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  1. Achieving adequate but not excessive sedation in critically ill, mechanically ventilated patients is a complex process. Analgesics and sedatives employed in this context are extremely potent, and drug requirem...

    Authors: William D Schweickert and John P Kress
    Citation: Critical Care 2008 12(Suppl 3):S6
    Content type: Review Published on:

    This article is part of a Supplement: Volume 12 Supplement 3

  2. Pain is among the worst possible experiences for the critically ill. Therefore, nearly all intensive care patients receive some kind of pain relief, and opioids are most frequently administered. Morphine has a...

    Authors: Wolfram Wilhelm and Sascha Kreuer
    Citation: Critical Care 2008 12(Suppl 3):S5
    Content type: Review Published on:

    This article is part of a Supplement: Volume 12 Supplement 3

  3. Delirium, an acute and fluctuating disturbance of consciousness and cognition, is a common manifestation of acute brain dysfunction in critically ill patients, occurring in up to 80% of the sickest intensive c...

    Authors: Timothy D Girard, Pratik P Pandharipande and E Wesley Ely
    Citation: Critical Care 2008 12(Suppl 3):S3
    Content type: Review Published on:

    This article is part of a Supplement: Volume 12 Supplement 3

  4. Management of analgesia and sedation in the intensive care unit requires evaluation and monitoring of key parameters in order to detect and quantify pain and agitation, and to quantify sedation. The routine us...

    Authors: Curtis N Sessler, Mary Jo Grap and Michael AE Ramsay
    Citation: Critical Care 2008 12(Suppl 3):S2
    Content type: Review Published on:

    This article is part of a Supplement: Volume 12 Supplement 3

  5. The optic nerve sheath diameter (ONSD) may be increased in brain-injured patients, especially children, with intracranial hypertension. We investigated whether measurements of ONSD correlated with simultaneous...

    Authors: Theodoros Soldatos, Dimitrios Karakitsos, Katerina Chatzimichail, Matilda Papathanasiou, Athanasios Gouliamos and Andreas Karabinis
    Citation: Critical Care 2008 12:R67
    Content type: Research Published on:

  7. Critically ill patients might present complex acid–base disorders, even when the pH, PCO2, [HCO3-], and base excess ([BE]) levels are normal. Our hypothesis was that the acidifying effect of severe hyperlactatemi...

    Authors: Graciela Tuhay, María Carolina Pein, Fabio Daniel Masevicius, Daniela Olmos Kutscherauer and Arnaldo Dubin
    Citation: Critical Care 2008 12:R66
    Content type: Research Published on:

  8. Adrenal insufficiency is common in critically ill patients and affects their prognosis, but little is known about how adrenal function changes during prolonged critical illness. This study was conducted to inv...

    Authors: Jenn-Yu Wu, Szu-Chun Hsu, Shih-Chi Ku, Chao-Chi Ho, Chong-Jen Yu and Pan-Chyr Yang
    Citation: Critical Care 2008 12:R65
    Content type: Research Published on:

  10. Sepsis is caused by infection, and knowing what type of organism is causing the infection certainly matters in terms of both epidemiology and selecting antibiotic therapy. Although there is considerable labora...

    Authors: Jonathan Cohen
    Citation: Critical Care 2008 12:145
    Content type: Commentary Published on:

  11. Animal studies of acute lung injury (ALI) suggest nebulised heparin may limit damage from fibrin deposition in the alveolar space and microcirculation. No human studies have been undertaken to date. We assesse...

    Authors: Barry Dixon, John D Santamaria and Duncan J Campbell
    Citation: Critical Care 2008 12:R64
    Content type: Research Published on:

  12. The pathophysiology of sepsis-associated delirium is not completely understood and the data on cerebral perfusion in sepsis are conflicting. We tested the hypothesis that cerebral perfusion and selected serum ...

    Authors: David Pfister, Martin Siegemund, Salome Dell-Kuster, Peter Smielewski, Stephan Rüegg, Stephan P Strebel, Stephan CU Marsch, Hans Pargger and Luzius A Steiner
    Citation: Critical Care 2008 12:R63
    Content type: Research Published on:

  14. Ventilator-associated tracheobronchitis (VAT) is associated with increased duration of mechanical ventilation. We hypothesized that, in patients with VAT, antibiotic treatment would be associated with reduced ...

    Authors: Saad Nseir, Raphaël Favory, Elsa Jozefowicz, Franck Decamps, Florent Dewavrin, Guillaume Brunin, Christophe Di Pompeo, Daniel Mathieu and Alain Durocher
    Citation: Critical Care 2008 12:R62
    Content type: Research Published on:

  17. Severe traumatic brain injury (TBI) has been increasing with greater incidence of injuries from traffic or sporting accidents. Although there are a number of animal models of TBI using progesterone for head in...

    Authors: Guomin Xiao, Jing Wei, Weiqi Yan, Weimin Wang and Zhenhui Lu
    Citation: Critical Care 2008 12:R61
    Content type: Research Published on:

  19. Assessing and managing pain in the critically ill patient is challenging. Reproducible and clinically applicable pain measurement scales have yet to be validated and ubiquitously applied in the intensive care ...

    Authors: Yoanna Skrobik
    Citation: Critical Care 2008 12:142
    Content type: Commentary Published on:

  21. Patients requiring prolonged acute mechanical ventilation (PAMV) represent one-third of those who need mechanical ventilation, but they utilize two-thirds of hospital resources devoted to mechanical ventilatio...

    Authors: Marya D Zilberberg, Lee S Stern, Daniel P Wiederkehr, John J Doyle and Andrew F Shorr
    Citation: Critical Care 2008 12:R60
    Content type: Research Published on:

  25. Eosinopenia is a cheap and forgotten marker of acute infection that has not been evaluated previously in intensive care units (ICUs). The aim of the present study was to test the value of eosinopenia in the di...

    Authors: Khalid Abidi, Ibtissam Khoudri, Jihane Belayachi, Naoufel Madani, Aicha Zekraoui, Amine Ali Zeggwagh and Redouane Abouqal
    Citation: Critical Care 2008 12:R59
    Content type: Research Published on:

  30. In March 2001, the results of the Recombinant Human Activated Protein C Worldwide Evaluation in Severe Sepsis (PROWESS) study were published, which indicated a 6.1% absolute reduction in 28-day mortality. Drot...

    Authors: Kathryn M Rowan, Catherine A Welch, Emma North and David A Harrison
    Citation: Critical Care 2008 12:R58
    Content type: Research Published on:

  31. Many patients presenting with acute gastrointestinal hemorrhage (GIH) are admitted to the intensive care unit (ICU) for monitoring. A simple triage protocol based upon validated risk factors could decrease ICU...

    Authors: Aneesa M Das, Namita Sood, Katherine Hodgin, Lydia Chang and Shannon S Carson
    Citation: Critical Care 2008 12:R57
    Content type: Research Published on:

  33. Early, accurate diagnosis is fundamental in the management of patients with ventilator-associated pneumonia (VAP). The aim of this qualitative review was to compare various criteria of diagnosing VAP in the in...

    Authors: Alvaro Rea-Neto, Nazah Cherif M Youssef, Fabio Tuche, Frank Brunkhorst, V Marco Ranieri, Konrad Reinhart and Yasser Sakr
    Citation: Critical Care 2008 12:R56
    Content type: Research Published on:

  34. The helmet may be an effective interface for the delivery of noninvasive positive pressure ventilation. The high internal gas volume of the helmet can act as a 'mixing chamber', in which the humidity of the pa...

    Authors: Davide Chiumello, Monica Chierichetti, Federica Tallarini, Paola Cozzi, Massimo Cressoni, Federico Polli, Riccardo Colombo, Antonio Castelli and Luciano Gattinoni
    Citation: Critical Care 2008 12:R55
    Content type: Research Published on:

  35. Preoperative hemodilution is an established practice that is applied to reduce surgical blood loss. It has been proposed that polyethylene glycol (PEG) surface decorated proteins such as PEG-conjugated human s...

    Authors: Judith Martini, Pedro Cabrales, Ananda K, Seetharama A Acharya, Marcos Intaglietta and Amy G Tsai
    Citation: Critical Care 2008 12:R54
    Content type: Research Published on:

  36. Alveolar dead space reflects phenomena that render arterial partial pressure of carbon dioxide higher than that of mixed alveolar gas, disturbing carbon dioxide exchange. Right-to-left shunt fraction (Qs/Qt) l...

    Authors: Lisbet Niklason, Johannes Eckerström and Björn Jonson
    Citation: Critical Care 2008 12:R53
    Content type: Research Published on:

  37. Sleep disturbances are common in critically ill patients and when sleep does occur it traverses the day-night periods. The reduction in plasma melatonin levels and loss of circadian rhythm observed in critical...

    Authors: Richard S Bourne, Gary H Mills and Cosetta Minelli
    Citation: Critical Care 2008 12:R52
    Content type: Research Published on:

  38. The use of noninvasive positive-pressure mechanical ventilation (NPPV) has been investigated in several acute respiratory failure situations. Questions remain about its benefits when used in weaning patients f...

    Authors: Cristiane E Trevisan and Silvia R Vieira
    Citation: Critical Care 2008 12:R51
    Content type: Research Published on:

  39. Alveolar derecruitment may occur during low tidal volume ventilation and may be prevented by recruitment maneuvers (RMs). The aim of this study was to compare two RMs in acute respiratory distress syndrome (AR...

    Authors: Jean-Michel Constantin, Samir Jaber, Emmanuel Futier, Sophie Cayot-Constantin, Myriam Verny-Pic, Boris Jung, Anne Bailly, Renaud Guerin and Jean-Etienne Bazin
    Citation: Critical Care 2008 12:R50
    Content type: Research Published on:

  40. Stress-induced hyperglycaemia is prevalent in critical care. Control of blood glucose levels to within a 4.4 to 6.1 mmol/L range or below 7.75 mmol/L can reduce mortality and improve clinical outcomes. The Spe...

    Authors: JGeoffrey Chase, Geoffrey Shaw, Aaron Le Compte, Timothy Lonergan, Michael Willacy, Xing-Wei Wong, Jessica Lin, Thomas Lotz, Dominic Lee and Christopher Hann
    Citation: Critical Care 2008 12:R49
    Content type: Research Published on:

  43. Complex interventions, such as the introduction of medical emergency teams or an early goal-directed therapy protocol, are developed from a number of components that may act both independently and inter-depend...

    Authors: Anthony Delaney, Derek C Angus, Rinaldo Bellomo, Peter Cameron, D James Cooper, Simon Finfer, David A Harrison, David T Huang, John A Myburgh, Sandra L Peake, Michael C Reade, Steve AR Webb and Donald M Yealy
    Citation: Critical Care 2008 12:210
    Content type: Review Published on:

  44. New statistical models for analysing survival data in an intensive care unit context have recently been developed. Two models that offer significant advantages over standard survival analyses are competing ris...

    Authors: Adrian Barnett and Nick Graves
    Citation: Critical Care 2008 12:134
    Content type: Commentary Published on:

  45. Without specific strategies to address tracheostomy care on the wards, patients discharged from the intensive care unit (ICU) with a tracheostomy may receive suboptimal care. We formed an intensivist-led multi...

    Authors: Antony E Tobin and John D Santamaria
    Citation: Critical Care 2008 12:R48
    Content type: Research Published on:

  47. In patients with hyperdynamic hemodynamics, infusing arginine vasopressin (AVP) in advanced vasodilatory shock is usually accompanied by a decrease in cardiac output and in visceral organ blood flow. Depending...

    Authors: Balázs Hauser, Pierre Asfar, Enrico Calzia, Régent Laporte, Michael Georgieff and Peter Radermacher
    Citation: Critical Care 2008 12:132
    Content type: Commentary Published on:

  49. We describe a case of Saccharomyces boulardii fugaemia in a critically ill patient with septic shock treated with a probiotic agent containing this yeast. We attributed this fugaemia to gut translocation. Our use...

    Authors: Nikolaos Lolis, Dimitrios Veldekis, Hellen Moraitou, Sofia Kanavaki, Aristea Velegraki, Charis Triandafyllidis, Chronis Tasioudis, Angellos Pefanis and Ioannis Pneumatikos
    Citation: Critical Care 2008 12:414
    Content type: Letter Published on:
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  • ISSN: 1364-8535 (electronic)

Critical Care

ISSN: 1364-8535