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- Open Access
Prehospital pulse oximetry: a red flag for early detection of silent hypoxemia in COVID-19 patients
Critical Care volume 24, Article number: 313 (2020)
The COVID-19 pandemic, which has been expanding since the first cases in Asia in late 2019, may result in acute respiratory failure (ARF) with severe hypoxemia [1,2,3]. In prehospital settings, the paucity of clinical respiratory signs has made assessing the severity of some COVID-19 patients challenging. Indeed, even though hypoxic ARF generally leads to an increase in respiratory rate (RR) , in some COVID-19 patients, a persistent normal RR was inconsistent with the severity of hypoxia.
Based on retrospective data, we aimed to describe the discrepancy between prehospital initial RR (RRi) and initial SpO2 (Spo2i; i.e., before oxygen supplementation, FiO2 = 21%) in COVID-19 patients suffering from ARF.
We retrospectively examined consecutive COVID-19 patients suffering from ARF who were treated by the Paris Fire Brigade’s basic life-support (BLS) teams in the prehospital setting. Data were provided from primary home care providers. Based on a previous study , we used the SpO2i/RRi ratio as an estimator of the discrepancy insofar as a low numerator is associated with hypoxia, whereas a high denominator is typically associated with respiratory failure.
After having measured the SpO2i/RRi values in COVID-19 patients, we compared them to those of non-COVID-19 patients (i.e., patients with other causes of ARF treated by the BLS teams over the previous 3 years in the same period).
Continuous data were described as median (interquartile range) and were compared by applying the Kruskal-Wallis test. The French Society of Anaesthesia and Intensive Care approved the trial protocol on April 7, 2020 (IRB 00010254-2020-055).
The study examined 1201 patients who experienced COVID-19 between March 13 and 29, 2020. The median SpO2i/RRi value was significantly higher than that of patients treated in the previous 3 years (5 [4, 5] in 2020 versus 3.4 [2.4–4.5] in 2019, 3.3[2.2–4.4] in 2018, and 3.5[2.5–4.6] in 2017, p < 0.001, Fig. 1).
In summary, this retrospective study based on prehospital first responder data highlighted a relatively higher discrepancy between SpO2i and RRi in COVID-19 ARF patients, in comparison with previous non-COVID-19 ARF patients. Without a systematic SpO2i measurement, a normal breathing rate could mask profound hypoxia and make severity assessment in COVID-19 patients all the more difficult in an out-of-hospital setting.
Despite differences in worldwide prehospital emergency medical services, pulse oximetry is an accessible tool that prehospital healthcare providers can easily use.
In conclusion, prehospital pulse oximetry might be used as a red flag for early detection of “silent hypoxemia” in COVID-19 patients. The prehospital SpO2i/RRi ratio needs further investigation because it might help to identify non-clinically obvious ARFs.
Availability of data and materials
The datasets used and/or analyzed during the current study are available from the corresponding author on reasonable request.
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Thanks to the Paris Fire Brigade Basic Life Support Teams for their daily engagement during the pandemic.
Ethics approval and consent to participate
As a retrospective study design, the study protocol has been submitted to the Ethics Committee of “The French Society of Anaesthesia and Intensive Care.” The trial protocol was approved on April 7, 2020 (IRB 00010254-2020-055).
Consent for publication
The authors declare that they have no competing interests.
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Jouffroy, R., Jost, D. & Prunet, B. Prehospital pulse oximetry: a red flag for early detection of silent hypoxemia in COVID-19 patients. Crit Care 24, 313 (2020). https://doi.org/10.1186/s13054-020-03036-9