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Factors that predict outcome of intensive care treatment in very elderly patients: a review
Critical Care volume 9, Article number: R307 (2005)
Advanced age is thought to be associated with increased mortality in critically ill patients. This report reviews available data on factors that determine outcome, on the value of prognostic models, and on preferences regarding life-sustaining treatments in (very) elderly intensive care unit (ICU) patients.
We searched the Medline database (January 1966 to January 2005) for English language articles. Selected articles were cross-checked for other relevant publications.
Mortality rates are higher in elderly ICU patients than in younger patients. However, it is not age per se but associated factors, such as severity of illness and premorbid functional status, that appear to be responsible for the poorer prognosis. Patients' preferences regarding life-sustaining treatments are importantly influenced by the likelihood of a beneficial outcome. Commonly used prognostic models have not been calibrated for use in the very elderly. Furthermore, they do not address long-term survival and functional outcome.
We advocate the development of new prognostic models, validated in elderly ICU patients, that predict not only survival but also functional and cognitive status after discharge. Such a model may support informed decision making with respect to patients' preferences.
Projections by the US Census Bureau  suggest that the population aged 85 years and older is likely to grow from about 4 million in 2000 to 19 million by 2050. This 'greying' of the population has also been identified in European countries and in Japan. Ageing of the population increases the proportion of people with chronic conditions, with corresponding expectations of eventual decline in function. Advanced age is associated with increased mortality in intensive care unit (ICU) patients . Furthermore, the life expectancy of all elderly patients, remains limited, even after successful ICU treatment. In the UK life expectancy at age 80 years increased from 5.8 years in 1981 to 7.2 years in 2002 for males, and from 7.5 to 8.7 years for females . Thus, the costs per year of life gained, both economical and emotional, are relatively high for elderly patients. Indeed, life-sustaining treatment is more often withdrawn or withheld in older patients. However, few data are available to help identify patients who will benefit from ICU treatment from those who will not.
In this review we focus on the most important factors that may influence outcomes in very elderly critically ill patients, on models that predict short-term and long-term outcome, and on the available data on patients' preferences regarding life-sustaining treatment and how these preferences are influenced by the likelihood of a beneficial outcome.
Materials and methods
A Medline search (January 1966 to January 2005) was performed using the terms 'frail elderly', 'geriatric', 'very elderly' and 'octogenarians'; and 'critical illness', 'critical care', 'intensive care' and 'intensive care units'; in combination with the terms 'prognosis', 'predictor', or 'outcome'.
Based on title and abstract, we selected English language articles containing clinical data on the outcomes of ICU treatment in very elderly patients. The reference lists of all reports were cross-checked for other potentially relevant articles. In the reports identified in this search, we examined factors that influence outcome in elderly patients such as age, diagnosis, comorbidity, functional status (including cognitive functioning) before hospital admittance, delirium, malnutrition, dehydration, acute renal failure, length of stay, and complications such as nosocomial infections and pressure ulcers. It was envisaged that the studies would be too heterogeneous to combine in a formal meta-analysis, and therefore a narrative synthesis, mainly focusing on prospective studies or very large retrospective studies, was undertaken.
In accordance with published criteria , we consider patients aged 80 years and older to be 'very elderly'. However, as several published studies used different criteria for defining a patient as elderly, we also consider data based on studies in other patient groups (e.g. those older than 70 years). Where data specific to elderly patients are not available, we briefly review best knowledge based on studies in patients of all ages.
Results and discussion
Factors influencing outcome in elderly patients
When discussing the influence of age on ICU outcome, it is important to appreciate that all published studies, either prospective or retrospective, were performed in selected populations of elderly patients after admission to an ICU. Because intensive treatments, including intensive care, are often withheld in elderly patients [4, 5], patients with severe comorbidity may be under-represented in these studies. This could result in an over-optimistic view on the effects of age on ICU outcome in the selected patient groups. On the other hand, high mortality rates in the studies may partly be accounted for by decisions to withhold life-sustaining treatments because of advanced age.
For this overview, we consider those patients aged 80 years or older to be 'very elderly' patients, in accordance with the definitions proposed by the SUPPORT (Study to Understand Prognosis and Preferences for Outcomes and Risks of Treatment) investigators .
We found 12 prospective cohort studies or retrospective studies based on large databases that addressed the influence of age on outcome in ICU patients (Table 1) [6–17]. In 1995 Cohen and Lambrinos  presented the results of a study of the impact age has on outcome of mechanical ventilation in a 41,848-patient, state-wide database. They found that in-hospital mortality in patients receiving mechanical ventilation aged 85 years or older was 70%, as compared with 32% in patients aged 29 years or younger. Only 14% of patients aged 85 years or older went home without home health care, as compared with 47% in patients aged 29 years or younger. Another large retrospective cohort study , conducted in data from consecutive ICU admissions to 38 ICUs, showed increased risk for hospital death with more advanced age. Relative to patients younger than 35 years, the adjusted odds of death in patients aged 80–84 years and ≥90 years were 3.9 and 4.7, respectively. These findings were adjusted for severity of illness, Acute Physiology Score, admission source, diagnosis and comorbidity. These conclusions are in accordance with the findings of the SUPPORT study . In that study the risk of death was shown to increase by 1.0% for year of age in patients aged 18–70 years, and by 2.0% for patients aged 70 years or older.
Figure 1 shows the effect of age on in-hospital mortality in 54,021 patients admitted to various ICUs participating in the Dutch National Intensive Care Evaluation (NICE) registry . The in-hospital mortality rate in patients aged 85 years or older was fourfold higher than in patients younger than 65 years.
Although advanced age clearly increases the risk for not surviving an ICU stay, this does not mean that all critically ill elderly patients have a poor prognosis. Studies in specific subgroups of elderly patients have shown that mortality may be as low as 4.3% or 22.1% for patients older than 85 years admitted to a surgical ICU [19, 20], 15–25% in neurosurgical ICU patients, and 39–48% for medical ICU patients .
Despite potential bias in all studies, many suggest that older patients are more likely to die or experience adverse outcomes of their ICU treatment. However, several studies, using multivariate analysis, showed that age was not an independent predictor of mortality [6, 16, 21–23]. It appears that it is not advanced age per se but other factors associated with advanced age that determine prognosis in elderly patients.
The conclusion that very elderly ICU patients are at substantially increased risk for dying may not hold true for all subgroups of patients. It was found that the effects of age on prognosis very much depend on other factors such as diagnosis. In patients aged 80–84 years hospital mortality was 85% for those with infection as their reason for admission, as compared with 58% for those with diagnoses of gastrointestinal disorder . In another study , whereas in-hospital mortality in elderly patients on mechanical ventilation due to pneumonia was 62%, it was 40% in ventilated trauma patients. Outcome after brain injury in geriatric trauma patients is notoriously poor, with mortality and functional disability rates twice those in younger patients . In a general population (all ages), it was shown that 13.6% of the predictive power of the Acute Physiology and Chronic Health Evaluation (APACHE) III model was due to admitting diagnosis . Our data from the Dutch NICE database  show that, between 1997 and 2002, in-hospital mortality in ICU patients aged 80 years or older was 16.5% in those who had undergone cardiac surgery but 46% in other patients.
We can conclude that the reason for admission to an ICU has a major influence on prognosis.
Comorbidity, defined as the total burden of illness unrelated to a patient's principal diagnosis, contributes to clinical outcomes (e.g. mortality, surgical results, complication rates, functional status and length of stay) as well as to economic outcomes (e.g. resource utilization, discharge destination and intensity of treatments) [27–29]. Most information on the influence of comorbidity on outcome after ICU admission comes from studies in patients of all ages. In 1987, Charlson and coworkers  developed a weighted index of comorbidity that takes into account the number as well as the seriousness of comorbid diseases. This index was shown to predict the 1-year mortality of hospitalized medical patients.
Some studies investigated the relationship between comorbidity and mortality in critically ill patients of all ages. Among the severity of illness models that predict mortality in critically ill patients, comorbidity is included in APACHE II and III [30, 31] but not in the Simplified Acute Physiology Score (SAPS) II  or Mortality Probability Model (MPM) II . It was shown that the APACHE II model was a very good predictor of mortality in critically ill patients, but that the chronic health points components of APACHE II did not have discriminating ability . Furthermore, it was also shown that the Charlson index had some predictive value in critically ill patients but with an area under the receiver operating characteristic (ROC) curve of only 0.67, indicating limited discriminating ability. In a retrospective cohort study conducted in more than 17,000 ICU patients , comorbidity was found to account for only 8.4% of the predictive ability of APACHE II, as compared with 67.7% for laboratory values and 17.7% for diagnosis .
Comorbidity is commonly present in elderly patients. However, we could not find any study of the possible influence of comorbidity on outcome conducted specifically in (very) elderly critically ill patients.
Functional status before hospital admittance
Functional status, including physical, cognitive and social functioning, has been shown to be an important predictor of the hospital outcomes of older patients. Not surprisingly, impaired functioning in daily life is more likely to be prevalent in older patients and was found to form an independent predictor of mortality [36–38].
Functional status is generally not assessed by physiologically based models such as SAPS II and APACHE II and III. In ICU patients of all ages, an association between functional status and mortality was found by some investigators  but not by others [22, 40]. Few clinical studies described the value of premorbid functional status in predicting ICU outcomes in the very elderly.
In 1991, Mayer-Oakes and coworkers  found in older ICU patients that those who died were significantly more likely to be totally dependent on help for activities of daily living than were those who survived. It was recently reported that long-term survival after admission to a medical ICU is dependent on functional status before admission . In a more recent study , the prognosis of elderly patients hospitalized in a medical ICU depended not only on APACHE II scores but also on the loss of functional independence and on the presence of moderate to severe cognitive impairment before ICU admission. Mortality was 30% in patients who had an Activities of Daily Living score of 1–6 (dependent), as compared with 7.8% in patients with a score of 0 (independent). Likewise, mortality was 55.9% in patients with severe cognitive impairment versus 8.2% in those without cognitive impairment. Also, in older patients with severe pneumonia requiring mechanical ventilation, the Activities of Daily Living score before admission was shown to be an important predictor of discharge outcome .
Another recent study  showed that, in a population of very old patients, mortality after ICU discharge occurred predominantly during the first 3 months.
Although various instruments for measurement of impaired functioning were employed in the reviewed studies, both age and prior limitation of activity were associated with risk for dying during the ICU stay.
In a recent prospective cohort study conducted in 817 adult patients receiving prolonged mechanical ventilation, long-term ICU outcome, defined as mortality after 1 year of follow up, was also found to be associated with advanced age and poor functional status before hospitalization [22, 43].
Other factors related to intensive care outcome in very elderly patients
Risk adjustment indices, which are mainly based on demographic data, and the existing prognostic models may underestimate the effects on prognosis of complicating conditions that are frequently present in older patients and that are under-reported in administrative databases. Examples of these are malnutrition and delirium.
Low body mass index has been shown to be an independent predictor of in-hospital mortality [36, 44, 45]. Malnutrition was common in older hospitalized patients with medical illness, and was also associated with delayed functional recovery and higher rates of nursing home use. These adverse outcomes were not accounted for by greater severity of acute illness, comorbidity, or functional dependence in malnourished patients on hospital admission . This relation between nutrition, in some studies expressed as a low body mass index, and mortality was also confirmed in ICU patients aged 65 years and older . Delirium, an often overlooked complication in older ICU patients, is an independent predictor of reintubation, prolonged hospital stay and mortality [46–48].
Other factors that may have an effect on prognosis are complications, such as adverse drug events , nosocomial infections  and pressure ulcers . However, no studies were found concerning the impacts of these complications on outcome specifically in very elderly critically ill patients treated in ICUs.
Patients do not necessarily prefer life-extending treatment over care focused on relieving pain and discomfort. The willingness to receive life-sustaining treatment depends on the burden of treatment, the outcome and the likelihood of the outcome. In a population of patients with limited life expectancy and aged 60 years or older, 74% stated that they would not choose treatment if the burden of treatment were high and the anticipated outcome survival with severe functional impairment . Under the same conditions, 88% of patients opted not to undergo treatment if cognitive impairment was the expected outcome. The number of participants who stated that they would choose treatment declined as the likelihood of an adverse outcome increased. In another study conducted in patients aged 65 years and older , patients' willingness to receive cardiopulmonary resuscitation if they suffered a cardiac arrest decreased from 41% to 22% after learning the probability of survival (10–17%). Only 6% of patients aged 86 years or older opted for cardiopulmonary resuscitation under these conditions. Substantial differences in the willingness to receive life-sustaining treatment exist that may depend on ethnicity, religion, the role of family and other variables .
Unfortunately, physicians are often unaware of the treatment preferences of their patients. In a study conducted in 4556 patients , physicians did not know the preference of their patient in 25% of cases. Furthermore, their assessments of patients preferences were correct for 45% and incorrect for the remaining 30% of patients. Physicians were more likely to believe incorrectly that patients did not want life-extending care when patients were older (79% of the time for patients older than 80 years, as compared with 36% for patients younger than 50 years).
Prognostic models in intensive care
Patients and their representatives base their decisions regarding what treatments they wish to undergo to a large extent on the likelihood of a favourable outcome. This underscores the importance of reliable information on what outcome can be expected. In order to help physicians to estimate the likelihood of survival of their patients, several severity-of-illness based mortality prediction models were developed for use in multidiagnostic patient groups. They were developed using logistic regression and incorporate information about physiological derangement, admitting diagnosis, age and sometimes comorbid disease. In the general ICU population, these prognostic models, such as SAPS II , MPM II  and APACHE II and III [30, 31], predict the probability of survival of critically ill patients reasonably well.
The information derived from these models can be used to evaluate ICU performance and to improve medical decision making, and perhaps it can also provide patients and their relatives with better information about the ICU stay and its possible outcomes. Unfortunately, when using prognostic models for individual decision making, the risk cannot be ruled out that these models will become self-fulfilling prophecies. If treatment is withdrawn in patients with a high risk for dying, then all high-risk patients indeed will die.
A potential limitation of these models is the fact that they are exclusively based on data obtained during the first 24 hours after ICU admission and that they do not take into account complications that may develop during treatment. It has been shown that the accuracy of prognostic models based on data from the first 24 hours after ICU admission is maintained at an acceptable level only in patients who stay in the ICU for a short period of time . After this period has elapsed discriminative power decreases, probably resulting from excess risk for death associated with acquired infections or other iatrogenic complications during the ICU stay. Different models have been developed that use scores calculated on a daily basis in a general ICU patient population, showing good discriminating value [55, 56]. Other potential limitations of prognostic models include the influence of organizational factors on patient outcomes [57, 58], between country differences in performance of models  and mistakes in data collection .
The commonly used prognostic models have not been calibrated for use in the elderly. In a prospective cohort study conducted in patients on mechanical ventilation for pneumonia , the predictive values for mortality of the APACHE II, SAPS II and MPM II models were found to be significantly lower for patients aged 75 years or older as compared with younger patients.
Using the technique of recursive partitioning, El Solh and coworkers  developed a classification tree to predict hospital mortality in elderly ICU patients with pneumonia. This model exhibited good accuracy, with an area under the ROC of 0.93 versus 0.71 for the APACHE II model. However, that study is limited by the limited number of studied patients (n = 104) and the lack of a different population in which to validate the model.
Another model specifically developed to predict mortality and functional outcome in very elderly ICU patients used demographic and physiologic data as well as attributes of ICU treatment and ICU illnesses, such as the use of mechanical ventilation and the development of sepsis . Although the model was developed in a relatively small number of patients (n = 243), it exhibited good discriminating performance for short-term outcome (predicting death and discharge to home or to a nursing facility).
The ICU population is ageing, and it may be concluded that very elderly patients admitted to ICUs represent a distinct and important subgroup of patients. In general, very elderly patients have poorer outcomes than do younger patients, but prognosis is more dependent on severity of illness and functional status before admission than on high age itself. A number of prognostic models have been developed that predict survival in critically ill patients, but these models are not calibrated for use in very old patients. Furthermore, they do not take into account some known risk factors, such as comorbid conditions, and functional and cognitive status before ICU admission. Finally, they do not give a prognosis regarding (long-term) functional status after hospital discharge. We suggest that a model should be developed for predicting outcome of ICU treatment in very old patients, taking into account all discussed prognostic factors. Such a model could more precisely predict the (long-term) discharge outcome of these patients and support informed decision making, in accordance with the preferences of the patients and their relatives.
ICU mortality is higher in elderly patients.
High age alone is not responsible for the poorer outcome, but premorbid functional status and severity of illness also contribute.
Present prognostic models are not suited for elderly individuals
All (premorbid) prognostic factors should be taken into account in a prognostic model to support informed decision making.
Acute Physiology and Chronic Health Evaluation
intensive care unit
Mortality Probability Model
receiver operating characteristic
Simplified Acute Physiology Score.
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The author(s) declare that they have no competing interests
EdJ acquired and interpreted data, and participated in preparing the manuscript. SEdR interpreted data and participated in preparing the manuscript. AA-H analyzed and interpreted data. ML interpreted data. All authors read and approved the final manuscript.
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de Rooij, S.E., Abu-Hanna, A., Levi, M. et al. Factors that predict outcome of intensive care treatment in very elderly patients: a review. Crit Care 9, R307 (2005). https://doi.org/10.1186/cc3536
- Intensive Care Unit
- Intensive Care Unit Admission
- Intensive Care Unit Patient
- Prognostic Model
- Simplified Acute Physiology Score