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Complement activation in relation to age in patients with severe sepsis
Critical Care volume 6, Article number: P108 (2002)
Severe sepsis is still associated with a mortality of 29% . Sepsis mortality is highest in elderly patients . Another factor, which is related to outcome in sepsis is the extent of complement activation . The aim of this study was to evaluate complement activation in relation to age in severe septic patients.
This observational study was performed in 20 patients with severe sepsis (SOFA-Score = 9 ± 3) and grouped according to age: = 60 years ('adult', n = 10) and > 65 years ('elderly', n = 10). Complement proteins Bb, C3a, C4d were performed by ELISA technique. C1-Inhibitor (C1-Inh) activity was measured by Berichrom® C1-Inactivator, and C1-Inh protein concentration by NOR-Partigen®. To compare values at onset of severe sepsis with those on the 8 th day Friedman test with post-hoc Wilcoxon test was performed. Data are presented as median and range. *P < 0.05 was considered significant.
See Table 1.
Activation of the classical pathway of complement was found to be more marked in adult patients than in elderly. Thus, our results suggest age-related differences in the complement activation in severe sepsis.
Angus DC, et al.: Crit Care Med 2001, 29: 1303-1310. 10.1097/00003246-200107000-00002
Hack CE, et al.: Intensive Care Med 1993,19(suppl 1):19-28. 10.1007/BF01738946
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Marx, G., Vangerow, B., Rueckoldt, H. et al. Complement activation in relation to age in patients with severe sepsis. Crit Care 6, P108 (2002). https://doi.org/10.1186/cc1561
- Public Health
- Elderly Patient
- Protein Concentration
- Observational Study
- Adult Patient