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  • Open Access

Evaluation of a continuous blood glucose monitoring system using central venous microdialysis

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Critical Care201115 (Suppl 1) :P405

  • Published:


  • Continuous Glucose Monitoring
  • Arterial Blood Sample
  • Grid Analysis
  • Continuous Glucose Monitoring System
  • Microdialysis Catheter


Glycemic control in critically ill patients has been shown to be beneficial. In this prospective study we therefore evaluated the accuracy and technical feasibility of a continuous glucose monitoring system using intravascular microdialysis.


Fifty patients undergoing cardiac surgery were monitored using a 4Fr intravenous microdialysis catheter (Eirus SLC®; CMA Micro-dialysis AB, Solna, Sweden), percutaneously placed with the tip of the catheter positioned in the superior vena cava. The catheter was connected to the Eirus monitoring system and the patients were monitored for up to 48 hours postoperatively in the ICU. As reference, arterial blood samples were taken every hour and analyzed in a blood gas analyzer (ABL800 FLEX®; Radiometer Medical, Copenhagen, Denmark).


Data were available from 48 patients. A total of 994 paired (arterial blood gas-microdialysis) samples were obtained. The glucose correlation coefficient (R2) was 0.85. Using Clarke error grid analysis, 100% of the paired samples were in region AB and 99% in region A Figure 1). The mean glucose level was 8.3 mmol/l, bias 0.2% and the mean absolute relative difference was 5%. A total 99.2% of the paired samples were correct according to ISO criteria. Bland-Altman analysis showed bias ± limits of agreement were 0.02 ± 1.1 mmol/l.
Figure 1
Figure 1

Error grid analysis of arterial blood gas and microdialysis glucose samples.


Central venous microdialysis is a highly accurate and reliable method for continuous blood glucose monitoring up to 48 hours in ICU patients undergoing cardiac surgery. The system may thus be useful in critically ill ICU patients.

Authors’ Affiliations

Karolinska Institutet, Stockholm, Sweden


© Möller et al. 2011

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.