Published on: 24 September 2016
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Published on: 24 September 2016
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Published on: 19 April 2013
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Published on: 18 March 2014
Recently, a new generation of direct-acting oral anticoagulants (DOACs) with a greater specificity towards activated coagulation factors was introduced based on encouraging results for efficacy and safety in clinical studies. This study discusses the initial limitation of these new drugs; the absence of an adequate strategy to reverse the effect if a bleeding event occurs or an urgent invasive procedure has to be carried out.
Critical illness is characterized by a loss of commensal flora and an overgrowth of potentially pathogenic bacteria, leading to a high susceptibility to nosocomial infections. Probiotics are living non-pathogenic microorganisms, which may protect the gut barrier, attenuate pathogen overgrowth, decrease bacterial translocation and prevent infection. The purpose of this updated systematic review is to evaluate the overall efficacy of probiotics and synbiotic mixtures on clinical outcomes in critical illness.
When almost 60% of the world’s population is predicted to be overweight by 2030, dosing regimens that are developed and tested in non-obese patients will be inappropriate for the future use of drugs. The authors of this study discuss whether we should no longer accept the “one-size-fits-all” mentality of antibiotic dosing and accept that individuals may in fact need to be dosed individually.
Critical Care is affiliated with The International Symposium on Intensive Care and Emergency Medicine (ISICEM).
ISICEM is held every March and is organised by the Departments of Intensive Care and Emergency Medicine of Erasme University Hospital, Université Libre de Bruxelles, in association with the Belgian Society of Intensive Care and Emergency Medicine (SIZ).
Physiology of the circulation
Edited by Sheldon Magder
Echography in critically ill patients
Edited by Daniel De Backer
Pyrexia in the ICU
Edited by Lui Forni
Acute Kidney Injury
Edited by Michael Joannidis
Prof Jean-Louis Vincent, Editor-in-Chief
Prof Vincent is Professor of intensive care at the University of Brussels, and intensivist in the Department of Intensive Care at the Erasme University Hospital in Brussels. He is President of the World Federation of Societies of Intensive and Critical Care Medicine (WFSICCM) and a Past-President of the Belgian Society of Intensive Care Medicine (SIZ), the European Society of Intensive Care Medicine (ESICM), the European Shock Society (ESS), and the International Sepsis Forum (ISF). He is member of the Royal Medical Academy of Belgium.
Selected articles from the Annual Update in Intensive Care and Emergency Medicine 2016
Published: 16 March 2016
36th International Symposium on Intensive Care and Emergency Medicine (ISICEM)
Brussels, Belgium 15-18 March 2016
Agra, India 5-6 February 2016
We recognise that scientifically sound, high quality manuscripts are often turned away from broad-scope "high-impact" journals based on the issue of "general interest." Critical Care will consider rapid publication of such manuscripts if they are submitted together with the original peer reviewer reports, letter of rejection, and a rebuttal. Please also mention this in your cover letter.
Additional peer review may be necessary and the final decision will be made by the Editor.