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Table 3 Commonly seen autoimmune antibodies, their related encephalitidis and associated abnormal movements listed in alphabetical order

From: Abnormal movements in critical care patients with brain injury: a diagnostic approach

Autoantibody Clinical syndrome Associated disease Abnormal movement
Anti-amphiphysin Encephalomyelitis Breast cancer, SCLC Myoclonus and seizures
Anti-CV2/CRMP-5 Encephalomyelitis, limbic encephalitis, retinitis and sensory neuropathy SCLC, lymphoma Seizures, chorea
Anti-Ri Brain stem encephalitis SCLC, breast cancer Opsoclonus-myoclonus
Anti-NMDA Limbic encephalitis Ovarian teratoma Seizures, orofacial dyskinesia, choreoathetosis, dystonia and combination of abnormal movements
Anti-AMPA Limbic encephalitis SCLC, thymoma Seizures
Anti-GABA Limbic encephalitis SCLC Seizures
Anti-TPO Encephalitis May be associated with thyroiditis Seizures, myoclonus, tremor and chorea
Antiphospholipid antibodies Encephalitis, strokes Primary or in the setting of SLE Seizures, chorea
  1. Paraneoplastic antibodies, their associated tumors, clinical syndromes and abnormal movements. AMPA α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid, CRMP-5 collapsin response mediator protein, GABA gamma aminobutyric acid, NMDA N-methyl-D-aspartate, SCLC small cell lung cancer, SLE systemic lupus erythematosus, TPO thyroid peroxidase