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  1. Considerable political, structural, environmental and epidemiological change will affect high socioeconomic index (SDI) countries over the next 25 years. These changes will impact healthcare provision and cons...

    Authors: Tobias Gauss, Mariska de Jongh, Marc Maegele, Elaine Cole and Pierre Bouzat
    Citation: Critical Care 2024 28:84
  2. Prone positioning (PP) homogenizes ventilation distribution and may limit ventilator-induced lung injury (VILI) in patients with moderate to severe acute respiratory distress syndrome (ARDS). The static and dy...

    Authors: Christoph Boesing, Joerg Krebs, Alice Marguerite Conrad, Matthias Otto, Grietje Beck, Manfred Thiel, Patricia R. M. Rocco, Thomas Luecke and Laura Schaefer
    Citation: Critical Care 2024 28:82
  3. Fluid resuscitation has long been a cornerstone of pre-hospital trauma care, yet its optimal approach remains undetermined. Although a liberal approach to fluid resuscitation has been linked with increased com...

    Authors: M. F. Bath, J. Schloer, J. Strobel, W. Rea, R. Lefering, M. Maegele, H. De’Ath and Z. B. Perkins
    Citation: Critical Care 2024 28:81
  4. Near-infrared spectroscopy regional cerebral oxygen saturation (rSO2) has gained interest as a raw parameter and as a basis for measuring cerebrovascular reactivity (CVR) due to its noninvasive nature and high sp...

    Authors: Alwyn Gomez, Logan Froese, Donald Griesdale, Eric P. Thelin, Rahul Raj, Levi van Iperenburg, Jeanette Tas, Marcel Aries, Kevin Y. Stein, Clare Gallagher, Francis Bernard, Andreas H. Kramer and Frederick A. Zeiler
    Citation: Critical Care 2024 28:78
  5. Posttraumatic stress disorder (PTSD) after a stay in the intensive care unit (ICU) can affect one in five ICU survivors. At the beginning of the coronavirus disease 2019 (COVID-19) pandemic, admission to the I...

    Authors: Pierre Kalfon, Wissam El-Hage, Marie-Agnès Geantot, Constance Favier, Laetitia Bodet-Contentin, Khaldoun Kuteifan, Pierre-Yves Olivier, Didier Thévenin, Julien Pottecher, Jullien Crozon-Clauzel, Bénédicte Mauchien, Arnaud Galbois, Roland de Varax, Sabine Valera, Philippe Estagnasie, Audrey Berric…
    Citation: Critical Care 2024 28:77
  6. A real-time model for predicting short-term mortality in critically ill patients is needed to identify patients at imminent risk. However, the performance of the model needs to be validated in various clinical...

    Authors: Leerang Lim, Ukdong Gim, Kyungjae Cho, Dongjoon Yoo, Ho Geol Ryu and Hyung-Chul Lee
    Citation: Critical Care 2024 28:76
  7. Flow starvation is a type of patient-ventilator asynchrony that occurs when gas delivery does not fully meet the patients’ ventilatory demand due to an insufficient airflow and/or a high inspiratory effort, an...

    Authors: Candelaria de Haro, Verónica Santos-Pulpón, Irene Telías, Alba Xifra-Porxas, Carles Subirà, Montserrat Batlle, Rafael Fernández, Gastón Murias, Guillermo M. Albaiceta, Sol Fernández-Gonzalo, Marta Godoy-González, Gemma Gomà, Sara Nogales, Oriol Roca, Tai Pham, Josefina López-Aguilar…
    Citation: Critical Care 2024 28:75
  8. Endotype classification may guide immunomodulatory management of patients with bacterial and viral sepsis. We aimed to identify immune endotypes and transitions associated with response to anakinra (human inte...

    Authors: Evdoxia Kyriazopoulou, Yehudit Hasin-Brumshtein, Uros Midic, Garyfallia Poulakou, Haralampos Milionis, Simeon Metallidis, Myrto Astriti, Archontoula Fragkou, Aggeliki Rapti, Eleonora Taddei, Ioannis Kalomenidis, Georgios Chrysos, Andrea Angheben, Ilias Kainis, Zoi Alexiou, Francesco Castelli…
    Citation: Critical Care 2024 28:73
  9. New onset refractory status epilepticus (NORSE) is a neurologic emergency without an immediately identifiable cause. The complicated and long ICU stay of the patients can lead to perceiving a prolongation of t...

    Authors: Federica Stretti, Stefan Yu Bögli, Francesca Casagrande, Amanda Eisele, Marian Galovic, Emanuela Keller and Giovanna Brandi
    Citation: Critical Care 2024 28:72
  10. Several bedside assessments are used to evaluate respiratory muscle function and to predict weaning from mechanical ventilation in patients on the intensive care unit. It remains unclear which assessments perf...

    Authors: Diego Poddighe, Marine Van Hollebeke, Yasir Qaiser Choudhary, Débora Ribeiro Campos, Michele R. Schaeffer, Jan Y. Verbakel, Greet Hermans, Rik Gosselink and Daniel Langer
    Citation: Critical Care 2024 28:70
  11. Chimeric antigen receptor T cells are a promising new immunotherapy for haematological malignancies. Six CAR-T cells products are currently available for adult patients with refractory or relapsed high-grade B...

    Authors: Mathieu Bellal, Jolan Malherbe, Gandhi Damaj and Damien Du Cheyron
    Citation: Critical Care 2024 28:69
  12. Molecular oxygen is typically delivered to patients via oxygen inhalation or extracorporeal membrane oxygenation (ECMO), potentially resulting in systemic hyperoxia from liberal oxygen inhalation or localized ...

    Authors: Ninan Dai, Juan Gu, Yanhong Luo, Yuanfa Tao, Yuehting Chou, Ying He, Han Qin, Tao Chen, Xiaoyun Fu, Miao Chen and Zhouxiong Xing
    Citation: Critical Care 2024 28:66
  13. SARS-CoV-2 can induce insulin resistance, which is, among others, mediated by adipose tissue dysfunction and reduced angiotensin-converting enzyme 2 (ACE2) enzymatic activity. In SARS-CoV-2-infected mice, the ...

    Authors: Erik Duijvelaar, Xiaoke Pan, Harm Jan Bogaard, Etto C. Eringa and Jurjan Aman
    Citation: Critical Care 2024 28:65
  14. After cardiac surgery, post-operative delirium (PoD) is acknowledged to have a significant negative impact on patient outcome. To date, there is no valuable and specific treatment for PoD. Critically ill patie...

    Authors: Olivier Huet, Thomas Gargadennec, Jean-Ferréol Oilleau, Bertrand Rozec, Nicolas Nesseler, Adrien Bouglé, Thomas Kerforne, Sigismond Lasocki, Vedat Eljezi, Géraldine Dessertaine, Julien Amour and Xavier Chapalain
    Citation: Critical Care 2024 28:64
  15. Acute respiratory distress syndrome (ARDS) is a life-threatening critical care syndrome commonly associated with infections such as COVID-19, influenza, and bacterial pneumonia. Ongoing research aims to improv...

    Authors: Chel Hee Lee, Mohammad M. Banoei, Mariam Ansari, Matthew P. Cheng, Francois Lamontagne, Donald Griesdale, David E. Lasry, Koray Demir, Vinay Dhingra, Karen C. Tran, Terry Lee, Kevin Burns, David Sweet, John Marshall, Arthur Slutsky, Srinivas Murthy…
    Citation: Critical Care 2024 28:63
  16. To assess the frequency, risk factors, consequences, and prevention of violence against healthcare workers in intensive care units.

    Authors: Sebastian Berger, Pascale Grzonka, Anja I. Frei, Sabina Hunziker, Sira M. Baumann, Simon A. Amacher, Caroline E. Gebhard and Raoul Sutter
    Citation: Critical Care 2024 28:61
  17. Extracorporeal cardiopulmonary resuscitation (ECPR) may reduce mortality and improve neurological outcomes in patients with cardiac arrest. We updated our existing meta-analysis and trial sequential analysis t...

    Authors: Christopher Jer Wei Low, Ryan Ruiyang Ling, Kollengode Ramanathan, Ying Chen, Bram Rochwerg, Tetsuhisa Kitamura, Taku Iwami, Marcus Eng Hock Ong and Yohei Okada
    Citation: Critical Care 2024 28:57

    The Matters Arising to this article has been published in Critical Care 2024 28:86

  18. Despite evidence associating inflammatory biomarkers with worse outcomes in hospitalized adults with COVID-19, trials of immunomodulatory therapies have met with mixed results, likely due in part to biological...

    Authors: Narges Alipanah-Lechner, James Hurst-Hopf, Kevin Delucchi, Lamorna Swigart, Andrew Willmore, Benjamin LaCombe, Robin Dewar, H. Clifford Lane, Perrine Lallemand, Kathleen D. Liu, Laura Esserman, Michael A. Matthay and Carolyn S. Calfee
    Citation: Critical Care 2024 28:56
  19. Both critically ill patients with coronavirus disease 2019 (COVID-19) and patients receiving extracorporeal membrane oxygenation (ECMO) support exhibit a high incidence of healthcare-associated infections (HAI...

    Authors: Nicolas Nesseler, Alexandre Mansour, Matthieu Schmidt, Marylou Para, Alizée Porto, Pierre-Emmanuel Falcoz, Nicolas Mongardon, Claire Fougerou, James T. Ross, Antoine Beurton, Lucie Gaide-Chevronnay, Pierre-Grégoire Guinot, Guillaume Lebreton, Erwan Flecher, André Vincentelli and Nicolas Massart
    Citation: Critical Care 2024 28:54
  20. Current recommendations support guiding fluid resuscitation through the assessment of fluid responsiveness. Recently, the concept of fluid tolerance and the prevention of venous congestion (VC) have emerged as...

    Authors: Felipe Muñoz, Pablo Born, Mario Bruna, Rodrigo Ulloa, Cecilia González, Valerie Philp, Roberto Mondaca, Juan Pablo Blanco, Emilio Daniel Valenzuela, Jaime Retamal, Francisco Miralles, Pedro D. Wendel-Garcia, Gustavo A. Ospina-Tascón, Ricardo Castro, Philippe Rola, Jan Bakker…
    Citation: Critical Care 2024 28:52

    The Matters Arising to this article has been published in Critical Care 2024 28:83

  21. There is no effective treatment for sepsis-associated acute kidney injury (SA-AKI). Ilofotase alfa (human recombinant alkaline phosphatase) has been shown to exert reno-protective properties, although it remai...

    Authors: Niklas Bruse, Katerina Pardali, Maarten Kraan, Matthijs Kox and Peter Pickkers
    Citation: Critical Care 2024 28:50
  22. Nebulisation of antibiotics is a promising treatment for ventilator-associated pneumonia (VAP) caused by multidrug-resistant organisms. Ensuring effective antibiotic concentrations at the site of infection in ...

    Authors: Jayesh Dhanani, Jason A. Roberts, Antoine Monsel, Antoni Torres, Marin Kollef and Jean-Jacques Rouby
    Citation: Critical Care 2024 28:49
  23. Tracheal intubation is a high-risk intervention commonly performed in critically ill patients. Due to its favorable cardiovascular profile, ketamine is considered less likely to compromise clinical outcomes. T...

    Authors: Takatoshi Koroki, Yuki Kotani, Takahiko Yaguchi, Taisuke Shibata, Motoki Fujii, Stefano Fresilli, Mayuko Tonai, Toshiyuki Karumai, Todd C. Lee, Giovanni Landoni and Yoshiro Hayashi
    Citation: Critical Care 2024 28:48
  24. Trauma burden is one of the leading causes of young human life and economic loss in low- and middle-income countries. Improved emergency and trauma care systems may save up to 2 million lives in these countries.

    Authors: Dinesh Bagaria, Amila S. Ratnayake, Aireen Madrid and Tamara J. Worlton
    Citation: Critical Care 2024 28:47
  25. Septic shock typically requires the administration of vasopressors. Adrenergic agents remain the first choice, namely norepinephrine. However, their use to counteract life-threatening hypotension comes with po...

    Authors: Julian Arias-Ortiz and Jean-Louis Vincent
    Citation: Critical Care 2024 28:46
  26. Improvements have been made in optimizing initial care of trauma patients, both in prehospital systems as well as in the emergency department, and these have also favorably affected longer term outcomes. Howev...

    Authors: Nicole P. Juffermans, Tarik Gözden, Karim Brohi, Ross Davenport, Jason P. Acker, Michael C. Reade, Marc Maegele, Matthew D. Neal and Philip C. Spinella
    Citation: Critical Care 2024 28:45
  27. Patients undergoing cardiac surgery are subject to infectious complications that adversely affect outcomes. Rapid identification is essential for adequate treatment. Procalcitonin (PCT) is a noninvasive blood ...

    Authors: Davide Nicolotti, Silvia Grossi, Valeria Palermo, Federico Pontone, Giuseppe Maglietta, Francesca Diodati, Matteo Puntoni, Sandra Rossi and Caterina Caminiti
    Citation: Critical Care 2024 28:44
  28. Albumin has potential endothelial protective effects through antioxidant and anti-inflammatory properties. However, the effect of albumin on peripheral tissue perfusion in human sepsis remains poorly known.

    Authors: Paul Gabarre, Cyrielle Desnos, Alexandra Morin, Louai Missri, Tomas Urbina, Vincent Bonny, Matthieu Turpin, Jean-Luc Baudel, Laurence Berard, Melissa Montil, Bertrand Guidet, Guillaume Voiriot, Jérémie Joffre, Eric Maury and Hafid Ait-Oufella
    Citation: Critical Care 2024 28:43

    The Matters Arising to this article has been published in Critical Care 2024 28:79

  29. Sepsis guidelines suggest immediate start of resuscitation for patients with quick Sequential Organ Failure Assessment (qSOFA) 2 or 3. However, the interpretation of qSOFA 1 remains controversial. We investiga...

    Authors: Maria Evangelia Adami, Antigone Kotsaki, Nikolaos Antonakos, Efthymia Giannitsioti, Stamatios Chalvatzis, Maria Saridaki, Christina Avgoustou, Karolina Akinosoglou, Konstantina Dakou, Georgia Damoraki, Konstantina Katrini, Panagiotis Koufargyris, Vasileios Lekakis, Antonia Panagaki, Asimina Safarika, Jesper Eugen-Olsen…
    Citation: Critical Care 2024 28:42
  30. This is a post hoc analysis of combined cohorts from two previous Phase II clinical trials to assess the effect of thiamine administration on kidney protection and mortality in patients with septic shock.

    Authors: Jacob Vine, John H. Lee, Max S. Kravitz, Anne V. Grossestreuer, Lakshman Balaji, Shannon B. Leland, Noa Berlin, Ari Moskowitz and Michael W. Donnino
    Citation: Critical Care 2024 28:41
  31. Ventilator associated pneumonia (VAP) due to wild-type AmpC-producing Enterobacterales (wtAE) is frequent in intensive care unit (ICU) patients. Despite a low level of evidence, definitive antimicrobial therap...

    Authors: Matthieu Petit, Frank Bidar, Quentin Fosse, Lucie Lefevre, Marine Paul, Tomas Urbina, Paul Masi, Florent Bavozet, Jérémie Lemarié, Etienne de Montmollin, Chloé Andriamifidy-Berti, Julien Dessajan, Benjamin Zuber, Lara Zafrani, Edwige Peju, Paris Meng…
    Citation: Critical Care 2024 28:40
  32. Volume replacement with crystalloid fluid is the conventional treatment of hemorrhage. We challenged whether a standardized amount of 5% or 20% albumin could be a viable option to maintain the blood volume dur...

    Authors: François Jardot, Robert G. Hahn, Dominique Engel, Christian M. Beilstein and Patrick Y. Wuethrich
    Citation: Critical Care 2024 28:39
  33. The optimal feeding strategy for critically ill patients is still debated, but feeding must be adapted to individual patient needs. Critically ill patients are at risk of muscle catabolism, leading to loss of ...

    Authors: Renée Blaauw, Philip C. Calder, Robert G. Martindale and Mette M. Berger
    Citation: Critical Care 2024 28:38
  34. Authors: Aiko Tanaka, Tetsuhisa Kitamura, Akinori Uchiyama, Yusuke Enokidani, Yukiko Koyama, Takeshi Yoshida and Yuji Fujino
    Citation: Critical Care 2024 28:37

    The original article was published in Critical Care 2023 27:378

    The original article was published in Critical Care 2023 27:395