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Fig. 2 | Critical Care

Fig. 2

From: Targeting circulating high mobility group box-1 and histones by extracorporeal blood purification as an immunomodulation strategy against critical illnesses

Fig. 2

© 2022 by the authors)

Preparation, characterization and anti-histone properties of heparin-grated chitosan (CSCEHEP) beads. a Scheme of the heparin-grafting procedure on chitosan beads; b Chemical structure of the CSCEHEP beads determined by Fourier transform infrared spectroscopy; c Clotting times of plasma after incubation with the CSCEHEP beads; d Histone and BSA adsorption capacities of the CSCEHEP and CSCE beads in batch adsorption experiments; e Histone adsorption capacities of the CSCEHEP beads under different histone concentrations; f Effect of the CSCEHEP beads on antagonizing histone-induced cytotoxicity (

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Critical Care

ISSN: 1364-8535