Skip to main content
  • Poster presentation
  • Open access
  • Published:

Evaluation of a continuous blood glucose monitoring system using central venous microdialysis


Glycemic control in critically ill patients has been shown to be beneficial. In this prospective study we therefore evaluated the accuracy and technical feasibility of a continuous glucose monitoring system using intravascular microdialysis.


Fifty patients undergoing cardiac surgery were monitored using a 4Fr intravenous microdialysis catheter (Eirus SLC®; CMA Micro-dialysis AB, Solna, Sweden), percutaneously placed with the tip of the catheter positioned in the superior vena cava. The catheter was connected to the Eirus monitoring system and the patients were monitored for up to 48 hours postoperatively in the ICU. As reference, arterial blood samples were taken every hour and analyzed in a blood gas analyzer (ABL800 FLEX®; Radiometer Medical, Copenhagen, Denmark).


Data were available from 48 patients. A total of 994 paired (arterial blood gas-microdialysis) samples were obtained. The glucose correlation coefficient (R2) was 0.85. Using Clarke error grid analysis, 100% of the paired samples were in region AB and 99% in region A Figure 1). The mean glucose level was 8.3 mmol/l, bias 0.2% and the mean absolute relative difference was 5%. A total 99.2% of the paired samples were correct according to ISO criteria. Bland-Altman analysis showed bias ± limits of agreement were 0.02 ± 1.1 mmol/l.

Figure 1
figure 1

Error grid analysis of arterial blood gas and microdialysis glucose samples.


Central venous microdialysis is a highly accurate and reliable method for continuous blood glucose monitoring up to 48 hours in ICU patients undergoing cardiac surgery. The system may thus be useful in critically ill ICU patients.

Author information

Authors and Affiliations


Rights and permissions

This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit The Creative Commons Public Domain Dedication waiver ( applies to the data made available in this article, unless otherwise stated in a credit line to the data.

Reprints and permissions

About this article

Cite this article

Möller, F., Liska, J. & Franco-Cereceda, A. Evaluation of a continuous blood glucose monitoring system using central venous microdialysis. Crit Care 15 (Suppl 1), P405 (2011).

Download citation

  • Published:

  • DOI: