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  1. Methicillin-resistant Staphylococcus aureus (MRSA) displays a remarkable array of resistance and virulence factors, which have contributed to its prominent role in infections of the critically ill. We are beginni...

    Authors: Lee P Skrupky, Scott T Micek and Marin H Kollef
    Citation: Critical Care 2009 13:222
    Content type: Review Published on:

  4. Use of terlipressin in septic shock relies on a series of European studies resulting in a better knowledge of this vasopressive agent. Additional studies demonstrate that this agent appears to have attractive ...

    Authors: Marc Leone
    Citation: Critical Care 2009 13:192
    Content type: Commentary Published on:

  6. In a recent issue of Critical Care, Qiao and colleagues showed in a rat model of sepsis that dexmedetomidine and midazolam suppress the generation of pro-inflammatory mediators but the effects vary between agents...

    Authors: Robert MacLaren
    Citation: Critical Care 2009 13:191
    Content type: Commentary Published on:

  7. It is well documented that transplants save lives and improve quality of life for patients suffering from kidney, liver, and heart failure. Uncontrolled donation after cardiac death (UDCD) is an effective and ...

    Authors: Bradley J Kaufman, Stephen P Wall, Alexander J Gilbert, Nancy N Dubler and Lewis R Goldfrank
    Citation: Critical Care 2009 13:189
    Content type: Commentary Published on:

  8. To investigate the effects of positive end-expiratory pressure (PEEP) on respiratory function and hemodynamics in patients with acute lung injury (ALI) or acute respiratory distress syndrome (ARDS) with normal...

    Authors: Joerg Krebs, Paolo Pelosi, Charalambos Tsagogiorgas, Markus Alb and Thomas Luecke
    Citation: Critical Care 2009 13:R160
    Content type: Research Published on:

  9. Invasive candidiasis and candidemia are life-threatening nosocomial infections in intensive care patients.

    Authors: Bertrand F Dupont, Olivier Lortholary, Luis Ostrosky-Zeichner, Flavie Stucker and Vijay Yeldandi
    Citation: Critical Care 2009 13:R159
    Content type: Research Published on:

  10. Matrix metalloproteinases (MMPs) play a role in infectious diseases through extracellular matrix (ECM) degradation, which favors the migration of immune cells from the bloodstream to sites of inflammation. Alt...

    Authors: Leonardo Lorente, María M Martín, Lorenzo Labarta, César Díaz, Jordi Solé-Violán, José Blanquer, Josune Orbe, José A Rodríguez, Alejandro Jiménez, Juan M Borreguero-León, Felipe Belmonte, Juan C Medina, Maria C LLimiñana, José M Ferrer-Agüero, José Ferreres, María L Mora…
    Citation: Critical Care 2009 13:R158
    Content type: Research Published on:

  11. Despite the key role of hemodynamic goals, there are few data addressing the question as to which hemodynamic variables are associated with outcome or should be targeted in cardiogenic shock patients. The aim ...

    Authors: Christian Torgersen, Christian A Schmittinger, Sarah Wagner, Hanno Ulmer, Jukka Takala, Stephan M Jakob and Martin W Dünser
    Citation: Critical Care 2009 13:R157
    Content type: Research Published on:

  13. Protein calorie malnutrition is a concern in critically ill patients. Prospective studies to define the ideal calorie/protein intake to administer not only to meet requirements but also to change outcome are l...

    Authors: Pierre Singer
    Citation: Critical Care 2009 13:188
    Content type: Commentary Published on:

  15. Candidemia results in substantial morbidity and mortality, especially if initial antifungal therapy is delayed or is inappropriate; however, candidemia is difficult to diagnose because of its nonspecific prese...

    Authors: Andrew F Shorr, Ying P Tabak, Richard S Johannes, Xiaowu Sun, James Spalding and Marin H Kollef
    Citation: Critical Care 2009 13:R156
    Content type: Research Published on:

  17. Sepsis has a high mortality despite advances in management. Microcirculatory and endothelial dysfunction contribute to organ failure, and better tools are needed to assess microcirculatory responses to adjunct...

    Authors: Joshua S Davis, Tsin W Yeo, Jane H Thomas, Mark McMillan, Christabelle J Darcy, Yvette R McNeil, Allen C Cheng, David S Celermajer, Dianne P Stephens and Nicholas M Anstey
    Citation: Critical Care 2009 13:R155
    Content type: Research Published on:

  19. Prolonged intensive care unit lengths of stay (ICU LOS) for critical illness can have acceptable mortality rates and quality of life despite significant costs. Only a few studies have specifically addressed pr...

    Authors: Adrian W Ong, Laurel A Omert, Diane Vido, Brian M Goodman, Jack Protetch, Aurelio Rodriguez and Elan Jeremitsky
    Citation: Critical Care 2009 13:R154
    Content type: Research Published on:

  20. There is a limited understanding of the long-term needs of survivors of the acute respiratory distress syndrome (ARDS) as they recover from their episode of critical illness. The Timing it Right (TIR) framewor...

    Authors: Christie M Lee, Margaret S Herridge, Andrea Matte and Jill I Cameron
    Citation: Critical Care 2009 13:R153
    Content type: Research Published on:

  21. Indexes predicting weaning outcome are frequently inaccurate. We developed a new integrative weaning index aimed at improving the accuracy of the traditional indexes.

    Authors: Sergio N Nemer, Carmen SV Barbas, Jefferson B Caldeira, Thiago C Cárias, Ricardo G Santos, Luiz C Almeida, Leandro M Azeredo, Rosângela A Noé, Bruno S Guimarães and Paulo C Souza
    Citation: Critical Care 2009 13:R152
    Content type: Research Published on:

  22. In critically ill patients the relationship between the storage age of red blood cells (RBCs) transfused and outcomes are controversial. To determine if duration of RBC storage is associated with adverse outco...

    Authors: Philip C Spinella, Christopher L Carroll, Ilene Staff, Ronald Gross, Jacqueline Mc Quay, Lauren Keibel, Charles E Wade and John B Holcomb
    Citation: Critical Care 2009 13:R151
    Content type: Research Published on:

  25. Sepsis-induced acute lung injury (ALI) has been reported to have a higher case fatality rate than other causes of ALI. However, differences in the severity of illness in septic vs. non-septic ALI patients migh...

    Authors: Jonathan E Sevransky, Gregory S Martin, Carl Shanholtz, Pedro A Mendez-Tellez, Peter Pronovost, Roy Brower and Dale M Needham
    Citation: Critical Care 2009 13:R150
    Content type: Research Published on:

  26. During cardiac surgery with cardiopulmonary bypass (CPB) haemodilution occurs. Hepatic dysfunction after CPB is a rare, but serious, complication. Clinical data have validated the plasma-disappearance rate of ...

    Authors: Michael Sander, Claudia D Spies, Katharina Berger, Torsten Schröder, Herko Grubitzsch, Klaus D Wernecke and Christian von Heymann
    Citation: Critical Care 2009 13:R149
    Content type: Research Published on:

  28. Patients with influenza A (H1N1)v infection have developed rapidly progressive lower respiratory tract disease resulting in respiratory failure. We describe the clinical and epidemiologic characteristics of th...

    Authors: Jordi Rello, Alejandro Rodríguez, Pedro Ibañez, Lorenzo Socias, Javier Cebrian, Asunción Marques, José Guerrero, Sergio Ruiz-Santana, Enrique Marquez, Frutos Del Nogal-Saez, Francisco Alvarez-Lerma, Sergio Martínez, Miquel Ferrer, Manuel Avellanas, Rosa Granada, Enrique Maraví-Poma…
    Citation: Critical Care 2009 13:R148
    Content type: Research Published on:

  29. Prolonged critically ill patients reveal low circulating thyroid hormone levels without a rise in thyroid stimulating hormone (TSH). This condition is labeled "low 3,5,3'-tri-iodothyronine (T3) syndrome" or "nont...

    Authors: Liese Mebis, Yves Debaveye, Björn Ellger, Sarah Derde, Eric-Jan Ververs, Lies Langouche, Veerle M Darras, Eric Fliers, Theo J Visser and Greet Van den Berghe
    Citation: Critical Care 2009 13:R147
    Content type: Research Published on:

  31. Prevention of lymphocyte apoptosis by caspase inhibition has been proposed as a novel treatment approach in sepsis. However, it has not been clearly demonstrated that caspase inhibitors improve survival in sep...

    Authors: Peter Weber, Ping Wang, Stephane Maddens, Paul SH Wang, Rongqian Wu, Michael Miksa, Weifeng Dong, Michael Mortimore, Julian MC Golec and Peter Charlton
    Citation: Critical Care 2009 13:R146
    Content type: Research Published on:

  32. Disturbed alveolar fibrin turnover is a cardinal feature of severe pneumonia. Clinical studies suggest that natural inhibitors of coagulation exert lung-protective effects via anticoagulant and possibly also a...

    Authors: Jorrit J Hofstra, Alexander D Cornet, Bart F de Rooy, Alexander P Vlaar, Tom van der Poll, Marcel Levi, Sebastian AJ Zaat and Marcus J Schultz
    Citation: Critical Care 2009 13:R145
    Content type: Research Published on:

  34. The current debate about the side effects of induction agents, e.g. possible adrenal suppression through etomidate, emphasizes the relevance of choosing the correct induction agent in septic patients. However,...

    Authors: York A Zausig, Hendrik Busse, Dirk Lunz, Barbara Sinner, Wolfgang Zink and Bernhard M Graf
    Citation: Critical Care 2009 13:R144
    Content type: Research Published on:

  35. There is mounting evidence, including the recent report by Maggiore and colleagues, of an association between hypernatremia and mortality in patients with traumatic brain injury. This mandates a re-evaluation ...

    Authors: David A Zygun
    Citation: Critical Care 2009 13:184
    Content type: Commentary Published on:

  37. The application in clinical practice of evidence-based guidelines for the management of patients with severe sepsis/septic shock is still poor in the emergency department, while little data are available for p...

    Authors: Massimo Girardis, Laura Rinaldi, Lara Donno, Marco Marietta, Mauro Codeluppi, Patrizia Marchegiano and Claudia Venturelli
    Citation: Critical Care 2009 13:R143
    Content type: Research Published on:

  38. Although several parameters have been proposed to predict the hemodynamic response to fluid expansion in critically ill patients, most of them are invasive or require the use of special monitoring devices. The...

    Authors: Manuel Ignacio Monge García, Anselmo Gil Cano and Juan Carlos Díaz Monrové
    Citation: Critical Care 2009 13:R142
    Content type: Research Published on:

  39. To counter the shortage of kidney grafts in France, a non heart beating donor (NHBD) program has recently been implemented. The aim of this study was to describe this pilot program for kidney retrieval from "u...

    Authors: Fabienne Fieux, Marie-Reine Losser, Eric Bourgeois, Francine Bonnet, Olivier Marie, François Gaudez, Imad Abboud, Jean-Luc Donay, France Roussin, François Mourey, Frédéric Adnet and Laurent Jacob
    Citation: Critical Care 2009 13:R141
    Content type: Research Published on:

  40. Delayed gastric emptying occurs frequently in critically ill patients and has the potential to adversely affect both the rate, and extent, of nutrient absorption. However, there is limited information about nu...

    Authors: Marianne J Chapman, Robert JL Fraser, Geoffrey Matthews, Antonietta Russo, Max Bellon, Laura K Besanko, Karen L Jones, Ross Butler, Barry Chatterton and Michael Horowitz
    Citation: Critical Care 2009 13:R140
    Content type: Research Published on:

  42. Chlorhexidine bed baths seem to reduce the incidence of methicillin-resistant Staphylococcus aureus and vancomycin-resistant enterococcus detected by surveillance cultures. There is also some evidence on the bene...

    Authors: James Hayward and Richard Venn
    Citation: Critical Care 2009 13:181
    Content type: Commentary Published on:

  43. The inducible nitric oxide synthase (iNOS) plays a crucial role in early sepsis-related microcirculatory dysfunction. Compared to a catecholamine therapy we tested effects of a specific iNOS-inhibitor (1400W) ...

    Authors: Bernhard Rosengarten, Stephanie Wolff, Sabine Klatt and Ralf T Schermuly
    Citation: Critical Care 2009 13:R139
    Content type: Research Published on:

  44. Cardiovascular failure is the leading cause of death in severe acute drug intoxication. In this setting, we report the feasibility, complications, and outcome of emergency extracorporeal life support (ECLS) in...

    Authors: Cédric Daubin, Philippe Lehoux, Calin Ivascau, Marine Tasle, Mehdi Bousta, Olivier Lepage, Charlotte Quentin, Massimo Massetti and Pierre Charbonneau
    Citation: Critical Care 2009 13:R138
    Content type: Research Published on:

  45. Patients with haematological malignancy admitted to intensive care have a high mortality. Adverse prognostic factors include the number of organ failures, invasive mechanical ventilation and previous bone marr...

    Authors: Peter A Hampshire, Catherine A Welch, Lawrence A McCrossan, Katharine Francis and David A Harrison
    Citation: Critical Care 2009 13:R137
    Content type: Research Published on:
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  • ISSN: 1364-8535 (electronic)

Critical Care

ISSN: 1364-8535