Influence of adverse drug events on the mortality and the length of hospital stay in ICUs in Japan: the JADE Study

Table 1 Patient characteristics

	Patients	Patients
	with	without
	ADEs	ADEs
Characteristic	( n = 70)	( n = 389)	P value
Age ≥65 years, n (%)	49 (70)	227 (58)	0.08
Male, n (%)	40 (57)	250 (64)	0.2
Department
Medicine	35 (50)	228 (59)	0
Surgery	35 (50)	161 (41)	0.2
Unconsciousness, GCS ≤8	13 (19)	91 (23)	0.4
Heart failure, NYHA = 4	37 (53)	216 (56)	0.7
Respiratory failure	44 (62)	262 (67)	0.5
Kidney failure	6 (9)	58 (15)	0.2
Clinical laboratory measurements, median (25%, 75%)
Blood urea nitrogen (mg/dl)	21 (15, 39)	19 (14, 31)	0.2
Creatinine (mg/dl)	0.8 (0.5, 1.5)	0.9 (0.7, 1.7)	0.8
Aspartate aminotransferase (IU/l)	27 (20, 47)	30 (22, 48)	0.5
Alanine transaminase (IU/l)	20 (13, 42)	20 (12, 33)	1.0
Total protein (g/dl)	6.7 (5.9, 7.4)	6.6 (5.9, 7.3)	0.8
Number of medications on admission ≥4,	38 (54)	223 (57)	0.6
n (%)
Number of medications on admission,	5 (3, 7)	5 (4, 8)	0.7
median (25%, 75%)

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