Skip to main content

Articles

Page 258 of 376

  1. In November 2001, drotrecogin alfa (activated) was approved by the US Food and Drug Administration; in August 2002 it was approved by the European Medicines Agency. Since the approval of drotrecogin alfa (acti...

    Authors: Luigi Camporota and Duncan Wyncoll
    Citation: Critical Care 2007 11(Suppl 5):S7
    Content type: Review Published on:

    This article is part of a Supplement: Volume 11 Supplement 5

  4. The predictive value of plasma protein C level in sepsis has been demonstrated in a number of studies in which depressed protein C levels were associated with increased likelihood of negative outcome. Data fro...

    Authors: Burkhard Vangerow, Andrew F Shorr, Duncan Wyncoll, Jonathan Janes, David R Nelson and Konrad Reinhart
    Citation: Critical Care 2007 11(Suppl 5):S4
    Content type: Review Published on:

    This article is part of a Supplement: Volume 11 Supplement 5

  5. Impairment of the protein C pathway plays a central role in the pathogenesis of sepsis. Administration of recombinant human activated protein C (rhAPC) may correct the dysregulated anticoagulant mechanism and ...

    Authors: Marcel Levi and Tom van der Poll
    Citation: Critical Care 2007 11(Suppl 5):S3
    Content type: Review Published on:

    This article is part of a Supplement: Volume 11 Supplement 5

  6. The burden of infection in industrialized countries has prompted considerable effort to improve the outcomes of patients with sepsis. This has been formalized through the Surviving Sepsis Campaign 'bundles', d...

    Authors: Yann-Erick Claessens and Jean-François Dhainaut
    Citation: Critical Care 2007 11(Suppl 5):S2
    Content type: Review Published on:

    This article is part of a Supplement: Volume 11 Supplement 5

  7. Infusing arginine vasopressin (AVP) in advanced vasodilatory shock is usually accompanied by a decrease in cardiac index and systemic oxygen transport. Whether or not such a vasoconstriction impedes regional b...

    Authors: Hendrik Bracht, Pierre Asfar, Peter Radermacher and Enrico Calzia
    Citation: Critical Care 2007 11:178
    Content type: Commentary Published on:

  9. Metabolic acidosis during hemorrhagic shock is common and conventionally considered to be due to hyperlactatemia. There is increasing awareness, however, that other nonlactate, unmeasured anions contribute to ...

    Authors: Dirk Bruegger, Gregor I Kemming, Matthias Jacob, Franz G Meisner, Christoph J Wojtczyk, Kristian B Packert, Peter E Keipert, N Simon Faithfull, Oliver P Habler, Bernhard F Becker and Markus Rehm
    Citation: Critical Care 2007 11:R130
    Content type: Research Published on:

  10. Vasopressin has been shown to increase blood pressure in catecholamine-resistant septic shock. The aim of this study was to measure the effects of low-dose vasopressin on regional (hepato-splanchnic and renal)...

    Authors: Vladimir Krejci, Luzius B Hiltebrand, Stephan M Jakob, Jukka Takala and Gisli H Sigurdsson
    Citation: Critical Care 2007 11:R129
    Content type: Research Published on:

  12. In patients with acute respiratory distress syndrome, positive end-expiratory pressure is associated with alveolar recruitment and lung hyperinflation despite the administration of a low tidal volume. The best...

    Authors: Jean-Jacques Rouby, Fabio Ferrari, Bélaïd Bouhemad and Qin Lu
    Citation: Critical Care 2007 11:180
    Content type: Commentary Published on:

  13. Recombinant human activated protein C (APC) therapy has been shown to reduce short-term mortality in patients with severe sepsis. However, survivors of sepsis may have long-term complications affecting health-...

    Authors: Christopher J Longo, Daren K Heyland, Harold N Fisher, Robert A Fowler, Claudio M Martin and Andrew G Day
    Citation: Critical Care 2007 11:R128
    Content type: Research Published on:

  14. Acute kidney injury (AKI) is a frequent complication of cardiopulmonary bypass (CPB). The lack of early biomarkers has impaired our ability to intervene in a timely manner. We previously showed in a small coho...

    Authors: Catherine L Dent, Qing Ma, Sudha Dastrala, Michael Bennett, Mark M Mitsnefes, Jonathan Barasch and Prasad Devarajan
    Citation: Critical Care 2007 11:R127
    Content type: Research Published on:

  15. The objective of this study was to determine and compare the effectiveness of different prophylactic antifungal therapies in critically ill patients on the incidence of yeast colonisation, infection, candidemi...

    Authors: JW Olivier van Till, Oddeke van Ruler, Bas Lamme, Roy JP Weber, Johannes B Reitsma and Marja A Boermeester
    Citation: Critical Care 2007 11:R126
    Content type: Research Published on:

  16. Microvascular dysfunction causing intravascular leakage of fluid and protein contributes to hypotension and shock in sepsis. We tested the hypothesis that abrogation of inducible nitric oxide synthase (iNOS) a...

    Authors: Steven M Hollenberg, Massimiliano Guglielmi and Joseph E Parrillo
    Citation: Critical Care 2007 11:R125
    Content type: Research Published on:

  21. An evaluation of critical care outreach services was published in the previous issue of Critical Care that fails to demonstrate any important outcome benefit associated with these services. It is now time to ask ...

    Authors: Brian H Cuthbertson
    Citation: Critical Care 2007 11:179
    Content type: Commentary Published on:

  22. Most patients with sepsis develop potentially irreversible cerebral dysfunctions. It is yet not clear whether cerebral haemodynamics are altered in these sepsis patients at all, and to what extent. We hypothes...

    Authors: Christof Thees, Markus Kaiser, Martin Scholz, Alexander Semmler, Michael T Heneka, Georg Baumgarten, Andreas Hoeft and Christian Putensen
    Citation: Critical Care 2007 11:R123
    Content type: Research Published on:

  23. Adequate fluid loading is the first step of hemodynamic optimization in cardiac patients undergoing surgery. Neither a clinical approach alone nor conventional parameters like central venous pressure (CVP) and...

    Authors: Michael Sander, Claudia D Spies, Katharina Berger, Herko Grubitzsch, Achim Foer, Michael Krämer, Matthias Carl and Christian von Heymann
    Citation: Critical Care 2007 11:R121
    Content type: Research Published on:

  27. Atrial fibrillation occurs frequently in medical intensive care unit patients. Most intensivists tend to treat this rhythm disorder because they believe it is detrimental. Whether atrial fibrillation contribut...

    Authors: Mengalvio E Sleeswijk, Trudeke Van Noord, Jaap E Tulleken, Jack JM Ligtenberg, Armand RJ Girbes and Jan G Zijlstra
    Citation: Critical Care 2007 11:233
    Content type: Review Published on:

  28. Mechanical ventilation associated lung injury (VALI) negatively impacts the outcomes of critically ill patients. Research during the past two decades has led to a better understanding of key physiologic mechan...

    Authors: Richard A Oeckler and Rolf D Hubmayr
    Citation: Critical Care 2007 11:177
    Content type: Commentary Published on:

  29. Enteral nutrition (EN) gives a legacy of under nutrition in intensive care patients but few appreciate that parenteral nutrition (PN) carries the other risk of overfeeding if used injudiciously. Over-feeding p...

    Authors: Richard D Griffiths
    Citation: Critical Care 2007 11:176
    Content type: Commentary Published on:

  30. Mechanisms underlying inotropic failure in septic shock are incompletely understood. We previously identified the presence of exosomes in the plasma of septic shock patients. These exosomes are released mainly...

    Authors: Luciano Cesar Pontes Azevedo, Mariano Janiszewski, Vera Pontieri, Marcelo de Almeida Pedro, Estevão Bassi, Paulo José Ferreira Tucci and Francisco Rafael Martins Laurindo
    Citation: Critical Care 2007 11:R120
    Content type: Research Published on:

  31. Herpes simplex virus (HSV) type 1 was identified in respiratory specimens from a cluster of eight patients on a surgical intensive care unit within 8 weeks. Six of these patients suffered from HSV-related trac...

    Authors: Ilka Engelmann, Jens Gottlieb, Astrid Meier, Dorit Sohr, Arjang Ruhparwar, Cornelia Henke-Gendo, Petra Gastmeier, Tobias Welte, Thomas Friedrich Schulz and Frauke Mattner
    Citation: Critical Care 2007 11:R119
    Content type: Research Published on:

  32. One of the holy grails of modern medicine, across a range of clinical sub-specialties, is establishing highly sensitive and specific biomarkers for various diseases. Significant success has been achieved in so...

    Authors: Gareth L Ackland and Michael G Mythen
    Citation: Critical Care 2007 11:175
    Content type: Commentary Published on:

  33. Previous studies have shown through theoretical analyses that the ratio of the partial pressure of oxygen in arterial blood (PaO2) to the inspired oxygen fraction (FiO2) varies with the FiO2 level. The aim of the...

    Authors: Dan S Karbing, Søren Kjærgaard, Bram W Smith, Kurt Espersen, Charlotte Allerød, Steen Andreassen and Stephen E Rees
    Citation: Critical Care 2007 11:R118
    Content type: Research Published on:

  34. Extracorporeal circulation induces hemostatic alterations that lead to inflammatory response (IR) and postoperative bleeding. Tranexamic acid (TA) reduces fibrinolysis and blood loss after cardiopulmonary bypa...

    Authors: Juan J Jimenez, Jose L Iribarren, Leonardo Lorente, Jose M Rodriguez, Domingo Hernandez, Ibrahim Nassar, Rosalia Perez, Maitane Brouard, Antonio Milena, Rafael Martinez and Maria L Mora
    Citation: Critical Care 2007 11:R117
    Content type: Research Published on:

  36. Septic shock is a medical emergency that is associated with mortality rates of 40–70%. Prompt recognition and institution of effective therapy is required for optimal outcome. When the shock state persists aft...

    Authors: Gourang P Patel and Robert A Balk
    Citation: Critical Care 2007 11:174
    Content type: Commentary Published on:

  37. Early diagnosis of acute kidney injury (AKI) is often problematic, due to the lack of suitable early biomarkers of renal damage and kidney function. Neutrophil gelatinase-associated lipocalin (NGAL) as an earl...

    Authors: Claudio Ronco
    Citation: Critical Care 2007 11:173
    Content type: Commentary Published on:

  38. The receptor for advanced glycation end products (RAGE), a multi-ligand member of the immunoglobulin superfamily, contributes to acute and chronic disease processes, including sepsis.

    Authors: Emily C Lutterloh, Steven M Opal, Debra D Pittman, James C Keith Jr, Xiang-Yang Tan, Brian M Clancy, Helen Palmer, Kim Milarski, Ying Sun, John E Palardy, Nicholas A Parejo and Noubar Kessimian
    Citation: Critical Care 2007 11:R122
    Content type: Research Published on:

  42. Prognostic factors in intentional insulin self-poisoning and the significance of plasma insulin levels are unclear. We therefore conducted this study to investigate prognostic factors in insulin poisoning, in ...

    Authors: Bruno Mégarbane, Nicolas Deye, Vanessa Bloch, Romain Sonneville, Corinne Collet, Jean-Marie Launay and Frédéric J Baud
    Citation: Critical Care 2007 11:R115
    Content type: Research Published on:

  45. The incidence of acute lung injury (ALI) is influenced by nature of the underlying clinical condition. The frequency with which ALI is likely to be encountered by those practicing outside the intensive care un...

    Authors: Simon J Finney and Timothy W Evans
    Citation: Critical Care 2007 11:169
    Content type: Commentary Published on:

  49. The treatment of patients with large hemispheric ischaemic stroke accompanied by massive space-occupying oedema represents one of the major unsolved problems in neurocritical care medicine. Despite maximum int...

    Authors: Eric Jüttler, Peter D Schellinger, Alfred Aschoff, Klaus Zweckberger, Andreas Unterberg and Werner Hacke
    Citation: Critical Care 2007 11:231
    Content type: Review Published on:

  50. Patients receiving total parenteral nutrition (TPN) are at high risk for bloodstream infections (BSI). The notion that intravenous calories and glucose lead to hyperglycemia, which in turn contributes to BSI r...

    Authors: Sharmila Dissanaike, Marilyn Shelton, Keir Warner and Grant E O'Keefe
    Citation: Critical Care 2007 11:R114
    Content type: Research Published on:
CC logo
Submit manuscript

Follow

  • ISSN: 1364-8535 (electronic)

Critical Care

ISSN: 1364-8535