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  1. Research

    Treatment of severe hospital-acquired and ventilator-associated pneumonia: a systematic review of inclusion and judgment criteria used in randomized controlled trials

    Hospital-acquired and ventilator-associated pneumonia (HAP/VAP) are often selected for randomized clinical trials (RCTs) aiming at new drug approval. Guidelines for the design of such RCTs have been repeatedly...

    Emmanuel Weiss, Wafa Essaied, Christophe Adrie, Jean-Ralph Zahar and Jean-François Timsit

    Critical Care 2017 21:162

    Published on: 27 June 2017

  2. Research

    Untangling glycaemia and mortality in critical care

    Hyperglycaemia is associated with adverse outcomes in the intensive care unit, and initial studies suggested outcome benefits of glycaemic control (GC). However, subsequent studies often failed to replicate th...

    Vincent Uyttendaele, Jennifer L. Dickson, Geoffrey M. Shaw, Thomas Desaive and J. Geoffrey Chase

    Critical Care 2017 21:152

    Published on: 24 June 2017

  3. Research

    Marked regional endothelial dysfunction in mottled skin area in patients with severe infections

    Mottling around the knee, reflecting a reduced skin blood flow, is predictive of mortality in patients with septic shock. However, the causative pathophysiology of mottling remains unknown. We hypothesized tha...

    Simon Bourcier, Jérémie Joffre, Vincent Dubée, Gabriel Preda, Jean-Luc Baudel, Naïke Bigé, Guillaume Leblanc, Bernard I. Levy, Bertrand Guidet, Eric Maury and Hafid Ait-Oufella

    Critical Care 2017 21:155

    Published on: 23 June 2017

  4. Research

    Influence of low-flow time on survival after extracorporeal cardiopulmonary resuscitation (eCPR)

    Venoarterial extracorporeal membrane oxygenation (VA-ECMO) support under extracorporeal cardiopulmonary resuscitation (eCPR) is the last option and may be offered to selected patients. Several factors predict ...

    Tobias Wengenmayer, Stephan Rombach, Florian Ramshorn, Paul Biever, Christoph Bode, Daniel Duerschmied and Dawid L. Staudacher

    Critical Care 2017 21:157

    Published on: 22 June 2017

  5. Research

    Protein S100 as outcome predictor after out-of-hospital cardiac arrest and targeted temperature management at 33 °C and 36 °C

    We aimed to investigate the diagnostic performance of S100 as an outcome predictor after out-of-hospital cardiac arrest (OHCA) and the potential influence of two target temperatures (33 °C and 36 °C) on serum ...

    Pascal Stammet, Josef Dankiewicz, Niklas Nielsen, François Fays, Olivier Collignon, Christian Hassager, Michael Wanscher, Johan Undèn, Jorn Wetterslev, Tommaso Pellis, Anders Aneman, Jan Hovdenes, Matt P. Wise, Georges Gilson, David Erlinge, Janneke Horn…

    Critical Care 2017 21:153

    Published on: 20 June 2017

  6. Research

    Impact of Gram stain results on initial treatment selection in patients with ventilator-associated pneumonia: a retrospective analysis of two treatment algorithms

    Ventilator-associated pneumonia (VAP) is a common and serious problem in intensive care units (ICUs). Several studies have suggested that the Gram stain of endotracheal aspirates is a useful method for accurat...

    Jumpei Yoshimura, Takahiro Kinoshita, Kazuma Yamakawa, Asako Matsushima, Naoki Nakamoto, Toshimitsu Hamasaki and Satoshi Fujimi

    Critical Care 2017 21:156

    Published on: 19 June 2017

  7. Review

    Transpulmonary thermodilution: advantages and limits

    For complex patients in the intensive care unit or in the operating room, many questions regarding their haemodynamic management cannot be answered with simple clinical examination. In particular, arterial pre...

    Xavier Monnet and Jean-Louis Teboul

    Critical Care 2017 21:147

    Published on: 19 June 2017

  8. Research

    Hemoglobin concentrations and RBC transfusion thresholds in patients with acute brain injury: an international survey

    The optimal hemoglobin (Hb) threshold at which to initiate red blood cell (RBC) transfusion in patients with acute brain injury is unknown. The aim of this survey was to investigate RBC transfusion practices u...

    Rafael Badenes, Mauro Oddo, José I. Suarez, Massimo Antonelli, Jeffrey Lipman, Giuseppe Citerio and Fabio Silvio Taccone

    Critical Care 2017 21:159

    Published on: 17 June 2017

  9. Research

    Transcriptome modulation by hydrocortisone in severe burn shock: ancillary analysis of a prospective randomized trial

    Despite shortening vasopressor use in shock, hydrocortisone administration remains controversial, with potential harm to the immune system. Few studies have assessed the impact of hydrocortisone on the transcr...

    Jonathan Plassais, Fabienne Venet, Marie-Angélique Cazalis, Diane Le Quang, Alexandre Pachot, Guillaume Monneret, Sylvie Tissot and Julien Textoris

    Critical Care 2017 21:158

    Published on: 16 June 2017

  10. Research

    Effect of perioperative goal-directed hemodynamic therapy on postoperative recovery following major abdominal surgery—a systematic review and meta-analysis of randomized controlled trials

    Goal-directed hemodynamic therapy (GDHT) has been used in the clinical setting for years. However, the evidence for the beneficial effect of GDHT on postoperative recovery remains inconsistent. The aim of this...

    Yanxia Sun, Fang Chai, Chuxiong Pan, Jamie Lee Romeiser and Tong J. Gan

    Critical Care 2017 21:141

    Published on: 12 June 2017

  11. Research

    A randomized controlled pilot study to evaluate the effect of an enteral formulation designed to improve gastrointestinal tolerance in the critically ill patient—the SPIRIT trial

    Diarrhea is frequent in patients in intensive care units (ICU) and is associated with discomfort and complications and may increase the length of stay and nursing workload.

    Stephan M. Jakob, Lukas Bütikofer, David Berger, Michael Coslovsky and Jukka Takala

    Critical Care 2017 21:140

    Published on: 10 June 2017

  12. Research

    Transthoracic echocardiography: an accurate and precise method for estimating cardiac output in the critically ill patient

    Cardiac output (CO) monitoring is a valuable tool for the diagnosis and management of critically ill patients. In the critical care setting, few studies have evaluated the level of agreement between CO estimat...

    Pablo Mercado, Julien Maizel, Christophe Beyls, Dimitri Titeca-Beauport, Magalie Joris, Loay Kontar, Antoine Riviere, Olivier Bonef, Thierry Soupison, Christophe Tribouilloy, Bertrand de Cagny and Michel Slama

    Critical Care 2017 21:136

    Published on: 9 June 2017

  13. Research

    A randomized trial of supplemental parenteral nutrition in underweight and overweight critically ill patients: the TOP-UP pilot trial

    Nutrition guidelines recommendations differ on the use of parenteral nutrition (PN), and existing clinical trial data are inconclusive. Our recent observational data show that amounts of energy/protein receive...

    Paul E. Wischmeyer, Michel Hasselmann, Christine Kummerlen, Rosemary Kozar, Demetrios James Kutsogiannis, Constantine J. Karvellas, Beth Besecker, David K. Evans, Jean-Charles Preiser, Leah Gramlich, Khursheed Jeejeebhoy, Rupinder Dhaliwal, Xuran Jiang, Andrew G. Day and Daren K. Heyland

    Critical Care 2017 21:142

    Published on: 9 June 2017

  14. Research

    The negative effect of initial high-dose methylprednisolone and tapering regimen for acute respiratory distress syndrome: a retrospective propensity matched cohort study

    The efficacy of corticosteroid use in acute respiratory distress syndrome (ARDS) remains controversial. Generally, short-term high-dose corticosteroid therapy is considered to be ineffective in ARDS. On the ot...

    Makoto Takaki, Kazuya Ichikado, Kodai Kawamura, Yasuhiro Gushima and Moritaka Suga

    Critical Care 2017 21:135

    Published on: 8 June 2017

  15. Research

    Potential survival benefit of polymyxin B hemoperfusion in patients with septic shock: a propensity-matched cohort study

    The purpose of this study was to investigate whether polymyxin B hemoperfusion (PMX-HP) improves the survival of patients with septic shock.

    Yoshihiko Nakamura, Taisuke Kitamura, Fumiaki Kiyomi, Mineji Hayakawa, Kota Hoshino, Yasumasa Kawano, Reiko Yamasaki, Takeshi Nishida, Mariko Mizunuma and Hiroyasu Ishikura

    Critical Care 2017 21:134

    Published on: 7 June 2017

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