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Septic shock is a medical emergency that is associated with mortality rates of 40–70%. Prompt recognition and institution of effective therapy is required for optimal outcome. When the shock state persists aft...
In the previous issue of Critical Care, Mori and colleagues demonstrate that glutamine supplementation in mechanically ventilated patients as part of parenteral nutrition increases plasma glutamine concentration ...
This article is part of a Supplement: Volume 16 Supplement 3
Traumatic brain injury (TBI) affects over 1.5 million Americans annually and consumes a significant amount of healthcare dollars. Identification of complications and factors that impact recovery from TBI is impor...
This article is part of a Supplement: Volume 18 Supplement 2
Recent studies indicate that mitochondrial dysfunction plays a role in the pathogenesis of a number of disease states. The importance of these organelles in shock and multiple organ dysfunction is of particula...
After years and years of consensus expert opinion as to mean arterial pressure (MAP) target and vasopressor choice in septic shock management, literature is now emerging that supports the MAP target of 65 mm H...
Smith and Perner report an observational cohort study of 164 patients with septic shock. For patients still alive on day 3, higher compared with lower fluid volume resuscitation was associated with lower 90-da...
This article is part of a Supplement: Volume 18 Supplement 2
Sepsis and shock result in disturbances in microcirculatory...2) and provides information on local microvascular and mitochondrial function. This measure could be incorporated with existing targets of goal-direct...
This article is part of a Supplement: Volume 7 Supplement 2
The recent study by Bloos and colleagues demonstrates that early initiation of antimicrobial therapy is not associated with improved survival in sepsis. We contend that these findings should not...
Severe community-acquired pneumonia is a major cause of admission to intensive care units and its mortality rates remain exceedingly high. In the search for adjunctive therapies, clinicians who were encouraged by...
Myburgh JA, Finfer S, Bellomo R, Billot L, Cass A, Gattas D, Glass P, Lipman J, Liu B, McArthur C, McGuinness S, Rajbhandari D, Taylor CB, Webb SA; CHEST Investigators; Australian and New Zealand Intensive Car...
The sepsis-induced intramyocardial inflammatory response results in decreased ... the complex pathway leading to ventricular dysfunction during sepsis, why this might be an age-dependent ... and what this implies...
Fever is considered a key actor of innate immunity aimed to fight infection. A new investigation reports an association of the use of antipyretic drugs with poorer outcome among patients with sepsis. In contrast,...
The original article was published in Critical Care 2024 28:42
The Matters Arising to this article has been published in Critical Care 2024 28:190
Increased microvascular permeability resulting in tissue edema is a hallmark of sepsis-related microcirculatory failure, and leukocyte–endothelium interaction...et al. now report, in the previous issue of Critica...
Increasing evidence suggests that the secondary phase of sepsis (that is, after the first proinflammatory ... with regard to 28 day-mortality after severe sepsis.
Whereas the pulmonary artery catheter (PAC) is still widely used in guiding assessment and treatment of heart failure, controversy surrounding its safety and efficacy has prompted development of newer, less in...
This article is part of a Supplement: Volume 17 Supplement 4
Septic acute kidney injury (S-AKI) is the most common cause of kidney injury in the ICU. Decreased renal blood flow and inflammation have both been suggested as mechanisms of S-AKI. Benes and colleagues present a...
In the previous issue of Critical Care..., Vermont and colleagues presented a simple but well-executed observational study describing the levels of chemokines in the serum of 58 children with meningococcal sepsis
The authors offer a commentary on the study by Dhainaut et al.... on the cost-effectiveness of activated protein C in severe sepsis. Using data from "real world" conditions...
The extracellular matrix (ECM) plays a significant role in the mechanical behaviour of the lung parenchyma. The ECM is composed of a three-dimensional fibre mesh that is filled with various macromolecules, amo...
Several guidelines recommend initial empirical treatment with two antibiotics instead of one to decrease mortality in community-acquired pneumonia (CAP) requiring intensive-care-unit (ICU) admission. We compar...
We searched Pubmed, Embase, Scopus and Cochrane databases from inception until 1st June 2021, and included all relevant publications reporting on > 5 adult patients requiring VA ECMO for septic shock. Study quali...
A specific match code was applied to identify certain patients with pelvic disruptions from both PIR and TR anonymous trauma databases, admitted between 2004 and 2009. From the resulting intersection set, a retro...
Sepsis-associated brain dysfunction has been linked to...
This was a monocentric, randomized, double-blind, placebo-controlled study that included patients with sepsis or acute respiratory distress syndrome. Patients received...
Critical Care