted or published in 2012 in Critical Care and, when considered relevant or directly linked to this research, in other journals. Three m...

    Authors: Zaccaria Ricci and Claudio Ronco
    Citation: Critical Care 2013 17:246
    Content type: Review Published on:
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  • ISSN: 1364-8535 (electronic)

Critical Care

ISSN: 1364-8535