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  1. Research

    Prolonged acute care and post-acute care admission and recovery of physical function in survivors of acute respiratory failure: a secondary analysis of a randomized controlled trial

    The proportion of survivors of acute respiratory failure is growing; yet, many do not regain full function and require prolonged admission in an acute or post-acute care facility. Little is known about their t...

    Anna Neumeier, Amy Nordon-Craft, Dan Malone, Margaret Schenkman, Brendan Clark and Marc Moss

    Critical Care 2017 21:190

    Published on: 21 July 2017

  2. Research

    Markers of nitric oxide are associated with sepsis severity: an observational study

    Nitric oxide (NO) regulates processes involved in sepsis progression, including vascular function and pathogen defense. Direct NO measurement in patients is unfeasible because of its short half-life. Surrogate...

    Martin Sebastian Winkler, Stefan Kluge, Maximilian Holzmann, Eileen Moritz, Linda Robbe, Antonia Bauer, Corinne Zahrte, Marion Priefler, Edzard Schwedhelm, Rainer H. Böger, Alwin E. Goetz, Axel Nierhaus and Christian Zoellner

    Critical Care 2017 21:189

    Published on: 15 July 2017

  3. Research

    Monocyte programmed death ligand-1 expression is an early marker for predicting infectious complications in acute pancreatitis

    Acute pancreatitis (AP) is a life-threatening disease that requires early identification of patients at risk of developing infectious complications. Immunosuppression is an initial event that is key to AP path...

    Tingting Pan, Tianyun Zhou, Lei Li, Zhaojun Liu, Ying Chen, Enqiang Mao, Meiling Li, Hongping Qu and Jialin Liu

    Critical Care 2017 21:186

    Published on: 14 July 2017

  4. Research

    Severity of acute gastrointestinal injury grade is a predictor of all-cause mortality in critically ill patients: a multicenter, prospective, observational study

    In 2012, the European Society of Intensive Care Medicine proposed a definition for acute gastrointestinal injury (AGI) based on current medical evidence and expert opinion. The aim of the present study was to ...

    Bangchuan Hu, Renhua Sun, Aiping Wu, Yin Ni, Jingquan Liu, Feng Guo, Lijun Ying, Guoping Ge, Aijun Ding, Yunchao Shi, Changwen Liu, Lei Xu, Ronglin Jiang, Jun Lu, Ronghai Lin, Yannan Zhu…

    Critical Care 2017 21:188

    Published on: 14 July 2017

  5. Research

    Low-dose immunoglobulin G is not associated with mortality in patients with sepsis and septic shock

    The administration of low-dose intravenous immunoglobulin G (IVIgG) (5 g/day for 3 days; approximate total 0.3 g/kg) is widely used as an adjunctive treatment for patients with sepsis in Japan, but its efficac...

    Yusuke Iizuka, Masamitsu Sanui, Yusuke Sasabuchi, Alan Kawarai Lefor, Mineji Hayakawa, Shinjiro Saito, Shigehiko Uchino, Kazuma Yamakawa, Daisuke Kudo, Kohei Takimoto, Toshihiko Mayumi, Takeo Azuhata, Fumihito Ito, Shodai Yoshihiro, Katsura Hayakawa, Tsuyoshi Nakashima…

    Critical Care 2017 21:181

    Published on: 13 July 2017

  6. Research

    Association of baseline steroid use with long-term rates of infection and sepsis in the REGARDS cohort

    Prior studies associate steroid use with infection risk but were limited to select populations and short follow-up periods. The association of steroid use with long-term risk of community-acquired infections i...

    Ninad S. Chaudhary, John P. Donnelly, Justin X. Moore, John W. Baddley, Monika M. Safford and Henry E. Wang

    Critical Care 2017 21:185

    Published on: 13 July 2017

  7. Research

    Outcomes of subsyndromal delirium in ICU: a systematic review and meta-analysis

    Subsyndromal delirium (SSD) is a frequent condition and has been commonly described as an intermediate stage between delirium and normal cognition. However, the true frequency of SSD and its impact on clinical...

    Rodrigo B. Serafim, Marcio Soares, Fernando A. Bozza, José R. Lapa e Silva, Felipe Dal-Pizzol, Maria Carolina Paulino, Pedro Povoa and Jorge I. F. Salluh

    Critical Care 2017 21:179

    Published on: 12 July 2017

  8. Research

    Electrical impedance tomography for predicting failure of spontaneous breathing trials in patients with prolonged weaning

    Spontaneous breathing trials (SBTs) on a T-piece can be difficult in patients with prolonged weaning because of remaining de-recruitment phenomena and/or insufficient ventilation. There is no clinically establ...

    Johannes Bickenbach, Michael Czaplik, Mareike Polier, Gernot Marx, Nikolaus Marx and Michael Dreher

    Critical Care 2017 21:177

    Published on: 12 July 2017

  9. Research

    High-flow nasal cannula oxygen therapy is superior to conventional oxygen therapy but not to noninvasive mechanical ventilation on intubation rate: a systematic review and meta-analysis

    High-flow nasal cannula oxygen (HFNC) is a relatively new therapy used in adults with respiratory failure. Whether it is superior to conventional oxygen therapy (COT) or to noninvasive mechanical ventilation (...

    Huiying Zhao, Huixia Wang, Feng Sun, Shan Lyu and Youzhong An

    Critical Care 2017 21:184

    Published on: 12 July 2017

  10. Review

    The future of mechanical ventilation: lessons from the present and the past

    The adverse effects of mechanical ventilation in acute respiratory distress syndrome (ARDS) arise from two main causes: unphysiological increases of transpulmonary pressure and unphysiological increases/decrea...

    Luciano Gattinoni, John J. Marini, Francesca Collino, Giorgia Maiolo, Francesca Rapetti, Tommaso Tonetti, Francesco Vasques and Michael Quintel

    Critical Care 2017 21:183

    Published on: 12 July 2017

  11. Research

    Combined use of serum (1,3)-β-d-glucan and procalcitonin for the early differential diagnosis between candidaemia and bacteraemia in intensive care units

    This study aimed to assess the combined performance of serum (1,3)-β-d-glucan (BDG) and procalcitonin (PCT) for the differential diagnosis between candidaemia and bacteraemia in three intensive care units (ICUs) ...

    Daniele Roberto Giacobbe, Malgorzata Mikulska, Mario Tumbarello, Elisa Furfaro, Marzia Spadaro, Angela Raffaella Losito, Alessio Mesini, Gennaro De Pascale, Anna Marchese, Marco Bruzzone, Paolo Pelosi, Michele Mussap, Alexandre Molin, Massimo Antonelli, Brunella Posteraro, Maurizio Sanguinetti…

    Critical Care 2017 21:176

    Published on: 10 July 2017

  12. Research

    Association of neuron-specific enolase values with outcomes in cardiac arrest survivors is dependent on the time of sample collection

    Despite marked advances in intensive cardiology care, current options for outcome prediction in cardiac arrest survivors remain significantly limited. The aim of our study was, therefore, to compare the day-sp...

    Dagmar Vondrakova, Andreas Kruger, Marek Janotka, Filip Malek, Vlasta Dudkova, Petr Neuzil and Petr Ostadal

    Critical Care 2017 21:172

    Published on: 8 July 2017

  13. Research

    New setting of neurally adjusted ventilatory assist for noninvasive ventilation by facial mask: a physiologic study

    Noninvasive ventilation (NIV) is generally delivered using pneumatically-triggered and cycled-off pressure support (PSP) through a mask. Neurally adjusted ventilatory assist (NAVA) is the only ventilatory mode th...

    Federico Longhini, Chun Pan, Jianfeng Xie, Gianmaria Cammarota, Andrea Bruni, Eugenio Garofalo, Yi Yang, Paolo Navalesi and Haibo Qiu

    Critical Care 2017 21:170

    Published on: 7 July 2017

  14. Research

    The common promoter polymorphism rs11666254 downregulates FPR2/ALX expression and increases risk of sepsis in patients with severe trauma

    Formyl peptide receptor 2-lipoxin receptor (FPR2/ALX) modulates the anti-inflammatory response and therefore may be a target for treating sepsis. The purpose of this study was to investigate the association be...

    Han Zhang, Yao Lu, Guixiang Sun, Fang Teng, Nian Luo, Jianxin Jiang and Aiqing Wen

    Critical Care 2017 21:171

    Published on: 6 July 2017

  15. Research

    Double carbapenem as a rescue strategy for the treatment of severe carbapenemase-producing Klebsiella pneumoniae infections: a two-center, matched case–control study

    Recent reports have suggested the efficacy of a double carbapenem (DC) combination, including ertapenem, for the treatment of carbapenem-resistant Klebsiella pneumoniae (CR-Kp) infections. We aimed to evaluate th...

    Gennaro De Pascale, Gennaro Martucci, Luca Montini, Giovanna Panarello, Salvatore Lucio Cutuli, Daniele Di Carlo, Valentina Di Gravio, Roberta Di Stefano, Guido Capitanio, Maria Sole Vallecoccia, Piera Polidori, Teresa Spanu, Antonio Arcadipane and Massimo Antonelli

    Critical Care 2017 21:173

    Published on: 5 July 2017

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