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We conducted the present study to examine the effects of hypertonic saline solution (7.5%) on cardiovascular function and splanchnic perfusion in experimental sepsis.
Development of organ dysfunction associated with sepsis is now accepted to be due at ... beneficial effect of antioxidant supplementation in patients with sepsis. This may be because the antioxidants are...in vit...
The mechanisms of lung repair and fibrosis in the acute respiratory distress syndrome (ARDS) are poorly known. Since the role of WNT/β-catenin signaling appears to be central to lung healing and fibrosis, we hypo...
Pathophysiology of brain dysfunction due to sepsis remains poorly understood. Cerebral microcirculatory alterations may...
Severe sepsis and septic shock are common problems in ... preventing the progression of the biological cascade of sepsis. We performed a systematic review to describe...
C-reactive protein (CRP) has been shown to be a valuable marker in the diagnosis of infection and in monitoring its response to antibiotics. Our objective was to evaluate serial CRP measurements after prescriptio...
A secondary analysis of a prospective, multicenter, observational study of children with septic shock admitted to the pediatric intensive care unit from 1/2019 to 12/2022. The primary outcome was severe AKI (≥ KD...
Muscle ultrasound is emerging as a promising tool in the diagnosis of neuromuscular diseases. The current observational study evaluates the usefulness of muscle ultrasound in patients with severe sepsis for asses...
Impact of gender on severe infections is in highly controversial discussion with natural survival advantage of females described in animal studies but contradictory to those described human data. This study aims ...
Microvascular alterations impair tissue oxygenation during sepsis. A red blood cell (RBC) transfusion...2) delivery but rarely improves tissue O2 uptake in patients with sepsis. Possible causes include RBC altera...
The burden of infection in industrialized countries has prompted considerable effort to improve the outcomes of patients with sepsis. This has been formalized through the Surviving Sepsis Campaign 'bundles', deri...
This article is part of a Supplement: Volume 11 Supplement 5
To validate the Japanese Association for Acute Medicine (JAAM) disseminated intravascular coagulation (DIC) scoring system in patients with severe sepsis, we conducted a multicenter, prospective study...
Sepsis-induced myocardial injury is a serious complication of sepsis. QT prolongation is a proarrhythmic state which ... on the clinical value of QT prolongation in sepsis is limited.
Although the formation of neutrophil (PMN) extracellular traps (NETs) has been detected during infection and sepsis, their role in vivo...is still unclear. This study was performed in order to evaluate the influe...
Few investigations have prospectively examined extravascular lung water (EVLW) in patients with severe sepsis. We sought to determine whether EVLW may...
Thrombotic microangiopathy-induced thrombocytopenia-associated multiple organ failure and hyperinflammatory macrophage activation syndrome are important causes of late pediatric sepsis mortality that are often mi...
The Comment to this article has been published in Critical Care 2022 26:387
Post-traumatic stress has been identified as a frequent long-term complication in survivors of critical illnesses after sepsis. Little is known about long-term trajectories ... clinical trajectories of post-traum...
In this study, we sought to determine the association between red blood cell (RBC) transfusion and outcomes in patients with acute lung injury (ALI), sepsis and shock.
Elderly patients have a blunted host response, which may influence vital signs and clinical outcomes of sepsis. This study was aimed to investigate whether ... different in elderly and non-elderly patients with sepsis
The Letter to this article has been published in Critical Care 2020 24:606
Sepsis and septic shock remain drivers for morbidity...2 removal or extracorporeal membrane oxygenation), and renal support (haemofiltration, haemodialysis, or ultrafiltration). The sequence of events and the use...
The Correspondence to this article has been published in Critical Care 2023 27:121
In China’s Henan province, 26 hospitals participated in a randomized controlled trial. We included patients with sepsis caused by carbapenem-resistant Gram-negative bacteria...0–24) of 50–100 mg h/L. The primary ...
Several studies have reported the presence of electroencephalography (EEG) abnormalities or altered evoked potentials (EPs) during sepsis. However, the role of these tests in the diagnosis and prognostic assessme...
Sepsis is a common consequence of infection, associated ... mortality rate > 25%. Although community-acquired sepsis is more common, hospital-acquired infection is ... infection and urinary tract infection. Gram-...
Mechanical ventilation with even moderate-sized tidal volumes synergistically increases lung injury in sepsis and has been associated with proinflammatory low- ... HMW HA would inhibit lung injury associated with...
Early multimodal treatment of severe sepsis, including the use of drotrecogin alfa ( ... predicting which infected patients will progress to severe sepsis and the need for aggressive intervention continues ... ea...
The treatment of septic conditions in critically ill patients is still one of medicine's major challenges. Cyclic nucleotides, adenosine and its receptors play a pivotal role in the regulation of inflammatory res...
Recent publications suggest potential benefits from statins as a preventive or adjuvant therapy in sepsis. Whether ongoing statin therapy should be continued ... in the intensive care unit (ICU) for sepsis is ope...
Timely antimicrobial treatment and source control are strongly recommended by sepsis guidelines, however, their impact on clinical...
Close monitoring and repeated risk assessment of sepsis patients in the intensive care unit (ICU...
Activated protein C (APC) induces release of microparticles (MP) from primary physiological cells, which are found in patients undergoing treatment with recombinant human APC (rhAPC) for severe sepsis. We hypothe...
Liver dysfunction can derive from severe sepsis and might be associated with poor prognosis. ... study was to evaluate the LiMAx test during sepsis in comparison to biochemical tests and the...
Sepsis has been identified as a risk factor ... CMV reactivation on outcome in patients with severe sepsis.
To evaluate whether alkaline phosphatase (AP) treatment improves renal function in sepsis-induced acute kidney injury (AKI), a ... controlled study in critically ill patients with severe sepsis or septic shock wi...
A poor correlation between renal RI and MAP, age, or PaO2/FiO2...ratio was found in septic and critically ill patients without AKI compared to patients with AKI. These findings suggest that determinants of RI are...
Speckle tracking echocardiography (STE) is a relatively novel and sensitive method for assessing ventricular function and may unmask myocardial dysfunction not appreciated with conventional echocardiography. The ...
Evidence on the changes in the absolute counts of monocyte subpopulations in sepsis is missing.
Although tissue perfusion is often decreased in patients with sepsis, the relationship between macrohemodynamics and microcirculatory blood...
The Commentary to this article has been published in Critical Care 2017 21:148
The receptor for advanced glycation end products (RAGE) is a transmembrane receptor of the immunoglobulin superfamily, it plays pivotal roles in the pathogenesis of sepsis in several ways. Our previous study show...
Acute kidney injury and hyperchloremia are commonly present in critically ill septic patients. Our study goal was to evaluate the association of hyperchloremia and acute kidney injury in severe sepsis and septic ...
The use of in vivo videomicroscopy at the bedside has demonstrated microcirculatory flow disturbances in sepsis. The ability of in vivo videomicroscopy to ... of rolling and adhered leukocytes that occur in sepsis
The founding tenet of evidence-based medicine is to combine best evidence with clinical expertise. As David Sackett opined ‘Without clinical expertise, practice risks becoming tyrannised by evidence’. Rigid pr...
This article is part of a Supplement: Volume 23 Supplement 1
The dysbiosis of intestinal microbiota plays an important role in the development of gut-derived infections, making it a potential therapeutic target against multiple organ dysfunction syndrome (MODS) after sepsis
The Editorial to this article has been published in Critical Care 2016 20:398
The safety and efficacy of recombinant human soluble thrombomodulin (rhTM) have been demonstrated, with promising evidence suggestive of efficacy for patients with severe sepsis involving coagulopathy in a phase ...
We assessed the effect of liberal versus restrictive red blood cell transfusion strategy on survival outcome in sepsis or septic shock by systematically reviewing the...
Sepsis and related multiple organ dysfunction result in ... the effect of Ang-(1–7) on sepsis is unknown, in this study we aimed ... changes in a clinically relevant model of polymicrobial sepsis induced by cecal...
During resuscitation in severe sepsis and septic shock, several goals are set...2) and central to forefoot temperature (delta-T), and how they relate to intensive care unit (ICU) and hospital mortality.
In sub-Saharan Africa, vital signs are a feasible option for monitoring critically ill patients. We assessed how admission vital signs data predict in-hospital mortality among patients with sepsis. In particular,...
Intravenous fluid administration is an essential component of sepsis management, but a positive fluid balance has...
Pediatric severe sepsis (PSS) continues to be a major...
This article is one of ten reviews selected from the Annual Update in Intensive Care and Emergency Medicine 2017. Other selected articles can be found online at
Critical Care