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Table 2 Nutritional intake

From: A randomized controlled pilot study to evaluate the effect of an enteral formulation designed to improve gastrointestinal tolerance in the critically ill patient—the SPIRIT trial

  Peptamen® AF (n = 46) Isosource® Energy (n = 44) Treatment effect p value
  n Median (IQR) n Median (IQR) Median differencea (95% CI)  
Calorie intake, Kcal/kg/day 41 18.0 (12.5–20.9) 38 19.7 (17.3–23.1) −2.6 (−5.3 to 0.2) 0.08
Protein intake, g/kg/day 41 1.13 (0.78–1.31) 38 0.80 (0.70–0.94) 0.27 (0.12–0.43) <0.001
Accumulated caloric deficit during EN/day, Kcal 45 −410 (−984 to −115) 43 −171 (−455 to −4) −222 (−438 to −45) 0.014
  n Median (95% CI) n Median (95% CI) HR (95% CI)  
Length of EN, days 46 5.0 (3.6– to 6.4) 44 7.0 (5.3– to 8.7) 1.35 (0.80–2.26) 0.26
Time to reach the full caloric goal, days 46 2.2 (0.8– to 3.7) 44 2.0 (1.3– to 2.7) 0.70 (0.42–1.16) 0.16
  n No. of events (pd) n No. of events (pd) Rate ratio (95% CI)  
Days with parenteral nutrition supplementation 46 5 (253 pd) 44 2 (287 pd) 2.84 (0.28–28.61) 0.38
  1. a Hodges–Lehmann median differences
  2. CI confidence interval, EN enteral nutrition, HR hazard ratio, IQR interquartile range, pd person days