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Citation: Critical Care 2024 28:147
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Effects of extracorporeal CO2 removal on gas exchange and ventilator settings: a systematic review and meta-analysis
A systematic review and meta-analysis to evaluate the impact of extracorporeal carbon dioxide removal (ECCO2R) on gas exchange and respiratory settings in critically ill adults with respiratory failure.
Citation: Critical Care 2024 28:146 -
The effectiveness of a brief intervention for intensive care unit patients with hazardous alcohol use: a randomized controlled trial
Screening for hazardous alcohol use and performing brief interventions (BIs) are recommended to reduce alcohol-related negative health consequences. We aimed to compare the effectiveness (defined as an at leas...
Citation: Critical Care 2024 28:145 -
Assessing the safety of physical rehabilitation in critically ill patients: a Delphi study
Physical rehabilitation of critically ill patients is implemented to improve physical outcomes from an intensive care stay. However, before rehabilitation is implemented, a risk assessment is essential, based ...
Citation: Critical Care 2024 28:144 -
Intermittent intravenous paracetamol versus continuous morphine in infants undergoing cardiothoracic surgery: a multi-center randomized controlled trial
To determine whether intermittent intravenous (IV) paracetamol as primary analgesic would significantly reduce morphine consumption in children aged 0–3 years after cardiac surgery with cardiopulmonary bypass.
Citation: Critical Care 2024 28:143 -
Clinical validation of a capnodynamic method for measuring end-expiratory lung volume in critically ill patients
End-expiratory lung volume (EELV) is reduced in mechanically ventilated patients, especially in pathologic conditions. The resulting heterogeneous distribution of ventilation increases the risk for ventilation...
Citation: Critical Care 2024 28:142 -
Stress & strain in mechanically nonuniform alveoli using clinical input variables: a simple conceptual model
Clinicians currently monitor pressure and volume at the airway opening, assuming that these observations relate closely to stresses and strains at the micro level. Indeed, this assumption forms the basis of cu...
Citation: Critical Care 2024 28:141 -
Fluid responsiveness and venous congestion: unraveling the nuances of fluid status
Citation: Critical Care 2024 28:140 -
Beta-blockade in V-V ECMO
Citation: Critical Care 2024 28:139 -
Quantitative analysis of apparent diffusion coefficients to predict neurological prognosis in cardiac arrest survivors: an observational derivation and internal–external validation study
This study aimed to validate apparent diffusion coefficient (ADC) values and thresholds to predict poor neurological outcomes in out-of-hospital cardiac arrest (OHCA) survivors by quantitatively analysing the ...
Citation: Critical Care 2024 28:138 -
Adapting NeuroVanguard to real-world challenges
Citation: Critical Care 2024 28:137 -
Respiratory drive heterogeneity associated with systemic inflammation and vascular permeability in acute respiratory distress syndrome
In acute respiratory distress syndrome (ARDS), respiratory drive often differs among patients with similar clinical characteristics. Readily observable factors like acid–base state, oxygenation, mechanics, and...
Citation: Critical Care 2024 28:136 -
Transforming research to improve therapies for trauma in the twenty-first century: an alternative perspective
Citation: Critical Care 2024 28:135 -
Case study observational research: inflammatory cytokines in the bronchial epithelial lining fluid of COVID-19 patients with acute hypoxemic respiratory failure
In this study, the concentrations of inflammatory cytokines were measured in the bronchial epithelial lining fluid (ELF) and plasma in patients with acute hypoxemic respiratory failure (AHRF) secondary to seve...
Citation: Critical Care 2024 28:134 -
Lower airway microbiota compositions differ between influenza, COVID-19 and bacteria-related acute respiratory distress syndromes
Acute respiratory distress syndrome (ARDS) is responsible for 400,000 deaths annually worldwide. Few improvements have been made despite five decades of research, partially because ARDS is a highly heterogeneo...
Citation: Critical Care 2024 28:133 -
Rapidly improving ARDS differs clinically and biologically from persistent ARDS
Rapidly improving acute respiratory distress syndrome (RIARDS) is an increasingly appreciated subgroup of ARDS in which hypoxemia improves within 24 h after initiation of mechanical ventilation. Detailed clini...
Citation: Critical Care 2024 28:132 -
Ventilator-associated pneumonia related to extended-spectrum beta-lactamase producing Enterobacterales during severe acute respiratory syndrome coronavirus 2 infection: risk factors and prognosis
Patients infected with the severe acute respiratory syndrome coronavirus 2 (SARS-COV 2) and requiring mechanical ventilation suffer from a high incidence of ventilator associated pneumonia (VAP), mainly relate...
Citation: Critical Care 2024 28:131 -
ACE inhibitors and angiotensin receptor blockers differentially alter the response to angiotensin II treatment in vasodilatory shock
Angiotensin-converting enzyme inhibitor (ACEi) and angiotensin receptor blockers (ARB) medications are widely prescribed. We sought to assess how pre-admission use of these medications might impact the respons...
Citation: Critical Care 2024 28:130 -
Time-dependent effect of prone position in ARDS: considerations for future research
Citation: Critical Care 2024 28:129 -
Policy framework for the utilization of generative AI
Citation: Critical Care 2024 28:128 -
Significance of critical closing pressures (starling resistors) in arterial circulation
Citation: Critical Care 2024 28:127 -
Extracorporeal cardiopulmonary resuscitation versus conventional CPR in cardiac arrest: be aware of the temporal selection bias
Citation: Critical Care 2024 28:126 -
Effect of intra-arrest transport, extracorporeal cardiopulmonary resuscitation and immediate invasive assessment in refractory out-of-hospital cardiac arrest: a long-term follow-up of the Prague OHCA trial
Randomized data evaluating the impact of the extracorporeal cardiopulmonary resuscitation (ECPR) approach on long-term clinical outcomes in patients with refractory out-of-hospital cardiac arrest (OHCA) are la...
Citation: Critical Care 2024 28:125 -
Contribution of electrical impedance tomography to personalize positive end-expiratory pressure under ECCO2R
Extracorporeal Carbon Dioxide Removal (ECCO2R) is used in acute respiratory distress syndrome (ARDS) patients to facilitate lung-protective ventilatory strategies. Electrical Impedance Tomography (EIT) allows ind...
Citation: Critical Care 2024 28:124 -
Impact of attaining aggressive vs. conservative PK/PD target on the clinical efficacy of beta-lactams for the treatment of Gram-negative infections in the critically ill patients: a systematic review and meta-analysis
To perform a systematic review with meta-analysis with the dual intent of assessing the impact of attaining aggressive vs. conservative beta-lactams PK/PD target on the clinical efficacy for treating Gram-nega...
Citation: Critical Care 2024 28:123 -
Smoking on the risk of acute respiratory distress syndrome: a systematic review and meta-analysis
The relationship between smoking and the risk of acute respiratory distress syndrome (ARDS) has been recognized, but the conclusions have been inconsistent. This systematic review and meta-analysis investigate...
Citation: Critical Care 2024 28:122 -
Correction to: Interventions to promote cost-effectiveness in adult intensive care units: consensus statement and considerations for best practice from a multidisciplinary and multinational eDelphi study
Citation: Critical Care 2024 28:121 -
Neo-epitope detection identifies extracellular matrix turnover in systemic inflammation and sepsis: an exploratory study
Sepsis is associated with high morbidity and mortality, primarily due to systemic inflammation-induced tissue damage, resulting organ failure, and impaired recovery. Regulated extracellular matrix (ECM) turnov...
Citation: Critical Care 2024 28:120 -
Job description and perception of clinical research personnel working in a network of French intensive care units
There is a lack of information about the organisation and management of clinical research personnel in Europe and of their professional activity in intensive care. We therefore conducted a cross-sectional surv...
Citation: Critical Care 2024 28:119 -
Outcome prediction of cardiac arrest with automatically computed gray-white matter ratio on computed tomography images
This study aimed to develop an automated method to measure the gray-white matter ratio (GWR) from brain computed tomography (CT) scans of patients with out-of-hospital cardiac arrest (OHCA) and assess its sign...
Citation: Critical Care 2024 28:118 -
Correction: Non-ventilator-associated ICU-acquired pneumonia (NV-ICU-AP) in patients with acute exacerbation of COPD: From the French OUTCOMEREA cohort
Citation: Critical Care 2024 28:117 -
Plasma glial fibrillary acidic protein and tau: predictors of neurological outcome after cardiac arrest
The purpose was to evaluate glial fibrillary acidic protein (GFAP) and total-tau in plasma as predictors of poor neurological outcome after out-of-hospital (OHCA) and in-hospital cardiac arrest (IHCA), includi...
Citation: Critical Care 2024 28:116 -
Characteristics, predictors and outcomes of new-onset QT prolongation in sepsis: a multicenter retrospective study
Sepsis-induced myocardial injury is a serious complication of sepsis. QT prolongation is a proarrhythmic state which reflects myocardial injury in a group of heterogeneous disorders. However, the study on the ...
Citation: Critical Care 2024 28:115 -
Anti-inflammatory therapies are associated with delayed onset of anemia and reduction in transfusion requirements in critically ill patients: results from two studies
Anemia is a hallmark of critical illness, which is largely inflammatory driven. We hypothesized that the use of anti-inflammatory agents limits the development of anemia and reduces the need for red blood cell...
Citation: Critical Care 2024 28:114 -
Use of artificial intelligence in critical care: opportunities and obstacles
Perhaps nowhere else in the healthcare system than in the intensive care unit environment are the challenges to create useful models with direct time-critical clinical applications more relevant and the obstac...
Citation: Critical Care 2024 28:113 -
Effects of robotic-assisted early mobilization versus conventional mobilization in intensive care unit patients: prospective interventional cohort study with retrospective control group analysis
Approximately one in three survivors of critical illness suffers from intensive-care-unit-acquired weakness, which increases mortality and impairs quality of life. By counteracting immobilization, a known risk...
Citation: Critical Care 2024 28:112 -
Volatile versus propofol sedation after cardiac valve surgery: a single-center prospective randomized controlled trial
Optimal intensive care of patients undergoing valve surgery is a complex balancing act between sedation for monitoring and timely postoperative awakening. It remains unclear, if these requirements can be fulfi...
Citation: Critical Care 2024 28:111 -
Correction: Selected articles from the annual update in Intensive Care and Emergency Medicine 2021
Citation: Critical Care 2024 28:110 -
GFAP point-of-care measurement for prehospital diagnosis of intracranial hemorrhage in acute coma
Prehospital triage and treatment of patients with acute coma is challenging for rescue services, as the underlying pathological conditions are highly heterogenous. Recently, glial fibrillary acidic protein (GF...
Citation: Critical Care 2024 28:109 -
Vitamin D metabolism in critically ill patients with acute kidney injury: a prospective observational study
Vitamin D deficiency in critically ill patients is associated with poor outcomes, and vitamin D supplementation is recommended for patients with chronic kidney disease. Whether acute kidney injury (AKI) is ass...
Citation: Critical Care 2024 28:108 -
Dyssynchronous diaphragm contractions impair diaphragm function in mechanically ventilated patients
Pre-clinical studies suggest that dyssynchronous diaphragm contractions during mechanical ventilation may cause acute diaphragm dysfunction. We aimed to describe the variability in diaphragm contractile loadin...
Citation: Critical Care 2024 28:107 -
Facial appearance associates with longitudinal multi-organ failure: an ICU cohort study
Facial appearance, whether consciously or subconsciously assessed, may affect clinical assessment and treatment strategies in the Intensive Care Unit (ICU). Nevertheless, the association between objective clin...
Citation: Critical Care 2024 28:106 -
The management of heart failure cardiogenic shock: an international RAND appropriateness panel
Observational data suggest that the subset of patients with heart failure related CS (HF-CS) now predominate critical care admissions for CS. There are no dedicated HF-CS randomised control trials completed to...
Citation: Critical Care 2024 28:105 -
“NeuroVanguard”: a contemporary strategy in neuromonitoring for severe adult brain injury patients
Severe acute brain injuries, stemming from trauma, ischemia or hemorrhage, remain a significant global healthcare concern due to their association with high morbidity and mortality rates. Accurate assessment o...
Citation: Critical Care 2024 28:104 -
Response to commentary “The importance of assessing left ventricular longitudinal function in presence of increased afterload”
Citation: Critical Care 2024 28:103 -
Quality of life-related and non-quality of life-related issues in ICU survivors and non-ICU-treated controls: a multi-group exploratory factor analysis
Quality of life (QoL) is a key outcome measure in healthcare. However, the heterogeneity in its definitions presents challenges in the objective evaluation of improvement. Universal questionnaires, tailored fo...
Citation: Critical Care 2024 28:102 -
Hydrocortisone rapidly and significantly reduces the IL-6 level in blood and lungs of patients with COVID-19-related ARDS
Citation: Critical Care 2024 28:101 -
Unraveling the role of HIF-1α in sepsis: from pathophysiology to potential therapeutics—a narrative review
Sepsis is characterized by organ dysfunction resulting from a dysregulated inflammatory response triggered by infection, involving multifactorial and intricate molecular mechanisms. Hypoxia-inducible factor-1α...
Citation: Critical Care 2024 28:100 -
Association between intensive care unit nursing grade and mortality in patients with cardiogenic shock and its cost-effectiveness
Despite the high workload of cardiac intensive care unit (ICU), there is a paucity of evidence on the association between nurse workforce and mortality in patients with cardiogenic shock (CS). This study aimed...
Citation: Critical Care 2024 28:99 -
Physical activity is associated with a lower risk of contracting and dying in infection and sepsis: a Swedish population-based cohort study
Sepsis is a condition where the immune response to infection becomes dysregulated and life-threatening. It is not known whether lifestyle factors influence the risk of sepsis. The aim of the present study is t...
Citation: Critical Care 2024 28:98
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- ISSN: 1364-8535 (electronic)