Skip to main content


Volume 21 Supplement 3

Future of Critical Care Medicine (FCCM) 2016


Publication of this supplement was supported by Fresenius Kabi. Information about the source of funding for publication charges can be found in the individual articles. The articles have undergone the journal's standard peer review process for supplements. The Supplement Editors declare that they have no competing interests.

Edited by John Marini and Jean-Louis Vincent.

  1. Content type: Review

    With imprecise definitions, inexact measurement tools, and flawed study execution, our clinical science often lags behind bedside experience and simply documents what appear to be the apparent faults or validi...

    Authors: John J. Marini, Daniel De Backer, Can Ince, Mervyn Singer, Frank Van Haren, Martin Westphal and Paul Wischmeyer

    Citation: Critical Care 2017 21(Suppl 3):315

    Published on:

  2. Content type: Review

    The acute respiratory distress (ARDS) lung is usually characterized by a high degree of inhomogeneity. Indeed, the same lung may show a wide spectrum of aeration alterations, ranging from completely gasless re...

    Authors: Luciano Gattinoni, Tommaso Tonetti and Michael Quintel

    Citation: Critical Care 2017 21(Suppl 3):312

    Published on:

  3. Content type: Review

    Without doubt, in medicine as in life, one size does not fit all. We do not administer the same drug or dose to every patient at all times, so why then would we live under the illusion that we should give the ...

    Authors: Paul E. Wischmeyer

    Citation: Critical Care 2017 21(Suppl 3):316

    Published on:

  4. Content type: Review

    This paper introduces the concept of personalized physiological medicine that is specifically directed at the needs of the critically ill patient. This differs from the conventional view of personalized medici...

    Authors: Can Ince

    Citation: Critical Care 2017 21(Suppl 3):308

    Published on:

  5. Content type: Review

    Evaluation of the cardiovascular profile of critically ill patients is one of the most important actions performed in critically ill patients. It allows recognition that the patient is in shock and characteriz...

    Authors: Daniel De Backer

    Citation: Critical Care 2017 21(Suppl 3):311

    Published on:

  6. Content type: Review

    Recent advances in technology and better understanding of mechanisms underlying disease are beginning to enable us to better characterize critically ill patients. Instead of using nonspecific syndromic groupin...

    Authors: Jean-Louis Vincent

    Citation: Critical Care 2017 21(Suppl 3):314

    Published on:

  7. Content type: Review

    Much of what we now do in Critical Care carries an air of urgency, a pressing need to discover and act, with priorities biased toward a reactive response. However, efficacy often depends not simply upon what w...

    Authors: John J. Marini

    Citation: Critical Care 2017 21(Suppl 3):317

    Published on:

  8. Content type: Review

    Red blood cell (RBC) transfusion might be life-saving in settings with acute blood loss, especially uncontrolled haemorrhagic shock. However, there appears to be a catch-22 situation reflected by the facts tha...

    Authors: Susilo Chandra, Hrishikesh Kulkarni and Martin Westphal

    Citation: Critical Care 2017 21(Suppl 3):310

    Published on:

  9. Content type: Review

    An exaggerated, dysregulated host response to insults such as infection (i.e. sepsis), trauma and ischaemia-reperfusion injury can result in multiple organ dysfunction and death. While the focus of research in...

    Authors: Mervyn Singer

    Citation: Critical Care 2017 21(Suppl 3):309

    Published on: