Acute kidney injury following cardiac surgery: current understanding and future directions
© The Author(s). 2016
Published: 4 July 2016
Acute kidney injury (AKI) complicates recovery from cardiac surgery in up to 30 % of patients, injures and impairs the function of the brain, lungs, and gut, and places patients at a 5-fold increased risk of death during hospitalization. Renal ischemia, reperfusion, inflammation, hemolysis, oxidative stress, cholesterol emboli, and toxins contribute to the development and progression of AKI. Preventive strategies are limited, but current evidence supports maintenance of renal perfusion and intravascular volume while avoiding venous congestion, administration of balanced salt as opposed to high-chloride intravenous fluids, and the avoidance or limitation of cardiopulmonary bypass exposure. AKI that requires renal replacement therapy occurs in 2–5 % of patients following cardiac surgery and is associated with 50 % mortality. For those who recover from renal replacement therapy or even mild AKI, progression to chronic kidney disease in the ensuing months and years is more likely than for those who do not develop AKI. Cardiac surgery continues to be a popular clinical model to evaluate novel therapeutics, off-label use of existing medications, and nonpharmacologic treatments for AKI, since cardiac surgery is fairly common, typically elective, provides a relatively standardized insult, and patients remain hospitalized and monitored following surgery. More efficient and time-sensitive methods to diagnose AKI are imperative to reduce this negative outcome. The discovery and validation of renal damage biomarkers should in time supplant creatinine-based criteria for the clinical diagnosis of AKI.
KeywordsCardiac surgery Acute kidney injury Renal failure Cardiopulmonary bypass Extracorporeal circulation Hypoperfusion Inflammation Pigment nephropathy Intravenous fluid management
Risk factors for the development of acute kidney injury following cardiac surgery
Cardiopulmonary bypass (CPB) duration
Need to return to CPB
Chronic kidney disease
Low hematocrit during CPB
Aortic cross-clamp time
Peripheral vascular disease
Emboli (cholesterol and other)
Strategies to prevent AKI are integral to the routine management of cardiac surgery patients. For example, intravenous fluid management, surgical and extracorporeal circulation techniques, and hemodynamic stability affect AKI development. Pharmacologic and many nonpharmacologic treatments have largely failed to reduce cardiac surgery-associated AKI in clinical trials, although some treatments may be effective in specific patients. Recent trials of high-dose perioperative atorvastatin and remote ischemic preconditioning (RIPC) therapy unfortunately have provided minimal evidence that these treatments reduce AKI following cardiac surgery .
When prevention fails, a prompt diagnosis of AKI is required to allow physicians to implement the few strategies that are known to improve renal function. The diagnosis of AKI typically includes the use of serum creatinine (SCr) concentrations and urine output. Urine output is relatively nonspecific, and increases in SCr concentration require several days, extending the time to diagnose AKI and initiate treatment. Measurement of urinary markers of kidney damage may provide a more rapid diagnosis, although candidate biomarkers require further validation before clinicians will incorporate them into routine patient care and expert groups implement them into AKI diagnostic criteria .
Renal perfusion is complex and highly regulated. Although 20 % of cardiac output perfuses the kidneys, the majority of blood filtered by cortex glomeruli is shunted away from the vasa recta. This shunt may help maintain the electrolyte and water concentration gradients in the renal medulla required for tubule and collecting system reabsorption, but renders the renal medulla and corticomedullary junction hypoxic relative to other tissues (PO2 10–20 mmHg) . This may be a protective mechanism for oxidative injury but increases susceptibility to ischemia. During surgery many factors alter renal perfusion, and tubules at the corticomedullary junction and in the medulla are often damaged.
CPB provides nonpulsatile blood flow and may dysregulate the balance between cortical and medullary perfusion. Paradoxically, increased cortical perfusion may precipitate corticomedullary ischemia due to increased medullary oxygen consumption from increased solute transport . Aorta cannulation and cross-clamping increase atheroemboli to the kidneys, further exacerbating ischemia and inducing inflammation . Other factors including sympathetic nervous system activation, the endogenous release of circulating catecholamines, and induction of the renin–angiotensin–aldosterone cascade may further impair renal oxygenation during surgery [12–14].
Cardiac surgery also induces renal and systemic inflammation. Elevated postoperative plasma concentrations of inflammatory cytokines are associated with a subsequent diagnosis of AKI and increased mortality . The mechanisms that increase inflammation during cardiac surgery are not fully understood, but contact activation from the exposure of blood to the CPB circuit, ischemia reperfusion injury, and oxidative damage all contribute [12, 16]. For example, ischemia and most notably reperfusion induce reactive oxygen species production [17, 18], and reactive oxygen species induce inflammation by upregulation of proinflammatory transcription factors, including nuclear factor kappa-B [19, 20]. Cytokines and chemokines recruit neutrophils, macrophages, and lymphocytes into the renal parenchyma. Parenchymal infiltration and activation of these immune cells increases AKI and leads to fibrosis .
Establishing an accurate and timely diagnosis of AKI enables prompt treatment. Current consensus guidelines for AKI diagnosis use Kidney Disease Improving Global Outcomes (KDIGO) criteria . KDIGO criteria define AKI as a 0.3 mg/dl (≥26.5 mol/l) SCr increase from baseline within 48 hours of surgery, a 50 % SCr increase from baseline within 7 days of surgery, or a decrease in urine output below 0.5 ml/kg/hour for 6 hours. All recent consensus criteria for AKI diagnosis, including RIFLE, AKIN, and KDIGO, use changes in SCr concentrations and urine output [6, 28]. Oliguria is common following cardiac surgery and typically occurs prior to SCr increase following renal injury, but often is an appropriate response to intravascular hypovolemia. For this reason and because accurate hourly urine output documentation is frequently poor, AKI is most often diagnosed by clinicians using SCr measurements. In a heterogeneous cohort of ICU patients, however, AKI using urine output criteria was common (60 % of the cohort) and associated with similar poor outcomes (dialysis and mortality) to AKI by SCr criteria alone . AKI that met oliguria and creatinine threshold criteria in this study was associated with significantly worse outcomes than AKI from oliguria or creatinine alone. These results need replicating in cardiac surgery cohorts. Creatinine endpoints are better validated than oliguria endpoints but unfortunately require many hours or days to diagnose AKI after a renal insult and may be insensitive to mild kidney injury since the kidney can maintain glomerular filtration as nephrons are damaged. Conversely, small changes in SCr may reflect an ongoing systemic inflammatory process nonspecific to AKI. Nonetheless, the 0.3 mg/dl threshold is strongly associated with poor outcomes [30, 31]. What remains unclear is whether poor outcomes associated with stage 1 AKI result from the AKI or from an independent systemic process associated with the AKI.
Scientists have identified proteins released from the kidney during injury and others filtered by the kidneys that more closely reflect glomerular filtration. These markers of renal damage (e.g., NGAL, KIM 1, IL-18, NAG, and GST) and function (cystatin C) offer several theoretical advantages over SCr. Concentrations of damage biomarkers increase in the plasma and urine within hours of injury, may be more specific, and are more sensitive. Haase et al.  validated these benefits for NGAL when they demonstrated that NGAL-positive but creatinine-negative AKI independently predicted the duration of ICU and hospital length of stay. Further validation of these damage and function markers versus short-term and long-term clinical outcomes including dialysis, length of stay, mortality, and progression of chronic kidney disease (CKD) remains insufficient. These markers are most frequently judged relative to SCr-based AKI criteria, and SCr-based criteria provide a poor standard due to the sensitivity and specificity concerns related to renal injury outlined in the preceding paragraph. For this reason (limited validation) and others (limited availability and reimbursement), the aforementioned biomarkers are confined to research purposes and are not used in clinical practice today. The FDA recently approved the measurement of urinary tissue inhibitor of metalloproteinases (TIMP) 2 and insulin-like growth factor–binding protein (IGFBP) 7, markers of growth phase cell-cycle arrest, to aid in the risk assessment for moderate or severe AKI within 12 hours of cardiac surgery. Clinical use of these markers, marketed as Nephrocheck®, to predict AKI has been limited, and their validation versus acute and more persistent renal injury is ongoing. The ability to measure AKI damage markers in routine clinical practice, however, may help the renal community advance past the use of SCr to diagnose, predict, prognosticate, or monitor AKI.
Just as intensivists and nephrologists developed consensus criteria for AKI diagnosis, clinician scientists are hoping to adopt unified criteria for persistent renal injury. This will enable therapeutic, clinical practice, and epidemiologic data to be compared against a consistent benchmark – the same benefits AKI consensus criteria brought to the AKI field. The Major Adverse Kidney Events (MAKE) composite, consisting of a 25 % or greater eGFR reduction, dialysis, or death, meets this objective. Because some physicians believe AKI is transient and not a clinically relevant endpoint, the adaptation of MAKE as a primary endpoint may advance the field . MAKE are often assessed at 30, 90, or 365 days after surgery. MAKE90 may be the best time point, because 90 days is a threshold that nephrologists use to declare AKI has progressed to CKD.
Accurate prediction of AKI provides the opportunity for clinicians to optimize high-risk patients, increase monitoring, enroll patients in clinical trials, and initiate preventative and therapeutic treatments. Several risk stratification systems exist for cardiac surgery patients. The best-validated scores predict severe AKI requiring dialysis and include the Cleveland Clinic Score and the Mehta Score [34, 35]. These scores use similar risk factors to predict AKI, although the Cleveland Clinic score offers the best discrimination .
Prediction of mild and moderate AKI is also important . As such, Birnie et al.  analyzed data collected prospectively from over 30,000 subjects undergoing cardiac surgery at three hospitals in the UK to develop a model using KDIGO criteria for predicting all stages of AKI. The model’s risk prediction score for any stage of AKI (AUC, 0.74 (95 % CI: 0.72–0.76)) demonstrated better discrimination compared with the Cleveland Clinic Score and equivalent discrimination to the Mehta score. This is the first predictive model for all stages of AKI.
Incorporation of novel markers into prediction algorithms may provide additional opportunities to identify patients at high risk. To date, most studies have evaluated the ability of damage and functional markers to predict AKI as compared with clinical risk factors, but to our knowledge these have yet to be incorporated into prediction scores for AKI following cardiac surgery.
Several practical interventions are available for the prevention of AKI, starting with the management of intravenous fluid administration. Although cardiac surgery is associated with microvasculature injury and tissue edema , colloid administration is not clearly superior to crystalloid. Colloid administration marginally improves maintenance of intravascular volume compared with crystalloid , and both albumin administration and hydroxyethyl starch administration have been associated with increased rates of AKI in some studies [41, 42]. However, a recent clinical trial of hypoalbuminemic patients undergoing off-pump coronary artery bypass surgery (OpCAB) demonstrated that albumin administration decreased the incidence of AKI compared with crystalloid . The results suggest hypoalbuminemia may be a modifiable risk factor for AKI associated with OpCAB. It is not clear whether benefit was derived from improved renal perfusion or direct effects of albumin on the kidneys . Additional studies are needed, particularly in on-pump surgery where inflammation and tissue edema are often worse than in off-pump surgery. With regard to crystalloid composition, isotonic normal saline administration has recently been associated with AKI, possibly as a result of the excess chloride load [40, 45]. A meta-analysis of 21 studies that included 6253 subjects found high-chloride solution administration to be independently associated with increased risk of AKI (relative risk (RR), 1.64 (95 % CI: 1.27–2.13); P < 0.001) and metabolic acidosis (RR, 2.87 (95 % CI: 1.95–4.21); P < 0.001), although mortality was unaffected . Interventional trials of hyperchloremic and balanced-salt crystalloid solutions have thus far confirmed that administration of normal saline may be harmful or at least no different from administration of a balanced-salt solution during critical illness [47, 48].
“Goal-directed therapy” incorporates specific monitoring techniques to guide intravenous fluid and vasoactive agent administration and may reduce AKI and length of stay when employed during cardiac surgery [49, 50]. One study demonstrated that stroke volume optimization—achieved by monitoring the effects of 250 ml3 fluid challenges on left ventricle stroke volume—reduced the incidence of AKI following cardiac surgery from 19.9 % to 6.5 % (P = 0.002) . The optimal fluid type, vasoactive drug regimen, and guiding hemodynamic parameters for goal-directed therapy are not well established.
Discontinuation of angiotensin converting enzyme inhibitors (ACEi), angiotensin receptor blockers (ARBs), nonsteroidal anti-inflammatory drugs, metformin, and diuretics prior to surgery is typically recommended; however, the largest clinical trial of perioperative ACEi in cardiac surgery patients found higher rates of renal failure, defined as an increase in SCr above 2.5 mg/dl, in patients randomized to placebo compared with ramipril or spironolactone , and another clinical trial found evidence that ACEi or ARBs continued until the day of surgery were safe compared with placebo . Some studies indicate that intraoperative calcium channel blocker administration may limit AKI [54–56]. The use of these medications has not gained acceptance, possibly due to concern for vasodilation and reduced cardiac output.
To improve the balance between renal oxygen supply and consumption, physicians have tested treatments that increase blood flow or decrease oxygen consumption. Fenoldopam dilates renal vasculature and therefore increases perfusion. The evidence supporting its use is mixed. Some studies have demonstrated that intraoperative fenoldopam may reduce AKI following cardiac surgery [57, 58], while another showed no benefit and revealed a higher rate of hypotension . These mixed results may be explained by variable effects of fenoldopam on the two distinct renal capillary beds. If glomerular perfusion increases to a greater extent than tubule perfusion, increased solute delivery to the tubules may induce medullary ischemia because increased solute reabsorption requires more oxygen consumption . Dopamine activates D1 receptors like fenoldopam but also D2 receptors. Dopamine administration does not prevent AKI associated with cardiac surgery [61, 62].
Sodium bicarbonate administration also decreases renal oxygen consumption but has not been demonstrated to consistently prevent AKI after cardiac surgery. One study reported a reduction in the incidence of severe AKI (odds ratio (OR), 0.45 (99 % CI: 0.43–0.48); P < 0.001) and the need for renal replacement therapy (RRT) (OR, 0.38 (99 % CI: 0.25–0.58); P < 0.001) , while another showed no effect on AKI (RR, 0.99 (95 % CI: 0.78–1.24); P = 0.91) but increased the ICU length of stay for patients who received sodium bicarbonate (weighted mean difference between groups, 2.06 days (95 % CI: 0.54–3.58); P = 0.008) . The routine administration of sodium bicarbonate during cardiac surgery is not recommended to reduce AKI .
Intravenous acetaminophen reduced plasma concentrations of isofurans, in-vivo biomarkers of oxidative stress, in both adult and pediatric cardiac surgery clinical trials but did not affect AKI [66, 67]. Perioperative dexmedetomidine administration has been associated with a lower incidence of AKI following valvular heart surgery (OR, 0.331 (95 % CI: 0.164–0.667); P = 0.002) and a decreased likelihood of progression to a more advanced stage of AKI (OR, 0.307 (95 % CI: 0.152–0.620); P = 0.001) . This association may be related to the vasoactive or anti-inflammatory properties of dexmedetomidine and its effects on circulating levels of bone morphogenetic protein 7 (BMP7) [69, 70]. Propofol also increases circulating levels of BMP7, and in mice decreased septic AKI . Other anti-inflammatory regimens have been ineffective. Two recent large multicenter randomized clinical trials of perioperative steroid administration (the DECS trial and the SIRS trial) did not find data to support the routine use of high-dose corticosteroids to reduce AKI following cardiac surgery, although there may be benefit in patients younger than 65 years of age and those with severe (stage 5) CKD [72, 73].
RIPC induces brief transient episodes of ischemia at a site remote from vital organs (e.g., the arm or leg) before organs are exposed to prolonged periods of ischemia and reperfusion. RIPC is hypothesized to attenuate renal damage by inducing the release of signaling molecules in the circulation that activate Toll-like receptors in the proximal tubule epithelia, conditioning the epithelium to tolerate a subsequent inflammatory or ischemic stress [74, 75]. Until recently, studies on the effects of RIPC on AKI in cardiac surgery were small single-center randomized trials that produced conflicting results [76–78]. Three recent multicenter randomized trials were completed to further test the hypothesis that RIPC decreases AKI following cardiac surgery.
Zarbock et al. recruited 240 cardiac surgery patients from four medical centers in Germany at high risk for AKI (Cleveland Clinic score ≥ 6) and randomized them to RIPC or sham treatment. The RIPC treatment group had decreased AKI, RRT, duration of ICU stay, and urine concentrations of IGFBP-7 and TEMP2 compared with the sham treatment group . Shortly thereafter, Meybohm et al.  reported in a trial of 1385 patients that RIPC had no effect on moderate or severe AKI compared with sham treatment (6.1 % RIPC versus 5.1 % sham, P = 0.45). The study was also a multicenter, double-blind randomized clinical trial in patients undergoing elective cardiac surgery; however, in these patients total intravenous anesthesia with propofol was provided throughout surgery. This practice limits the generalizability of the results, and in addition previous studies have suggested that propofol blunts the protective effects of RIPC on myocardial damage when compared with isoflurane . A third multicenter randomized clinical trial of 1612 cardiac surgery patients performed by Hausenloy et al. found no effect of RIPC on stage 1, 2, or 3 AKI compared with control treatment . So although RIPC treatment is supported by solid preclinical studies, recent large randomized clinical trials in patients undergoing cardiac surgery do not support its use as a preventative measure for AKI.
OpCAB was developed in order to avoid the potential harm of CPB during myocardial revascularization. Clinical trials have not clearly demonstrated that OpCAB surgery reduces the major morbidities associated with cardiac surgery, although OpCAB may lead to marginally lower rates of AKI compared with on-pump surgery [82, 83]. Transcatheter aortic valve replacement (TAVR) might reduce AKI compared with on-pump aortic valve replacement (AVR), since hemodynamics may be more stable during TAVR compared with AVR  and systemic inflammation may be lower . The first large randomized trial of TAVR versus AVR found no difference in AKI defined as postoperative SCr > 3.0 mg/dl or initiation of RRT .
Treatment options for AKI have focused on attenuating ischemia, reducing intrarenal inflammation, and supportive care. Nutrition is an important component of perioperative care and should not be neglected. Malnourished patients with AKI have an increased risk of mortality . Goals to provide 20–30 kcal/kg/day in patients with any stage of AKI should be met with either parenteral or enteral feeding . If AKI is severe enough to require RRT, higher caloric intake via protein supplementation may be necessary . Glycemic control is also indicated in patients developing AKI . Maintaining a glucose concentration ≤ 150 mg/dl is an appropriate target, while avoiding hypoglycemia (≤80 mg/dl).
In severe AKI, RRT is frequently required to treat hyperkalemia, remove excess fluid, treat uremia, or reverse acidosis. Clinical trials of early versus late initiation of RRT in cardiac surgery patients with severe AKI suggest early RRT may lower mortality and shorten the ICU length of stay . In one study, early RRT was associated with lower mortality (51.5 versus 77.9 %, P = 0.001) and decreased time on the ventilator (12.8 versus 18.9 days, P = 0.03) . Studies of dialysis dose, frequency, and modality (continuous versus intermittent) have also failed to demonstrate a consistent benefit of one technique versus another. The undisputed benefit of continuous versus intermittent RRT is hemodynamic stability, but otherwise, if a patient meets dialysis criteria (i.e., electrolyte abnormality, acidosis, uremic sequelae, or volume overload), modality does not appear to affect outcomes.
Mesenchymal stem cells (MSCs) possess anti-inflammatory and immunoregulatory characteristics that promote cell survival and tissue repair, and therefore present an attractive potential treatment for AKI [92, 93]. Murine models of ischemic AKI have yielded positive results. Mice that received subcapsular renal injection of MSCs from human exfoliated deciduous teeth following ischemia had decreased SCr, blood urea nitrogen, and inflammatory cytokine concentrations compared with those injected with vehicle . A murine study of rhabdomyolysis AKI (glycerol injection) showed that human liver stem cells (HLSCs) decreased creatinine, urea, hyaline cast formation, and tubular necrosis while enhancing tubular cell proliferation compared with vehicle . The use of human-induced pluripotent stem cells (hiPSCs) was also found to be a potential therapeutic option for AKI because mice with ischemic AKI benefited from renal subcapsular transplantation of hiPSCs . A trial investigating the use of stem cells in cancer patients for the treatment of cisplatin-induced AKI is ongoing (ClinicalTrials.gov NCT01275612). Stem cells may provide a future therapy for AKI following cardiac surgery.
Another potential treatment for AKI is alkaline phosphatase [97, 98]. Alkaline phosphatase converts the proinflammatory adenosine triphosphate into anti-inflammatory adenosine, and in septic rats attenuated plasma concentrations of TNF-α, IL-6, and IL-8 . A randomized clinical trial of septic patients found that intravenous administration of recombinant alkaline phosphatase increased creatinine clearance from 50 ± 27 (mean ± SEM) ml/minute at baseline to 108 ± 73 ml/minute after treatment in the alkaline phosphatase group versus from 40 ± 37 to 65 ± 30 ml/minute in the placebo group (P = 0.01), although this functional benefit did not translate into a decreased need for RRT .
AKI after cardiac surgery is common, although most often mild. The development of any AKI remains a major predictor of adverse outcomes, including progression of CKD. Effective prevention and treatment strategies for AKI after cardiac surgery may be on the horizon, and the discovery, validation, and adaptation of biomarkers of nephron damage may accelerate their development as well as shorten the time for diagnosis. For now, efforts to reduce AKI following cardiac surgery and its influence on patient morbidity are confined to hemodynamic manipulations, close attention to intravenous resuscitation strategies including goal-directed therapy and balanced-salt fluid administration, reduced exposure to CPB, and the identification and mitigation of modifiable risk factors.
ACEi, angiotensin converting enzyme inhibitors; AKI, acute kidney injury; ARBs, angiotensin receptor blockers; AVR, aortic valve replacement; BMP7, bone morphogenetic protein 7; CKD, chronic kidney disease; CPB, cardiopulmonary bypass; hiPSC, human induced pluripotent stem cell; HLSC, human liver stem cell; IGFBP, insulin-like growth factor–binding protein; KDIGO, Kidney Disease Improving Global Outcomes; MAKE, Major Adverse Kidney Events; MSC, mesenchymal stem cell; OpCAB, off-pump coronary artery bypass surgery; OR, odds ratio; RIPC, remote ischemic preconditioning; RR, relative risk; RRT, renal replacement therapy; SCr, serum creatinine; TAVR, transcatheter aortic valve replacement; TEMP, tissue inhibitor of metalloproteinases.
Research reported in this publication was supported by the National Institutes of Health under award numbers T32GM108554, K23GM102676, and R01GM112871. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.
JBO, ADS, and FTB were involved in the preparation of the article. All authors read and approved the final manuscript.
The authors declare that they have no competing interests.
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- Parolari A, Pesce LL, Pacini D, Mazzanti V, Salis S, Sciacovelli C, et al. Risk factors for perioperative acute kidney injury after adult cardiac surgery: role of perioperative management. Ann Thorac Surg. 2012;93(92):584–91. doi:https://doi.org/10.1016/j.athoracsur.2011.09.073.View ArticlePubMedGoogle Scholar
- Lagny MG, Jouret F, Koch JN, Blaffart F, Donneau AF, Albert A, et al. Incidence and outcomes of acute kidney injury after cardiac surgery using either criteria of the RIFLE classification. BMC Nephrol. 2015;16:76.View ArticlePubMedPubMed CentralGoogle Scholar
- Lopez-Delgado JC EF, Torrado H, Rodríguez-Castro D, Carrio ML, Farrero E, Javierre C, et al. Influence of acute kidney injury on short- and long-term outcomes in patients undergoing cardiac surgery: risk factors and prognostic value of a modified RIFLE classification. Crit Care. 2013;17(16):R293. doi:210.1186/cc13159Google Scholar
- Gomez H, Ince C, De Backer D, Pickkers P, Payen D, Hotchkiss J, et al. A unified theory of sepsis-induced acute kidney injury: inflammation, microcirculatory dysfunction, bioenergetics, and the tubular cell adaptation to injury. Shock. 2014;41(41):3–11. doi:https://doi.org/10.1097/SHK.0000000000000052.View ArticlePubMedPubMed CentralGoogle Scholar
- Meybohm P, Bein B, Brosteanu O, Cremer J, Gruenewald M, Stoppe C, et al. A multicenter trial of remote ischemic preconditioning for heart surgery. N Engl J Med. 2015;373(15):1397–407.View ArticlePubMedGoogle Scholar
- Khwaja A. KDIGO clinical practice guidelines for acute kidney injury. Nephron Clin Pract. 2012;120:c179–84.View ArticlePubMedGoogle Scholar
- Huen SC, Parikh CR. Predicting acute kidney injury after cardiac surgery: a systematic review. Ann Thorac Surg. 2012;93(1):337–47.PubMedPubMed CentralGoogle Scholar
- Billings FT, Pretorius M, Schildcrout JS, Mercaldo ND, Byrne JG, Ikizler TA, et al. Obesity and oxidative stress predict AKI after cardiac surgery. J Am Soc Nephrol. 2012;23(7):1221–8.View ArticlePubMedPubMed CentralGoogle Scholar
- Brezis M, Rosen S. Hypoxia of the renal medulla—its implications for disease. N Engl J Med. 1995;332(10):647–55.View ArticlePubMedGoogle Scholar
- Ricksten SE, Bragadottir G, Redfors B. Renal oxygenation in clinical acute kidney injury. Crit Care. 2013;17(2):221.View ArticlePubMedPubMed CentralGoogle Scholar
- Granata A, Insalaco M, Di Pietro F, Di Rosa S, Romano G, Scuderi R. Atheroembolism renal disease: diagnosis and etiologic factors. Clin Ter. 2012;163(4):313–22.PubMedGoogle Scholar
- Sreedharan RDP, Van Why S. Pathogenesis of acute renal failure. Pediatric Nephrology 2009. Heidleberg: Springer-Verlag; pp. 1579–1602.Google Scholar
- Fleming GA, Billings FT, Klein TM, Bichell DP, Christian KG, Pretorius M. Angiotensin-converting enzyme inhibition alters the inflammatory and fibrinolytic response to cardiopulmonary bypass in children. Pediatr Crit Care Med. 2011;12(5):532–8.View ArticlePubMedPubMed CentralGoogle Scholar
- Fujii T, Kurata H, Takaoka M, Muraoka T, Fujisawa Y, Shokoji T, et al. The role of renal sympathetic nervous system in the pathogenesis of ischemic acute renal failure. Eur J Pharmacol. 2003;481(2–3):241–8.View ArticlePubMedGoogle Scholar
- Zhang WR, Garg AX, Coca SG, Devereaux PJ, Eikelboom J, Kavsak P, et al. Plasma IL-6 and IL-10 concentrations predict AKI and long-term mortality in adults after cardiac surgery. J Am Soc Nephrol. 2015;26(12):3123–32.View ArticlePubMedGoogle Scholar
- Schrier CLEaRW. Pathophysiology of ischemic acute renal injury. In: Diseases of the kidney and urinary tract. 8th ed. Philadelphia: Lippincott Williams & Wilkins; 2007. p. 930–61.Google Scholar
- Stoner JD, Clanton TL, Aune SE, Angelos MG. O2 delivery and redox state are determinants of compartment-specific reactive O2 species in myocardial reperfusion. Am J Physiol Heart Circ Physiol. 2007;292(1):H109–16.View ArticlePubMedGoogle Scholar
- Reilly MP, Delanty N, Roy L, Rokach J, Callaghan PO, Crean P, et al. Increased formation of the isoprostanes IPF2alpha-I and 8-epi-prostaglandin F2alpha in acute coronary angioplasty: evidence for oxidant stress during coronary reperfusion in humans. Circulation. 1997;96(10):3314–20.View ArticlePubMedGoogle Scholar
- Wei C, Li L, Kim IK, Sun P, Gupta S. NF-kappaB mediated miR-21 regulation in cardiomyocytes apoptosis under oxidative stress. Free Radic Res. 2014;48(3):282–91.View ArticlePubMedGoogle Scholar
- Ali F, Sultana S. Repeated short-term stress synergizes the ROS signalling through up regulation of NFkB and iNOS expression induced due to combined exposure of trichloroethylene and UVB rays. Mol Cell Biochem. 2012;360(1–2):133–45.View ArticlePubMedGoogle Scholar
- Billings FT, Yu C, Byrne JG, Petracek MR, Pretorius M. Heme oxygenase-1 and acute kidney injury following cardiac surgery. Cardiorenal Med. 2014;4(1):12–21.View ArticlePubMedPubMed CentralGoogle Scholar
- Loebl EC, Baxter CR, Curreri PW. The mechanism of erythrocyte destruction in the early postburn period. Ann Surg. 1973;178(176):681–6.View ArticlePubMedPubMed CentralGoogle Scholar
- Ronco CBR, Kellum JA. Acute kidney injury. Contrib Nephrol. 2007;156:340–53.View ArticlePubMedGoogle Scholar
- Keene WRJJ. The sites of hemoglobin catabolism. Blood. 1965;26:705–19.PubMedGoogle Scholar
- Haase M, Bellomo R, Haase-Fielitz A. Novel biomarkers, oxidative stress, and the role of labile iron toxicity in cardiopulmonary bypass-associated acute kidney injury. J Am Coll Cardiol. 2010;55(19):2024–33.View ArticlePubMedGoogle Scholar
- Haase M, Haase-Fielitz A, Bagshaw SM, Ronco C, Bellomo R. Cardiopulmonary bypass-associated acute kidney injury: a pigment nephropathy? Contrib Nephrol. 2007;156:340–53.View ArticlePubMedGoogle Scholar
- Billings 4th FT, Roberts 2nd LJ, Pretorius M. Postoperative acute kidney injury is associated with hemoglobinemia and an enhanced oxidative stress response. Free Radic Biol Med. 2011;50(11):1480–7. doi:https://doi.org/10.1016/j.freeradbiomed.2011.02.011.View ArticlePubMedPubMed CentralGoogle Scholar
- Bellomo R, Ronco C, Kellum JA, Mehta RL, Palevsky P. Acute Dialysis Quality Initiative workgroup. Acute renal failure—definition, outcome measures, animal models, fluid therapy and information technology needs: the Second International Consensus Conference of the Acute Dialysis Quality Initiative (ADQI) Group. Crit Care. 2004;8(4):R204–12.View ArticlePubMedPubMed CentralGoogle Scholar
- Kellum JA, Sileanu FE, Murugan R, Lucko N, Shaw AD, Clermont G. Classifying AKI by urine output versus serum creatinine level. J Am Soc Nephrol. 2015;26(9):2231–8.View ArticlePubMedGoogle Scholar
- Chertow GM, Burdick E, Honour M, Bonventre JV, Bates DW. Acute kidney injury, mortality, length of stay, and costs in hospitalized patients. J Am Soc Nephrol. 2005;16(11):3365–70.View ArticlePubMedGoogle Scholar
- Lassnigg A, Schmidlin D, Mouhieddine M, Bachmann LM, Druml W, Bauer P, et al. Minimal changes of serum creatinine predict prognosis in patients after cardiothoracic surgery: a prospective cohort study. J Am Soc Nephrol. 2004;15(6):1597–605.View ArticlePubMedGoogle Scholar
- Haase M, Devarajan P, Haase-Fielitz A, Bellomo R, Cruz DN, Wagener G, et al. The outcome of neutrophil gelatinase-associated lipocalin-positive subclinical acute kidney injury: a multicenter pooled analysis of prospective studies. J Am Coll Cardiol. 2011;57(17):1752–61.View ArticlePubMedPubMed CentralGoogle Scholar
- Billings FT, Shaw AD. Clinical trial endpoints in acute kidney injury. Nephron Clin Pract. 2014;127(1-4):89–93.View ArticlePubMedPubMed CentralGoogle Scholar
- Thakar CV, Arrigain S, Worley S, Yared JP, Paganini EP. A clinical score to predict acute renal failure after cardiac surgery. J Am Soc Nephrol. 2005;16(1):162–8.View ArticlePubMedGoogle Scholar
- Mehta RH, Grab JD, O’Brien SM, Bridges CR, Gammie JS, Haan CK, et al. Bedside tool for predicting the risk of postoperative dialysis in patients undergoing cardiac surgery. Circulation. 2006;114(21):2208–16. quiz 2208.View ArticlePubMedGoogle Scholar
- Kiers HD, van den Boogaard M, Schoenmakers MC, van der Hoeven JG, van Swieten HA, Heemskerk S, et al. Comparison and clinical suitability of eight prediction models for cardiac surgery-related acute kidney injury. Nephrol Dial Transplant. 2013;28(2):345–51.View ArticlePubMedGoogle Scholar
- Machado MN, Nakazone MA, Maia LN. Acute kidney injury based on KDIGO (Kidney Disease Improving Global Outcomes) criteria in patients with elevated baseline serum creatinine undergoing cardiac surgery. Rev Bras Cir Cardiovasc. 2014;29(3):299–307.PubMedPubMed CentralGoogle Scholar
- Birnie K, Verheyden V, Pagano D, Bhabra M, Tilling K, Sterne JA, et al. Predictive models for kidney disease: improving global outcomes (KDIGO) defined acute kidney injury in UK cardiac surgery. Crit Care. 2014;18(6):606.View ArticlePubMedPubMed CentralGoogle Scholar
- Rehm M, Bruegger D, Christ F, Conzen P, Thiel M, Jacob M, et al. Shedding of the endothelial glycocalyx in patients undergoing major vascular surgery with global and regional ischemia. Circulation. 2007;116(17):1896–906.View ArticlePubMedGoogle Scholar
- Raghunathan K, Murray PT, Beattie WS, Lobo DN, Myburgh J, Sladen R, et al. Choice of fluid in acute illness: what should be given? An international consensus. Br J Anaesth. 2014;113(5):772–83.View ArticlePubMedGoogle Scholar
- Frenette AJ, Bouchard J, Bernier P, Charbonneau A, Nguyen LT, Rioux JP, et al. Albumin administration is associated with acute kidney injury in cardiac surgery: a propensity score analysis. Crit Care. 2014;18(16):602. doi:https://doi.org/10.1186/s13054-014-0602-1.View ArticlePubMedPubMed CentralGoogle Scholar
- Myburgh FS, Finfer S, Bellomo R, Billot L, Cass A, Gattas D, et al. Hydroxyethyl starch or saline for fluid resuscitation in intensive care. N Engl J Med. 2012;367(320):1901–11. doi:1910.1056/NEJMoa1209759Google Scholar
- Lee EH, Kim WJ, Kim JY, Chin JH, Choi DK, Sim JY, et al. Effect of exogenous albumin on the incidence of postoperative acute kidney injury in patients undergoing off-pump coronary artery bypass surgery with a preoperative albumin level of less than 4.0 g/dl. Anesthesiology. 2016;124(5):1001–11.View ArticlePubMedGoogle Scholar
- Jiang Y, Shaw AD. Albumin supplementation as a therapeutic strategy in cardiac surgery: useful tool or expensive hobby? Anesthesiology. 2016;124(5):983–5.View ArticlePubMedGoogle Scholar
- Kim JY, Joung KW, Kim KM, Kim MJ, Kim JB, Jung SH, et al. Relationship between a perioperative intravenous fluid administration strategy and acute kidney injury following off-pump coronary artery bypass surgery: an observational study. Crit Care. 2015;19:350.View ArticlePubMedPubMed CentralGoogle Scholar
- Krajewski ML, Raghunathan K, Paluszkiewicz SM, Schermer CR, Shaw AD. Meta-analysis of high- versus low-chloride content in perioperative and critical care fluid resuscitation. Br J Surg. 2015;102(101):124–36. doi:110.1002/bjs.9651Google Scholar
- Yunos NM, Bellomo R, Hegarty C, Story D, Ho L, Bailey M. Association between a chloride-liberal vs chloride-restrictive intravenous fluid administration strategy and kidney injury in critically ill adults. JAMA. 2012;308(315):1566–72. doi:1510.1001/jama.2012.13356Google Scholar
- Young P, Bailey M, Beasley R, Henderson S, Mackle D, McArthur C, et al. Effect of a buffered crystalloid solution vs saline on acute kidney injury among patients in the intensive care unit: the SPLIT Randomized Clinical Trial. JAMA. 2015;314(316):1701–10. doi:1710.1001/jama.2015.12334Google Scholar
- Giglio M, Dalfino L, Puntillo F, et al. Haemodynamic goal-directed therapy in cardiac and vascular surgery. A systematic review and meta-analysis. Interact Cardiovasc Thorac Surg. 2012;15(15):878–87. doi:810.1093/icvts/ivs1323Google Scholar
- Aya HD, Cecconi M, Hamilton M, Rhodes A. Goal-directed therapy in cardiac surgery: a systematic review and meta-analysis. Br J Anaesth. 2013;110(114):510–7. doi:110.1093/bja/aet1020Google Scholar
- Thomson R, Meeran H, Valencia O, Al-Subaie N. Goal-directed therapy after cardiac surgery and the incidence of acute kidney injury. J Crit Care. 2014;29(26):997–1000. doi:1010.1016/j.jcrc.2014.1006.1011Google Scholar
- Pretorius M, Murray KT, Yu C, Byrne JG, Billings FT, Petracek MR, et al. Angiotensin-converting enzyme inhibition or mineralocorticoid receptor blockade do not affect prevalence of atrial fibrillation in patients undergoing cardiac surgery. Crit Care Med. 2012;40(10):2805–12.View ArticlePubMedPubMed CentralGoogle Scholar
- Billings 4th FT, Balaguer JM CY, Wright P, Petracek MR, Byrne JG, et al. Comparative effects of angiotensin receptor blockade and ACE inhibition on the fibrinolytic and inflammatory responses to cardiopulmonary bypass. Clin Pharmacol Ther. 2012;91(6):1065–73.View ArticlePubMedPubMed CentralGoogle Scholar
- Antonucci FCL, Rizzolo M, Cantaro S, Bertolissi M, Travaglini M, Geatti O, et al. Nifedipine can preserve renal function in patients undergoing aortic surgery with infrarenal crossclamping. Nephron. 1996;74(74):668–73.View ArticlePubMedGoogle Scholar
- Bergman AS, Odar-Cederlöf I, Westman L. Renal and hemodynamic effects of diltiazem after elective major vascular surgery—a potential renoprotective agent? Ren Fail. 1995;17(12):155–63.View ArticlePubMedGoogle Scholar
- Colson P, Ribstein J, Séguin JR, Marty-Ane C, Roquefeuil B. Mechanisms of renal hemodynamic impairment during infrarenal aortic cross-clamping. Anesth Analg. 1992;75(71):18–23.PubMedGoogle Scholar
- Zangrillo A, Biondi-Zoccai GG, Frati E, Covello RD, Cabrini L, Guarracino F, et al. Fenoldopam and acute renal failure in cardiac surgery: a meta-analysis of randomized placebo-controlled trials. J Cardiothorac Vasc Anesth. 2012;26(23):407–13. doi:410.1053/j.jvca.2012.1001.1038Google Scholar
- Landoni G, Biondi-Zoccai GG, Marino G, Bove T, Fochi O, Maj G, et al. Fenoldopam reduces the need for renal replacement therapy and in-hospital death in cardiovascular surgery: a meta-analysis. J Cardiothorac Vasc Anesth. 2008;22(21):27–33. doi:https://doi.org/10.1053/j.jvca.2007.1007.1015.View ArticlePubMedGoogle Scholar
- Bove T, Zangrillo A, Guarracino F, Alvaro G, Persi B, Maglioni E, et al. Effect of fenoldopam on use of renal replacement therapy among patients with acute kidney injury after cardiac surgery: a randomized clinical trial. JAMA. 2014;312(321):2244–53. doi:2210.1001/jama.2014.13573Google Scholar
- Hansell P, Welch WJ, Blantz RC, Palm F. Determinants of kidney oxygen consumption and their relationship to tissue oxygen tension in diabetes and hypertension. Clinical and experimental pharmacology & physiology 2013;40(2):123-137.Google Scholar
- Lassnigg A, Donner E, Grubhofer G, Presterl E, Druml W, Hiesmayr M. Lack of renoprotective effects of dopamine and furosemide during cardiac surgery. J Am Soc Nephrol. 2000;11(1):97–104.PubMedGoogle Scholar
- Myles PS, Buckland MR, Schenk NJ, Cannon GB, Langley M, Davis BB, et al. Effect of “renal-dose” dopamine on renal function following cardiac surgery. Anaesth Intensive Care. 1993;21(1):56–61.PubMedGoogle Scholar
- Bailey M, McGuinness S, Haase M, Haase-Fielitz A, Parke R, Hodgson CL, et al. Sodium bicarbonate and renal function after cardiac surgery: a prospectively planned individual patient meta-analysis. Anesthesiology. 2015;122(2):294–306.View ArticlePubMedGoogle Scholar
- Tie HT, Luo MZ, Luo MJ, Zhang M, Wu QC, Wan JY. Sodium bicarbonate in the prevention of cardiac surgery-associated acute kidney injury: a systematic review and meta-analysis. Crit Care. 2014;18(5):517.View ArticlePubMedPubMed CentralGoogle Scholar
- McGuinness SP, Parke RL, Bellomo R, Van Haren FM, Bailey M. Sodium bicarbonate infusion to reduce cardiac surgery-associated acute kidney injury: a phase II multicenter double-blind randomized controlled trial. Crit Care Med. 2013;41(47):1599–607. doi:1510.1097/CCM.1590b1013e31828a31823f31899Google Scholar
- Billings FT, Petracek MR, Roberts 2nd LJ, Pretorius M. Perioperative intravenous acetaminophen attenuates lipid peroxidation in adults undergoing cardiopulmonary bypass: a randomized clinical trial. PLoS One. 2015;10(2):e0117625.View ArticlePubMedGoogle Scholar
- Simpson SA, Zaccagni H, Bichell DP, Christian KG, Mettler BA, Donahue BS, et al. Acetaminophen attenuates lipid peroxidation in children undergoing cardiopulmonary bypass. Pediatr Crit Care Med. 2014;15(6):503–10.View ArticlePubMedPubMed CentralGoogle Scholar
- Cho JS, Shim JK, Soh S, Kim MK, Kwak YL. Perioperative dexmedetomidine reduces the incidence and severity of acute kidney injury following valvular heart surgery. Kidney Int. 2016;89(3):693-700.Google Scholar
- Hsing CH, Lin CF, So E, Sun DP, Chen TC, Li CF, et al. alpha2-Adrenoceptor agonist dexmedetomidine protects septic acute kidney injury through increasing BMP-7 and inhibiting HDAC2 and HDAC5. Am J Physiol Renal Physiol. 2012;303(10):F1443–53.View ArticlePubMedGoogle Scholar
- Billings FT, Chen SW, Kim M, Park SW, Song JH, Wang S, et al. alpha2-Adrenergic agonists protect against radiocontrast-induced nephropathy in mice. Am J Physiol Renal Physiol. 2008;295(3):F741–8.View ArticlePubMedGoogle Scholar
- Hsing CH, Chou W, Wang JJ, Chen HW, Yeh CH. Propofol increases bone morphogenetic protein-7 and decreases oxidative stress in sepsis-induced acute kidney injury. Nephrol Dial Transplant. 2011;26(4):1162–72.View ArticlePubMedGoogle Scholar
- Jacob KA, Leaf DE, Dieleman JM, van Dijk D, Nierich AP, Rosseel PM, et al. Intraoperative high-dose dexamethasone and severe AKI after cardiac surgery. J Am Soc Nephrol. 2015;26(12):2947–51.View ArticlePubMedGoogle Scholar
- Whitlock RP, Devereaux PJ, Teoh KH, Lamy A, Vincent J, Pogue J, et al. Methylprednisolone in patients undergoing cardiopulmonary bypass (SIRS): a randomised, double-blind, placebo-controlled trial. Lancet. 2015;386(10000):1243–53.View ArticlePubMedGoogle Scholar
- Kharbanda RK, Nielsen TT, Redington AN. Translation of remote ischaemic preconditioning into clinical practice. Lancet. 2009;374(9700):1557–65.View ArticlePubMedGoogle Scholar
- Gassanov N, Nia AM, Caglayan E, Er F. Remote ischemic preconditioning and renoprotection: from myth to a novel therapeutic option? J Am Soc Nephrol. 2014;25(2):216–24.View ArticlePubMedGoogle Scholar
- Gallagher SM, Jones DA, Kapur A, Wragg A, Harwood SM, Mathur R, et al. Remote ischemic preconditioning has a neutral effect on the incidence of kidney injury after coronary artery bypass graft surgery. Kidney Int. 2015;87(2):473–81.View ArticlePubMedGoogle Scholar
- Choi YS, Shim JK, Kim JC, Kang KS, Seo YH, Ahn KR, et al. Effect of remote ischemic preconditioning on renal dysfunction after complex valvular heart surgery: a randomized controlled trial. J Thorac Cardiovasc Surg. 2011;142(1):148–54.View ArticlePubMedGoogle Scholar
- Zimmerman RF, Ezeanuna PU, Kane JC, Cleland CD, Kempananjappa TJ, Lucas FL, et al. Ischemic preconditioning at a remote site prevents acute kidney injury in patients following cardiac surgery. Kidney Int. 2011;80(8):861–7.View ArticlePubMedGoogle Scholar
- Zarbock A, Schmidt C, Van Aken H, Wempe C, Martens S, Zahn PK, et al. Effect of remote ischemic preconditioning on kidney injury among high-risk patients undergoing cardiac surgery: a randomized clinical trial. Jama. 2015;313(21):2133–41.View ArticlePubMedGoogle Scholar
- Kottenberg E, Thielmann M, Bergmann L, Heine T, Jakob H, Heusch G, et al. Protection by remote ischemic preconditioning during coronary artery bypass graft surgery with isoflurane but not propofol—a clinical trial. Acta Anaesthesiol Scand. 2012;56(1):30–8.View ArticlePubMedGoogle Scholar
- Hausenloy DJ, Candilio L, Evans R, Ariti C, Jenkins DP, Kolvekar S, et al. Remote ischemic preconditioning and outcomes of cardiac surgery. N Engl J Med. 2015;373(15):1408–17.View ArticlePubMedGoogle Scholar
- Nigwekar SU, Kandula P, Hix JK, Thakar CV. Off-pump coronary artery bypass surgery and acute kidney injury: a meta-analysis of randomized and observational studies. Am J Kidney Dis. 2009;54(53):413–23. doi:410.1053/j.ajkd.2009.1001.1267Google Scholar
- Seabra VF, Alobaidi S, Balk EM, Poon AH, Jaber BL. Off-pump coronary artery bypass surgery and acute kidney injury: a meta-analysis of randomized controlled trials. Clin J Am Soc Nephrol. 2010;5(10):1734–44. doi:1710.2215/CJN.02800310Google Scholar
- Kamperidis V, van Rosendael PJ, de Weger A, Katsanos S, Regeer M, van der Kley F, et al. Surgical sutureless and transcatheter aortic valves: hemodynamic performance and clinical outcomes in propensity score-matched high-risk populations with severe aortic stenosis. JACC Cardiovasc Interv. 2015;28(25):670–7. doi:610.1016/j.jcin.2014.1010.1029Google Scholar
- Lindman BR, Goldstein JS, Nassif ME, Zajarias A, Novak E, Tibrewala A, et al. Systemic inflammatory response syndrome after transcatheter or surgical aortic valve replacement. Heat. 2015;101(107):537–45. doi:110.1136/heartjnl-2014-307057Google Scholar
- Smith CR, Leon MB, Mack MJ, Miller DC, Moses JW, Svensson LG, et al. Transcatheter versus surgical aortic-valve replacement in high-risk patients. N Engl J Med. 2011;364(23):2187–98.View ArticlePubMedGoogle Scholar
- Fiaccadori E, Lombardi M, Leonardi S, et al. Prevalence and clinicaloutcome associated with preexisting malnutrition in acute renal failure: a prospective cohort study. J Am Soc Nephrol. 1999;10:581–93.PubMedGoogle Scholar
- Brochard L, Abroug F, Brenner M, Broccard AF, Danner RL, Ferrer M, et al. An Official ATS/ERS/ESICM/SCCM/SRLF Statement: Prevention and Management of Acute Renal Failure in the ICU Patient: an international consensus conference in intensive care medicine. Am J Respir Crit Care Med. 2010;181(10):1128–55.View ArticlePubMedGoogle Scholar
- Palevsky PMMP. Acute kidney injury and critical care nephrology. NephSAP. 2006;5(2):72–120.Google Scholar
- Liu Y, Davari-Farid S, Arora P, Porhomayon J, Nader ND. Early versus late initiation of renal replacement therapy in critically ill patients with acute kidney injury after cardiac surgery: a systematic review and meta-analysis. J Cardiothorac Vasc Anesth. 2014;28(3):557–63.View ArticlePubMedGoogle Scholar
- Leite TT, Macedo E, Pereira SM, Bandeira SR, Pontes PH, Garcia AS, et al. Timing of renal replacement therapy initiation by AKIN classification system. Crit Care. 2013;17(2):R62.View ArticlePubMedPubMed CentralGoogle Scholar
- Bianchi F, Sala E, Donadei C, Capelli I, La Manna G. Potential advantages of acute kidney injury management by mesenchymal stem cells. World J Stem Cells. 2014;6(5):644–50.View ArticlePubMedPubMed CentralGoogle Scholar
- Du T, Zhu YJ. The regulation of inflammatory mediators in acute kidney injury via exogenous mesenchymal stem cells. Mediators Inflamm. 2014;2014:261697.View ArticlePubMedPubMed CentralGoogle Scholar
- Hattori Y, Kim H, Tsuboi N, Yamamoto A, Akiyama S, Shi Y, et al. Therapeutic potential of stem cells from human exfoliated deciduous teeth in models of acute kidney injury. PLoS One. 2015;10(10):e0140121.View ArticlePubMedPubMed CentralGoogle Scholar
- Herrera Sanchez MB, Bruno S, Grange C, Tapparo M, Cantaluppi V, Tetta C, et al. Human liver stem cells and derived extracellular vesicles improve recovery in a murine model of acute kidney injury. Stem Cell Res Ther. 2014;5(6):124.View ArticlePubMedGoogle Scholar
- Toyohara T, Mae S, Sueta S, Inoue T, Yamagishi Y, Kawamoto T, et al. Cell therapy using human induced pluripotent stem cell-derived renal progenitors ameliorates acute kidney injury in mice. Stem Cells Transl Med. 2015;4(9):980–92.View ArticlePubMedGoogle Scholar
- Peters E, Masereeuw R, Pickkers P. The potential of alkaline phosphatase as a treatment for sepsis-associated acute kidney injury. Nephron Clin Pract. 2014;127(1-4):144–8.View ArticlePubMedGoogle Scholar
- Peters E, van Elsas A, Heemskerk S, Jonk L, van der Hoeven J, Arend J, et al. Alkaline phosphatase as a treatment of sepsis-associated acute kidney injury. J Pharmacol Exp Ther. 2013;344(1):2–7.View ArticlePubMedGoogle Scholar
- Peters E, Geraci S, Heemskerk S, Wilmer MJ, Bilos A, Kraenzlin B, et al. Alkaline phosphatase protects against renal inflammation through dephosphorylation of lipopolysaccharide and adenosine triphosphate. Br J Pharmacol. 2015;172(20):4932–45.View ArticlePubMedGoogle Scholar
- Pickkers P, Heemskerk S, Schouten J, Laterre PF, Vincent JL, Beishuizen A, et al. Alkaline phosphatase for treatment of sepsis-induced acute kidney injury: a prospective randomized double-blind placebo-controlled trial. Crit Care. 2012;16(1):R14.View ArticlePubMedPubMed CentralGoogle Scholar