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Mechanical ventilation affects local and systemic TNF-alpha and IL-10 in normal swine lung


Ventilatory strategies can produce or worsen lung injury and induce a cytokine response in the lung and increase serum cytokine levels [1]. We examined whether ventilatory strategies affect local and systemic inflammatory mediators in a normal swine lung model.


Five ventilatory strategies were employed in 25 swine animals: group A: low-volume zero PEEP (LVZP): VT, 10 ml/kg, group B: medium-volume zero PEEP (MVZP): VT, 20 ml/kg, group C: high-volume zero PEEP (HVZP): VT, 40 ml/kg, group D: low-volume PEEP (LVP): VT, 10 ml/kg, PEEP, 10 cmH2O, group E: high-volume PEEP (HVP): VT 40 ml/kg, PEEP 10 cmH2O. TNF-a and IL-10 were measured in BAL fluid and serum by ELISA.


Mean cytokine concentration in lung fluid and serum during the experiment are shown in the Table. One animal in LVZP (1 h) and 3 in HVP (2, 3, 2 h) group died before the end of the experiment.



Different injurious ventilatory strategies may induce TNF-a and IL-10 response from alveolar space that may lead to an increase in serum cytokine levels in normal swine lung.


  1. 1.

    Chiumello D, Pristine G, Slutsky A: Mechanical ventilation affects local and systemic cytokines in an animal model of ARDS. Am J Respir Crit Care Med 1999, 160: 109.

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Myrianthefs, P., Boutzouka, E., Papalois, A. et al. Mechanical ventilation affects local and systemic TNF-alpha and IL-10 in normal swine lung. Crit Care 5, P060 (2001).

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  • Mechanical Ventilation
  • Emergency Medicine
  • Lung Injury
  • Inflammatory Mediator
  • Cytokine Response