Skip to main content

Assessment of bedside lower limb angiography combined with continuous NIRS monitoring for the detection of lower limb complications of VA-ECMO: an observational monocentric study

Abstract

Trial registration: ClinicalTrials.gov Identifier: NCT03910062.

Dear Editor,

Peripheral VA-ECMO is used as a temporary cardiac support in stage D and E of cardiogenic shock [1]. To prevent lower limb ischemia due to the occlusive effect of the arterial cannula in the femoral artery, a limb reperfusion cannula is usually placed in the ipsilateral superficial femoral artery [2]. A few published case reports suggest that angiography through the reperfusion cannula is efficient to detect and monitor the treatment of the arterial adverse events during VA-ECMO [3, 4]. This procedure has never been correctly formalized and evaluated.

This monocentric study is a prospective evaluation of a strategy to prevent lower limb complications during VA-ECMO with a systematic arterial angiography through the reperfusion line, on VA-ECMO implantation and when limb ischemia is suspected, in addition to continuous lower-limb near infrared spectroscopy (NIRS) monitoring (https://clinicaltrials.gov/ct2/show/NCT03910062). When performed in the ICU, a digital mobile X-ray device was used with the panel sensor placed underneath the patient's leg to ensure the of visualization of both the superficial femoral and the popliteal arteries. A 10 ml to 20 ml dose of iodinated contrast was injected through the three-way stopcock towards the reperfusion cannula, followed by the X-ray acquisition. Lower limb tissue oxygenation was continuously monitored by NIRS (Masimo-Root® with O3®-Regional Oximetry). Limb ischemia was defined as a NIRS value < 50% on the ipsilateral limb and/or a differential between lower limbs >15% [5]. The primary outcome was the incidence of severe lower limb ischemia (ischemia leading to a surgical intervention, functional sequelae, extremities necrosis or compartment syndrome) at day 60.

From June 2019 to April 2020, 39 consecutive patients were included at Nancy's Teaching Hospital. Patients’ characteristics and outcomes are reported in Table 1. Indication for VA-ECMO was refractory cardiogenic shock (n = 14) or refractory cardiac arrest (n = 25). Eleven (28%) patients were cannulated with a percutaneous ultrasound-guided technique and 28 (72%) by surgical cut-down. The high rate of refractory cardiac arrest explains the high rate of surgical cut-downs as the surgical technique being preferred at our center for extracorporeal cardiopulmonary resuscitation. The reperfusion cannula was a 6F (AVANTI® + , Cordis, USA) sheath introducer (ultrasound-guided percutaneous insertion or under visual control in case of surgical cut-down).

Table 1 Characteristics of the study population and outcomes

Forty-three angiographies were performed during the study period. Thirty-seven angiographies were performed at VA-ECMO implantation (not performed = 2). Six adverse events related to the reperfusion cannula were detected at VA-ECMO implantation: four misplacements (in the deep femoral artery or the femoral vein), one reperfusion cannula kinking and one hemorrhage secondary to an arterial puncture (Fig. 1). The detection of reperfusion cannula abnormalities at VA-ECMO implantation allowed a prompt intervention without subsequent limb ischemia. The four misplacements occurred with the surgical technique under high doses of norepinephrine.

Fig. 1
figure1

Common findings on the bedside-angiography after VA-ECMO implantation. a Normal angiography showing an opacification of the superficial femoral and popliteal arteries. b Angiography of a reperfusion cannula misplaced in the deep femoral vein. c Reperfusion cannula misplaced in the deep femoral artery. d An active hemorrhage following a previous failed attempt of placing the reperfusion cannula

During the run of VA-ECMO, nine ischemic events were suspected based on NIRS criteria. The cause for limb ischemia was obvious in three cases (e.g. reperfusion cannula thrombosis) and a bedside angiography was performed for the six remaining. The angiographic findings were: two thrombosis, one vasospasm, one with both and two normal. One patient (arterial thrombosis on angiography) ultimately required an amputation. The remaining ischemic events were all resolutive with a medical treatment (e.g. vasodilators, ECMO flow increase). There was no complication recorded due to the angiography procedure.

In conclusion, bedside angiography through the lower limb reperfusion is a safe and efficient procedure in the management of arterial complications during VA-ECMO. Combined with continuous NIRS monitoring, this technique allows a fast diagnosis of vasospasm or thrombosis when ischemia is suspected. Performed at VA-ECMO implantation, it confirms that the reperfusion cannula is properly positioned in the superficial femoral artery.

Availability of data and materials

The datasets used and/or analysed during the current study are available from the corresponding author on reasonable request.

References

  1. 1.

    de Chambrun MP, Donker DW, Combes A. What’s new in cardiogenic shock? Intensive Care Med mai. 2020;46(5):1016–9.

    Article  Google Scholar 

  2. 2.

    Bonicolini E, Martucci G, Simons J, Raffa GM, Spina C, Coco VL, et al. Limb ischemia in peripheral veno-arterial extracorporeal membrane oxygenation: a narrative review of incidence, prevention, monitoring, and treatment. Crit Care Lond Engl. 2019;23(1):266.

    Article  Google Scholar 

  3. 3.

    Gordon C, Ghodsizad A, Brehm C, Koerner MM, El-Banayosy A. Improved angiographic findings of superficial femoral artery after verapamil injection into the reperfusion cannula of a patient on peripheral venoarterial ECMO. Heart Surg Forum. 2014;17(5):E261-262.

    Article  Google Scholar 

  4. 4.

    Arroyo D, Bendjelid K, Robert-Ebadi H, Rigamonti F, Siegenthaler N, Giraud R. Suspected Arterial Vasospasm in Femoro-Femoral Venoarterial Extracorporeal Life Support. ASAIO J. 2017;63(3):e35-8.

    Article  Google Scholar 

  5. 5.

    Patton-Rivera K, Beck J, Fung K, Chan C, Beck M, Takayama H, et al. Using near-infrared reflectance spectroscopy (NIRS) to assess distal-limb perfusion on venoarterial (V–A) extracorporeal membrane oxygenation (ECMO) patients with femoral cannulation. Perfusion. 2018;267659118777670.

Download references

Acknowledgements

None.

Funding

This research received no specific grant from any funding agency in the public, commercial, or not-for-profit sectors.

Author information

Affiliations

Authors

Contributions

MK drafted the manuscript and participated in the design of the study. AK participated in the design of the study, performed the statistical analysis and helped to draft the manuscript. MM, JPM and BL participated in the design and coordination of the study and helped to draft the manuscript. All authors read and approved the final manuscript.

Corresponding author

Correspondence to Bruno Levy.

Ethics declarations

Ethics approval and consent to participate

The protocol was submitted to and validated by an ethics committee (Comité d’Ethique CHRU de Nancy, Ref 2019/215). Considering that post cannulation angiography is a standard of care procedure in our unit, this research is classified, according to French law, MR00-3: “Research in the Field of Health Without Collection of Consent”. All patients were informed that their medical data were anonymously included in the study. Patients had the possibility not to participate in the study.

Consent for publication

Not applicable.

Competing interests

Pr Kimmoun received speaker’s honoraria from Aspen and Aguettant. Pr Levy received speaker’s honoraria from Getinge and Abiomed. The other authors declare no conflict of interest related to the submitted paper.

Additional information

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Koszutski, M., Mattei, M., Maureira, J.P. et al. Assessment of bedside lower limb angiography combined with continuous NIRS monitoring for the detection of lower limb complications of VA-ECMO: an observational monocentric study. Crit Care 25, 270 (2021). https://doi.org/10.1186/s13054-021-03703-5

Download citation