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Table 5 Characteristics of patients who received steroids (n = 10) compared to matched controlled patients (n = 60) who did not received steroidsa

From: Severe varicella-zoster virus pneumonia: a multicenter cohort study

  No steroid use (n = 60) Steroids use (n = 10) p
Demographics
 Age, years 43 (34–56) 48 (35.5–60.75) 0.60
 Male gender 38 (63%) 5 (50%) 0.49
 Co-morbidities 55 (92%) 9 (90%) 1.00
 Underlying immunosuppression 33 (55%) 7 (70%) 0.50
Year of ICU admission 2009 (2006–2012) 2010 (2008–2012) 0.48
Time (days) from dyspnea onset to ICU admission 2 (1–3) 2 (1–3.25) 0.79
Parameters at ICU admission
 Temperature, °C 39.1 (38.25–39.7) 39.4 (38.85–40.8) 0.22
 Respiratory rate, breaths/min 30 (26.5–38.5) 35 (32–35) 0.34
 Oxygen flow, L/min 10 (5–15) 8.5 (1.5–15) 0.55
 Hemoptysis 6 (10%) 0 (0%) 0.58
 PaO2:FiO2 ratio, mmHg 105 (75.5–174.5) 86 (80.5–210) 1.00
 SOFA score at day 1 5 (4–9) 7 (5–7.75) 0.55
ICU management
 Invasive mechanical ventilation 36 (60%) 9 (90%) 0.08
 Time (days) from ICU admission to intubation 1 (1–2) 1 (1–1) 0.30
 ARDS criteria according to the Berlin definition 31 (52%) 7 (70%) 0.33
 Length of invasive mechanical ventilation, days 13.5 (7–17.25) 28 (13–53) 0.06
 Bacterial superinfection 26 (43%) 8 (80%) 0.04
Outcome data
 ICU length of stay, days 10 (4–17) 32 (10.75–69.5) 0.01
 Hospital length of stay, days 16.5 (10–32.25) 40.5 (21.25–74) 0.02
 ICU mortality 12 (20%) 2 (20%) 1.00
 Hospital mortality 15 (25%) 6 (60%) 0.06
  1. Values are shown as n (%) or median (25th–75th percentiles)
  2. aPatients who received steroids were matched in a 1:6 ratio to a control group of patients who did not receive steroids. Matched controls were screened from the current cohort with the following four matching criteria: age, year of ICU admission, SOFA score at day 1, and ARDS criteria according to the Berlin definition
  3. ARDS acute respiratory distress syndrome, ICU intensive care unit, PaO 2 :FiO 2 ratio of arterial oxygen partial pressure to fractional inspired oxygen, SOFA Sequential Organ Failure Assessment