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Table 3 Cerebral haemodynamics in critical illness

From: Regulation of the cerebral circulation: bedside assessment and clinical implications

Critical illness Effect of disease on cerebral haemodynamics Does the cerebral haemodynamic parameter relate to prognosis?
Flow Cerebral autoregulation CO2 reactivity Flow Cerebral autoregulation CO2 reactivity
TBI Decreased [45, 46, 111] then increased [46, 112] Decreased [44, 113] Decreased [44, 49, 114, 115] Yes: decreased [4446, 111] and increased [44, 112] CBF related to poor outcome Yes [44, 47] Most studies find yes [44, 49], while some find no [51]
SAH Decreased (vasospasm) [14, 55] Decreased [54, 56] Decreased [55] Yes [62] Yes [60, 62, 116] Yes [117]
Stroke Decreased [66, 67, 118] Decreased [70, 71] Decreased [68, 69] Yes [66, 67] Yes [71] Yes [69]
Sepsis Unchanged [78, 81], or decreased [5] Unchanged [82], decreased [78, 79], or increased [83, 84] Unchanged [82] or decreased [77] Unknown Unknown Unknown
Preterm infants Decreased [87, 89, 119] Unchanged [93] or decreased [87, 88] Decreased [88, 90] Yes [119] Yes [88, 95, 120] Yes [88, 90]
  1. CBF cerebral blood flow, CO 2 carbon dioxide, SAH, subarachnoid haemorrhage; TBI, traumatic brain injury