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  2. Subarachnoid hemorrhage may be complicated by neurogenic stunned myocardium, a catecholamine-induced transient cardiomyopathy that displays a wide clinical spectrum of cardiac abnormalities, including electroc...

    Authors: John Papanikolaou, Demosthenes Makris and Epaminondas Zakynthinos
    Citation: Critical Care 2014 18:490
    Content type: Commentary Published on:

  3. The combination antiretroviral therapy (cART) has led to decreased opportunistic infections and hospital admissions in human immunodeficiency virus (HIV)-infected patients, but the intensive care unit (ICU) ad...

    Authors: José Medrano, Alejando Álvaro-Meca, Alexandre Boyer, María A Jiménez-Sousa and Salvador Resino
    Citation: Critical Care 2014 18:475
    Content type: Research Published on:

  5. The adverse effects of delayed admission to the intensive care unit (ICU) have been recognized in previous studies. However, the definitions of delayed admission vary across studies. This study proposed a mode...

    Authors: Shih-Chiang Hung, Chia-Te Kung, Chih-Wei Hung, Ber-Ming Liu, Jien-Wei Liu, Ghee Chew, Hung-Yi Chuang, Wen-Huei Lee and Tzu-Chi Lee
    Citation: Critical Care 2014 18:485
    Content type: Research Published on:

  6. Sepsis-induced myopathy and critical illness myopathy (CIM) are possible causes of muscle weakness in intensive care patients. They have been attributed to muscle membrane dysfunction. The aim of this study wa...

    Authors: Karin A Ackermann, Hugh Bostock, Lukas Brander, Ralph Schröder, Siamak Djafarzadeh, Daniel Tuchscherer, Stephan M Jakob, Jukka Takala and Werner J Z’Graggen
    Citation: Critical Care 2014 18:484
    Content type: Research Published on:

  7. Glucose measurement in intensive care medicine is performed intermittently with the risk of undetected hypoglycemia. The workload for the ICU nursing staff is substantial. Subcutaneous continuous glucose monit...

    Authors: Daphne T Boom, Marjolein K Sechterberger, Saskia Rijkenberg, Susanne Kreder, Rob J Bosman, Jos PJ Wester, Ilse van Stijn, J Hans DeVries and Peter HJ van der Voort
    Citation: Critical Care 2014 18:453
    Content type: Research Published on:

  8. Because of ongoing controversy, renal and vital outcomes are compared between systemically administered unfractionated heparin and regional anticoagulation with citrate-buffered replacement solution in predilu...

    Authors: Louise Schilder, S Azam Nurmohamed, Frank H Bosch, Ilse M Purmer, Sylvia S den Boer, Cynthia G Kleppe, Marc G Vervloet, Albertus Beishuizen, Armand RJ Girbes, Pieter M ter Wee and AB Johan Groeneveld
    Citation: Critical Care 2014 18:472
    Content type: Research Published on:

  9. Fast-track treatment in cardiac surgery has become the global standard of care. We compared the efficacy and safety of a specialised post-anaesthetic care unit (PACU) to a conventional intensive care unit (ICU...

    Authors: Stefan Probst, Christof Cech, Dirk Haentschel, Markus Scholz and Joerg Ender
    Citation: Critical Care 2014 18:468
    Content type: Research Published on:

  10. Research has demonstrated that intensivist-led care of the critically ill is associated with reduced intensive care unit (ICU) and hospital mortality. The objective of this study was to evaluate whether a rela...

    Authors: M Elizabeth Wilcox, David A Harrison, Alasdair Short, Max Jonas and Kathryn M Rowan
    Citation: Critical Care 2014 18:491
    Content type: Research Published on:

  12. Based on the potential interest in sodium lactate as an energy substrate and resuscitative fluid, we investigated the effects of hypertonic sodium lactate in a porcine endotoxic shock.

    Authors: Thibault Duburcq, Raphaël Favory, Daniel Mathieu, Thomas Hubert, Jacques Mangalaboyi, Valery Gmyr, Laurence Quintane, Patrice Maboudou, François Pattou and Mercé Jourdain
    Citation: Critical Care 2014 18:467
    Content type: Research Published on:

  13. The rapid emergence and dissemination of antimicrobial-resistant microorganisms in ICUs worldwide constitute a problem of crisis dimensions. The root causes of this problem are multifactorial, but the core iss...

    Authors: Charles-Edouard Luyt, Nicolas Bréchot, Jean-Louis Trouillet and Jean Chastre
    Citation: Critical Care 2014 18:480
    Content type: Review Published on:

  14. Continuous renal replacement therapy (CRRT) has been widely used in critically ill acute kidney injury (AKI) patients. Moreover, some centers operate a specialized CRRT team (SCT) composed of physicians and nu...

    Authors: Hyung Jung Oh, Mi Jung Lee, Chan Ho Kim, Dae Young Kim, Hye Sun Lee, Jung Tak Park, Sungwon Na, Seung Hyeok Han, Shin-Wook Kang, Shin Ok Koh and Tae-Hyun Yoo
    Citation: Critical Care 2014 18:454
    Content type: Research Published on:

  15. Takotsubo cardiomyopathy (TCM) is a life-threatening systemic consequence early after subarachnoid hemorrhage (SAH), but precise hemodynamics and related outcomes have not been studied. The purpose of this stu...

    Authors: Tatsushi Mutoh, Ken Kazumata, Shunsuke Terasaka, Yasuyuki Taki, Akifumi Suzuki and Tatsuya Ishikawa
    Citation: Critical Care 2014 18:482
    Content type: Research Published on:

  16. Sigh improves oxygenation and lung mechanics during pressure control ventilation (PCV) and pressure support ventilation (PSV) in patients with acute respiratory distress syndrome. However, so far, no study has...

    Authors: Lillian Moraes, Cíntia Lourenco Santos, Raquel Souza Santos, Fernanda Ferreira Cruz, Felipe Saddy, Marcelo Marcos Morales, Vera Luiza Capelozzi, Pedro Leme Silva, Marcelo Gama de Abreu, Cristiane Sousa Nascimento Baez Garcia, Paolo Pelosi and Patricia Rieken Macedo Rocco
    Citation: Critical Care 2014 18:474
    Content type: Research Published on:

  17. Since 2008, severe cases of emerging human adenovirus type 55 (HAdV-55) in immunocompetent adults have been reported sporadically in China. The clinical features and outcomes of the most critically ill patient...

    Authors: Bing Sun, Hangyong He, Zheng Wang, Jiuxin Qu, Xuyan Li, Chengjun Ban, Jun Wan, Bin Cao, Zhaohui Tong and Chen Wang
    Citation: Critical Care 2014 18:456
    Content type: Research Published on:

  19. For almost two decades, studies have shown collectins to be critical for effective antimicrobial defense of the airways. Members of this protein family, which includes surfactant proteins (SP)-A and D, provide...

    Authors: Monica Fern Tolosa and Nades Palaniyar
    Citation: Critical Care 2014 18:479
    Content type: Commentary Published on:

  20. The production of antimicrobial peptides by airway epithelial cells is an important component of the innate immune response to pulmonary infection and inflammation. Hepcidin is a β-defensin-like antimicrobial ...

    Authors: Qi Xing Chen, Sheng Wen Song, Qing Hua Chen, Cong Li Zeng, Xia Zheng, Jun Lu Wang and Xiang Ming Fang
    Citation: Critical Care 2014 18:470
    Content type: Research Published on:

  21. This narrative review summarizes the role of vitamin C in mitigating oxidative injury-induced microcirculatory impairment and associated organ failure in ischemia/reperfusion or sepsis. Preclinical studies sho...

    Authors: Heleen M Oudemans-van Straaten, Angelique ME Spoelstra-de Man and Monique C de Waard
    Citation: Critical Care 2014 18:460
    Content type: Review Published on:

  22. Impaired T cell function in sepsis is associated with poor outcome, but the mechanisms are unclear. In cancer, arginase-expressing myeloid derived suppressor cells (MDSCs) deplete arginine, impair T cell recep...

    Authors: Christabelle J Darcy, Gabriela Minigo, Kim A Piera, Joshua S Davis, Yvette R McNeil, Youwei Chen, Alicia D Volkheimer, J Brice Weinberg, Nicholas M Anstey and Tonia Woodberry
    Citation: Critical Care 2014 18:R163
    Content type: Research Published on:

  23. The aim of this study was to conduct a systematic review and meta-analysis for determining the effects of prehospital adrenaline administration on return of spontaneous circulation, hospital admission, surviva...

    Authors: Pongsakorn Atiksawedparit, Sasivimol Rattanasiri, Mark McEvoy, Colin A Graham, Yuwares Sittichanbuncha and Ammarin Thakkinstian
    Citation: Critical Care 2014 18:463
    Content type: Research Published on:

  24. Many intensive care unit (ICU) survivors suffer from physical disability for months after ICU stay. There is no structured method to identify patients at risk for such problems. The purpose of the study was to...

    Authors: Anna Schandl, Matteo Bottai, Ulrika Holdar, Elisabeth Hellgren and Peter Sackey
    Citation: Critical Care 2014 18:455
    Content type: Research Published on:

  26. Induced hypothermia is increasingly applied as a therapeutic intervention in ICUs. One of the underlying mechanisms of the beneficial effects of hypothermia is proposed to be reduction of the inflammatory resp...

    Authors: Charlotte J Beurskens, Janneke Horn, Anita M Tuip de Boer, Marcus J Schultz, Ester MM van Leeuwen, Margreeth B Vroom and Nicole P Juffermans
    Citation: Critical Care 2014 18:R162
    Content type: Research Published on:

  27. Sepsis is a disease that affects primarily the aged. Although mortality is higher in both older septic patients and aged septic mice, the mechanisms underlying decreased survival in older hosts are incompletel...

    Authors: Rohit Mittal, Mandy L Ford and Craig M Coopersmith
    Citation: Critical Care 2014 18:465
    Content type: Commentary Published on:

  28. Despite studies demonstrating benefit, patients with femoral vascular catheters placed for continuous renal replacement therapy are frequently restricted from mobilization. No researchers have reported filter ...

    Authors: Yi Tian Wang, Terry P Haines, Paul Ritchie, Craig Walker, Teri A Ansell, Danielle T Ryan, Phaik-Sim Lim, Sanjiv Vij, Rebecca Acs, Nigel Fealy and Elizabeth H Skinner
    Citation: Critical Care 2014 18:R161
    Content type: Research Published on:

  29. Invasive aspergillosis has been mainly reported among immunocompromised patients during prolonged periods of neutropenia. Recently, however, non-neutropenic patients in the ICU population have shown an increas...

    Authors: Matteo Bassetti, Elda Righi, Gennaro De Pascale, Raffaele De Gaudio, Antonino Giarratano, Tereesita Mazzei, Giulia Morace, Nicola Petrosillo, Stefania Stefani and Massimo Antonelli
    Citation: Critical Care 2014 18:458
    Content type: Review Published on:

  30. Pain assessment is associated with important outcomes in ICU patients but remains challenging, particularly in non-communicative patients. Use of a reliable tool is paramount to allow any implementation of sed...

    Authors: Gerald Chanques, Anne Pohlman, John P Kress, Nicolas Molinari, Audrey de Jong, Samir Jaber and Jesse B Hall
    Citation: Critical Care 2014 18:R160
    Content type: Research Published on:

  32. To establish a plasma metabolomics fingerprint spectrum for severe burn patients and to use it to identify a set of biomarkers that could be used for clinical monitoring.

    Authors: Yong Zhang, Bin Cai, Hua Jiang, Hong Yan, Hao Yang, Jin Peng, Wenyuan Wang, Siyuan Ma, Xiuwen Wu and Xi Peng
    Citation: Critical Care 2014 18:R159
    Content type: Research Published on:

  33. Stress-induced hyperglycemia has been considered an adaptive mechanism to stress up to the first intensive insulin therapy trial, which showed a 34% reduction in relative risk of in-hospital mortality when nor...

    Authors: Aurélien Mazeraud, Andrea Polito and Djillali Annane
    Citation: Critical Care 2014 18:232
    Content type: Review Published on:

  34. Circulatory failure during brain death organ donor resuscitation is a problem that compromises recovery of organs. Combined administration of steroid, thyroxine and vasopressin has been proposed to optimize th...

    Authors: Michel Pinsard, Stéphanie Ragot, Paul Michel Mertes, Jean Paul Bleichner, Samira Zitouni, Fabrice Cook, Marc Pierrot, Laurent Dube, Edgard Menguy, Laurent Martin Lefèvre, Laurence Escaravage, Pierre-François Dequin, Philippe Vignon and Nicolas Pichon
    Citation: Critical Care 2014 18:R158
    Content type: Research Published on:

  36. We compared the economic impacts of linezolid and vancomycin for the treatment of hospitalized patients with methicillin-resistant Staphylococcus aureus (MRSA)–confirmed nosocomial pneumonia.

    Authors: Dipen A Patel, Andrew F Shorr, Jean Chastre, Michael Niederman, Andrew Simor, Jennifer M Stephens, Claudie Charbonneau, Xin Gao and Dilip Nathwani
    Citation: Critical Care 2014 18:R157
    Content type: Research Published on:

  37. Sedation overuse is frequent and possibly associated with poor outcomes in the intensive care unit (ICU) patients. However, the association of early oversedation with clinical outcomes has not been thoroughly ...

    Authors: Lilian Maria Sobreira Tanaka, Luciano Cesar Pontes Azevedo, Marcelo Park, Guilherme Schettino, Antonio Paulo Nassar Jr, Alvaro Réa-Neto, Luana Tannous, Vicente Ces de Souza-Dantas, André Torelly, Thiago Lisboa, Claudio Piras, Frederico Bruzzi Carvalho, Marcelo de Oliveira Maia, Fabio Poianas Giannini, Flavia Ribeiro Machado, Felipe Dal-Pizzol…
    Citation: Critical Care 2014 18:R156
    Content type: Research Published on:

  38. Current severity-of-illness indexes are unable to assess the long-term prognosis of patients requiring prolonged mechanical ventilation. A prognostic scoring system (Prognosis for Prolonged Ventilation score -...

    Authors: Guillaume Leroy, Patrick Devos, Fabien Lambiotte, Didier Thévenin and Olivier Leroy
    Citation: Critical Care 2014 18:R155
    Content type: Research Published on:

  39. There is a complex interplay between changes in acid–base components and inflammation. This manuscript aims to explore associations between plasma cytokines and chemokines and acid–base status on admission to ...

    Authors: Fernando G Zampieri, John A Kellum, Marcelo Park, Otavio T Ranzani, Hermes V Barbeiro, Heraldo P de Souza, Luiz Monteiro da Cruz Neto and Fabiano Pinheiro da Silva
    Citation: Critical Care 2014 18:R154
    Content type: Research Published on:

  40. Albumin solutions have been used worldwide for the treatment of critically ill patients since they became commercially available in the 1940s. However, their use has become the subject of criticism and debate ...

    Authors: Jean-Louis Vincent, James A Russell, Matthias Jacob, Greg Martin, Bertrand Guidet, Jan Wernerman, Ricard Ferrer Roca, Stuart A McCluskey and Luciano Gattinoni
    Citation: Critical Care 2014 18:231
    Content type: Review Published on:

    The Erratum to this article has been published in Critical Care 2014 18:630

  41. We evaluate an innovative device consisting of an enteral feeding tube equipped with a photoplethysmography (PPG) sensor in contact with the duodenal mucosa. This study aims to determine if the PPG signal, com...

    Authors: Matthias Jacquet-Lagrèze, Jeanne-Marie Bonnet-Garin, Bernard Allaouchiche, Olivia Vassal, Damien Restagno, Christian Paquet, Jean-Yves Ayoub, Jérôme Etienne, François Vandenesch, Olivier Daulwader and Stéphane Junot
    Citation: Critical Care 2014 18:R153
    Content type: Research Published on:

  42. Timely administration of appropriate antibiotic therapy has been shown to improve outcome in hospital-acquired pneumonia (HAP). Empirical treatment guidelines tailored to local ecology have been advocated in a...

    Authors: Liesbet De Bus, Lies Saerens, Bram Gadeyne, Jerina Boelens, Geert Claeys, Jan J De Waele, Dominique D Benoit, Johan Decruyenaere and Pieter O Depuydt
    Citation: Critical Care 2014 18:R152
    Content type: Research Published on:

  43. The reported mortality rates range from 28% to 100% in burn patients who develop acute kidney injury (AKI) and from 50% to 100% among such patients treated with renal replacement therapy. Recently, the serum c...

    Authors: Hyeong Tae Yang, Haejun Yim, Yong Suk Cho, Dohern Kym, Jun Hur, Jong Hyun Kim, Wook Chun and Hyun Soo Kim
    Citation: Critical Care 2014 18:R151
    Content type: Research Published on:

  45. It is well known that etomidate may cause adrenal insufficiency. However, the clinical relevance of adrenal suppression after a single dose of etomidate remains vague. The aim of this study was to investigate ...

    Authors: Sebastian Heinrich, Joachim Schmidt, Andreas Ackermann, Andreas Moritz, Frank Harig and Ixchel Castellanos
    Citation: Critical Care 2014 18:R150
    Content type: Research Published on:

  46. Speckle tracking echocardiography (STE) is a relatively novel and sensitive method for assessing ventricular function and may unmask myocardial dysfunction not appreciated with conventional echocardiography. T...

    Authors: Sam R Orde, Juan N Pulido, Mitsuru Masaki, Shane Gillespie, Jocelyn N Spoon, Garvan C Kane and Jae K Oh
    Citation: Critical Care 2014 18:R149
    Content type: Research Published on:

  48. Severe infections in intensive care patients show high morbidity and mortality rates. Linezolid is an antimicrobial drug frequently used in critically ill patients. Recent data indicates that there might be hi...

    Authors: Michael Zoller, Barbara Maier, Cyrill Hornuss, Christina Neugebauer, Gundula Döbbeler, Dorothea Nagel, Lesca Miriam Holdt, Mathias Bruegel, Thomas Weig, Béatrice Grabein, Lorenz Frey, Daniel Teupser, Michael Vogeser and Johannes Zander
    Citation: Critical Care 2014 18:R148
    Content type: Research Published on:

  50. Purified prothrombin complex concentrate (PCC) is increasingly used as hemostatic therapy for trauma-induced coagulopathy (TIC). However, the impact of PCC administration on coagulation status among patients w...

    Authors: Herbert Schöchl, Wolfgang Voelckel, Marc Maegele, Lukas Kirchmair and Christoph J Schlimp
    Citation: Critical Care 2014 18:R147
    Content type: Research Published on:
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  • ISSN: 1364-8535 (electronic)

Critical Care

ISSN: 1364-8535