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- Open Access
Early administration of hydrocortisone replacement after advent of septic shock is a major determinant of final outcome
- Published: 1 March 2011
Keywords
- Public Health
- Regression Analysis
- Hydrocortisone
- Septic Shock
- Emergency Medicine
Introduction
The CORTICUS trial doubts the value of hydrocortisone replacement for final outcome of septic shock [1]. We hypothesized that the time of starting hydrocortisone may impact on the final outcome.
Methods
Retrospective analysis was made of prospectively collected data for 41 patients with septic shock (ACCP/SCCM 1992 definition) in the past year in two ICUs. Hydrocortisone was infused as suggested [2]. The time lapsing from start of vasopressors until start of hydrocortisone was determined by the patients' charts.
Results
Survival in relation to start of hydrocortisone.
Conclusions
Despite the observational approach, early start of hydrocortisone replacement in septic shock is a critical factor for outcome.
Authors’ Affiliations
References
- Sprung CL, et al.: N Engl J Med. 2008, 358: 111. 10.1056/NEJMoa071366View ArticlePubMedGoogle Scholar
- Marik PE, et al.: Crit Care Med. 2008, 36: 1937. 10.1097/CCM.0b013e31817603baView ArticlePubMedGoogle Scholar
Copyright
This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.