- Research Letter
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Orthodeoxia and its implications on awake-proning in COVID-19 pneumonia
Critical Care volume 25, Article number: 429 (2021)
When caring for patients with respiratory failure, decubitus is a daily challenge. In the acute-respiratory-distress-syndrome (ARDS), seated and prone position increase lung volume and, consequently, oxygenation . In COVID-19, however, gas-exchange is often independent of lung volume , and rather affected by perfusion dysregulation . In similar settings, like the hepato-pulmonary syndrome (HPS), recumbency may revert hypoxemia : this phenomenon goes under the name of orthodeoxia, and here we hypothesize its presence in COVID-19. Clinical implications might be relevant: recumbency is the state of lying horizontally at 0°, supine or prone. Awake-proning has already proven beneficial on oxygenation in spontaneously breathing patients with early COVID-19 pneumonia . However, as a heritage from ARDS, these patients are usually seated or semi-recumbent, thereby the ventral decubitus is rarely compared to supination at 0°: the finding of orthodeoxia may lead to partially ascribe the oxygenation benefits of awake-proning  to recumbency rather than to the ventral decubitus itself.
At the University Hospital of Turin (Italy), following ethical approval (Città della Salute e della Scienza 00581/2020), we studied non-sedated COVID-19 patients requiring early (< 7 days) respiratory support with helmet continuous positive airway pressure (HCPAP) or high flow nasal cannula (HFNC). Concomitant pulmonary embolism and/or bacterial pneumonia represented exclusion criteria. After signing a written informed consent, participants were assigned to a random sequence of seated (trunk elevation > 60°, legs down at 45°), supine and prone position (both recumbent at 0°) during constant respiratory support as set by the attending physician. Blood gases, respiratory rate, dyspnea and discomfort, basic hemodynamics and, when available, cardiac output (CNAP®, CNSystems Medizintechnik GmbH) were assessed twenty minutes from each decubitus. A threshold of ≥ 20% increase in PaO2 defined supine responders (supine vs seated) and prone responders (prone vs supine). The primary outcome was the frequency of orthodeoxia (supine responders). R-3.5.2 was used for statistical computing: Wilcoxon test for median comparisons, Fisher exact test for contingency tables, two-sided p < 0.05 for significance.
After excluding 28 eligible patients (21 for pulmonary embolism, 7 for superimposed bacterial pneumonia), 30 were recruited in two months (February–March 2021); two declined to participate. Results and baseline characteristics of the 28 enrolled patients are summarized in Table 1. Orthodeoxia was detected in 14 (50%) of them, with a far higher PaO2 increase (31 [26–44] mmHg), than what normally required to define it (4 mmHg) . Neither the starting decubitus (p = 0.33), nor the type of respiratory support (HCPAP or HFNC, p = 1.00) affected this result, and the stability of cardiac output from seated to supine minimizes the possibility that macro-hemodynamics played any significant role. A decrease in respiratory rate in the absence of dyspnea and discomfort was also associated with supination in our population. During proning, patients with and without orthodeoxia behaved similarly: respectively, 6 (46%) and 5 (36%) were prone responders (p = 0.70, median PaO2 increase 65[30–92] mmHg). This suggests that orthodeoxia cannot anticipate the response to proning, likely because of the unpredictable balance between perfusion redistribution and parenchymal reaeration in the ventral position . However, the finding of orthodeoxia avoided overestimating the benefits of awake-pronation in 6 patients (22%) whose oxygenation improvement was due to lying recumbent at 0°, irrespective of prone or supine specifically (Fig. 1, green dots). Considering that the ventral decubitus was associated with discomfort, higher respiratory and heart rate, the decision to prone would be questionable in these patients.
In conclusion, orthodeoxia appears a common clinical feature of early COVID-19 pneumonia. This novel finding contributes to further distinguishing COVID-19 from other causes of ARDS [1, 2, 6], while reinforcing its advocated similarity with HPS [3, 4]. Additionally, detecting orthodeoxia may help avoid awake-pronation when oxygenation simply benefits from recumbency: in a pandemic scenario, this possibly relevant clinical implication would deserve confirmation by larger studies.
Availability of data and materials
The dataset used and analysed for this study is available from the corresponding author upon reasonable request.
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Ethics approval and consent for participation
This study was approved by Città della Salute e della Scienza (00581/2020) University Hospitals’ Research Ethics Board (Turin, Italy). Every patient approved to participate by signing a written informed consent.
Patient consent for publication
Acquired (written and signed by each participant).
The authors declare that they have no competing interests.
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Giosa, L., Payen, D., Busana, M. et al. Orthodeoxia and its implications on awake-proning in COVID-19 pneumonia. Crit Care 25, 429 (2021). https://doi.org/10.1186/s13054-021-03859-0