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Table 4 Variation in relative differences in total costs between on-demand and planned relaparotomy strategies across various clinical subgroups

From: Costs of relaparotomy on-demand versus planned relaparotomy in patients with severe peritonitis: an economic evaluation within a randomized controlled trial

  Relaparotomy strategy   
   On demand   Planned Differencea  
  Mean costs p.p. n Mean costs p.p. n % from planned P valueb
Overall 66,216 112 84,152 113 -23.8%  
Comorbidity       0.26
   No 64,948 48 89,738 41 -32.8%  
   Yes 67,168 64 80,971 72 -17.1%  
Apache II       0.58
   11-20 66,956 96 84,683 94 -22.3%  
   >20 61,777 16 81,525 19 -32.3%  
Etiology       0.09
   Inflammation (1) 40,810 4 81,074 5 -21.7%  
   Perforation (2) 62,236 63 88,985 67 -37.0%  
   Ischemia (1) 59,591 6 72,080 8 --  
   Anastomotic leakage (3) 76,171 35 72,751 27 6.8%  
   Other (4) 77,153 4 100,149 6 -6.9%  
   Elimination of infectious source       0.81
   No 71,113 10 90,254 11 -24.2%  
   Yes 65,736 102 83,494 102 -18.3%  
Localization       0.45
   Upper GT (1) 69,828 30 81,146 27 -25.9%  
   Lower GT (2) 67,402 70 82,446 74 -42.7%  
   Biliary tract (3) 63,496 2 100,115 5 -28.8%  
   Appendix (3) 32,075 3 26,575 1 --  
   Pancreas (3) 59,352 5 92,446 2 --  
   Gynecol (3) 41,650 2 67,720 1 --  
   Other (3)    145,821 3 --  
Extent of index operation       0.49
   1 quadrant 66,079 9 73,381 16 3.0%  
   2 quadrants 62,439 34 84,791 26 -30.6%  
   Diffuse 68,096 70 86,102 69 -24.8%  
Nature of contamination       0.18
   Clear (1) 59,306 6 97,791 8 -25.9%  
   Turbid (2) 57,179 18 96,672 29 -42.7%  
   Purulent (3) 55,746 43 77,003 30 -28.8%  
   Fecal (4) 84,707 41 81,977 41 -2.4%  
   Bile (3) 40,281 4 61,984 3 -  
Survival (at 12 mo)       
   No 73,275 80 85,326 72 -17.8% 0.13
   Yes 48,569 32 82,089 41 -38.6%  
  1. aModel estimates of difference between On demand and Planned relaparotomy strategy based on analyses of geometric means; bFor the interaction effect in regression model; (x) numbers between brackets indicate collapsed categories used as interaction effect. The P value for the interaction effect in the regression model tests the hypothesis that the relative differences between the two surgical strategies are the same across clinical subgroups (for example, for comorbidity, that -32.8% = -17.1%). P values > 0.05 indicate that this hypothesis cannot be rejected at a 5% statistical significance level.