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Development of a work of breathing scale and monitoring need of intubation in COVID-19 pneumonia

COVID-19 pneumonia presents in most patients with scattered areas of lung involvement within healthy lungs displaying hypoxemia and tachypnea but with relatively minor reductions in lung compliance [1, 2]. Noninvasive ventilation and high-flow nasal cannula (HFNC) are reasonable initial interventions reserving endotracheal intubation for worsening disease severity evidenced by increased work of breathing (WOB), risking respiratory muscle fatigue leading to hypoventilation, hypoxemia, and cardiac arrest and large transpulmonary pressure swings risking patient self-inflicted lung injury (SILI) [3, 4].

Experts have suggested use of esophageal manometry (as surrogate of pleural pressure) and consider intubation when pressure swings exceeds 15 cm H2O identifying risk of SILI [5]. However, monitoring esophageal manometry in non-intubated patients is not a practical option. We previously developed a noninvasive WOB scale ranging from 1 to 7 based on respiratory physiology, combining the respiratory rate with use of respiratory accessory muscles (Fig. 1).

Fig. 1
figure1

Work of breathing scale assigning points to the respiratory frequency and activation of respiratory accessory muscles. Nasal flaring is determined visually by noticing widening of the nostrils during inspiration while standing at approximately one-meter from the patient. Activation of the sternocleidomastoid is determined by gentle palpation of its clavicular insertion using two fingers from the hand ipsilateral to the patient’s side noticing increased tension during inspiration. Activation of abdominal muscles is determined by gentle palpation of the abdomen using the hand ipsilateral to the patient’s side noticing increased tension during expiration

We tested the ability of healthcare providers to rapidly learn and apply our WOB scale. We first trained a team of “super-raters” composed of ICU nurses and internal medicine residents. Next, we identified a group of nurses, medical students, residents, and attendings naïve to the WOB scale and designated them as “raters”. Super-raters trained raters using a 4-min WOB scale video and tested their ability to correctly rate the WOB level in 80 non-intubated patients from the Emergency Department, medical wards, and the ICU with WOB ranging from 1 to 5. A total of three assessments per patient were completed showing a high correlation between the super-raters and raters 1 (r = 0.93; p < 0.001), super-raters and raters 2 (r = 0.91; p < 0.001), and between the two raters (r = 0.84; p < 0.001). In addition, the interrater reliability between the two raters measured by the Krippendorf’s α test was also high at 0.85 (95% CI, 0.78–0.91).

We then examined the relationship between the respiratory rate and activation of respiratory accessory muscles in 110 patients (by adding 30 patients to the original 80 patients). As shown in Fig. 2, there was a low incidence of accessory respiratory muscle use when the respiratory rate was ≤ 20, yet with increased respiratory rate, the use of accessory respiratory muscles proportionally increased.

Fig. 2
figure2

Left graph shows the percentage of patients who had activation of at least one of the accessory muscles assessed by the work breathing scale as a function of respiratory rate. Right graph shows the mean and standard deviation of the work breathing scale as a function of respiratory rate with the discontinuous line indicating the contribution of the respiratory rate alone (right). Analysis performed in 110 patients. Overall differences were analyzed using SigmaPlot 12.5 by chi-square on the left and by one-way analysis of variance on the right

We examined the performance of our WOB scale in 10 patients admitted to the ICU with radiographic evidence of extensive COVID-19 pneumonia, significant hypoxemia, and multiple risk factors associated with poor outcome. Their mean age was 63 years (95% CI 50 to 75) and stayed in the ICU for 8 days (95% CI 5 to 10). Nine patients received HFNC over 6 days (95% CI 3 to 8). The WOB level was measured every 4 h. The maximum WOB was 4.3 (95% CI 3.6 to 5.0), contributed primarily by respiratory rate with a score of 3.6 (95% CI 3.2 to 4.0) and infrequent use of respiratory accessory muscles. All 10 patients survived without need of intubation. For comparison, three other patients who needed intubation had a maximal work of breathing within the preceding 24 h of 5.3 (95% CI 2.5 to 8.2). The respiratory rate score was 3.8 (95% CI 2.2 to 5.1) similar to non-intubate patients but with more often use of respiratory accessory muscles.

Our data suggest that patients with COVID-19 pneumonia can be supported for extended periods using HFNC despite tachypnea provided there is only infrequent and modest use of respiratory accessory muscles, corresponding to a WOB scale ≤ 4, prompting closer assessment for possible intubation when WOB > 4. This approach would be especially advantageous under conditions of high disease intensity when avoidance of intubation is likely to result in a better outcome [6]. Further work in a larger cohort of patients is awaited.

Availability of data and materials

The dataset used for the current study is available from the corresponding author on reasonable request.

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Contributions

MA worked on the development of the work of breathing scale and clinical testing along with data gathering. JS, ND, and MAT conducted the clinical assessment of the work of breathing scale and interrater reliability. RJG led the project, collected and analyzed the data, and wrote the manuscript. The authors read and approved the final manuscript.

Authors’ information

The first author (MA) is a Clinical Nurse Leader for the ICU and the Medical-Surgical ward who has led the incorporation of the reported work of breathing scale in the ICU as part of routine patient assessment. She has also helped incorporate the work of breathing scale as part of the hospital rapid response system, with specific emphasis on its use during the COVID-19 pandemic to recognize worsening of respiratory status of COVID-19 patients outside the ICU.

The corresponding author (RJG) is Section Chief of Critical Care Medicine and ICU Director leading the management of critically ill patients including COVID-19 patients that prompted this communication. He has had a long history of contribution to the field of Critical Care Medicine especially related to research on resuscitation from cardiac arrest and more recently from other low-flow estates including hemorrhagic shock and septic shock. He also implemented the rapid response system at his institution and was instrumental in the development of the work of breathing scale herein reported after recognizing that a high incidence of in-hospital cardiac arrests are preceded by unrecognized worsening of respiratory muscle function followed by respiratory muscle fatigue.

Corresponding author

Correspondence to Raúl J. Gazmuri.

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The study “Work of Breathing: Development and Validation of a Simple Bedside Scale” was approved by the Edward Hines, Jr. VA Hospital/Capt. James Lovell FHCC Institutional Review Board, protocol number 1025647-7.

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Written informed consent was obtained from the volunteer for publication of this Research Letter and any accompanying images.

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The authors declare that they have no competing interests.

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Apigo, M., Schechtman, J., Dhliwayo, N. et al. Development of a work of breathing scale and monitoring need of intubation in COVID-19 pneumonia. Crit Care 24, 477 (2020). https://doi.org/10.1186/s13054-020-03176-y

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