- Poster presentation
- Open Access
The normobaric oxygen paradox: does it increase haemoglobin?
© Theunissen et al. 2011
- Published: 1 March 2011
- Public Health
- Healthy Volunteer
- Clinical Application
- Emergency Medicine
A novel approach to increase erythropoietin (EPO) using oxygen has been reported in healthy volunteers. The purpose of this study is to investigate whether the EPO increase is sufficient to induce erythropoiesis.
We compared exposure to daily versus every other day oxygen administration on haemoglobin variation during a 12-day period. Each subject underwent the two protocols at a 6-week interval period to achieve the same baseline values.
The normobaric oxygen paradox seems effective to increase haemoglobin in non-anaemic healthy volunteers assuming there is a sufficient time interval between the two oxygen applications. This could permit interesting clinical applications in perioperative medicine as an adjunct therapy to EPO for blood predonation.
This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.