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A longitudinal cohort of stress cardiomyopathy assessed with speckle-tracking echocardiography after moderate to severe traumatic brain injury

Research letter

Stress cardiomyopathy is common after subarachnoid haemorrhage (SAH): 36% of patients display stress cardiomyopathy patterns assessed with speckle-tracking echography [1], which is a gold standard in the evaluation of left ventricular longitudinal systolic function. After traumatic brain injury (TBI), stress cardiomyopathy has been little described [2]. We performed a monocentric longitudinal study in moderate to severe TBI patients (Glasgow coma score ≤ 12). Consecutive patients were included. This study was approved by the local ethics committee (Groupe Nantais d’Ethique dans le Domaine de la Santé – IRB No. 6.02.2014). We a priori decided to include 100 patients in order to potentially detect 30 patients with sub-clinical stress cardiomyopathy [1]. The primary goal was to assess the incidence of stress cardiomyopathy with speckle-tracking echocardiography and the evolution of the global longitudinal strain (GLS) at day 1, day 3, and day 7. The secondary outcomes were the evolution of 2-dimensional echocardiographic parameters (LVEF, mitral E/A and E/E’ ratio, mitral S wave, TAPSE). Since stress cardiomyopathy is due to a major catecholamine increase in plasma [3], we explored the adrenergic response by comparing baseline blood levels of metanephrine and normetanephrine in patients with TBI and SAH admitted in our institution, matched on age and baseline GCS (biocollection IBIS – NCT 02426255). We included 100 patients from March 2014 to August 2017. The mean age was 42.6 (± 19.6) years and the baseline Glasgow coma score was 7 [4–10]. We included 75 (75%) male and 25 (25%) female patients. Twenty (20%) patients died in the ICU. At day 1, GLS (− 20.3 [± 3.6]%) and LVEF (66 [± 11]%) were preserved. The mean GLS was preserved at day 3 (− 22.2 [± 3.6] %) and at day 7 (− 20.7 [± 3.3] %). Nine (9%) patients displayed impaired GLS (− 13.3[− 14.5; − 11.6]%) at baseline. In these patients, there was a significant improvement at day 3 (− 22.2 [− 25.1; − 18.7]%) and day 7 (− 21.1 [− 23.2; − 18.1]%) (p < 0.0001), compatible with stress cardiomyopathy. These 9 patients had the same age (32 [23–48] vs 46 [23–60], p = 0.4), had a non-significant baseline ultra-sensitive troponin increase (16 [8–229] vs 9 [5–29] ng/mL−1, p = 0.1), and had similar Glasgow (10 [3–12] vs 7 [4–9], p = 0.3) and Marshall scores (p = 0.8) compared to the rest of the cohort. Three patients suffered from isolated TBI, and two from TBI associated with mild abdominal trauma or vertebral fracture, all due to road traffic accidents. The remaining four patients suffered from isolated TBI after a fall. These mechanisms did not seem to differ from the rest of the cohort.

In the overall cohort, right ventricular TAPSE at day 1 was preserved (21.6 (± 7.6) mm) and significantly improved at day 3 (24.8 (± 5.3) mm, p = 0.003). There was no significant modification of LVEF, the E/A and E/E’ ratios, or lateral S wave. In order to assess the adrenergic response, we measured baseline metanephrine and normetanephrine blood levels in 15 SAH and 15 TBI patients. There was no significant difference in normetanephrine (2.5 [0.7–4.2] nmol/L−1 vs 2.9 [1–4.4] nmol/L−1, p = 0.6) and metanephrine (0.2 [0.17–0.23] nmol/L−1 vs 0.17 [0.1–0.21] nmol/L−1, p = 0.2) plasma levels between SAH and TBI patients (Fig. 1), which challenges the adrenergic response as the only trigger for stress cardiomyopathy. However, the plasma levels were not measured just after the onset of brain injury, and considering that the catecholamine levels may rapidly change over time along with the modest sample size, we cannot ascertain that blood levels are comparable between TBI and SAH patients.

Fig. 1
figure1

Baseline blood levels of metanephrine and normetanephrine in 30 patients with TBI or SAH admitted in a single institution

Stress cardiomyopathy occurs after traumatic brain injury, recovers promptly, but is less common (≈ 10%) than after SAH (≈ 35%). The raised baseline metanephrine and normetanephrine was comparable in our sample of TBI and SAH patients. Sympathetic hyperactivation is perhaps not the only mechanism involved in stress cardiomyopathy.

Availability of data and materials

The datasets used and/or analysed during the current study are available from the corresponding author on reasonable request.

Abbreviations

TBI:

Traumatic brain injury

GLS:

Global longitudinal strain

TTE:

Trans-thoracic echocardiography

SAH:

Aneurysmal subarachnoid haemorrhage

LVEF:

Left ventricular ejection fraction

LV:

Left ventricle

ICU:

Intensive care unit

GCS:

Glasgow Coma Score

TAPSE:

Tricuspid annular plane systolic excursion

References

  1. 1.

    Cinotti R, Piriou N, Launey Y, Le Tourneau T, Lamer M, Delater A, et al. Speckle tracking analysis allows sensitive detection of stress cardiomyopathy in severe aneurysmal subarachnoid hemorrhage patients. Intensive Care Med. 2016;42:173–82.

  2. 2.

    Krishnamoorthy V, Rowhani-Rahbar A, Gibbons EF, Rivara FP, Temkin NR, Pontius C, et al. Early systolic dysfunction following traumatic brain injury. Crit Care Med. 2017;45:1028–36.

  3. 3.

    Lyon AR, Rees PS, Prasad S, Poole-Wilson PA, Harding SE. Stress (Takotsubo) cardiomyopathy—a novel pathophysiological hypothesis to explain catecholamine-induced acute myocardial stunning. Nat Clin Pract Cardiovasc Med. 2008;5:22–9.

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Acknowledgements

We thank the biological resource centre for biobanking (CHU Nantes, Hôtel Dieu, Centre de ressources biologiques (CRB), Nantes, F-44093, France (BRIF: BB-0033-00040)).

Funding

Support was provided solely from institutional and/or departmental sources.

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Authors

Contributions

RC and TLT designed the study. RC included the patients, performed the TTEs and GLS analysis and statistical analysis, analysed the results, and wrote the article. KA and TLT analysed the results and wrote the article. KNB performed the metanephrine and normetanephrine dosages, analysed the results, and edited the manuscript. MLM included the patients on site and edited the manuscript. BR analysed the results and edited the manuscript. The author(s) read and approved the final manuscript.

Corresponding author

Correspondence to Karim Asehnoune.

Ethics declarations

Ethics approval and consent to participate

Study approved by the local ethics committee (Groupe Nantais d’Ethique dans le Domaine de la Santé – IRB No. 6.02.2014). Biocollection IBIS, CPP Nantes Ouest IV, IRB approval no. 46/11.

Consent for publication

Not applicable

Competing interests

Pr Karim Asehnoune received fees from Baxter, Edwards, LFB, Fisher and Payckel. Pr Bertrand Rozec received fees from Baxter, Ethypharm, LFB, NordicPharma, Haemonetics, Fisher and Payckel, AstraZeneca. Pr Thierry Le Tourneau received speaker fees from Philips, Bayer and Shire. The other authors do not have other conflicts of interest to declare.

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Cinotti, R., Le Tourneau, T., Bach-Ngohou, K. et al. A longitudinal cohort of stress cardiomyopathy assessed with speckle-tracking echocardiography after moderate to severe traumatic brain injury. Crit Care 24, 216 (2020). https://doi.org/10.1186/s13054-020-02935-1

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Keywords

  • Stress cardiomyopathy
  • Traumatic brain injury
  • Speckle-tracking echocardiography