Fig. 2
From: Myocardial effects of angiotensin II compared to norepinephrine in an animal model of septic shock
Hemodynamic variables before and during vasopressor exposure in the three groups. Cardiac output and heart rate were not statistically significantly different in the two intervention groups. Norepinephrine (NE) was associated with a higher left ventricular (LV) dP/dTmax and higher triple product (heart rate*ventricular systolic pressure*dP/dTmax), surrogate of myocardial consumption, than angiotensin (Ang) II. This difference persisted during the 8 h of vasopressor administration. LV end diastolic volume (LVEDV) increased during fluid resuscitation and pulse pressure variation was maintained at <13% throughout the vasopressor administration T0 to T8 correspond to the eight hours of vasopressor exposure, the time-point “vasopressor 1” correspond to T3; time-point “vasopressor 2” correspond to T8. NE: black lines (n = 8); Ang II: blue lines (n = 8); Sham: white lines (n = 4). Values are expressed as mean ± standard deviation. *p value < 0.05 between NE and ANG II. †p value < 0.05 between NE and Sham. ‡p value < 0.05 between ANG II and Sham. p value < 0.05 compared to baseline for NE (§), Ang II (ll) and Sham (**) groups