Two regional ventilation–perfusion patterns of lung consolidation assessed by electrical impedance tomography and ultrasound
Critical Care volume 26, Article number: 357 (2022)
The perfusion of lung consolidation regions varies, depending on hypoxic vasoconstriction, obstruction or compression of pulmonary capillaries and unobstructed degree of related pulmonary arteries. The electrical impedance tomography (EIT) could make a rapid assessment of functional ventilation and perfusion in the related lung regions, which was helpful for the broad diagnosis and further treatment . However, EIT could not identify a precise anatomical location or the etiology that causes the change of regional perfusion. Ultrasound had been used to map the bronchial arteries, pulmonary arteries and venous in lung consolidation . In this study, we proposed two typical patterns of regional V-Q matching of lung consolidation by EIT and ultrasound at the bedside.
Dead-space pattern (D-pattern) was defined as a severe perfusion defect with mild impaired ventilation that results in a regional dead-space in the related lung quasi-consolidated regions (still some ventilation in these regions). In EIT image, high regional Dead-space% should be identified, whereas in ultrasound, absent or dot-like vascularity should be observed in the quasi-consolidated regions. The potential pathophysiologic mechanism could be obstruction or compression of pulmonary capillaries and unobstructed degree of related pulmonary arteries. Respiratory treatment for patients with D-pattern should not only focus on improving regional ventilation but also restoring pulmonary perfusion.
To illustrate the typical EIT and ultrasound images, a case with D-pattern was present.
A 66-year-old man, who had obstructive pneumonia due to central non-small-cell lung cancer in the right lung, was mechanically ventilated. A lower regional ventilation distribution, pleural effusion and consolidation were found in the right lower lobe (Fig. 1A). Color Doppler found an absent vascularity in the consolidation region of right lung. Moreover, using saline bolus EIT also found the perfusion was poor in the right lung that caused a high dead-space. With aim to improve regional ventilation, an increase of PEEP (from 8cmH2O to 14cmH2O) and drainage of pleural effusion were used. The high PEEP caused a significant improvement of ventilation but less correction of perfusion defect. The range of consolidated region decreased; however, no vascularity was seen within this consolidated lung at the higher PEEP level. The CTPA implied multiple pulmonary artery stenosis of the upper and lower lobe in the right lung. In this case, some shunt% region present in the left lung without pulmonary artery embolism, which indicated redistribution of lung blood perfusion. Moreover, the V/Q match was impaired in the high PEEP that cause leading to heterogeneity in pulmonary perfusion.
Not only pulmonary artery embolism but also pulmonary capillaries compression and micro-embolism could cause a perfusion defect in the lung consolidation. COVID-19 also has a high dead-space percentage, which is similar to D-pattern . It might be helpful to determine the location of blood obstruction in the consolidation by assessing pulmonary vessel by color Doppler. Here, we stressed only use ultrasound to associate lung consolidation with dead-space(D pattern) is insufficient, and combined EIT is recommended.
Shunt pattern (S-pattern) was defined as a well or relatively normal perfusion with severe impaired ventilation that result in a regional shunt in the related region of lung consolidation. In EIT image, high regional Shunt% is observed, whereas in ultrasound, pulsatile tree-like, tortuous or homogeneously distributed fragmented vascular structures could be identified through several respiratory cycles in any part of the consolidated tissue . Potential pathophysiologic mechanisms for the S-pattern are dysfunction of hypoxic pulmonary vasoconstriction, regional vessels dilation by inflammation. Intrapulmonary shunt has been taken as an important impact on oxygenation in the lung consolidation. With aim to improve regional V-Q matching, improving lung aeration and redistributed lung blood flow (recruitment maneuver, prone positioning) are important in the S-pattern.
To demonstrate the idea, a clinical case of S-pattern was presented. A 55-year-old man, who received the aortic valve replacement due to the severe aortic insufficiency, suffered from refractory hypoxemia on the first postoperative day. The ventilation defect was worse than perfusion defect, which result in intrapulmonary shunt in dependent regions (Fig. 1B). Moreover, pleural effusion and massive tissue-like pattern consolidation were found in the dependent regions. The color Doppler found two parallel vascular flows in the centric part of the consolidated tissue, which also indicate intrapulmonary shunting in dependent regions . After prone positioning for 17 h, the V/Q match was significantly improved.
To our best knowledge, this is the first clinical report combined ultrasound and electrical impedance tomography for categorizing regional perfusion in lung consolidation. The compute and incorporate the anatomical dead-space and cardiac output could provide EIT map of regional ventilation-perfusion matching . Ultrasound has advantage of non-invasive cardiac output monitoring at the bedside, which further combine with EIT for more accurate regional V/Q mapping. There might be gray zone between S pattern and D pattern. Further studies are required to determine the specific parameters and cutoff value for the two typical patterns.
Availability of data and materials
Electrical impedance tomography
Computed tomography pulmonary angiography
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This work was supported by the CAMS Innovation Fund for Medical Sciences (No. CAMS Innovation Fund for Medical Sciences (No. 2020-I2M-C&T-B-042), Capital’s Funds for Health Improvement and Research (No. 2020-2-40111), Excellence Program of Key Clinical Specialty of critical care medicine of Beijing in 2020, and Beijing Municipal Science and Technology Commission (No. Z201100005520051).
Ethical approval and consent to participate
The Institutional Research and Ethics Committee of the Peking Union Medical College Hospital approved this study on human subjects. Written informed consent was obtained from the patients’ next of kin.
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All authors read and approved the final manuscript.
Zhanqi Zhao receives consultant fee from Draeger Medical. Other authors declare no conflict of interest.
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Wang, N., He, H., Long, Y. et al. Two regional ventilation–perfusion patterns of lung consolidation assessed by electrical impedance tomography and ultrasound. Crit Care 26, 357 (2022). https://doi.org/10.1186/s13054-022-04235-2