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Bone - a casualty of ICU survival?
Critical Care volume 19, Article number: 253 (2015)
We read with great interest the pilot study on fracture risk in 46 critically ill patients by Rawal and colleagues . Bone mineral density (BMD) was assessed with portable calcaneal dual X-ray absorptiometry (DXA) on days 1 and 10. The authors found no overall change in BMD, but increased fracture risk in the subgroup with 'ARDS' (acute respiratory distress syndrome) (n = 34). There are several serious methodological problems: it is unclear if the group assignment is valid as only one of the four Berlin definition criteria  for the diagnosis of ARDS is given: oxygenation (no information on timing, chest imaging and origin of the edema). Although peripheral DXA devices are certainly an interesting option for BMD in critically ill and other patients , precision errors supplied by the manufacturer should not be used. In fact, each center must determine its (own) precision error and least significant change, which is also operator dependent . The manufacturer stated a 0.9 % coefficient of variation, which is not necessarily applicable to the study setting where it remains unclear how the measurements were performed. This could be an important limitation. Hence, it is unlikely that a 2 % BMD change within such a short time frame as described would reflect anything else other than random variability. Lastly, it is also unclear what the described statistical difference refers to - it should be noted that the smaller subgroup (n = 12) numerically increased their BMD. Undoubtedly, fracture risk following critical illness is a very important topic that requires further high-quality studies .
Acute respiratory distress syndrome
Bone mineral density
Dual energy X-ray absorptiometry
Rawal J, McPhail MJ, Ratnayake G, Chan P, Moxham J, Harridge SD, et al. A pilot study of change in fracture risk in patients with acute respiratory distress syndrome. Crit Care. 2015;19:165.
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The authors declare that they have no competing interests.
HPD is Vice Rector for Teaching and Studies at the Medical University of Graz.
See related research by Rawal et al., http://ccforum.com/content/19/1/165
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Amrein, K., Fahrleitner-Pammer, A. & Dimai, H.P. Bone - a casualty of ICU survival?. Crit Care 19, 253 (2015). https://doi.org/10.1186/s13054-015-0977-7
- Bone Mineral Density
- Fracture Risk
- Respiratory Distress Syndrome
- Acute Respiratory Distress Syndrome
- Critical Illness