Association between timing of speech and language therapy initiation and outcomes among post-extubation dysphagia patients: a multicenter retrospective cohort study

Table 3 Multivariable logistic regression analysis of association between the timing of SLT initiation and outcomes

Outcomes	All (n = 272)	Unadjusted OR (95% CI)	p-value	Adjusted OR (95% CI)	p-value
Primary outcomes
Dysphagia or death on hospital discharge, n (%)	82 (30.1)	1.12 (1.04–1.20)	0.002	1.09 (1.02–1.18)	0.009
Secondary outcomes
Dysphagia or death at the 7th day after extubation, n (%)	188 (69.1)	1.36 (1.13–1.65)	0.001	1.28 (1.05–1.55)	0.011
Dysphagia or death at the 14th day after extubation, n (%)^a	137 (51.8)	1.38 (1.18–1.61)	< 0.001	1.34 (1.13–1.58)	< 0.001
Dysphagia or death at the 28th day after extubation, n (%)^b	92 (42.9)	1.21 (1.08–1.36)	0.001	1.21 (1.07–1.36)	0.001
Aspiration pneumonia after extubation, n (%)	79 (29.0)	1.11 (1.04–1.19)	0.002	1.09 (1.02–1.17)	0.012
In-hospital mortality, n (%)	31 (11.4)	1.04 (0.98–1.11)	0.135	1.04 (0.97–1.12)	0.203

Variables for the outcomes in the multivariable logistic regression included timing of SLT initiation, institutions, age, ICU admission type, preexisting dementia, cerebrovascular disease, duration of mechanical ventilation, delirium on the day of extubation, SOFA score on the day of extubation, EN, and PN. SLT: speech and language therapy, CI: confidence interval, OR: odds ratio, ICU: intensive care unit, SOFA: Sequential Organ Failure Assessment, EN: enteral nutrition, PN: parenteral nutrition
^aOf 272 patients, eight were missing
^bOf 272 patients, 58 were missing

ISSN: 1364-8535