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Hemodynamic and metabolic features of a porcine systemic low flow state model
Critical Care volume 11, Article number: P6 (2007)
To describe a new experimental systemic low flow state model induced by cardiac tamponade.
Ten Large White pigs (43 ± 5 kg) were instrumented with arterial and pulmonary catheters, cystostomy and splenectomy, and a latex balloon was inserted anterior to the heart. Pigs were randomized to a shock group or a control group. The shock group had the balloon inflated with 620 ± 344 ml to keep the mean arterial blood pressure at 45–55 mmHg (mean = 49 ± 4 mmHg) for 1 hour. Hemodynamic data were collected and shown as the mean ± SD. Two-way ANOVA was used with Bonferroni's correction.
During shock, the SvO2 was 34 ± 8%, the heart rate was 173 ± 36 bpm, and the stroke volume was 18 ± 12 ml/min/beat. After shock, see Table 1.
In our model, transient cardiac tamponade caused persistent hypotension and cardiovascular dysfunction. Hyperthermia was an interesting finding in the last hours of the experiment in animals submitted to cardiac tamponade.
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Azevedo, L., Maciel, A., Noritomi, D. et al. Hemodynamic and metabolic features of a porcine systemic low flow state model. Crit Care 11, P6 (2007) doi:10.1186/cc5793
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