- Poster presentation
- Open access
- Published:
Influence of adverse drug events on the mortality and the length of hospital stay in ICUs in Japan: the JADE Study
Critical Care volume 17, Article number: P510 (2013)
Introduction
Adverse drug events (ADEs) are associated with a substantial increase in morbidity and mortality in any setting. Because patients in ICUs were critically ill with complex diseases and varied organ dysfunction, the incidence of ADEs on such patients is much more crucial than the counterparts. We thus assessed the nature of ADEs and their influence in ICUs.
Methods
We conducted a prospective cohort study at ICUs at three large tertiary-care hospitals in Japan. Trained research nurses reviewed all medical charts, incident reports and reconciliations from the pharmacy to identify suspected ADEs as well as the background of patients. ADEs are any injuries that result from the use of a drug. After suspected ADEs are collected by research nurses, physician reviewers independently evaluated them and classified them as ADEs or rule violations. We used the validated methodology [1].
Results
We included 459 patients with 3,231 patient-days. The median age was 70 years and the median length of stay was 3 days. In total, 70 patients (15%) had at least one ADE during their stay in the ICU. The median ICU stay in patients who had ADEs was 14 days while 2 days in patients who had no ADEs (P 0.0001). The median length of the ADE onset days since admission was 3 days. Regarding the mortality, 73 patients (16%) were dead during their ICU stay: 12 deaths (17%) in patients who had ADEs and three of 12 deaths were caused by an ADE, and 61 deaths (16%) in counterparts (P = 0.8). There were no significant differences of patients' characteristics between patients with ADEs and without ADEs (Table 1).
Conclusion
ADEs were associated with longer stay and caused a part of death in ICU (4%) although they did not increase the mortality. Because the characteristics of patients were not associated with ADEs, early detection and intervention for ADEs could be important to improve the morbidity and reduce the death caused by ADEs in ICUs.
References
Morimoto T, et al.: Qual Saf Health Care. 2004, 13: 306-314. 10.1136/qshc.2004.010611
Author information
Authors and Affiliations
Rights and permissions
This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
About this article
Cite this article
Ohta, Y., Sakuma, M., Bates, D. et al. Influence of adverse drug events on the mortality and the length of hospital stay in ICUs in Japan: the JADE Study. Crit Care 17 (Suppl 2), P510 (2013). https://doi.org/10.1186/cc12448
Published:
DOI: https://doi.org/10.1186/cc12448